LOCUS       NM_001347081            6720 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family A member 7 (Abca7),
            transcript variant 1, mRNA.
ACCESSION   NM_001347081 XM_006513710
VERSION     NM_001347081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6720)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   2  (bases 1 to 6720)
  AUTHORS   Butler,C.A., Mendoza Arvilla,A., Milinkeviciute,G., Da Cunha,C.,
            Kawauchi,S., Rezaie,N., Liang,H.Y., Javonillo,D., Thach,A.,
            Wang,S., Collins,S., Walker,A., Shi,K.X., Neumann,J.,
            Gomez-Arboledas,A., Henningfield,C.M., Hohsfield,L.A., Mapstone,M.,
            Tenner,A.J., LaFerla,F.M., Mortazavi,A., MacGregor,G.R. and
            Green,K.N.
  TITLE     The Abca7V1613M variant reduces Abeta generation, plaque load, and
            neuronal damage
  JOURNAL   Alzheimers Dement 20 (7), 4914-4934 (2024)
   PUBMED   38506634
  REMARK    GeneRIF: The Abca7[V1613M] variant reduces Abeta generation, plaque
            load, and neuronal damage.
REFERENCE   3  (bases 1 to 6720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6720)
  AUTHORS   Kawatani,K., Holm,M.L., Starling,S.C., Martens,Y.A., Zhao,J.,
            Lu,W., Ren,Y., Li,Z., Jiang,P., Jiang,Y., Baker,S.K., Wang,N.,
            Roy,B., Parsons,T.M., Perkerson,R.B. 3rd, Bao,H., Han,X., Bu,G. and
            Kanekiyo,T.
  TITLE     ABCA7 deficiency causes neuronal dysregulation by altering
            mitochondrial lipid metabolism
  JOURNAL   Mol Psychiatry 29 (3), 809-819 (2024)
   PUBMED   38135757
  REMARK    GeneRIF: ABCA7 deficiency causes neuronal dysregulation by altering
            mitochondrial lipid metabolism.
REFERENCE   5  (bases 1 to 6720)
  AUTHORS   Dehghan,A., Pinto,R.C., Karaman,I., Huang,J., Durainayagam,B.R.,
            Ghanbari,M., Nazeer,A., Zhong,Q., Liggi,S., Whiley,L., Mustafa,R.,
            Kivipelto,M., Solomon,A., Ngandu,T., Kanekiyo,T., Aikawa,T.,
            Radulescu,C.I., Barnes,S.J., Graca,G., Chekmeneva,E., Camuzeaux,S.,
            Lewis,M.R., Kaluarachchi,M.R., Ikram,M.A., Holmes,E., Tzoulaki,I.,
            Matthews,P.M., Griffin,J.L. and Elliott,P.
  TITLE     Metabolome-wide association study on ABCA7 indicates a role of
            ceramide metabolism in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 119 (43), e2206083119 (2022)
   PUBMED   36269859
  REMARK    GeneRIF: Metabolome-wide association study on ABCA7 indicates a
            role of ceramide metabolism in Alzheimer's disease.
REFERENCE   6  (bases 1 to 6720)
  AUTHORS   Wang,N., Lan,D., Gerbod-Giannone,M., Linsel-Nitschke,P.,
            Jehle,A.W., Chen,W., Martinez,L.O. and Tall,A.R.
  TITLE     ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein
            A-I and mediates cellular phospholipid but not cholesterol efflux
  JOURNAL   J Biol Chem 278 (44), 42906-42912 (2003)
   PUBMED   12917409
  REMARK    GeneRIF: ABCA7 has the ability to bind apolipoproteins and promote
            efflux of cellular phospholipids without cholesterol, and has a
            possible role of ABCA7 in cellular phospholipid metabolism in
            peripheral tissues
REFERENCE   7  (bases 1 to 6720)
  AUTHORS   Honarpour,N., Gilbert,S.L., Lahn,B.T., Wang,X. and Herz,J.
  TITLE     Apaf-1 deficiency and neural tube closure defects are found in fog
            mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9683-9687 (2001)
   PUBMED   11504943
REFERENCE   8  (bases 1 to 6720)
  AUTHORS   Broccardo,C., Osorio,J., Luciani,M.F., Schriml,L.M., Prades,C.,
            Shulenin,S., Arnould,I., Naudin,L., Lafargue,C., Rosier,M.,
            Jordan,B., Mattei,M.G., Dean,M., Denefle,P. and Chimini,G.
  TITLE     Comparative analysis of the promoter structure and genomic
            organization of the human and mouse ABCA7 gene encoding a novel
            ABCA transporter
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 264-270 (2001)
   PUBMED   11435699
REFERENCE   9  (bases 1 to 6720)
  AUTHORS   Schriml,L.M., Peterson,R.J., Gerrard,B. and Dean,M.
  TITLE     Use of denaturing HPLC to map human and murine genes and to
            validate single-nucleotide polymorphisms
  JOURNAL   Biotechniques 28 (4), 740-745 (2000)
   PUBMED   10769753
REFERENCE   10 (bases 1 to 6720)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151846.3 and AC161120.5.
            
            On Jun 20, 2019 this sequence version replaced NM_001347081.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intracellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the ABC1 subfamily. Members of the ABC1
            subfamily comprise the only major ABC subfamily found exclusively
            in multicellular eukaryotes. This protein is widely expressed with
            highest detection in spleen and hematopoietic tissues. Defects in
            this gene cause an increase in amyloid-beta deposits in a mouse
            model of Alzheimer's disease, and a related human protein is
            thought to play a role in lipid homeostasis in cells of the immune
            system. [provided by RefSeq, Jan 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.12565.1,
                                           SRR10223971.10409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC151846.3         3411-3505           c
            96-168              AC151846.3         2319-2391           c
            169-262             AC151846.3         2137-2230           c
            263-404             AC151846.3         1844-1985           c
            405-517             AC151846.3         1643-1755           c
            518-591             AC151846.3         1475-1548           c
            592-672             AC151846.3         1162-1242           c
            673-883             AC151846.3         408-618             c
            884-1023            AC151846.3         179-318             c
            1024-1140           AC161120.5         166120-166236
            1141-1308           AC161120.5         166331-166498
            1309-1538           AC161120.5         166898-167127
            1539-1715           AC161120.5         167443-167619
            1716-1938           AC161120.5         167915-168137
            1939-2160           AC161120.5         168239-168460
            2161-2362           AC161120.5         168540-168741
            2363-2473           AC161120.5         169205-169315
            2474-2645           AC161120.5         169789-169960
            2646-2777           AC161120.5         170127-170258
            2778-2917           AC161120.5         170362-170501
            2918-3055           AC161120.5         171051-171188
            3056-3243           AC161120.5         171396-171583
            3244-3301           AC161120.5         171660-171717
            3302-3579           AC161120.5         171841-172118
            3580-3616           AC161120.5         172294-172330
            3617-3709           AC161120.5         172544-172636
            3710-3861           AC161120.5         172708-172859
            3862-3986           AC161120.5         173062-173186
            3987-4085           AC161120.5         173271-173369
            4086-4373           AC161120.5         173553-173840
            4374-4406           AC161120.5         173947-173979
            4407-4584           AC161120.5         174071-174248
            4585-4754           AC161120.5         174336-174505
            4755-4932           AC161120.5         175266-175443
            4933-5048           AC161120.5         175559-175674
            5049-5193           AC161120.5         176444-176588
            5194-5317           AC161120.5         176683-176806
            5318-5447           AC161120.5         177121-177250
            5448-5568           AC161120.5         177323-177443
            5569-5631           AC161120.5         177532-177594
            5632-5738           AC161120.5         178720-178826
            5739-5880           AC161120.5         179027-179168
            5881-6015           AC161120.5         179254-179388
            6016-6119           AC161120.5         179637-179740
            6120-6212           AC161120.5         179876-179968
            6213-6453           AC161120.5         180355-180595
            6454-6720           AC161120.5         180714-180980
FEATURES             Location/Qualifiers
     source          1..6720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..6720
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /note="ATP-binding cassette, sub-family A member 7"
                     /db_xref="GeneID:27403"
                     /db_xref="MGI:MGI:1351646"
     exon            1..95
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            96..168
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..6606
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette, sub-family A (ABC1), member 7"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family A member 7
                     isoform 1"
                     /protein_id="NP_001334010.1"
                     /db_xref="CCDS:CCDS83724.1"
                     /db_xref="GeneID:27403"
                     /db_xref="MGI:MGI:1351646"
                     /translation="MALGTQLMLLLWKNYTYRRRQPIQLLVELLWPLFLFFILVAVRH
                     SHPPLEHHECHFPNKPLPSAGTVPWLQGLVCNVNNSCFQHPTPGEKPGVLSNFKDSLI
                     SRLLADTRTVLGGHSIQDMLDALGKLIPVLRAVGGGARPQESDQPTSQGSVTKLLEKI
                     LQRASLDPVLGQAQDSMRKFSDAIRDLAQELLTLPSLMELRALLRRPRGSAGSLELVS
                     EALCSTKGPSSPGGLSLNWYEANQLNEFMGPEVAPALPDNSLSPACSEFVGTLDDHPV
                     SRLLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFN
                     FMNDSTNVAMLQRLLDVGGTGQRQQTPRAQKKLEAIKDFLDPSRGGYSWREAHADMGR
                     LAGILGQMMECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLDPSELS
                     SPALSPGHLRFKIRMDIDDVTRTNKIRDKFWDPGPSADPFMDLRYVWGGFVYLQDLLE
                     QAAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAV
                     VREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLGNILPYSHPVV
                     IFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLGG
                     LLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVI
                     YGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEEPPL
                     GLVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFP
                     PSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMG
                     PERERLIRDVGLTLKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASR
                     RGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGY
                     YLTLVKSSQSLVTHDAKGDSEDPRREKKSDGNGRTSDTAFTRGTSDKSNQAPAPGAVP
                     ITPSTARILELVQQHVPGAQLVEDLPHELLLVLPYAGALDGSFAMVFQELDQQLELLG
                     LTGYGISDTNLEEIFLKVVEDAHREGGDSRPQLHLRTCTPQPPTGPEASVLENGELAK
                     LVLDPQAPQGLAPNAAQVQGWTLTCQQLRALLHKRFLLARRSRRGLFAQVVLPALFVG
                     LALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMKLLEALLGEAGLQEP
                     SMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQPGARRLL
                     PDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRY
                     GGFSLGGRDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQWALGLDARNSLK
                     IWFNNKGWHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQLSEATLI
                     ASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDM
                     CNYLVAVCIVVFIFLAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPST
                     AYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDMV
                     RNQAMADAFERLGDKQFQSPLRWDIIGKNLLAMMAQGPLFLLITLLLQHRNRLLPQSK
                     PRLLPPLGEEDEDVAQERERVTKGATQGDVLVLRDLTKVYRGQRNPAVDRLCLGIPPG
                     ECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSMGYCPQSDAI
                     FDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLAT
                     ALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLTSHSMEECEALCTR
                     LAIMVNGRFRCLGSSQHLKGRFGAGHTLTLRVPPDQPEPAIAFIRITFPGAELREVHG
                     SRLRFQLPPGGRCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEES
                     SRQEAEEEEVSKPGRQHPKRVSRFLEDPSSVETMI"
     exon            169..262
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            263..404
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            405..517
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            518..591
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            592..672
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            673..883
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1023
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1140
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1308
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1538
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1715
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1938
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2160
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2362
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2473
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2645
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2777
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2917
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3055
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3243
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3301
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3579
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3616
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3709
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3861
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3986
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4085
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4373
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4374..4406
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..4584
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4585..4754
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4755..4932
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4933..5048
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5193
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5194..5317
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5318..5447
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5448..5568
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5569..5631
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5632..5738
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5739..5880
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5881..6015
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            6016..6119
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            6120..6212
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            6213..6453
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     exon            6454..6720
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6697..6702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /note="hexamer: AATAAA"
     regulatory      6703..6708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /note="hexamer: AAGAAA"
     polyA_site      6714
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
     polyA_site      6720
                     /gene="Abca7"
                     /gene_synonym="Abc51; ABCX"
                     /note="major polyA site"
ORIGIN      
        1 gtccgcaatt gagcggggct ccacttaaag gggccgcgct cccccgccga ggccgagagg
       61 agcgaaagtg gatggagttt gggggcctca gaacgagtca tcatggcctt aggcacacag
      121 ctgatgcttc tgctgtggaa aaattacacc tatcgacgga gacaaccgat ccaactacta
      181 gtggagttgc tttggcccct cttcctcttc ttcatcctag tggctgtccg tcactcccac
      241 ccccctctgg agcatcacga atgccacttt ccaaacaagc cattaccatc ggcgggcacg
      301 gtgccctggc tgcagggcct tgtctgcaac gtaaacaact cctgcttcca gcacccaacg
      361 cctggcgaga agcctggggt cctgagtaac tttaaggatt ccttgatctc gaggctcctc
      421 gctgataccc gcacagtgct cgggggccac agcatccagg acatgctgga tgccctgggg
      481 aaactgatcc ccgtgctcag ggcagttgga ggtggagcac gaccacagga gagtgaccag
      541 ccgaccagtc aagggtcagt gactaagctt ctggagaaga tcctgcaaag ggcatccctg
      601 gatcctgtgc tgggtcaagc ccaggattct atgagaaagt tctcagatgc tatcagggat
      661 cttgcccagg agctcctgac actgcccagc ctgatggagc tccgagcttt gctgcggagg
      721 ccccgagggt cagctggttc tctggagctg gtttcggagg ccctctgcag taccaaggga
      781 cccagcagtc cagggggcct gtccctcaat tggtacgaag ccaaccagct taatgagttc
      841 atggggccag aggtggcccc tgccctgcct gacaacagtc tcagccctgc ctgctctgag
      901 tttgtgggga cactggatga ccaccctgtg tctcggctgc tctggaggcg cctgaagcca
      961 ttgatcctcg ggaaaattct ctttgcacct gacacaaact tcactcggaa gctcatggct
     1021 caggtgaacc agaccttcga ggagctggct ctgttgaggg acctacacga actctggggg
     1081 gtgctgggac cccagatctt caacttcatg aatgacagta ccaacgtggc catgcttcag
     1141 aggcttctgg atgtgggggg cacagggcag aggcagcaga cacccagagc ccagaagaag
     1201 ttggaggcta tcaaagactt tctggatcct agtaggggtg gctacagctg gcgggaggcc
     1261 cacgcagata tgggacgcct ggctggaatc ctaggacaaa tgatggagtg tgtgtccctg
     1321 gacaagctgg aggctgtgcc ctcagaggaa gctcttgtgt cccgtgccct ggagctgctg
     1381 ggtgagcgcc gcctctgggc aggcatcgtg ttcctgagcc cagagcatcc tctggaccca
     1441 tccgaactgt catctccagc cctgagtcct ggccacctac gattcaagat tcgaatggat
     1501 atcgatgatg tcacaaggac caataagatc agggacaagt tttgggaccc aggtccgtca
     1561 gcagatcctt tcatggacct tcggtatgtg tggggaggct tcgtgtacct gcaggacctg
     1621 ctggagcagg cagctgtgcg agtgctcggt ggcgggaact cccgcacagg tctctacctg
     1681 cagcagatgc cacacccctg ctacgtggat gatgtgttcc tgcgggtgct gagccggtct
     1741 ctgcctctgt ttctgactct ggcctggatt tattcggtgg cgctcactgt gaaggccgtg
     1801 gtgcgtgaga aagagacacg gctgcgagaa accatgcgtg cgatggggct gagccgcgcg
     1861 gtgctctggc ttggttggtt cctcagctgc ctgggaccct tcctggtcag cgctgcgttg
     1921 ctggtattag tgcttaagct agggaacatc cttccttaca gccacccggt tgtaatcttc
     1981 cttttcttgg cggccttcgc ggtggccacc gtcgctcaga gttttctgct cagcgccttc
     2041 ttctccaggg ccaacctggc agcagcctgc ggggggctcg cctattttgc gctctatctg
     2101 ccctacgtac tgtgtgtggc ctggcgcgag cgcctgcacc tgggcggact cttagctgcg
     2161 agcctgctgt cccctgtagc ctttggcttt ggatgcgaaa gcctggcgct actagaggag
     2221 cagggagacg gggctcagtg gcacaatttg ggcacaggcc ccgcggagga cgtcttcagc
     2281 ctggcccagg tgtctgcctt cctgttgctt gatgccgtca tctacggcct tgccctctgg
     2341 tacctagagg ctgtgtgccc aggccagtat ggaatccctg aaccatggaa tttccctttt
     2401 cggaggagct actggtgtgg acctgggcct cccaagagtt ctgtcttggc ccctgcccca
     2461 caagatccca aggttctggt ggaagagcca ccccttggcc tggttcctgg tgtctccatt
     2521 cgaggcctga agaaacattt tcgtggctgt ccgcagccag ccctgcaagg actcaacctt
     2581 gacttctacg aaggccacat cactgccttt ttgggtcaca acggggctgg caagacaacc
     2641 acactgtcca ttttgagtgg tctcttccca cccagtagtg gctcggcctc catcctgggc
     2701 catgatgtac aaaccaacat ggcagccatc cggccccacc tgggcatctg cccgcagtac
     2761 aatgtgctgt ttgatatgct gacagtggaa gaacatgttt ggttctatgg ccgtttgaaa
     2821 ggcgtgagtg cagccgccat gggccccgag cgggaacgtc tgatacggga tgtggggctt
     2881 accctcaagc gggacacaca gacacgccac ctctctggtg gaatgcagag aaaactttct
     2941 gtggccattg cctttgtggg tggctctcgt gtggtcatca tggacgagcc cactgctggt
     3001 gtggaccccg cttcccgccg tggcatttgg gaattgctac ttaagtacag agaaggtcgg
     3061 acactgattc tctccactca ccacctggat gaggcagagc tcttgggaga tcgcgtggcc
     3121 atggtggcag gtggctcttt gtgctgctgt gggtccccgc ttttcttgcg ccgacacttg
     3181 ggctgcggtt actacctgac cctggtgaag agttctcagt ccctcgtcac ccatgatgct
     3241 aagggagaca gtgaggaccc cagacgggaa aagaagtcag atggcaatgg caggacgtca
     3301 gacacagcgt tcacacgagg aacctcagac aagagcaacc aggccccggc tcctggcgcc
     3361 gttcccatca ccccaagcac agcccggata ctagagctag tgcagcagca tgtgcctgga
     3421 gcacaactcg tggaggacct gccccatgag cttctgcttg tgctacccta tgcgggggcc
     3481 ctggatggca gcttcgccat ggtcttccag gagctggatc agcagctgga gctcctgggt
     3541 ctcacaggct acgggatctc ggacaccaac ctggaggaga tcttcctaaa ggtggtggag
     3601 gatgcgcaca gagaaggtgg ggactctaga ccgcagctgc accttcgcac atgcactcca
     3661 cagcccccca cagggccaga ggcatcagtt ctggagaatg gggagctggc taagctggtg
     3721 ctggatcccc aagccccaca gggcttggca cccaacgctg cccaagtgca aggctggaca
     3781 cttacctgtc aacagctccg ggctctgctc cacaagcgtt ttctgcttgc tcgccgcagc
     3841 cgccggggcc tgtttgcaca ggttgtgttg cctgccctct ttgtgggcct ggccctgttc
     3901 ttcagcctca ttgtgcctcc ttttggccag tacccacccc tgcagctcag ccctgctatg
     3961 tatggccctc aggtctcgtt cttcagtgag gatgcccctg gggaccccaa ccggatgaag
     4021 ctgctggagg ctctgctagg ggaggctggg ctgcaggaac ccagtatgca ggacaaagat
     4081 gccaggggat ctgagtgtac acactcccta gcttgctact tcacggtccc tgaggtccct
     4141 cctgatgtgg ccagcatcct ggccagtggc aactggacgc cagaatctcc atccccagct
     4201 tgccaatgca gtcagcctgg agcccgccgc ctgttgccag attgcccggc tggagctggg
     4261 ggtccaccac ccccccaggc tgtggctggc ttgggggagg tggtccagaa cctcactggc
     4321 cgaaatgtgt ctgacttttt ggtgaagaca taccccagcc tggtgcgccg aggcctaaag
     4381 accaagaagt gggtggatga ggtcagatat gggggcttct ccctgggagg ccgagatcca
     4441 gacctgccca cagggcatga ggtggtccgc acattggcag agattcgggc actgctgagc
     4501 ccccaacctg ggaatgcgct agaccgtatc ctgaacaacc tcactcagtg ggcccttggc
     4561 cttgatgctc ggaacagcct caagatctgg ttcaacaaca agggctggca tgccatggtg
     4621 gcctttgtga accgagccaa caatggactc ctacatgccc tcctaccatc tggtccagtc
     4681 cgccatgccc acagcatcac tacactcaac catcctttga acttgaccaa ggagcagcta
     4741 tctgaagcta cactgatagc ctcctctgtg gatgtccttg tctccatctg tgtggtcttc
     4801 gccatgtcat ttgtcccagc cagctttacc ctggtcctca tagaggaacg catcaccaga
     4861 gccaagcatc tgcagctggt cagcggcctg ccccaaaccc tctattggct tggcaacttc
     4921 ctctgggaca tgtgtaacta cttggtggca gtgtgcatag tggtgttcat cttcctagcc
     4981 tttcagcaga gagcctatgt ggccccagag aacctgcctg ctctcttact cttgcttctg
     5041 ctgtatgggt ggtctatcac accactcatg tacccagcct ccttcttctt ctcagtgccc
     5101 agcacggcct atgtggtgct cacctgcatc aacctcttca ttggcatcaa tagcagcatg
     5161 gccaccttcg tgctagaact gctttcagat cagaacctgc aagaagtgag ccggatcctg
     5221 aaacaagtgt ttcttatttt cccccacttt tgccttggcc gagggctcat tgacatggtt
     5281 cggaaccagg ccatggcaga tgcctttgag cgcttaggag acaagcaatt tcagtcaccc
     5341 ctacgctggg acatcattgg caagaacctc ctggccatga tggcccaggg acctctgttc
     5401 ctcctcatca cactcctgct ccaacaccgc aaccgtctcc tgccacaatc aaaaccaaga
     5461 ctgctgccgc ccctggggga ggaggatgag gatgtggctc aagagcgtga gcgggtgacc
     5521 aagggggcta cccaggggga tgtgctagtc ctcagggact tgaccaaggt ttaccgtggg
     5581 cagaggaacc cagctgtgga tcgcctgtgc ttagggatcc cccctgggga gtgtttcggg
     5641 ctgctgggtg tcaacggggc agggaagaca tccaccttcc gcatggtgac aggggacaca
     5701 ctgcccagca gtggtgaagc agtactggca ggccacaacg tggcccagga gcggtctgcc
     5761 gcacaccgca gcatgggcta ctgtccccag tctgatgcca tcttcgacct gctgaccggc
     5821 cgggaacatc tggaactgtt tgctcgcctg cgcggggtgc ccgaggccca agttgcccag
     5881 actgcgctct ctggcctggt gcgcctgggc cttcctagct atgcagaccg acccgcgggt
     5941 acctacagcg gaggcaacaa acggaagctg gcgacagcct tagctctggt tggtgaccca
     6001 gctgtggtct ttctggacga gcccaccaca ggcatggacc caagtgcgcg gcgatttctt
     6061 tggaacagct tgctgtccgt ggtgcgcgag ggccgctccg tagtgctcac gtcgcacagc
     6121 atggaggagt gcgaagcgct ctgcacgcgc ctggccatca tggtgaacgg gcggttccgc
     6181 tgtctgggaa gctctcagca tctcaaaggc aggttcgggg ctggccacac actgactcta
     6241 agggtcccac cggaccagcc tgagccggcg atagccttca tcaggatcac attccctggg
     6301 gctgaactcc gggaggtgca cggcagccgt ctgcgcttcc aactgccacc ggggggcaga
     6361 tgcaccctga cacgagtgtt cagggagctg gctgcccagg gcagggccca cggtgtggag
     6421 gacttctctg tgagccagac cactctggag gaggtgttcc tatatttctc caaagaccaa
     6481 ggggaagagg aagagagcag tcggcaggag gctgaagaag aggaggtttc caaacctggc
     6541 cggcagcatc ccaaacgtgt cagccgattc ctggaagacc ccagctctgt ggagaccatg
     6601 atctgagcat gcctgccttg ggactgagtg gcaaagctca gacagaggat ctctgtacca
     6661 tacgctggct cccagaaagc cttgggctct gggggaaata aaaagaaact agaatgagaa
//
