LOCUS       NM_019552               4325 bp    mRNA    linear   ROD 27-JUN-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 10 (Abcb10),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019552 XM_917783 XM_925245 XM_925251 XM_925254
VERSION     NM_019552.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4325)
  AUTHORS   Do,Y., Yagi,M., Hirai,H., Miki,K., Fukahori,Y., Setoyama,D.,
            Yamamoto,M., Furukawa,T., Kunisaki,Y., Kang,D. and Uchiumi,T.
  TITLE     Cardiomyocyte-specific deletion of the mitochondrial transporter
            Abcb10 causes cardiac dysfunction via lysosomal-mediated
            ferroptosis
  JOURNAL   Biosci Rep 44 (5) (2024)
   PUBMED   38655715
  REMARK    GeneRIF: Cardiomyocyte-specific deletion of the mitochondrial
            transporter Abcb10 causes cardiac dysfunction via
            lysosomal-mediated ferroptosis.
REFERENCE   2  (bases 1 to 4325)
  AUTHORS   Miljkovic,M., Seguin,A., Jia,X., Cox,J.E., Catrow,J.L.,
            Bergonia,H., Phillips,J.D., Stephens,W.Z. and Ward,D.M.
  TITLE     Loss of the mitochondrial protein Abcb10 results in altered
            arginine metabolism in MEL and K562 cells and nutrient stress
            signaling through ATF4
  JOURNAL   J Biol Chem 299 (7), 104877 (2023)
   PUBMED   37269954
  REMARK    GeneRIF: Loss of the mitochondrial protein Abcb10 results in
            altered arginine metabolism in MEL and K562 cells and nutrient
            stress signaling through ATF4.
REFERENCE   3  (bases 1 to 4325)
  AUTHORS   Sun,W., Jia,X., Liesa,M., Tantin,D. and Ward,D.M.
  TITLE     ABCB10 Loss Reduces CD4+ T Cell Activation and Memory Formation
  JOURNAL   J Immunol 208 (2), 328-337 (2022)
   PUBMED   34893527
  REMARK    GeneRIF: ABCB10 Loss Reduces CD4(+) T Cell Activation and Memory
            Formation.
REFERENCE   4  (bases 1 to 4325)
  AUTHORS   Shum,M., Segawa,M., Gharakhanian,R., Vinuela,A., Wortham,M.,
            Baghdasarian,S., Wolf,D.M., Sereda,S.B., Nocito,L., Stiles,L.,
            Zhou,Z., Gutierrez,V., Sander,M., Shirihai,O.S. and Liesa,M.
  TITLE     Deletion of ABCB10 in beta-cells protects from high-fat diet
            induced insulin resistance
  JOURNAL   Mol Metab 55, 101403 (2022)
   PUBMED   34823065
  REMARK    GeneRIF: Deletion of ABCB10 in beta-cells protects from high-fat
            diet induced insulin resistance.
REFERENCE   5  (bases 1 to 4325)
  AUTHORS   Shum,M., Shintre,C.A., Althoff,T., Gutierrez,V., Segawa,M.,
            Saxberg,A.D., Martinez,M., Adamson,R., Young,M.R., Faust,B.,
            Gharakhanian,R., Su,S., Chella Krishnan,K., Mahdaviani,K.,
            Veliova,M., Wolf,D.M., Ngo,J., Nocito,L., Stiles,L., Abramson,J.,
            Lusis,A.J., Hevener,A.L., Zoghbi,M.E., Carpenter,E.P. and Liesa,M.
  TITLE     ABCB10 exports mitochondrial biliverdin, driving metabolic
            maladaptation in obesity
  JOURNAL   Sci Transl Med 13 (594) (2021)
   PUBMED   34011630
REFERENCE   6  (bases 1 to 4325)
  AUTHORS   Tallack,M.R., Whitington,T., Yuen,W.S., Wainwright,E.N., Keys,J.R.,
            Gardiner,B.B., Nourbakhsh,E., Cloonan,N., Grimmond,S.M.,
            Bailey,T.L. and Perkins,A.C.
  TITLE     A global role for KLF1 in erythropoiesis revealed by ChIP-seq in
            primary erythroid cells
  JOURNAL   Genome Res 20 (8), 1052-1063 (2010)
   PUBMED   20508144
  REMARK    Erratum:[Genome Res. 2010 Dec;20(12):1748]
REFERENCE   7  (bases 1 to 4325)
  AUTHORS   Chen,W., Dailey,H.A. and Paw,B.H.
  TITLE     Ferrochelatase forms an oligomeric complex with mitoferrin-1 and
            Abcb10 for erythroid heme biosynthesis
  JOURNAL   Blood 116 (4), 628-630 (2010)
   PUBMED   20427704
  REMARK    GeneRIF: Ferrochelatase forms an oligomeric complex with Mfrn1 and
            Abcb10 to synergistically integrate mitochondrial iron importation
            and use for heme biosynthesis.
REFERENCE   8  (bases 1 to 4325)
  AUTHORS   Chen,W., Paradkar,P.N., Li,L., Pierce,E.L., Langer,N.B.,
            Takahashi-Makise,N., Hyde,B.B., Shirihai,O.S., Ward,D.M., Kaplan,J.
            and Paw,B.H.
  TITLE     Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance
            its stability and function in the erythroid mitochondria
  JOURNAL   Proc Natl Acad Sci U S A 106 (38), 16263-16268 (2009)
   PUBMED   19805291
  REMARK    GeneRIF: Data show that the binding domain of Mfrn1-Abcb10
            interaction maps to the N terminus of Mfrn1.
REFERENCE   9  (bases 1 to 4325)
  AUTHORS   Graf,S.A., Haigh,S.E., Corson,E.D. and Shirihai,O.S.
  TITLE     Targeting, import, and dimerization of a mammalian mitochondrial
            ATP binding cassette (ABC) transporter, ABCB10 (ABC-me)
  JOURNAL   J Biol Chem 279 (41), 42954-42963 (2004)
   PUBMED   15215243
REFERENCE   10 (bases 1 to 4325)
  AUTHORS   Shirihai,O.S., Gregory,T., Yu,C., Orkin,S.H. and Weiss,M.J.
  TITLE     ABC-me: a novel mitochondrial transporter induced by GATA-1 during
            erythroid differentiation
  JOURNAL   EMBO J 19 (11), 2492-2502 (2000)
   PUBMED   10835348
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC054793.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_925245.1, XM_917783.1, XM_925251.1, XM_925254.1, NM_019552.1.
            
            Summary: This gene encodes a member of the ATP-binding cassette
            superfamily of transporters. ATP-binding cassette proteins
            transport various molecules across extra- and intra-cellular
            membranes. The encoded protein is localized to the mitochondrial
            inner membrane where it interacts with and stabilizes mitoferrin-1,
            and is important for heme biosynthesis. Additional evidence
            suggests the encoded protein is involved in oxidative stress
            protection and erythropoisesis. [provided by RefSeq, May 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054793.1, AK081782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 15215243; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4325              BC054793.1         1-4325
FEATURES             Location/Qualifiers
     source          1..4325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.31 cM"
     gene            1..4325
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /note="ATP-binding cassette, sub-family B member 10"
                     /db_xref="GeneID:56199"
                     /db_xref="MGI:MGI:1860508"
     exon            1..721
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..2457
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /note="ATP-binding cassette sub-family B member 10,
                     mitochondrial; ABC-mitochondrial erythroid protein;
                     ATP-binding cassette transporter 10; ATP-binding cassette,
                     sub-family B (MDR/TAP), member 10"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family B member 10,
                     mitochondrial precursor"
                     /protein_id="NP_062425.1"
                     /db_xref="CCDS:CCDS22766.1"
                     /db_xref="GeneID:56199"
                     /db_xref="MGI:MGI:1860508"
                     /translation="MRAPSARALLLIPRRGPAVRAWAPAVSSRIWLASEWTPLVRAWT
                     SLIHKPGSGLRFPAPLSGLPGGVGQWATSSGARRCWVLAGPRAAHPLFARLQGAAATG
                     VRDLGNDSQRRPAATGRSEVWKLLGLVRPERGRLSAAVGFLAVSSVITMSAPFFLGRI
                     IDVIYTNPSEGYGDSLTRLCAVLTCVFLCGAAANGIRVYLMQSSGQSIVNRLRTSLFS
                     SILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVS
                     PSLATFVLSVVPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGK
                     EMTEVEKYTGRVDQLLQLAQKEALARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHMT
                     VGELSSFLMYAFWVGLSIGGLSSFYSELMKGLGAGGRLWELLERQPRLPFNEGMVLDE
                     KTFQGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRL
                     YDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQ
                     QVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLLDE
                     ATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEE
                     LLLKPNGLYRKLMNKQSFLSYNGAEQFLEPARA"
     exon            722..922
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1125
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1260
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1407
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1543
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1639
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1849
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1929
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2110
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2154
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2189
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..4306
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4284..4289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /note="hexamer: ATTAAA"
     polyA_site      4306
                     /gene="Abcb10"
                     /gene_synonym="Abc-me; Abcb12"
                     /note="major polyA site"
ORIGIN      
        1 gaaagggctc ggacgctcca ggttcacaag tcgtggaggg cgcaggagag cgaaaaagct
       61 tccgcgtgcg gctggcgggc gcaggcgctg gcgactgcct gccggacaag gcactgccgg
      121 ggagctagcg gctggtcgcc gcccaggggt ggaccctacg cggcggaagg cgcggcccgg
      181 gcgctggccc gatggggcgg gaggggcggg ccgctgctgc gtccccgccc tgtgctcggg
      241 ccgggcgggg agggtcccgg ggcgtgcggc ccggccggtt ggtgagactg tccgggcaga
      301 cgcagcgcca tgcgcgcccc ttctgctagg gcgctactgc tgattccgcg tcggggccct
      361 gccgtgcgag cgtgggcccc ggccgtctcc tctcggatat ggctggcttc tgaatggacc
      421 ccgctcgtac gcgcgtggac ctctctgatc cacaagccgg gttcgggcct ccgctttccc
      481 gcgcccctat ccgggctgcc tggcggcgtg gggcagtggg ccacctcctc gggggcccgc
      541 aggtgctggg tgctggcagg accccgcgcc gcacatcccc tgttcgccag gctccagggt
      601 gcagctgcca ccggtgtgcg agaccttggg aacgactcgc agcggcgtcc cgcggcgacc
      661 gggcgctcag aagtatggaa gctcctaggg ctggtgcgcc ccgagcgcgg gagactgtca
      721 gctgcagttg ggtttctggc tgtgtccagt gtcatcacca tgtctgcccc cttcttcctg
      781 ggaaggatca ttgatgtcat ctataccaac ccaagcgagg gctatggcga tagcttgact
      841 cggctctgtg ctgtgctcac ctgtgtgttc ctgtgcggcg ctgctgccaa cggcattcgt
      901 gtctacctca tgcagtcttc aggtcagagc attgtgaaca ggctgcgcac ctctctgttc
      961 tcctccattc taaggcaaga ggttgctttc tttgacaaga cccgcacagg cgaattaatt
     1021 aaccgcctct cctcggatac cgcactcctg gggcgctccg tgactgagaa cctctccgat
     1081 ggcctgagag ctggggccca ggcctccgtt ggtgttggca tgatgttttt tgtgtcacca
     1141 agtctggcca cctttgttct gagtgtggta ccgcccatct ctgtcctcgc tgtgatttat
     1201 gggcgatatc tacggaaact gtccaaagcc acacaggact ccttggcaga agccacacag
     1261 ctagccgagg agcggattgg aaacataaga accatccgag cttttgggaa ggagatgacg
     1321 gaagtggaga agtacaccgg ccgagtggac cagttgctgc agctggcaca gaaggaggcc
     1381 ttggcacgag ccggcttctt tggagcagct gggctctcag gaaacctgat tgtgctgtct
     1441 gtcctgtaca aaggaggcct gctgatgggc agtgcccata tgacagtggg cgagctctct
     1501 tccttcctca tgtacgcttt ctgggttgga ttgagcatcg gaggactgag ttcattctac
     1561 tccgagctga tgaaaggcct gggtgctggt gggcggctct gggagctgct ggagagacag
     1621 ccacggctgc cttttaacga ggggatggtg ttagatgaga aaaccttcca gggtgccctg
     1681 gagttcagaa acgtgcactt cacataccct gctcgcccag aggtgtccgt attccaggat
     1741 ttcagtcttt ccatcccatc tggatctgtc acagcgctgg ttggcccaag tggttctggg
     1801 aaatcaacag tggtttcgct cctgctgcgg ttgtacgacc ctaattctgg aacagtcagc
     1861 cttgatggcc atgacattcg tcagctaaac cccgtctggc tgagatccaa gattgggaca
     1921 gtgagtcagg agccagtcct gttctcctgc tctgtcgctg agaacattgc ctatggagct
     1981 gacaacctct cctcggtcac agcccagcag gtggagaggg ccgcagaggt ggccaacgcc
     2041 gctgagttca tccgaagctt cccacagggc ttcgacactg tggtcgggga gaagggcatc
     2101 ctcctgtcag gtgggcagaa gcagaggatt gcaatagcca gagccctgct gaagaacccc
     2161 aaaattcttc tccttgatga agcaaccagt gcactggatg ccgaaaatga gcacctggtc
     2221 caggaggccc ttgaccggct gatggaaggg agaaccgtgc tgatcatagc ccaccgcctg
     2281 tccaccatta agaatgccaa ctttgttgct gtccttgacc acggaaagat ctgtgaacac
     2341 gggacacatg aagagctgct cctgaagccc aatgggcttt acagaaaact gatgaacaag
     2401 cagagtttcc tgtcatataa tggagcagag cagttcctgg aacctgcacg ggcgtagcct
     2461 gcagtgcagg tattgggtaa ctgaagcagg gctgtgactc tatcatatac cctgtccaca
     2521 gacagaaaca gagcagcagc tacccgtggg ctgagagacc ttaaaaccaa acagcattgc
     2581 agagaacagg gcctggaggc cgtgtgaagc ctgggagcat acttcagtta tttgaaatat
     2641 gcctctttcc acaaagagtg cacaatgtca ttttacgatg tacctgtcct cccagacctt
     2701 tcttcagttg taaaatcgta gctctctaaa tgtctaaagc gctgaagtga ctgcagggtt
     2761 ccagtgtttg ctagccaagc agaacacctc acttcctgtg tgtgctgtca gagtcgagtt
     2821 gttctcaggt gacaacttta aaaagggaat tagaaactaa aggcctaact aatttaagcc
     2881 actgacgcac ctacctaggg ccactgaggg aaagtttgac gcgtccatcc tccattacct
     2941 tctggcgtca gagttctgga gcactacagg gctgtacctg tccaaatgtg cagtgctcac
     3001 catctgagca ccagagtctg atacattttg ccaaaggaag aagtcccgtt ctgtaaactg
     3061 gaaagcttct atttttttat tacctccttg tttaatgact ctttttgaga agcaaggtac
     3121 agataaccag gcgttatcaa cagaggtgga tgaaaatcca tggcgcatct gttgaagcat
     3181 gtattttgaa aaaaaaaata cccattttaa atatgtgatt cccaggtata ttgtagtttt
     3241 atattttaaa tttttattaa taaggctgaa tctgaataat ataattttca gccttgagta
     3301 tgatgactct tgcagaggca aggcatcaga aggaacatca gcctttggaa agtatcacag
     3361 ttaagtcaca tgtggtcctg ctgctgagac tctaagtcct agaaaccttc aggagtcacc
     3421 gtgtggcaag tgtggctgcc cttccaagca ccagagaaca tctaactgca gaaccaaggc
     3481 taggagatga aactctgctg ggtctggggg gaaggaggct cctgaattgt ttattgtgta
     3541 gacatggatc ctgtgaagga aaaacttaaa cccgagggta attgttgcag catccagttc
     3601 atgttgacga tttcaacagt catgaaataa accactctgg tttccaaaag aaaaagtaga
     3661 gtggctcaca cccacctgag ctttaaaacc agccagcgct tgagactttg tttcaaacag
     3721 agattggaag agtttggaag ccctgctcca tggagtgcat ggaaccttaa ctgggagctg
     3781 ccggataaag gtacccttgc tctctgtgct tatggtttgt cacctacagt gtcacagctc
     3841 ttacagcagt gacagtggct aatgaatatg aatttgctct tttttttttc ctttggtatc
     3901 agtgctgtta actggatgtt gcggaggaag tgggtttttt gtttgttttt ttgctggtga
     3961 tgtagagcct gagacacagc tacgctgaga ggtagttaaa tggacacacc tgccgtgcct
     4021 cttgatgaga agcagtgtca ccacttatgt tacctgggga accgggtaat gagcatgagg
     4081 ccccatggat gtgtgtgcag gtcttggggt gagtaggcag cacacctgtg acggtcacct
     4141 tccactgtcc acatctgctc agctccttgc agggtgtcct cagaactcgg agttgttgca
     4201 gatcagactg gtgagaaagc attatgaaaa ttgaattgag tcatcacgtt ttctttctta
     4261 atatggttaa cattttatat cagattaaaa tttatagtga acttaaaaaa aaaaaaaaaa
     4321 aaaaa
//
