LOCUS       NM_147219               8339 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family A member 5 (Abca5),
            mRNA.
ACCESSION   NM_147219
VERSION     NM_147219.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8339)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8339)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8339)
  AUTHORS   Ray,A.G., Choudhury,K.R., Chakraborty,S., Chakravarty,D.,
            Chander,V., Jana,B., Siddiqui,K.N. and Bandyopadhyay,A.
  TITLE     Novel Mechanism of Cholesterol Transport by ABCA5 in Macrophages
            and Its Role in Dyslipidemia
  JOURNAL   J Mol Biol 432 (17), 4922-4941 (2020)
   PUBMED   32687853
REFERENCE   4  (bases 1 to 8339)
  AUTHORS   Ye,D., Meurs,I., Ohigashi,M., Calpe-Berdiel,L., Habets,K.L.,
            Zhao,Y., Kubo,Y., Yamaguchi,A., Van Berkel,T.J., Nishi,T. and Van
            Eck,M.
  TITLE     Macrophage ABCA5 deficiency influences cellular cholesterol efflux
            and increases susceptibility to atherosclerosis in female LDLr
            knockout mice
  JOURNAL   Biochem Biophys Res Commun 395 (3), 387-394 (2010)
   PUBMED   20382126
  REMARK    GeneRIF: ABCA5 influences macrophage cholesterol efflux, and
            selective disruption of ABCA5 in macrophages leads to increased
            atherosclerotic lesion development in female LDLr(-/-) mice.
REFERENCE   5  (bases 1 to 8339)
  AUTHORS   Wakaumi,M., Ishibashi,K., Ando,H., Kasanuki,H. and Tsuruoka,S.
  TITLE     Acute digoxin loading reduces ABCA8A mRNA expression in the mouse
            liver
  JOURNAL   Clin Exp Pharmacol Physiol 32 (12), 1034-1041 (2005)
   PUBMED   16445568
REFERENCE   6  (bases 1 to 8339)
  AUTHORS   Kubo,Y., Sekiya,S., Ohigashi,M., Takenaka,C., Tamura,K., Nada,S.,
            Nishi,T., Yamamoto,A. and Yamaguchi,A.
  TITLE     ABCA5 resides in lysosomes, and ABCA5 knockout mice develop
            lysosomal disease-like symptoms
  JOURNAL   Mol Cell Biol 25 (10), 4138-4149 (2005)
   PUBMED   15870284
  REMARK    GeneRIF: ABCA5 is a protein related to a lysosomal disease and
            plays important roles, especially in cardiomyocytes and follicular
            cells
            Erratum:[Mol Cell Biol. 2005 Jul;25(13):5786]
REFERENCE   7  (bases 1 to 8339)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 8339)
  AUTHORS   Annilo,T., Chen,Z.Q., Shulenin,S. and Dean,M.
  TITLE     Evolutionary analysis of a cluster of ATP-binding cassette (ABC)
            genes
  JOURNAL   Mamm Genome 14 (1), 7-20 (2003)
   PUBMED   12532264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035955.1, CJ115212.1, AK047188.1, AK046203.1, AK138604.1,
            AK129463.1 and BC053340.1.
            
            On Apr 28, 2007 this sequence version replaced NM_147219.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF491842.1, SRR10223970.14893.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AK035955.1         2-124
            124-189             CJ115212.1         71-136
            190-352             AK047188.1         140-302
            353-719             AK046203.1         349-715
            720-1369            AK047188.1         670-1319
            1370-5015           AK138604.1         1187-4832
            5016-7478           AK129463.1         1669-4131
            7479-8339           BC053340.1         3030-3890
FEATURES             Location/Qualifiers
     source          1..8339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 73.53 cM"
     gene            1..8339
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /note="ATP-binding cassette, sub-family A member 5"
                     /db_xref="GeneID:217265"
                     /db_xref="MGI:MGI:2386607"
     exon            1..232
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            233..352
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..5179
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /note="ATP-binding cassette transporter sub-family A
                     member 5; ATP-binding cassette, sub-family A (ABC1),
                     member 5"
                     /codon_start=1
                     /product="cholesterol transporter ABCA5"
                     /protein_id="NP_671752.2"
                     /db_xref="CCDS:CCDS25591.1"
                     /db_xref="GeneID:217265"
                     /db_xref="MGI:MGI:2386607"
                     /translation="MATAIRDVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLF
                     WLILVSMMHPNKKYEEVSDIELSPMDKFSLSNVILGYTPVTNITSSIMQRVSTDHLPK
                     VIVTEEYANEKELVAASLSKSSNFVGVVFKDTMSYELRFFPEMIPVSSIYMNSREGCS
                     KTCDAAQYWSLGFTVLQASIDAAIIQLKTNVSVWSELESTKAVIMGEAAVVEIDTFPR
                     GVILIYLVIAFSPFGYFLAIHIVAEKEKKLKEFLKIMGLHDTAFWLSWVLLYASLIFL
                     MSLLMAVIATASSLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFV
                     TVVFGFVGLLIVLIESFPRSLVWLFSPLCQCAFLIGIAQVMHLEDFNEGALFSNLTEG
                     PYPLIITIIMLALDSVFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKNKRNYKEL
                     SEGNINGNISLNEIVEPVSSEFIGKEAIRISGIQKSYRKKTENVEALRNLSFDIYEGQ
                     ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQSDI
                     NFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQAIKDNQAKKLSGGQKRKLS
                     VGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADR
                     KAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQN
                     DQQLVYSLPFKDMDKFSGLFSALDIHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAD
                     YSVFTQQPREEETDSKSFDEMEQSLLILSETKASSVSTMSLWKQQVSTIAKFHFLSLK
                     RESKSVRAVLLLLLIFFAVQIFMFFLHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTS
                     LLLQNSTDSDINGLIEFFAHQNIMVAMFNDSDYVSAAPHSAALNVVRSEKDYVFSAVF
                     NSTMVYCLPVMMNIISNYYLYHLNVTEAIQTWSTPFIQEITDIVFKIELYFQAALLGI
                     IVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWVGQAVVDIPLFFVVLILMLGSL
                     FAFHHGLYFYPAKFLAVVFCLIAYVPSVILFTYIASFTFKKILNTKEFWSFIYSVTAL
                     ACVAITETTFFLQYAVTAVFHYTFCIAIPIYPLLGCLISFIKGSWKNMPKNENTYNPW
                     DRLLVAVIMPYLQCILWIFLLQHYEKIHGGRSIRKDPFFRALSQKAKNKKFPEPPINE
                     DEDEDVKAERLKVKELMGCQCCEEKPAIMVCNLHKEYDDKKDFLHSRKTTKVATKYIS
                     FCVKKGEILGLLGPNGAGKSTVINTLVGDVEPTSGKIFLGDYGSHSSEDDESIKCMGY
                     CPQTNPLWPDLTLQEHFEIYGAVKGMSPGDMKEVISRITKALDLKEHLQKTVKKLPAG
                     IKRKLCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYME
                     EAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEIDRLQREIQY
                     IFPNASRQESFSSILAFKIPKEDVQSLSQSFAKLEEAKRTFAIEEYSFSQATLEQVFV
                     ELTKEQEEEDNSCGTLASTLWWERTQEDRVVF"
     exon            353..557
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            558..719
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            720..808
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1038
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1180
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1369
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1517
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1686
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1745
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1856
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2032
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2152
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2291
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2382
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2522
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2642
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2844
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3014
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3142
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3280
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3394
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3565
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3679
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3814
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3889
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..3981
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            3982..4108
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4226
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            4227..4318
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4494
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4570
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4665
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            4666..4785
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            4786..4935
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5015
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            5016..5071
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     exon            5072..8269
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8244..8249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /note="hexamer: AATAAA"
     polyA_site      8269
                     /gene="Abca5"
                     /gene_synonym="ABC13; B930033A02Rik; mKIAA1888"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgcgc gcggctctct cggcgtagcg gggcggcggg cacgcgcgcg ctcggcctcg
       61 cggaccgcgt ctccgcgcag aatttccgag ctccgtcact taccgcggtc gcggtcgccg
      121 caggtaagct cgcggcttgg gcctgacagc gctgcggctg cgacgccggg gtgaggagac
      181 gccgaggccc gcggcgctcg aggtcgctcg ccattcgtgt ctgcggagag agtaaactga
      241 cctagaaaac atggctactg caattaggga tgtgggagtt tggagacaga ccagaacact
      301 tctactgaaa aattacctaa ttaaatgcag gactaaaaaa agtagtgttc aggaaattct
      361 ttttcctcta tttttcttat tttggctgat attagttagc atgatgcatc caaataagaa
      421 atatgaagag gtatctgata tagagctcag ccctatggac aaattcagcc tttccaacgt
      481 tattcttgga tacactcccg tgactaacat tacaagcagc attatgcaga gggtttctac
      541 cgatcatctt cccaaggtta tagttactga agaatacgca aatgagaaag aactggtagc
      601 cgcaagtctt tctaagtcca gcaacttcgt aggtgtggtt ttcaaagaca ccatgtccta
      661 tgaacttcgt ttttttcctg aaatgattcc agtgtcttct atttatatga attcaagaga
      721 aggctgttca aagacatgtg atgctgctca gtactggtct ttggggttta cagttctgca
      781 ggcatcgata gatgctgcca ttatacagct gaagaccaat gtttctgtgt ggagcgagct
      841 ggagtcgacc aaagctgtga tcatgggaga ggccgctgtt gtggagattg acaccttccc
      901 gcgaggggtc atcctcatct acctcgtcat agccttctcg cccttcggct acttcctggc
      961 aatccacatc gtggcagaaa aagaaaagaa gttaaaggaa tttttaaaga taatgggact
     1021 tcatgacact gctttttggc tttcctgggt tcttctgtac gcaagcttga ttttccttat
     1081 gtccctgctt atggctgtca tcgcaacagc ttcttcgtta ttccctcaga gtagcagcat
     1141 tgtgatcttt ctactgttct tcttatatgg attgtcatct gtgttttttg ctttaatgct
     1201 gacgcctctt tttaaaaaat caaaacacgt gggagtcgtt gagttttttg tcaccgtggt
     1261 gtttggattt gttggcctgc tgattgtcct catagaaagt ttccccaggt cgctggtgtg
     1321 gctcttcagt cctttgtgtc agtgtgcctt tctgattggg attgcacagg tcatgcattt
     1381 agaagatttt aatgagggtg ccttattttc taatttgact gaaggtccct atcctctaat
     1441 tattactatt atcatgctag ctcttgacag tgtgttctat gtcctcctgg ctgtgtatct
     1501 cgaccaagtc attccagggg aatttggctt gaggaggtca tctttgtatt ttttgaagcc
     1561 atcgtattgg tcaaaaaaca aaagaaacta taaggagcta tcggagggca acattaatgg
     1621 caatattagt ctcaatgaaa ttgttgagcc cgtttcttca gaatttatag ggaaagaagc
     1681 tataagaata agtggtattc agaaatccta tagaaagaaa actgagaacg tggaggcttt
     1741 gagaaatttg tcatttgaca tatatgaagg tcagattact gcactgctgg gccacagtgg
     1801 aacaggaaaa agcacactga tgaatattct gtgtggactg tgtccaccct ctgatgggtt
     1861 tgcttctata tatggacaca gagtctctga aatagatgaa atgtttgaag caagaaaaat
     1921 gattggcata tgtccgcagt cagatataaa ctttgatgtt ctgacagtag aagaaaattt
     1981 atcaattttg gcttcaatca aaggaatacc agccaacaat ataattcaag aagtgcagaa
     2041 agtgttgctg gatctggaca tgcaagccat caaagataat caagcgaaaa agttaagcgg
     2101 tggtcagaaa aggaagctgt ctgtaggaat tgcagttctc gggaatccaa agatactcct
     2161 gctagacgag cctacagcag gaatggaccc ctgctctcgc catattgttt ggaatcttct
     2221 aaagtataga aaggctaaca gagtgaccgt gtttagtact cacttcatgg atgaggctga
     2281 cattcttgcc gacaggaaag ctgtcatatc acaaggaatg ctgaagtgtg ttggttcttc
     2341 aattttccta aagagtaaat ggggaatcgg ctaccgcctg agcatgtata tagacagata
     2401 ctgtgccaca gagtcactgt cgtcgctggt taggcagcac atacccgcag ccgcgctact
     2461 gcagcagaat gaccagcagc tcgtgtacag cctgcctttc aaagacatgg acaaattttc
     2521 aggcttgttt tctgctctag acattcattc aaacctgggt gttatttctt atggtgtttc
     2581 catgacaaca ttggaagatg tattcttaaa gctagaagtt gaagcagaaa ttgaccaagc
     2641 agactatagt gtatttacac agcagccgcg ggaggaagaa acagattcaa aatcctttga
     2701 tgaaatggaa cagagtttac ttattctctc tgaaacgaaa gcttcttcag tgagcaccat
     2761 gagcctctgg aagcagcaag tgtctacgat tgcaaagttt catttcctct cattgaaacg
     2821 agaaagcaaa tcagtgcgcg ctgtgttgct tctgctttta attttttttg cagttcagat
     2881 ttttatgttt tttctccatc attcttttaa aaatgctgtg gttcccatca aactcgttcc
     2941 agacttgtat ttcctaaagc ctggagataa acctcataaa tacaaaacaa gcctgctgct
     3001 tcaaaattct actgactcag atatcaatgg tcttattgag ttttttgcac accagaacat
     3061 aatggtggca atgtttaatg acagtgacta tgtgtctgct gctcctcaca gtgcggctct
     3121 caatgtggtg cgttctgaaa aggactatgt tttttctgct gttttcaaca gtactatggt
     3181 ttattgtttg ccagtcatga tgaacatcat tagtaactac tatctttatc atttaaatgt
     3241 gactgaagcc atccagacct ggagtacccc gttcattcaa gaaattactg acattgtttt
     3301 taaaattgag ctatattttc aagcagcttt gcttggaatc attgttactg caatgccacc
     3361 ttactttgcc atggaaaatg cagagaatca taagatcaaa gcttatactc aacttaaact
     3421 ttcgggtctt ttgccatcag cctattgggt tggacaagct gttgtggata ttcccttgtt
     3481 ttttgttgtt ctgattttga tgctgggaag tttatttgca tttcatcatg gactgtattt
     3541 ttatcctgca aaatttcttg ctgtggtgtt ttgcctcatt gcttatgtgc cctccgtcat
     3601 tctgttcacg tacatagctt cgttcacttt caagaaaatt ttaaatacca aggaattttg
     3661 gtcatttatc tattctgtga ccgcattggc ttgtgtggca atcacggaaa caactttctt
     3721 tctgcaatat gcagttacgg ctgtctttca ttacaccttc tgcatagcca ttccaatcta
     3781 ccctctcctg ggttgtctga tttctttcat aaagggttct tggaagaata tgccaaaaaa
     3841 tgagaatacc tacaatccct gggatagact tttagttgct gtaatcatgc cctacctgca
     3901 gtgtatactg tggattttcc tcttacaaca ctatgagaaa atacatggag gcagatctat
     3961 aagaaaggat ccatttttca gggccctttc acaaaaggcc aaaaataaga agtttccaga
     4021 accacccatc aatgaggatg aagatgaaga tgtcaaagct gaaagactga aggttaaaga
     4081 gctgatgggt tgccagtgtt gtgaggagaa gccagccatt atggtatgca atttgcataa
     4141 agagtatgat gacaagaaag attttcttca ttcaagaaaa acaacaaaag tagcaacaaa
     4201 atacatctct ttctgtgtga aaaaaggaga gatcttggga ctgttgggtc caaatggagc
     4261 tggcaaaagc acagtcatta acactctggt tggggacgtt gagccaactt caggcaagat
     4321 ctttctagga gattatggtt cacattcaag tgaagatgac gaatccatta agtgtatggg
     4381 gtactgcccc cagacaaacc cactgtggcc agatctcact ctacaggaac attttgagat
     4441 ttacggagct gtgaaaggaa tgagtcctgg tgacatgaag gaagtcatca gtcgaataac
     4501 aaaagccctt gatttgaaag aacatcttca gaagactgta aagaagctac ctgcagggat
     4561 caagcgaaag ctgtgttttg ctctcagcat gctggggaac cctcaggtga cgctgctgga
     4621 tgagccgtcc acaggcatgg acccaagagc caagcagcac atgtggagag ctattcgaac
     4681 tgcatttaaa aacaaaaagc gggccgccct cctgactact cattacatgg aagaggcaga
     4741 ggctgtctgt gacagagtgg ccatcatggt atctgggcag ctaagatgta ttggaacagt
     4801 acaacatcta aagagtaagt ttggtaaagg ctactttttg gaaattaaat taaaggactg
     4861 gatagaaaac ctggaaatag atcgccttca aagagaaatt caatatattt tcccaaatgc
     4921 aagccgccaa gagagctttt cttctatttt ggcttttaaa attccaaaag aagatgttca
     4981 gtctctctca caatccttcg ctaagttgga agaagcaaaa cgcacttttg ccattgaaga
     5041 atacagcttt tctcaagcaa ccctggaaca ggtttttgta gaacttacta aagagcaaga
     5101 ggaagaagat aacagctgtg ggactttggc cagcactctc tggtgggaaa ggacgcagga
     5161 ggatagagta gtattttgaa tgtttatgct cacccagcct accgaccctg agttggttta
     5221 ttctttttta ttctattttt ttcttctttt atcttatctt tgattttaaa agcttattac
     5281 ttgaatagtt attaaaaaaa atgaaagcac ttggaaattt cttaaagtcc ttaattaaca
     5341 caccatggtt atggtttgga ttttctttca ataaatttgc gtgtaattgt ccatgtgcat
     5401 gtttatatct gaaggtagtc tatatgccta ccttcacgtt tcacaaaaac aatatttctc
     5461 aacttaggat ttaaagaaat aataaaagaa taattctgaa taatatttaa attttatact
     5521 atgttacata attatgtaat ttcccagtgc taattaaaaa gaccagtgcc tgactaataa
     5581 catagaagag agacacaaag caatgcagaa actggctttc cctttgatat gtctaaaaga
     5641 agctcttagt ggaagttggc ctgtgtaaat gtggaaccgt tgagaagtaa cgtccactag
     5701 gtggcagtcg ttggtcacag gaaataaagg gaagccgcag tctagtgact gcagatatgg
     5761 gcaattaaat gtttcaggtt gtatgtcttt tgtctacatt aaaattcaaa tgtgtttggt
     5821 gatcgttatt cacagaaaga ctctgactag agtcttagta tgtaagagtc caggtctctg
     5881 aaagtgcagt gacagctgtt tgtcgaggtg gccagttcat ctctacttcc ctccagacac
     5941 ccgactgcga gctgggagag agcgcgttgt tgcctttcct catacagggc tcatttaagt
     6001 ttattcttag atgagacatt taatggataa ccatctttat tactaaattt gattccttga
     6061 ctctcttgag ttttaagtag gtcagcatat accttccttt aaaaggtcac ctcagaacat
     6121 ggtagaatat aggagctctt tcaagggtta aattaagaaa taaaaattag agtttcactc
     6181 ttgtgacaga gttgaaatat gataattaat cttagaaata tttgatttta tgactcatat
     6241 ggacaggtat acaagtatat gatgtagttg atactgtatt tcaggctgtt gtatatgtgt
     6301 tagctttgta aaaacatata ttgtggtgtg acttttgcat cagagacgta aagaacaata
     6361 gcaagaacag agggcttgct accaactttc aatggtcaag ctttcagtga agttattaat
     6421 tatttaatgt tgggaagatt taatgaactt ttagtcctgt tgggtagtaa aatgtgtgac
     6481 tttaggcact agtggctaat tcaagttttc ctttctcagt acaaggtggc acatggctgg
     6541 caactttctc tattgctttg acagtttctt tccaccttcc taaaggcatc tgtgtagtct
     6601 cgtatctcag aggtactcta atgtaataga accatcctac aagtctgctt ggattttatg
     6661 acacgcccct cccccaagtt cttgtaaggt ttcattggca gtagcttgcc tcctgatacc
     6721 aaattataat tttggatcct ttaaggatct tacatttaat taatcattta attaatgatt
     6781 actgcatgac caatatagtc aagatgtatt taagatgaaa tctttatttt tgctgataaa
     6841 ttataaattg cacattgtat tttctcagca agtcattgct aaatggtgcc gtaaacttga
     6901 agagctatct tttagaattt aagtaccttg ggcctttttt tgggggggat gtgatttttg
     6961 taactctgta acctagaaca cataccctta aaaacaaaca aacaagctgc atttatagtt
     7021 tactaggaca gttaccgaaa agggtaggtt tcatttgtgt cttaaaagcg tttggccctc
     7081 ctaagacaga actgtctcat agagatggtg aacacaggcc atatcgcctt ctttctcata
     7141 tagacttggt cactgtctat tagcattgct cagtgtgtgc tcagtgtaaa atataatttt
     7201 cctagggaat gaaagtcgag actgcactgt ctagtcttct atattgtgtg ttcattcata
     7261 ttacagtgga tagtttggtt ttatacatgg atttatttta aattatctta aattattgct
     7321 ttcagaactt tgtttctttt caatacaggt aaagaaacaa gtgtatttgt tagcaacaaa
     7381 tgaaaacaaa ctgcagcgtc accttcctgc cttatatttt ccatctgtgg ccaaacagta
     7441 agagtagaac aaaggcagac tctgccgagt tgaaggcatt gctgtctgca gcagaggggc
     7501 cggtcaggag gaagcagtgg aaagcgttct gggaggtttg ccttctgtgg gctcttccct
     7561 gctttccatg ctgttcttag gaaaaagcag ggttcttttt tttcccccaa aactttaatt
     7621 tgtcagagat tatttgtagc cagttttggt tttctctgtt aaaacatgtt tcgatacttt
     7681 aagcacacct tccagtgact gcgtttcaga gtgggctctt tgggtagaag gatgaactgt
     7741 tcggctctgt aagatcttac attttattaa gacaaggata gatacttata accagttatg
     7801 atatgacaat gctttgctac tagtcttaag aatatcttct aggaaaatga atagcacagt
     7861 taattttact agggtgagtg ttggtttccc ggttctttgt tggtcactca gcgtctcatt
     7921 ccgatcgtgc gtttcacatt tgttacaatg ccatcttaca ttttcaggta gcattcaaaa
     7981 cgcaggactt tttttttttt aaatagcaaa tgcttttaaa tgctttttct taatgtattt
     8041 ttaatattgt taacattgag ttctcatctt tccccttgaa atagcatatt acataaagtg
     8101 agagaattta ttctcaggtg aattattttt gtatcagcta ttcttataag gtaaaaattt
     8161 acttgttttc tattcataat gtgttatatg tacaattctc aatgctgccc tttaagaaaa
     8221 atgaatgtgc ttatattatt aataataaac tttaagagct aaaaatctaa aaaaaaaaaa
     8281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
