LOCUS       NM_021022               4899 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 11 (Abcb11),
            transcript variant 1, mRNA.
ACCESSION   NM_021022
VERSION     NM_021022.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4899)
  AUTHORS   Zhu,L., Su,W., Xu,X., Shao,S., Qin,C., Gao,R., Wang,X., Ma,M.,
            Gao,J. and Zhang,Z.
  TITLE     Sphincter of Oddi Dysfunction Induces Gallstone by Inhibiting the
            Expression of ABCB11 via PKC-alpha
  JOURNAL   Appl Biochem Biotechnol 196 (8), 5373-5390 (2024)
   PUBMED   38158489
  REMARK    GeneRIF: Sphincter of Oddi Dysfunction Induces Gallstone by
            Inhibiting the Expression of ABCB11 via PKC-alpha.
REFERENCE   2  (bases 1 to 4899)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4899)
  AUTHORS   Pang,L., Cui,M., Wu,S. and Kong,J.
  TITLE     Cav-1 regulates the bile salt export pump on the canalicular
            membrane of hepatocytes by PKCalpha-associated signalling under
            cholesterol stimulation
  JOURNAL   J Cell Mol Med 28 (3), e18110 (2024)
   PUBMED   38164042
  REMARK    GeneRIF: Cav-1 regulates the bile salt export pump on the
            canalicular membrane of hepatocytes by PKCalpha-associated
            signalling under cholesterol stimulation.
REFERENCE   4  (bases 1 to 4899)
  AUTHORS   Keller,M.P., Hawes,E.M., Schueler,K.L., Stapleton,D.S., Mitok,K.A.,
            Simonett,S.P., Oeser,J.K., Sampson,L.L., Attie,A.D., Magnuson,M.A.
            and O'Brien,R.M.
  TITLE     An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse
            Pancreatic Islets
  JOURNAL   Diabetes 72 (11), 1621-1628 (2023)
   PUBMED   37552875
  REMARK    GeneRIF: An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse
            Pancreatic Islets.
REFERENCE   5  (bases 1 to 4899)
  AUTHORS   Machacek,T., Fuchs,C.D., Winkelmann,F., Frank,M., Scharnagl,H.,
            Stojakovic,T., Sombetzki,M. and Trauner,M.
  TITLE     Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver
            pathology by reducing parasite fecundity
  JOURNAL   Liver Int 43 (11), 2469-2478 (2023)
   PUBMED   37641872
  REMARK    GeneRIF: Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver
            pathology by reducing parasite fecundity.
REFERENCE   6  (bases 1 to 4899)
  AUTHORS   Wang,R., Salem,M., Yousef,I.M., Tuchweber,B., Lam,P., Childs,S.J.,
            Helgason,C.D., Ackerley,C., Phillips,M.J. and Ling,V.
  TITLE     Targeted inactivation of sister of P-glycoprotein gene (spgp) in
            mice results in nonprogressive but persistent intrahepatic
            cholestasis
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 2011-2016 (2001)
   PUBMED   11172067
REFERENCE   7  (bases 1 to 4899)
  AUTHORS   Paigen,B., Schork,N.J., Svenson,K.L., Cheah,Y.C., Mu,J.L.,
            Lammert,F., Wang,D.Q., Bouchard,G. and Carey,M.C.
  TITLE     Quantitative trait loci mapping for cholesterol gallstones in AKR/J
            and C57L/J strains of mice
  JOURNAL   Physiol Genomics 4 (1), 59-65 (2000)
   PUBMED   11074014
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4899)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (bases 1 to 4899)
  AUTHORS   Green,R.M., Hoda,F. and Ward,K.L.
  TITLE     Molecular cloning and characterization of the murine bile salt
            export pump
  JOURNAL   Gene 241 (1), 117-123 (2000)
   PUBMED   10607905
REFERENCE   10 (bases 1 to 4899)
  AUTHORS   Bouchard,G., Nelson,H.M., Lammert,F., Rowe,L.B., Carey,M.C. and
            Paigen,B.
  TITLE     High-resolution maps of the murine Chromosome 2 region containing
            the cholesterol gallstone locus, Lith1
  JOURNAL   Mamm Genome 10 (11), 1070-1074 (1999)
   PUBMED   10556425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK144553.1, AI316041.1,
            AF186585.1, AI116345.1, AL929170.16 and AI662666.1.
            
            On Dec 29, 2006 this sequence version replaced NM_021022.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance. The
            protein encoded by this gene is the major canalicular bile salt
            transporter in humans and mice. Mutations in the human gene cause a
            form of progressive familial intrahepatic cholestases which are a
            group of inherited disorders with severe cholestatic liver disease
            from early infancy. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AK144553.1         3-102
            101-282             AK144553.1         178-359
            283-397             AI316041.1         280-394
            398-1705            AK144553.1         473-1780
            1706-2023           AF186585.1         193-510
            2024-2797           AK144553.1         2099-2872
            2798-3152           AI116345.1         165-519
            3153-3311           AK144553.1         3228-3386
            3312-3340           AL929170.16        52917-52945         c
            3341-4886           AK144553.1         3416-4961
            4887-4899           AI662666.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..4899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 39.69 cM"
     gene            1..4899
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /note="ATP-binding cassette, sub-family B member 11"
                     /db_xref="GeneID:27413"
                     /db_xref="MGI:MGI:1351619"
     exon            1..100
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            101..203
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            204..225
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            226..277
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            278..516
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            517..604
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            605..738
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            739..910
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1035
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1210
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1324
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1435
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1561
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1765
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1936
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2138
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2208
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2308
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2470
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2575
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2737
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2941
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3183
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3340
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3538
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3745
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3892
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4895
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4874..4879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /note="hexamer: AGTAAA"
     polyA_site      4895
                     /gene="Abcb11"
                     /gene_synonym="ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP"
                     /note="major polyA site"
ORIGIN      
        1 ttattaccat gaaaactgaa cttggaaagg ggtgtacaac cctgactttc cacagtggcg
       61 tctctcgctt ctcctggctc cctcaaattc acatctgtag ggttgttgag tgaagattgc
      121 agacaccatg tctgactcag tgattcttcg cagtgtgaag aaatttggag aggagaatca
      181 tgctttcgaa tcagatggtt tccataacaa tgataagaaa tcaaggttac aagataagaa
      241 gaaaggggaa ggcgctcgag ttggcttctt tgaactgttt cgattttctt catcaaaaga
      301 caactggctg atgtttatgg gaagtgtgtg cgcattgctc catggaatgg cccagccagg
      361 catgattatt gtgtttggta tactgacaga tatttttgtt gaatatgaca ttgaaagaca
      421 agaactcagt attccagaaa aagtgtgtat gaataacacc attgtatgga tcaacagctc
      481 cttcaaccag aacatgacaa acggaacaag ctgtgggttg gtggacatta acagcgaagt
      541 catcaaattt tctggcatct acgcaggagt tggtgtggct gtccttatcc taggatactt
      601 tcaaataagg ttgtgggtaa tcactggggc tcgtcagata aggaaaatga ggaaatttta
      661 ctttcggaga ataatgagaa tggaaatcgg atggtttgac tgcacttctg tgggagagct
      721 caattcaaga ttctctgatg atattaataa aattgatgaa gccattgccg accagatggc
      781 ccttttcctt cagcgcctgt cgacagcttt gtctgggctc cttttagggt tctacagggg
      841 ttggaaatta accttggtga ttctcgctgt cagtcctctc attgggattg gggcagccgt
      901 cataggtctg agtgtggcca agttcacgga gcttgagttg aaggcttatg ctaaagctgg
      961 gtctattgcc gatgaagtcc tctcatctat tcgaacagtg gctgcttttg gtggtgagaa
     1021 taaggaggtg gaaaggtatg agaaaaatct tatgtttgct cagcgctggg gaatttggaa
     1081 aggaatggtg atgggcttct tcactgggta catgtggtgt ctcattttct tctgttatgc
     1141 actggccttc tggtacggct ccagacttgt cctggatgaa ggcgagtaca caccagggac
     1201 actgatccag attttcctct gtgtcataat agcagctatg aatattggca atgcatcttc
     1261 ttgtttggaa atcttctcca ctgggtgttc agcagcttcc agtattttcc aaacaataga
     1321 caggcaaccc gtcatggact gcatgtcagg agatggttac aagctagatc gaatcaaggg
     1381 cgaaattgag ttccacaatg tgaccttcca ttatccttct cgaccagagg tgaagatttt
     1441 aaataacctc agcatggtca ttaagccagg ggaaacgacg gcgttcgtgg gatccagtgg
     1501 ggcagggaag agcacagcac tacagctcat tcagagattc tatgacccct gcgaaggcat
     1561 ggtgactctg gatggccatg acattcgttc tcttaacatc cggtggctga gagatcaaat
     1621 tgggatcgtg gaacaggagc cagttctgtt ctccaccact atcgcagaaa acatccgcct
     1681 tggtagagaa gaggcgacaa tggaagacat agtccaagct gccaaggatg ctaatgcata
     1741 caacttcatt atggccctgc cacagcaatt tgacacccta gttggagaag gaggaggcca
     1801 gatgagtggt gggcagaagc aaagggtagc catcgcccgc gccctcatac ggaaacccaa
     1861 gatcctgctt ctggacatgg ctacctcagc actggacaat gagagtgagg ccaaagtaca
     1921 gggagcactg aataagatcc aacatggaca cacaatcatc tcagttgccc atcgcctatc
     1981 aacagtcaga tctgcagatg tgatcattgg ctttgagcat ggaacagctg tggaaagagg
     2041 cacccatgaa gaactgttag aaagaaaagg tgtctacttc atgcttgtga ccctgcaaag
     2101 ccaagaagat aatactcaca aagaaacagg cataaaggga aaagatacaa ccgaagggga
     2161 cacacctgag aggacctttt ccagaggcag ctatcaggac agtttaagag cttccatccg
     2221 tcaacgatct aagtctcagc tgtctcatct gtcacatgaa cctccactgg ctataggtga
     2281 tcacaagtcc tcttacgaag acagaaagga caatgatgtg cttgtggaag aagttgaacc
     2341 tgccccagtt aggaggattc taaaatacaa catctcagaa tggccctaca tactggtagg
     2401 ggctttgtgt gcagccatta atggggcagt cacacccatc tactcccttt tattcagcca
     2461 gatccttaag actttttcac tcgttgataa agaacaacaa aggtcagaga tttacagcat
     2521 gtgcctgttt tttgtcatcc tgggctgtgt atcacttttc acacaatttc tgcagggtta
     2581 caattttgcc aaatctggag agctcctcac aaaaaggctg cgtaaatttg gtttcaaggc
     2641 aatgttaaga caagatattg gctggttcga tgacctcaaa aataatcctg gagtactaac
     2701 aactaggctt gctacagatg cttcccaagt tcaaggggct actggctctc aagttgggat
     2761 gatggtcaat tccttcacta acatctttgt ggccgtgctc atcgccttcc tctttaactg
     2821 gaagctcagt ctggttatat cagtcttctt cccctttttg gctttatcgg gagctgtaca
     2881 gacaaaaatg ctgacaggat tcgcttctca agacaaggaa attctggaga aggctggcca
     2941 gatcaccaac gaagccctta gcaatatccg caccgtggct ggaattggag tggagggaag
     3001 atttattaaa gcatttgagg ttgagctgga gaagtcatac aagactgcca ttagaaaggc
     3061 aaatgtctat ggcctctgct atgccttttc ccaggggata tcatttcttg ccaattctgc
     3121 agcctataga tatggaggtt acttaatagt ctacgaagat ctgaacttca gctatgtttt
     3181 cagggtggtc tcttccattg caatgagcgc aacggctgtt ggaagaacat tctcttacac
     3241 accgagctat gccaaagcta aaatatcagc tgcacgcttt tttcaactgc tagacagaaa
     3301 acctccaatt gatgtgtaca gtggagcagg tgaaaaatgg gacaacttcc aagggaagat
     3361 tgattttatc gactgtaaat ttacatatcc ttctcgacct gatatacaag ttctgaatgg
     3421 actgtcggta tctgtggatc ctgggcagac gctggcattc gttgggagca gtgggtgtgg
     3481 taaaagcacc agcatccagc tgttggaacg gttctacgat cccgatcagg gaacggtgat
     3541 gatagatggt cacgacagca aaaaagtcaa tgttcagttc ctccgttcaa acattgggat
     3601 tgtctcccag gagcccgtgt tatttgactg tagcataatg gacaacatca agtatgggga
     3661 caacaccaaa gagatctccg tggagagagc tatagctgcc gcaaagcagg ctcagctgca
     3721 tgacttcgtc atgtcactcc cagagaaata tgaaactaat gttgggatcc agggctctca
     3781 actctctcgc ggggagaaac aacgcattgc tattgctcgg gccattgtac gagatcctaa
     3841 aatcttgcta ctggatgaag ctacatctgc cttagacaca gaaagtgaaa agacagtgca
     3901 gcttgctctg gacaaagcca gagagggtcg gacctgtatt gtcattgctc atcgcttgtc
     3961 tactatccag aactcagata tcatcgccgt catgtcacaa ggagtggtga ttgaaaaggg
     4021 gacccataag aaactgatgg accagaaggg ggcctactac aagctggtca tcactggagc
     4081 ccccatcagt tgaccctgac tggagacctt tacatacaga taatgatgtg ccaagcacag
     4141 gagggctgcg ggttgtcata gctctacaga gaattattaa tgctttacag acagaagtat
     4201 ccactggcat ccaaactaat cttgagtggc tttcagtaat aatttcagtt tgaaatgtct
     4261 atgtaggaag gagagaaccc agagtcactg tgagttcaag tccaagggca agcagctgct
     4321 tatctatcac tcagtgctgc tctcggtagg agctggtccc tgtctccatc aaggacttgg
     4381 tgacagagag catggagtcc tccttagggc agagggttgt cttttgcatt tgggaaagct
     4441 ccttgtacag agtctgctct gtaatctgga ctcaactgtt tgagccagct caaggtcaag
     4501 agctaagaac ttaaggctac tggtagtttt taatttaaaa agtttgcttg ttttctatag
     4561 ggaagcaaat gtctttacct ctgacacccg tgagtaggga gaggaacacg tttccattct
     4621 ggaatctccc aggctcaggg aggccaaagg tgagctaagg agaagtagag gttgacagtc
     4681 aggggtactg atttgctcag ggtgctattg tcacgataca ctacagtgga tctgccagtg
     4741 tggagcaggg actctttacc agggcttcta cttttcattc cctgccacca tgtcacctga
     4801 tgtcccttac tcctaggaaa tctatgcaag caatggaaat gcatcggaat cttaagttgt
     4861 tacattaaaa tctagtaaaa catagtagaa aaacaaaaa
//
