LOCUS       NM_013851               7407 bp    mRNA    linear   ROD 18-AUG-2023
DEFINITION  Mus musculus ATP-binding cassette, sub-family A member 8b (Abca8b),
            transcript variant 1, mRNA.
ACCESSION   NM_013851
VERSION     NM_013851.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7407)
  AUTHORS   Qiu T, Huteckova B, Seppala M, Cobourne MT, Chen Z, Hovorakova M,
            Buchtova M and Tucker AS.
  TITLE     Molecular profiling of the vestibular lamina highlights a key role
            for Hedgehog signalling
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36971701
REFERENCE   2  (bases 1 to 7407)
  AUTHORS   Liu Y, Castano D, Girolamo F, Trigueros-Motos L, Bae HG, Neo SP, Oh
            J, Narayanaswamy P, Torta F, Rye KA, Jo DG, Gunaratne J, Jung S,
            Virgintino D and Singaraja RR.
  TITLE     Loss of ABCA8B decreases myelination by reducing oligodendrocyte
            precursor cells in mice
  JOURNAL   J Lipid Res 63 (1), 100147 (2022)
   PUBMED   34752805
REFERENCE   3  (bases 1 to 7407)
  AUTHORS   Sasaki K, Tachikawa M, Uchida Y, Hirano S, Kadowaki F, Watanabe M,
            Ohtsuki S and Terasaki T.
  TITLE     ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal
            Efflux Transporter for Cholesterol and Taurocholate in Mouse and
            Human Liver
  JOURNAL   Mol Pharm 15 (2), 343-355 (2018)
   PUBMED   29300488
  REMARK    GeneRIF: Study results suggest that mABCA8b/ABCA8 functions as a
            sinusoidal efflux transporter for at least cholesterol and
            taurocholate in mouse and human liver.
REFERENCE   4  (bases 1 to 7407)
  AUTHORS   Trigueros-Motos L, van Capelleveen JC, Torta F, Castano D, Zhang
            LH, Chai EC, Kang M, Dimova LG, Schimmel AWM, Tietjen I, Radomski
            C, Tan LJ, Thiam CH, Narayanaswamy P, Wu DH, Dorninger F, Yakala
            GK, Barhdadi A, Angeli V, Dube MP, Berger J, Dallinga-Thie GM,
            Tietge UJF, Wenk MR, Hayden MR, Hovingh GK and Singaraja RR.
  TITLE     ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein
            Cholesterol Levels
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (11), 2147-2155 (2017)
   PUBMED   28882873
  REMARK    GeneRIF: ABCA8 facilitates cholesterol efflux and modulates
            HDL-cholesterol levels.
REFERENCE   5  (bases 1 to 7407)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (bases 1 to 7407)
  AUTHORS   Cheung CC, Martin IC, Zenger KR, Donald JA, Thomson PC, Moran C and
            Buckley MF.
  TITLE     Quantitative trait loci for steady-state platelet count in mice
  JOURNAL   Mamm Genome 15 (10), 784-797 (2004)
   PUBMED   15520881
REFERENCE   7  (bases 1 to 7407)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 7407)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 7407)
  AUTHORS   Annilo T, Chen ZQ, Shulenin S and Dean M.
  TITLE     Evolutionary analysis of a cluster of ATP-binding cassette (ABC)
            genes
  JOURNAL   Mamm Genome 14 (1), 7-20 (2003)
   PUBMED   12532264
REFERENCE   10 (bases 1 to 7407)
  AUTHORS   Schriml LM and Dean M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807245.17, AK138196.1, BC141401.1 and AK043744.1.
            
            [WARNING] On Nov 20, 2023 this sequence was replaced by
            NM_013851.4.
            
            On Apr 26, 2018 this sequence version replaced NM_013851.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF498362.1, BC141401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL807245.17        95766-95794         c
            30-66               AK138196.1         2-38
            67-5231             BC141401.1         1-5165
            5232-6207           AK043744.1         752-1727
            6208-7407           AL807245.17        32155-33354         c
FEATURES             Location/Qualifiers
     source          1..7407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 72.88 cM"
     gene            1..7407
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /note="ATP-binding cassette, sub-family A member 8b"
                     /db_xref="GeneID:27404"
                     /db_xref="MGI:MGI:1351668"
     exon            1..234
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            235..336
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..5103
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette sub-family A member 8-B; ABC-type
                     organic anion transporter ABCA8B; ATP-binding cassette,
                     sub-family A (ABC1), member 8b"
                     /codon_start=1
                     /product="ABC-type organic anion transporter ABCA8B
                     isoform 1"
                     /protein_id="NP_038879.2"
                     /db_xref="CCDS:CCDS25587.1"
                     /db_xref="GeneID:27404"
                     /db_xref="MGI:MGI:1351668"
                     /translation="MIKREISVRQQTCALLQKNLLKKWRLKRESLMEWVSSLLLLLFL
                     YWYPHGHGATDLSSVPTKDLGRVDSFRQSGFMIGYTPVTSMTQQIMEKVAATPFMADK
                     KVLGLLDEENIKELTESHAEIIRVIFSDTFSYHLKFQFDQRIPTSRELRDHNAHCDGL
                     YEDVNCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMKIHPFVRQEG
                     ILTDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFV
                     FIMALSLALVIKSVQFFILTSFMVVFSLFLLYGLSMITLAFLMSALVRKSVLTGLSVF
                     LLTIFWGSLGFTSLYRYLPAPVEWTLSLFSPFAFTLGMAQLLRVDYDLNSNAPPDPAS
                     GSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHV
                     ILEDGIDPVPSSGDSFEPVSPEFHGKESIRIRNISKEYKGKPNKIEALKDLTLDIYEG
                     QITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAGVCPQAN
                     VQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQKRKL
                     TFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILAD
                     RKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAE
                     GEGKLLYTLPLETTYRFPELCQSLDSCPGLGIENYGVSMTTLNEVFLKLEGKASIDEP
                     EVDIVGEGQTERSGDTERLMEMEQTLSSLRETEKTDGMALWRQQTCAIAKVRLLKLKH
                     ERKTLLSVLLILVVGICPFLFENISTKIRQSSYTWELSPHDYFLAPGQQPQGMLTQLL
                     IINKTEASIDDFIHSVERQNIALEVDASGTRDGTDDPSYNGALIVSGNEKNHSFSFAC
                     NTKRLNCFPVLMDILSNGLLGMVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILT
                     SACPPYIAMSSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYL
                     FRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVF
                     SVAVILLAFDVDGTQYYIIFLIPPSTLVGCLILSLHLFIGQIFEEGQVIEPFLVFLIP
                     FLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPEDEDEDVQMERMR
                     TANALVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATRNVSFCVRKGEILGLL
                     GHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGDTPGFLGYCPQENALWPNLTVKEHL
                     EIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSI
                     LLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRL
                     RCIGSIQHLKSKFGKDYLLEMKVKTLEQVEPLNTEILRLFPQASRQERYSSLMAYKLP
                     VEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELDGLELEELDSSI
                     KWKLLPQEEA"
     exon            337..541
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            542..703
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            704..807
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1034
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1176
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1362
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1510
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1679
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1738
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1849
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2025
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2145
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2284
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2375
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2515
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2635
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2831
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2998
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3132
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3270
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3378
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3552
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3666
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3786
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3849
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..3941
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            3942..4062
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4063..4180
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4181..4272
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4433
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4434..4509
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4510..4604
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4605..4724
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4725..4865
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4866..4945
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..5001
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
     exon            5002..7407
                     /gene="Abca8b"
                     /gene_synonym="Abca8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcagcca tgcgcggtca cgtgtccgtg gtgtttggca agaccaaccc agagctgaga
       61 tcataaactc ccgctgagag cagctttcac cagtcgcgtt cacggacagc aaacagttaa
      121 actctagaaa ggtgctggag aataggggga ggggaaggtg tctcacttta ttattctaaa
      181 cagagcccgt gattaaatgg tgcggctgga gtccctgctt ggcatttccc gaaaggcaac
      241 atgatcaaga gagagataag tgtgcgccaa caaacttgtg ctttattaca gaagaacctt
      301 cttaagaaat ggagactgaa aagggagtcc ttgatggagt gggtgagctc cttgctcctt
      361 ctgcttttct tgtattggta tccccatggt catggagcta ctgacctgtc ttcagtgccc
      421 accaaggatc tgggacgagt cgattctttc agacaatctg ggttcatgat agggtacacg
      481 cctgtcacca gcatgacaca acagataatg gagaaggtag ctgcaacccc tttcatggca
      541 gataaaaaag tcttgggact gttggatgaa gaaaatatca aggaattaac agaaagtcat
      601 gcagaaataa taagagtcat tttttctgac acattctcat accatctgaa attccagttt
      661 gatcagagaa tcccaacgtc gagggaactc agagaccata atgctcattg tgatggactg
      721 tatgaagatg tcaactgtct gatagccata ttctggaagg aaggatttgt ggctcttcaa
      781 gctgccatca atgctgccat catagaaacc acaacaaacc attcagtgat ggaggaactg
      841 ctatcagtgt cagggaaatt catgaagatc catccttttg tccgtcaaga aggaattctg
      901 actgatttct ttattttcac ctgcatcatt tccttctccc caatcaccta ttatgtgtca
      961 atcaatgttg caagagagag gaaaaggatg aagggcttga tgatgatgat gggccttcga
     1021 gatccagcat tctggctatc ttggggtctg ctctatgctg gctttgtctt cattatggct
     1081 ctatccctgg cacttgttat caaatctgtc cagtttttta ttctaaccag cttcatggtg
     1141 gtctttagcc tcttcctcct ttatggatta tctatgatca ctttggcttt cctaatgagt
     1201 gccttggtga ggaagtctgt cctcactggc ctgtctgtgt ttcttctcac catcttctgg
     1261 ggaagtctag gcttcacatc cctgtacaga tacctccctg cacctgtgga atggactctc
     1321 agtctcttta gcccctttgc cttcacacta ggaatggccc agctcttacg tgtggattat
     1381 gatttaaatt ctaatgcacc ccctgatcca gccagtggct caaatctgat tatagcaacc
     1441 aatttcatgc tggtatttga tgcgtttttg tatctggccc tgatgatgta cttcgaaaaa
     1501 gttctgccaa atgaatacgg acatcagcac tctcccctgt ttttcctgaa atcttcattt
     1561 tggctacaaa cacgaaagcc tgctcatgtg attcttgaag atggaataga ccccgttcct
     1621 tcatcaggtg actcgtttga accggtgtcc ccagaattcc acgggaaaga atccatcaga
     1681 atcagaaata tttcaaaaga atacaaagga aagcccaata aaatagaagc cttaaaagac
     1741 ctgacgttgg acatatatga aggccaaatc acagcagtac ttggtcacag tggagctggg
     1801 aaatcaacac tgttaaatat tcttagcgga ttatctgttc ctactaaagg ttctgtcacc
     1861 atctataata ataacttatc agaaatggct gaccttgaaa acatcttgag gattgctgga
     1921 gtttgtccac aagccaatgt tcaatttgac ttccttactg tgagagaaaa cctcaggctt
     1981 tttgctaaaa taagaggaat tccaccccaa gatgtggaga aagaggtgca aagggttttg
     2041 ctagaattgg aaatgaaaaa tatccaaaat atccttgctc aaaacctaag tgggggacag
     2101 aagagaaagc tgacttttgg aatcgccatt ttaggagatt ctcagatttt cctactggat
     2161 gagcccaccg ctggcctgga tcccttttca aggcaccggg tgtggaatct cctgaaggag
     2221 cgcagagcag accgtgtggt cctcttcagc acgcagttca tggatgaggc tgacatcctg
     2281 gctgatagga aagtgttcat ctccaatggg aggctgaagt gtgcaggatc atcgctcttt
     2341 ctgaagaaga aatggggagt tgggtatcac ttaagtttgc agctgaaaga agtctgtgtt
     2401 ccagaaaaca tcacatcgct tgttaaacag cacatccctg cagccaagct atcagctgaa
     2461 ggggaaggaa agcttctcta tacattaccc ttagaaacaa cttatagatt tccagagctt
     2521 tgccagagtc ttgacagctg tcctggactg ggaattgaaa actatggtgt ttccatgaca
     2581 actttgaatg aggtgttcct gaagctagaa ggaaaagcat caattgatga accagaggtt
     2641 gacatcgtgg gagaaggaca aacagagaga tctggggaca cagaaaggct tatggagatg
     2701 gagcaaactc tctcttcact tagggaaaca gagaagacag acggcatggc actctggagg
     2761 cagcaaacct gtgcgatcgc aaaggttcgc ctgttgaagt taaagcacga aaggaaaaca
     2821 cttttatctg tgctcttgat actggtagtc ggcatctgtc cttttctttt tgaaaatatc
     2881 tcaacgaaaa tacgtcaaag ctcttacact tgggaacttt ccccacacga ttacttcctt
     2941 gctccgggac aacagcccca gggcatgctc actcagttat tgatcattaa taagacagag
     3001 gcaagcattg acgactttat ccattctgtg gaacgccaga acatagcttt ggaagtcgat
     3061 gcttctggaa ccagagatgg tacagatgac ccatcctaca atggagccct tatagtgtct
     3121 ggcaatgaga agaaccacag cttttcgttt gcatgcaaca ccaagagact gaactgcttc
     3181 ccagttctga tggacatcct gagcaacggg ctacttggaa tggttaaacc gtcagcccgc
     3241 atccaaaccg acagaagcac atatctcatg gatgaaacta ttcatccttt agaagaccta
     3301 tggaagactg cattctggct gattctgacc tccgcttgcc ctccttatat tgccatgagc
     3361 agtgtcacag attataagaa cagagcttgg ttccagctgc gggtctccgg cctcttccct
     3421 tcggcttact gggtcgggca ggcaatggtg gacattcccc tgtactgctt tgtcttcctc
     3481 ttcatgtcgt taatggacta cctttttcgc ttcccagata ccatgttttc tattataagc
     3541 cacgtcatac aaatcccgtg ttctgttggc tatgccatat ccctgatctt cttaacatac
     3601 gtgatttcgt tcatttctcg caaggggaaa aaaaacagcg gcatttggtc acttagcttc
     3661 tatatcatca ctgtgttctc agtggctgta atattgctgg cttttgatgt ggatggtaca
     3721 cagtactaca tcatcttttt gataccaccg tccactctgg ttggatgctt gatcttgtct
     3781 ttgcatcttt tcataggtca aatctttgaa gaaggacaag ttatagagcc attcctggta
     3841 ttcctcattc ctttccttca tgttttcatt tttattttta cccttcgatg tctggaatgg
     3901 aagtttggaa agaaaacaat gaggaaagat cccatcttta gaatttctcc aagaaacaat
     3961 gatgtgtatc aaaacccaga agagccagaa gatgaggatg aagatgttca aatggagaga
     4021 atgagaacag cgaatgcctt ggtatccacc agttttgatg agaagccagt catcattgcc
     4081 agctgcctac gcaaagaata tgcagggaag cagaagcatt gcctttccaa gaagaaggcc
     4141 aagatagcca ctaggaatgt ctcgttttgt gtcaggaaag gtgagattct aggattgttg
     4201 ggacacaatg gagctggcaa aagtacatct cttaaaatga taagtggaga cacaaaagtc
     4261 acagctgggc aggtgttact gaaagggagc agagaagggg acaccccggg gttcctgggg
     4321 tactgtcctc aggagaatgc tctgtggccc aacctcactg tgaaggagca cctggagata
     4381 tttgctgcag tgaggggctt gcgcaaaagt cacgctgcag tcgccatcac aaggttggca
     4441 gatgcgctca agctgcagga ccagctgaag tctcctgtga agacgctgtc agagggagtg
     4501 aagagaaagc tgtgcttcgt gctgagcatc ctggggaacc catctatatt gcttctagat
     4561 gagccgtcca ctgggctgga tcctgagggg cagcagcaaa tatggcaagc aatcagggcc
     4621 atcataaaaa atacagacag gggtgccctg ctgaccaccc attacatggc agaggctgag
     4681 gctctgtgtg accgagtggc catcctggtg tctggaaggc tgaggtgtat tggatccatc
     4741 caacatctca aaagcaaatt tggcaaagat tacctgctgg agatgaaggt gaagaccctc
     4801 gagcaggtgg agcccctcaa tacggagatc ctcaggcttt ttccccaggc ttctaggcag
     4861 gaacggtact cttctctgat ggcttacaaa ttaccagtgg aagctgtaca gcctttatcc
     4921 caagctttct tcaagttaga gaaagttaag cagacctttg acctggagga gtacagcctc
     4981 tctcagtcta ccctggagca ggtcttccta gagctctcca aggagcagga gctggatggc
     5041 cttgaattag aagaattaga ctcctccata aagtggaagc tcctcccaca ggaagaggct
     5101 taagccaaaa atatctctcc tcttccttca taagactgtg ttgttcctta aagacatcta
     5161 tttttatgaa atattttagt acctatatta taaatactat gatgttcctc ggggattgga
     5221 gaacaggggt gagtaccgta tagaggctgg accacaggga accttgtcta gccttctcca
     5281 catcccttta ggacacttat agccatagtt ctgtagaatg ttgaataaac agttactttt
     5341 atacaattat ttccatttct gagtatgata tacttagtta aaatatttta gataattttt
     5401 tgtatcaaaa ccgtaggctt agatttttca aaaccaactt taataagggt tcttaagttc
     5461 ttcaacctct cttctagctc accaaccaaa ggtaggaaag aagaaaagtt aataggaaat
     5521 gagggatgtg aatatcattt ggaagtagtg ctttggggca gttccaaaca tgaatcagta
     5581 gcagctgtcc agtgcaatca caaacaccaa acacaaatca gtagcaggag gctcaatcca
     5641 gaagaaacct tgaggatcca ccaaataggt atgagcccac agaatgtcag gagccatcac
     5701 aggacaagct aataactagc aggtgatctt cctgagatga ctgccttaga ttaaaattta
     5761 tgacggaact tcaataggca aggcccagga gaaagtcgtt ttaggaaaga ttcctgctat
     5821 taatatgctt ttcctattat tattattatt attattatta ttattattat tatatacata
     5881 tgaccatcgc taggtattag tccacccttt tgagcagatc tctgcagatc tacaaagatg
     5941 tactgtcttg tactgatgct atgtagacaa atagatggct tcttaattct taatggtgat
     6001 cctataagaa tttctaaaat tatatcagta tttattaagc tcttatatag tgggactgct
     6061 attaggtcct tttctgatag tcaaaactgc aatgagaact ctgccagtct cccacgtgtc
     6121 accagttaat tgcctcttag atggtaaaaa gactttctac tactcagagc acattccaag
     6181 aggttgtaaa acaattaacc gaaggtcata aaaagagaac taacgattta ttataggtgc
     6241 taggagctgt gactggtgat ggatgcttag ctagatagtt actcctagtg gatatgcatg
     6301 taaacattct ctgttgtaaa cttctatttc agtttatgat ttgaattttt gtgtaaactt
     6361 gtaatgaact ttttaccatg tgatcatgta ttctgaacga tgtataagtg ctgaggacaa
     6421 agagaagaga cagaactgag ctgaggacag aactgagctg aggacagaac tgagctgagg
     6481 acagaactga gctgaggaca gaactgagct gaggagaact ttttagacag aagacttttt
     6541 agaaagatct gaacagaatt tttagaatag aactgagggg tttgttttgt tttgttttgt
     6601 ttttaaagtc aggacacaaa agaactttat agaaagattt caactcaaaa agagcataga
     6661 agtaaagaaa ggcacacctt tgggagaaag ggcattgaga gtaagagcat tattgtgata
     6721 tcagagtagg aggaaagagc aaaattataa ggagaatgaa cagtggaata acttagaaac
     6781 cataggttac aaactaagaa agcaatgtga agaattcaga gggaaagagg gaataagaag
     6841 aagctgtaga gaaagcagaa ggggcaggca agcttttcct tatcatggga cagaacaggt
     6901 cttttcttaa taacaagcca ggcttagtct tattaaaagg aaccaagctc tcttcttaca
     6961 aacttgagtt taattcactt agcatcaaaa ggtagaaact gttttgttcg ctatacaata
     7021 aagattggag ttcatttttc atccagaatg agtgaattct ttctgcactg ctgtttagtc
     7081 ttttgctcca aatgcatatg taagcatgaa tgtgtgtgta taagtatgca gttgtgagaa
     7141 tgtatgcaaa ctaagcccaa ctggtttgaa tggaaatgta taaatattca tgcatgaatc
     7201 tgtatgtgaa tctatgtgtg tttatgcata tttgcttctg taaaagtttt tttcttcagc
     7261 aagtgatatc ttttatgttt caatagaagt ctattgttcc aaacttcccc ctagcctgac
     7321 aagtgagagg catctggaca aaaatggaaa aggctctagc aattaatcct ttatttaatc
     7381 tcctgctgtt ttttttaata aaacaac
//
