LOCUS       NM_001405147            5760 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family A member 8a (Abca8a),
            transcript variant 4, mRNA.
ACCESSION   NM_001405147 XM_006533063
VERSION     NM_001405147.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5760)
  AUTHORS   Trigueros-Motos,L., van Capelleveen,J.C., Torta,F., Castano,D.,
            Zhang,L.H., Chai,E.C., Kang,M., Dimova,L.G., Schimmel,A.W.M.,
            Tietjen,I., Radomski,C., Tan,L.J., Thiam,C.H., Narayanaswamy,P.,
            Wu,D.H., Dorninger,F., Yakala,G.K., Barhdadi,A., Angeli,V.,
            Dube,M.P., Berger,J., Dallinga-Thie,G.M., Tietge,U.J.F., Wenk,M.R.,
            Hayden,M.R., Hovingh,G.K. and Singaraja,R.R.
  TITLE     ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein
            Cholesterol Levels
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (11), 2147-2155 (2017)
   PUBMED   28882873
  REMARK    GeneRIF: ABCA8 facilitates cholesterol efflux and modulates
            HDL-cholesterol levels.
REFERENCE   3  (bases 1 to 5760)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5760)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   5  (bases 1 to 5760)
  AUTHORS   Wakaumi,M., Ishibashi,K., Ando,H., Kasanuki,H. and Tsuruoka,S.
  TITLE     Acute digoxin loading reduces ABCA8A mRNA expression in the mouse
            liver
  JOURNAL   Clin Exp Pharmacol Physiol 32 (12), 1034-1041 (2005)
   PUBMED   16445568
REFERENCE   6  (bases 1 to 5760)
  AUTHORS   Annilo,T., Chen,Z.Q., Shulenin,S. and Dean,M.
  TITLE     Evolutionary analysis of a cluster of ATP-binding cassette (ABC)
            genes
  JOURNAL   Mamm Genome 14 (1), 7-20 (2003)
   PUBMED   12532264
REFERENCE   7  (bases 1 to 5760)
  AUTHORS   Nakamura,K., Funakoshi,H., Tokunaga,F. and Nakamura,T.
  TITLE     Molecular cloning of a mouse scavenger receptor with C-type lectin
            (SRCL)(1), a novel member of the scavenger receptor family
  JOURNAL   Biochim Biophys Acta 1522 (1), 53-58 (2001)
   PUBMED   11718900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603792.12 and AL662821.9.
            
            On Apr 20, 2022 this sequence version replaced XM_006533063.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.14854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AL603792.12        179510-179728
            220-321             AL603792.12        185467-185568
            322-526             AL603792.12        186973-187177
            527-691             AL603792.12        190457-190621
            692-795             AL603792.12        192822-192925
            796-1022            AL603792.12        193551-193777
            1023-1164           AL603792.12        197873-198014
            1165-1350           AL603792.12        198278-198463
            1351-1492           AL662821.9         62907-63048         c
            1493-1658           AL662821.9         61405-61570         c
            1659-1717           AL662821.9         59196-59254         c
            1718-1828           AL662821.9         58788-58898         c
            1829-2004           AL662821.9         57681-57856         c
            2005-2124           AL662821.9         57157-57276         c
            2125-2263           AL662821.9         56743-56881         c
            2264-2354           AL662821.9         56146-56236         c
            2355-2494           AL662821.9         55393-55532         c
            2495-2614           AL662821.9         52533-52652         c
            2615-2813           AL662821.9         50390-50588         c
            2814-2980           AL662821.9         47248-47414         c
            2981-3114           AL662821.9         45792-45925         c
            3115-3252           AL662821.9         44515-44652         c
            3253-3360           AL662821.9         43679-43786         c
            3361-3534           AL662821.9         41851-42024         c
            3535-3648           AL662821.9         40384-40497         c
            3649-3768           AL662821.9         38264-38383         c
            3769-3834           AL662821.9         30334-30399         c
            3835-3926           AL662821.9         29461-29552         c
            3927-4047           AL662821.9         27869-27989         c
            4048-4165           AL662821.9         25711-25828         c
            4166-4257           AL662821.9         23859-23950         c
            4258-4418           AL662821.9         18928-19088         c
            4419-4494           AL662821.9         18413-18488         c
            4495-4589           AL662821.9         18228-18322         c
            4590-4709           AL662821.9         17649-17768         c
            4710-4850           AL662821.9         17287-17427         c
            4851-4930           AL662821.9         15499-15578         c
            4931-4986           AL662821.9         14216-14271         c
            4987-5760           AL662821.9         13002-13775         c
FEATURES             Location/Qualifiers
     source          1..5760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 73.07 cM"
     gene            1..5760
                     /gene="Abca8a"
                     /note="ATP-binding cassette, sub-family A member 8a"
                     /db_xref="GeneID:217258"
                     /db_xref="MGI:MGI:2386846"
     exon            1..219
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            220..321
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..5085
                     /gene="Abca8a"
                     /note="isoform 1 is encoded by transcript variant 4;
                     ATP-binding cassette sub-family A member 8-A; ABC-type
                     organic anion transporter ABCA8A; ATP-binding cassette,
                     sub-family A (ABC1), member 8a"
                     /codon_start=1
                     /product="ABC-type organic anion transporter ABCA8A
                     isoform 1"
                     /protein_id="NP_001392076.1"
                     /db_xref="GeneID:217258"
                     /db_xref="MGI:MGI:2386846"
                     /translation="MVKREINVCQQTWALLCKNLLRKKRLKRDTFLEFLYTALILLSL
                     ILFLQLHEVYDFSSLPDVDLGRIDSFNDSTFMIVYTPITPTTQRIMDRVSLVSYMTGR
                     KILASPNEENMTELISMRFSDVVGVIFTNAYSYNLKFIKGARIPTIKEHQDHTAHCHS
                     YGEIIYCGLSEFWRDGFVALQAAINAAIIEVTTNHSVMEEMMSLTGKYIKIDSFVGQE
                     GTTTDCFLFFCIIRFSPLTYYISAGVTRERKKMKGLMAVMGLRDSAFWLSWGLLYGVI
                     VFVVTLLSTTIVKLVQFVFLTGFMVIFSLFFFYGLSLISLSFLMSVLLKKSFLTDLVV
                     FLLTVSCGSLGFTALYRYLPVSLEWLLSLLSPFAFMLGMVQLLRLDYDVNSNADPMGN
                     PNEVIGTIFMLFFDGVFYLLLTFYFEKVLPSEYGRRHPPLFFLKSSFWSGQNPANRTA
                     LDNETDYEFSDDSFEPVSMEFHGKEAIRIRNLTKDYIQKSKRTEALKDLTLDVYKGQI
                     TAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHNNKLSEMTDLENISKLTGVCPQCNVQ
                     FDFLTVRENLRLFAKIKGIQAHEVDNEVQRVLLELDMKNTQNILVQNLSGGQKRKLTF
                     GIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLKERRADRVVLFSTQFMDEADILADRK
                     VFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESE
                     GKLSYILPLERTNKFPDLYRDLERSPDLGIENYGVSITTLTEVFLKLEGKSSIDQSDI
                     GMTEDVQAGGARSPERFAEVEQLVSLLNGRCKMKGGMALWWQQLCAVTRLRFLKLKHE
                     RKSIVILILVLGIGLLHILSANIYRMVRQSDYCWELAPHMYFLTPGQQPQPPLTNLLI
                     VNKTGAKIDDFIHSLEQQNIALEVDAFGTRNGTEDSQYNGAIILSGDEKNYNFTLACN
                     TKRLNCFPVLVDIVSNGLLGLFAPSAHIQTDRSTFPEENDHRKFDYLAYFFLWVLLMA
                     CVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGQALFEVPVYCALILSIFIAFYAS
                     APPESKFTVGDLFIQILYVGGYAMSVIFMTYVISFIYRKGRKNSGLWSLCFYIVSFFS
                     MCFMLIDYFRDISLFVLIALVPPATLGGCTLLHFENREFSEIIFEPEREYSYLFFLAP
                     LLHFAIFVVILRCMERKFGMKTMRTDPVFRISPRSDRVFNNPEDPDGEDEDVSQERVW
                     TANALTSADFQEKPAIIASCLRKEYKGKKKCFVLKSKKKIATRNISFCVRKGEVVGLL
                     GHNGAGKSTSIKMITGETKPSAGQVLLKGSSTGDTPGFLGYCPQENALWLNLTVREHL
                     EIFAAIKGMRKSDANVAIERLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSV
                     VLLDEPSTGMDPEGQQQMWQAIQATFSNTERGALLTTHYMAEAEAVCDRVAIMVSGRL
                     RCIGSIQHLKSKFGKEYLLEMKVKTPSQVEPLNTEIMRLFPQAARQERYSSLMVYKLP
                     REDVQPLSQAFFKLETVKQSFDLEEYSLSQSTLEQVFLELSKEQELDGFEEELDPSVK
                     WKLLPQEEA"
     exon            322..526
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            527..691
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            692..795
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1022
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1164
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1350
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1492
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1658
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1717
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1828
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2004
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2124
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2263
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2354
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2494
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2614
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2813
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2980
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3114
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3252
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3360
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3534
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3648
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3768
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3834
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..3926
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4047
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4165
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4257
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4418
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4494
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4589
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4590..4709
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4850
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..4930
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4931..4986
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5760
                     /gene="Abca8a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5738..5743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abca8a"
                     /note="hexamer: AATAAA"
     polyA_site      5760
                     /gene="Abca8a"
                     /note="major polyA site"
ORIGIN      
        1 aaatgtggca ggcttctgga agtgaagtga agactctttt caaagacggc agcagcagtt
       61 atggaagaaa cagtcatttc tttgaacacc ctgacaggga agcttaaaat gagaacaaaa
      121 ccataggcat gaattcttac tgagcagcaa accctcccca gagctttcga gagtgtattc
      181 caaccagcga tagagaaacc atctgagaat tctgaataga ccaagatggt taagagagag
      241 ataaatgtgt gccaacaaac gtgggcctta ttgtgcaaga atcttctcag aaaaaagaga
      301 ctgaaaagag atacattttt ggaattcctg tacacagcac ttatactact tagtttaatt
      361 ttatttcttc aattgcatga agtttatgat ttttcgtcac tgcctgatgt ggacctggga
      421 cgcattgatt catttaatga ctccaccttt atgattgtgt acacacctat caccccaaca
      481 actcagagga taatggatag agtctctttg gtctcttaca tgacaggaag aaaaatattg
      541 gcttctccga atgaagaaaa tatgacagaa ctcatttcaa tgcgtttcag tgatgtagtg
      601 ggggtcatat tcaccaacgc ttactcctac aacttgaagt tcataaaagg agcaaggatc
      661 cccaccataa aggagcatca ggaccacaca gctcattgtc attcctatgg agagatcatt
      721 tattgtggcc tttcagaatt ctggagagat gggtttgtgg ctcttcaagc tgccattaac
      781 gctgccatca tagaagtcac aacaaatcac tcagtgatgg aagagatgat gtcacttacc
      841 ggaaaataca tcaagataga ttctttcgtt gggcaagaag ggacaacgac agactgcttc
      901 ctttttttct gtatcattcg tttctcccca cttacctatt atatctcagc tggtgttaca
      961 agagaaagga aaaagatgaa gggcttgatg gcagtgatgg gccttcggga ttcagcattc
     1021 tggctgtcct ggggtttgct ctatggtgtc attgtcttcg ttgtgaccct tctctcgaca
     1081 actattgtaa aactggtcca atttgtcttt ttgactggat ttatggtgat cttcagtctc
     1141 tttttcttct atggcttatc tctgatctct ttgtctttct tgatgagtgt tttactaaag
     1201 aagtcttttc tcactgacct ggtggtgttc ttgctcactg tttcctgtgg aagtcttgga
     1261 ttcacagcat tgtacagata ccttcctgta tccttggagt ggcttctaag tttgctcagt
     1321 ccctttgctt ttatgcttgg aatggtccag ctcttacgtt tagattatga tgtgaattca
     1381 aatgcagacc ccatgggcaa cccaaatgaa gtcattggca caatcttcat gctgttcttt
     1441 gatggtgtct tctacctgct cttgacattc tactttgaga aggttttacc aagtgaatat
     1501 ggacgtcgac acccaccctt gtttttcctg aagtcctcat tttggtcagg acaaaatcca
     1561 gccaatcgga ctgcccttga caatgaaaca gactatgagt tttctgatga ctcttttgaa
     1621 cctgtgtcta tggaattcca tgggaaggaa gccatcagaa tcagaaatct tacaaaagac
     1681 tacatacaaa agtctaagcg cacagaagct ttgaaagatc tgacactgga tgtatataaa
     1741 ggccagatta ctgcgatcct tggtcacagt ggagctggga aatcaacact gttaaatgtc
     1801 ctgagtgggt tgtgtgttcc caccaaaggt tgggtcacta tccataataa caaactctca
     1861 gaaatgactg acttggaaaa tatcagcaag ctcactggag tttgtccaca atgcaatgtg
     1921 caatttgact tcctcactgt aagagaaaat cttaggctat ttgctaaaat aaaagggatt
     1981 caagcccacg aagtggataa cgaggtacaa agagttttgc tggaattgga catgaaaaat
     2041 actcagaata ttcttgttca aaacctaagc ggcggacaga agagaaagct gacgtttgga
     2101 atcgccattt taggagaccc tcagattttc ctactggatg agcccaccgc tggcctggat
     2161 cccttttcaa ggcaccgggt gtggaatttc ctgaaggagc gcagagcaga ccgtgtggtc
     2221 ctcttcagca cgcagttcat ggatgaggct gacatcctgg ctgataggaa agtgttcatc
     2281 tccaagggga agctgaagtg tgcaggatct tctttgtttc tgaagaagaa atgggggatt
     2341 ggttatcact taagcttgca gctgagtgaa acgtgtgtgc atgaaagaat aacatcactt
     2401 gtcaaacagc acatccccga ttccaagttg tcagcagaaa gcgaagggaa actgagctac
     2461 atattacccc tggaaagaac aaacaagttt ccagatcttt atagggatct cgagagaagt
     2521 ccagacctgg gaattgagaa ctatggcgtt tctataacaa cactgactga ggtctttctg
     2581 aaactggaag gaaaatcatc tattgaccaa tcagatattg gtatgacaga agatgtacaa
     2641 gctggagggg caaggagccc agagaggttt gctgaagtag aacaacttgt ctctttactt
     2701 aatgggaggt gtaagatgaa ggggggcatg gctctatggt ggcagcaact ctgtgcagtg
     2761 accaggcttc gcttcttgaa gttaaagcat gaaaggaaat ccatcgttat tctgattctg
     2821 gttttgggga ttggacttct gcatattttg tcagcaaata tttacaggat ggtccgtcaa
     2881 agtgactact gttgggagct tgcccctcat atgtacttcc tcacaccagg ccagcaacca
     2941 cagccgcccc tcacgaactt actgatcgtc aacaaaacag gagcaaaaat cgatgacttt
     3001 atacattcac tggaacaaca gaacatagct ttggaagttg atgcctttgg gactagaaat
     3061 ggcaccgagg acagtcagta taatggagct atcatcctat caggtgacga gaagaattac
     3121 aactttaccc tggcatgcaa caccaagagg ctgaattgtt ttccggttct ggtggatatt
     3181 gtgagtaatg ggctacttgg actgttcgca ccatcagcac acattcaaac tgaccgcagc
     3241 acatttcctg aggaaaatga ccacagaaaa tttgattatt tggcttattt cttcttgtgg
     3301 gtacttctga tggcctgtgt tcctccttat atttccatga ccagcattga tgactataag
     3361 aacagagctc agttccagct gtggatttca gggctctccc catctgcata ctggttcggg
     3421 caggctctgt ttgaggttcc agtgtactgt gcactcattt tgtctatatt cattgcattc
     3481 tatgcctcgg cccctccaga gagtaagttc acagttggag atctgtttat tcagattctc
     3541 tatgttggtg gctatgccat gtcagttatt ttcatgactt atgtgatttc attcatttat
     3601 cgcaagggga gaaaaaatag tggcctttgg tcactttgct tctatattgt ctctttcttc
     3661 tctatgtgtt ttatgcttat tgattacttt agagatatct cactgtttgt tttaattgcc
     3721 ctggttccac ctgctacatt gggaggctgc acattattac attttgagaa tcgtgaattt
     3781 tctgaaataa tttttgagcc agaaagggag tattcctatc tgtttttcct agctcctctt
     3841 cttcattttg ccatcttcgt agttattctc cgatgtatgg aaaggaagtt tggaatgaaa
     3901 acaatgagaa cggatcctgt ctttagaatt tctccaagaa gcgatcgtgt atttaacaat
     3961 ccagaagacc cagatgggga agatgaagat gtgagtcagg aaagagtgtg gacagcaaat
     4021 gctttgactt ccgccgactt ccaggagaag ccagccatca ttgccagctg ccttcgcaag
     4081 gagtacaagg gaaagaagaa atgctttgtt cttaagagca agaagaagat tgccacaaga
     4141 aacatctctt tttgcgttcg aaaaggtgag gttgtaggat tactgggaca caatggagct
     4201 ggtaaaagta catccattaa gatgataact ggagaaacca agccaagcgc cggacaggtg
     4261 ctgctgaagg ggagcagcac aggggacacc ccggggttcc tggggtactg tcctcaggaa
     4321 aatgctctgt ggctcaacct gacagtgagg gaacacctgg agatatttgc agccataaag
     4381 gggatgagaa aaagtgacgc gaacgtggcc atcgaaaggt tggcagatgc gctcaagctg
     4441 caggaccagc tgaagtctcc tgtgaagacg ctgtcagagg gagtgaagag aaagctgtgc
     4501 tttgtgctga gcatcctggg gaacccttct gtggtacttc tggatgagcc atccaccggg
     4561 atggaccccg aggggcagca gcaaatgtgg caggctatcc aggccacctt ttcaaacaca
     4621 gaacggggcg ccctcctgac cacccattac atggcagagg ctgaggctgt gtgtgaccgc
     4681 gtggccatca tggtgtctgg gaggctgaga tgtattggat ccatccaaca tctgaagagc
     4741 aaattcggca aagaatatct cctggagatg aaggtgaaga ccccctcgca ggtggagccc
     4801 ttgaacacgg agatcatgag gctgttcccc caggctgctc ggcaggaaag gtactcttct
     4861 ctgatggtct ataaactgcc cagggaagat gtgcaacctt tatcccaggc cttcttcaaa
     4921 ttagagacag ttaaacagag ctttgacctg gaggagtaca gcctttcaca gtccaccctg
     4981 gagcaggtct tcctggagct ctctaaggag caggagctgg acggttttga agaggaactt
     5041 gatccctcag tcaagtggaa gctcctccca caggaagagg cgtaaccctg acatttttac
     5101 ctatggctgg tttctactct ctagtggctc aaagcaattt tgtctttaac attacatatc
     5161 cattgttgac gagtaaacca tttgaccatg gtgatagaag gtgttgatta catcatgaat
     5221 acacagctct tatgaatggg attaggatca tgggaaaaag ccactgagct agctctctct
     5281 acaatttttc tttgtaggat catcatttta aaacacatta agtgtgtgca ttcctgagtt
     5341 taactgtttg tttagctgtt cattacaact aaagttgtga tttttcagta tatgtatcta
     5401 ttgtgcataa agggtatcca tcctcttttc tgtcctgtct tagcatcctt ccctcagcac
     5461 ccttcatagc cctttatgtc cttctacttt acatatatgg tttggtgtgt atatctgcat
     5521 ataagagaaa gcatatactt ctggggtttg tgtctatctt agtttgttca acatggtgcc
     5581 ctccaattcc atgtattttc cttcagatgg caggattccc tttttgtcac agattaatga
     5641 tacttcattg taaatagata ttatgtttct tcaaacctcc atttgttgat gagtatctag
     5701 actgattctt tatcttgtat attgtgaata gtaccataat aaacatgaat gtgtatgcaa
//
