LOCUS       NM_007378               7268 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus ATP-binding cassette, sub-family A member 4 (Abca4),
            mRNA.
ACCESSION   NM_007378
VERSION     NM_007378.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7268)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7268)
  AUTHORS   Zhao,J., Kim,H.J., Montenegro,D., Dunaief,J.L. and Sparrow,J.R.
  TITLE     Iron overload and chelation modulates bisretinoid levels in the
            retina
  JOURNAL   Front Ophthalmol (Lausanne) 3, 1305864 (2023)
   PUBMED   38983013
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7268)
  AUTHORS   Riedmayr,L.M., Hinrichsmeyer,K.S., Thalhammer,S.B., Mittas,D.M.,
            Karguth,N., Otify,D.Y., Bohm,S., Weber,V.J., Bartoschek,M.D.,
            Splith,V., Brummer,M., Ferreira,R., Boon,N., Wogenstein,G.M.,
            Grimm,C., Wijnholds,J., Mehlfeld,V., Michalakis,S., Fenske,S.,
            Biel,M. and Becirovic,E.
  TITLE     mRNA trans-splicing dual AAV vectors for (epi)genome editing and
            gene therapy
  JOURNAL   Nat Commun 14 (1), 6578 (2023)
   PUBMED   37852949
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7268)
  AUTHORS   Matsuyama,M., Ortega,J.T., Fedorov,Y., Scott-McKean,J.,
            Muller-Greven,J., Buck,M., Adams,D., Jastrzebska,B., Greenlee,W.
            and Matsuyama,S.
  TITLE     Development of novel cytoprotective small compounds inhibiting
            mitochondria-dependent cell death
  JOURNAL   iScience 26 (10), 107916 (2023)
   PUBMED   37841588
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7268)
  AUTHORS   Ortega,J.T., Parmar,T. and Jastrzebska,B.
  TITLE     Galanin receptor 3 - A new pharmacological target in retina
            degeneration
  JOURNAL   Pharmacol Res 188, 106675 (2023)
   PUBMED   36693600
REFERENCE   6  (bases 1 to 7268)
  AUTHORS   Mata,N.L., Weng,J. and Travis,G.H.
  TITLE     Biosynthesis of a major lipofuscin fluorophore in mice and humans
            with ABCR-mediated retinal and macular degeneration
  JOURNAL   Proc Natl Acad Sci U S A 97 (13), 7154-7159 (2000)
   PUBMED   10852960
REFERENCE   7  (bases 1 to 7268)
  AUTHORS   Weng,J., Mata,N.L., Azarian,S.M., Tzekov,R.T., Birch,D.G. and
            Travis,G.H.
  TITLE     Insights into the function of Rim protein in photoreceptors and
            etiology of Stargardt's disease from the phenotype in abcr knockout
            mice
  JOURNAL   Cell 98 (1), 13-23 (1999)
   PUBMED   10412977
REFERENCE   8  (bases 1 to 7268)
  AUTHORS   Nasonkin,I., Illing,M., Koehler,M.R., Schmid,M., Molday,R.S. and
            Weber,B.H.
  TITLE     Mapping of the rod photoreceptor ABC transporter (ABCR) to
            1p21-p22.1 and identification of novel mutations in Stargardt's
            disease
  JOURNAL   Hum Genet 102 (1), 21-26 (1998)
   PUBMED   9490294
REFERENCE   9  (bases 1 to 7268)
  AUTHORS   Azarian,S.M. and Travis,G.H.
  TITLE     The photoreceptor rim protein is an ABC transporter encoded by the
            gene for recessive Stargardt's disease (ABCR)
  JOURNAL   FEBS Lett 409 (2), 247-252 (1997)
   PUBMED   9202155
REFERENCE   10 (bases 1 to 7268)
  AUTHORS   Allikmets,R., Singh,N., Sun,H., Shroyer,N.F., Hutchinson,A.,
            Chidambaram,A., Gerrard,B., Baird,L., Stauffer,D., Peiffer,A.,
            Rattner,A., Smallwood,P., Li,Y., Anderson,K.L., Lewis,R.A.,
            Nathans,J., Leppert,M., Dean,M. and Lupski,J.R.
  TITLE     A photoreceptor cell-specific ATP-binding transporter gene (ABCR)
            is mutated in recessive Stargardt macular dystrophy
  JOURNAL   Nat Genet 15 (3), 236-246 (1997)
   PUBMED   9054934
  REMARK    Erratum:[Nat Genet. 1997 Sep;17(1):122. doi: 10.1038/ng0997-122a.
            PMID: 9288113]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF000149.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ABC1 subfamily. Members of
            the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes. This protein was the first
            of the ABC transporters to be observed in photoreceptors and may
            play a role in the photoresponse. Mutations in the human gene are
            found in patients diagnosed with Stargardt disease and are
            associated with retinitis pigmentosa-19 and macular degeneration
            age-related 2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057853.1, AF000149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..7268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 52.94 cM"
     gene            1..7268
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /note="ATP-binding cassette, sub-family A member 4"
                     /db_xref="GeneID:11304"
                     /db_xref="MGI:MGI:109424"
     exon            1..153
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..7020
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /EC_number="7.6.2.1"
                     /note="rim protein; RmP; Rim protein; retinal-specific
                     ATP-binding cassette transporter; RIM ABC transporter;
                     ATP-binding cassette 10; ATP-binding cassette, sub-family
                     A (ABC1), member 4"
                     /codon_start=1
                     /product="retinal-specific phospholipid-transporting
                     ATPase ABCA4"
                     /protein_id="NP_031404.1"
                     /db_xref="CCDS:CCDS38617.1"
                     /db_xref="GeneID:11304"
                     /db_xref="MGI:MGI:109424"
                     /translation="MGFLRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRN
                     ANPLYSQHECHFPNKAMPSAGLLPWLQGIFCNMNNPCFQNPTPGESPGTVSNYNNSIL
                     ARVYRDFQELFMDTPEVQHLGQVWAELRTLSQFMDTLRTHPERFAGRGLQIRDILKDE
                     EALTLFLMRNIGLSDSVAHLLVNSQVRVEQFAYGVPDLELTDIACSEALLQRFIIFSQ
                     RRGAQTVRDALCPLSQVTLQWIEDTLYADVDFFKLFHVLPTLLDSSSQGINLRFWGGI
                     LSDLSPRMQKFIHRPSVQDLLWVSRPLLQNGGPETFTQLMSILSDLLCGYPEGGGSRV
                     FSFNWYEDNNYKAFLGIDSTRKDPAYSYDKRTTSFCNSLIQSLESNPLTKIAWRAAKP
                     LLMGKILFTPDSPAARRIMKNANSTFEELDRVRKLVKAWEEVGPQIWYFFEKSTQMTV
                     IRDTLQHPTVKDFINRQLGEEGITTEAVLNFFSNGPQEKQADDMTSFDWRDIFNITDR
                     FLRLANQYLECLVLDKFESYDDEVQLTQRALSLLEENRFWAGVVFPGMYPWASSLPPH
                     VKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGIVKSQM
                     QAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKGIVLEKELRL
                     KETLKNQGVSNAVIWCTWFLDSFSIMALSIFLLTLFIMHGRILHYSDPFILFLFLLAF
                     ATATIMQSFLLSTLFSKASLAAACSGVIYFTLYLPHVLCFAWQDRMTADLKTTVSLLS
                     SVAFGFGTEYLVRFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLLDAALYGLLAWY
                     LDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEEMEDPEHPEGMN
                     DSFFERELPGLVPGVCVKNLVKVFEPSGRPAVDRLNITFYENQITAFLGHNGAGKTTT
                     LSILTGLLPPTSGTVLIGGKDIETNLDVVRQSLGMCPQHNILFHHLTVAEHILFYAQL
                     KGRSWEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEP
                     TSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLF
                     LKNCFGTGFYLTLVRKMKNIQSQRGGCEGVCSCTSKGFSTRCPTRVDEITEEQVLDGD
                     VQELMDLVYHHVPEAKLVECIGQELIFLLPNKNFKQRAYASLFRELEETLADLGLSSF
                     GISDTPLEEIFLKVTEDAGAGSMFVGGAQQKREQAGLRHPCSAPTEKLRQYAQAPHTC
                     SPGQVDPPKGQPSPEPEDPGVPFNTGARLILQHVQALLVKRFHHTIRSRKDFVAQIVL
                     PATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQYTFFSMDEPNNEHLEVLADVLLNR
                     PGFGNRCLKEEWLPEYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPSCKCSTREK
                     LTMLPECPEGAGGLPPPQRTQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVN
                     EQRYGGISIGGKLPAIPISGEALVGFLSGLGQMMNVSGGPVTREASKEMLDFLKHLET
                     TDNIKVWFNNKGWHALVSFLNVAHNAILRASLPRDRDPEEYGITVISQPLNLTKEQLS
                     DITVLTTSVDAVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWLTN
                     FLWDIMNYAVSAGLVVGIFIGFQKKAYTSPDNLPALVSLLMLYGWAVIPMMYPASFLF
                     EVPSTAYVALSCANLFIGINSSAITFVLELFENNRTLLRFNAMLRKLLIVFPHFCLGR
                     GLIDLALSQAVTDVYAQFGEEYSANPFQWDLIGKNLVAMAIEGVVYFLLTLLIQHHFF
                     LTRWIAEPAREPVFDEDDDVAEERQRVMSGGNKTDILKLNELTKVYSGSSSPAVDRLC
                     VGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTSISDVHQNMGYC
                     PQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGN
                     KRKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVSIIREGRAVVLTSHSMEEC
                     EALCTRLAIMVKGTFQCLGTIQHLKYKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQG
                     NFPGSVQRERHHSMLQFQVPSSSLARIFQLLISHKDSLLIEEYSVTQTTLDQVFVNFA
                     KQQTETYDLPLHPRAAGASWQAKLEEKSGRLQTQEPLPAGSEQLANGSNPTAAEDKHT
                     RSPQ"
     exon            154..247
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            248..389
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            390..529
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            530..657
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            658..855
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            856..945
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1186
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1326
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1443
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1641
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1847
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2024
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2247
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2469
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2674
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2740
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2830
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3005
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3137
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3277
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3415
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3609
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..3694
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3900
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..3949
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4212
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4337
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            4338..4436
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4623
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4718
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..4751
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..4857
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            4858..4932
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            4933..5102
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            5103..5280
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            5281..5396
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            5397..5544
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            5545..5668
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            5669..5798
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            5799..5919
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            5920..5982
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            5983..6089
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            6090..6231
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            6232..6366
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            6367..6470
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            6471..6563
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            6564..6813
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            6814..6900
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     exon            6901..7248
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7225..7230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /note="hexamer: AATAAA"
     polyA_site      7248
                     /gene="Abca4"
                     /gene_synonym="Abc10; Abcr; D430003I15Rik; RmP"
                     /note="major polyA site"
ORIGIN      
        1 gctggacgtg gtcctagcgg cctttgtgtc cggtgcttgc ctgagcccca gctcggggtg
       61 attctcccgg tgctggggtg gtccggcatg ggcttcctca gacagataca gcttttgctt
      121 tggaagaact ggactctgag gaaaaggcag aagattcgct ttgtagtgga actcgtgtgg
      181 cctttgtctt tgtttttggt gttaatctgg ctgaggaatg ccaacccact ctatagtcag
      241 catgaatgcc attttcccaa caaggcgatg ccttcagcag gactgttacc gtggctccag
      301 gggattttct gcaatatgaa caacccttgt tttcaaaacc ccacccctgg agagtctcct
      361 ggaactgtct caaactataa caactccatc ttggcaagag tatatcgaga ttttcaagaa
      421 ctcttcatgg acaccccgga ggtccagcac cttggccagg tttgggccga gctccgcacc
      481 ttgtcgcagt tcatggacac cctgaggact caccctgaga gatttgcagg aagaggatta
      541 caaatccgag acatcctaaa agatgaagag gcgctgaccc tatttctcat gagaaacatt
      601 ggcctgtctg actcggttgc ccatcttctg gtcaactccc aagttcgtgt ggagcagttt
      661 gcttatggag tcccagactt ggaactgaca gacattgcct gcagcgaggc cctcctgcag
      721 cgcttcatca tcttcagcca gcgtcggggg gcacagacgg tacgcgatgc cctgtgtccc
      781 ctctcccagg tcaccctaca gtggatagaa gacactctgt atgccgatgt ggacttcttc
      841 aaactcttcc atgtgctccc cacactcctg gacagcagtt ctcaaggaat caacttgaga
      901 ttttggggag gaatattatc tgatctgtca ccaagaatgc aaaagtttat ccatcggcca
      961 agtgttcaag acttgctatg ggtgagcaga cctctcctgc agaacggtgg tcctgagacc
     1021 ttcacacagc tgatgagcat cctgtctgac ctcctgtgtg ggtacccaga gggaggaggc
     1081 tcccgagtgt tctcctttaa ctggtatgaa gacaataact ataaagcctt cctggggatt
     1141 gattccacaa ggaaagaccc cgcctattct tacgacaaaa gaacaacatc cttttgtaat
     1201 tcattgatcc agagcctgga gtcaaaccct ttaaccaaaa tagcctggag ggcggcaaag
     1261 ccattgctga tgggaaaaat cctctttact ccagattccc ctgctgctcg aaggataatg
     1321 aagaatgcca actcaacttt tgaagaactg gatcgagtta ggaagttggt aaaagcctgg
     1381 gaggaagtgg ggccccagat ctggtacttc tttgagaaga gcacacagat gaccgtgatc
     1441 cgagacaccc tgcagcaccc aaccgtcaaa gacttcataa ataggcagct cggagaagaa
     1501 ggcattacca ccgaagccgt attaaacttc ttctctaacg gtccccaaga gaagcaggct
     1561 gatgatatga ccagctttga ctggagggac atattcaaca tcactgaccg attcctacgc
     1621 ttggctaatc aatacctgga gtgtctggtc ctggataagt ttgaaagtta tgatgatgaa
     1681 gtgcagctca cccaacgagc cctgtctctc ctggaggaga acaggttctg ggccggagtg
     1741 gtgttccctg gcatgtatcc ctgggccagc tccttacctc ctcatgtgaa gtacaagatt
     1801 cggatggaca tagatgtggt ggagaagacc aataagatca aagacaggta ctgggattct
     1861 ggtcccaggg cggatcctgt cgaagatttc cggtacatct ggggaggttt tgcctatcta
     1921 caggacatgg tggagcaagg aatcgtgaag agtcagatgc aggcagagcc tccaattgga
     1981 gtctatctcc aacagatgcc ttatccctgc tttgtggatg actccttcat gatcatcctg
     2041 aatcgctgtt tccctatctt catggtgctg gcgtggatct actctgtctc catgaccgtt
     2101 aagggcattg ttttggagaa ggagctgagg ctgaaggaga ccttgaaaaa ccaaggcgtc
     2161 tctaatgctg tcatctggtg tacctggttc ctggatagct tctccatcat ggcgctgagt
     2221 atcttcctcc tgacgctgtt catcatgcat ggaaggatcc tccattacag cgatcccttc
     2281 attctcttcc tgttcttgtt ggcctttgcc actgcgacca tcatgcagag cttcctgctc
     2341 agtactttgt tttccaaggc cagccttgca gcagcctgca gtggggtcat ctacttcacc
     2401 ctctacctac cacacgttct gtgctttgcc tggcaggacc ggatgacggc cgacctgaag
     2461 acgactgtga gcctactttc ttccgtggca tttgggtttg gcaccgagta cctggtccgc
     2521 tttgaggagc aaggcctggg gctgcaatgg agcaacattg ggaagagtcc cctggaaggg
     2581 gatgagttca gtttcctgct gtctatgaag atgatgcttc tcgatgctgc tctctacggc
     2641 ttgcttgctt ggtatcttga ccaggttttc ccaggagact atgggacccc acttccctgg
     2701 tacttccttc tgcaggagtc ctactggctt ggtggtgaag gttgttcgac cagagaagaa
     2761 agggctctgg aaaagactga acccttaaca gaggagatgg aggatccaga gcacccagaa
     2821 ggaatgaatg actccttttt tgaacgcgag cttccagggc tggtgcctgg tgtgtgtgtg
     2881 aagaacctgg tgaaggtttt tgagcccagt ggccggccag ctgtggaccg tctgaacatc
     2941 actttctatg agaaccaaat cacggcgttc ctgggtcaca acggagcggg aaagaccacc
     3001 accttgtcca tcctgacagg actgttgcca ccgacgtcag gaactgtgct cattggggga
     3061 aaagacattg aaaccaacct ggatgtagta cggcagagcc tgggcatgtg tccacaacac
     3121 aacatcctgt ttcatcacct cacggtggct gagcacatct tgttctatgc ccagctgaaa
     3181 gggagatcct gggaggaggc ccagcttgag atggaagcca tgctagaaga cacgggcctc
     3241 caccataaga ggaatgaaga agctcaggac ctttcaggtg gcatgcagag gaagctgtct
     3301 gttgccattg cttttgtggg agattctaag gtggtggtcc tggatgagcc cacctctggg
     3361 gtggacccct actccagacg ctccatctgg gacctgctcc tgaagtatcg ctcaggcaga
     3421 accatcatca tgtccactca ccacatggac gaggcagacc tccttgggga ccgcattgcc
     3481 atcatttctc agggaaggct ctactgctct ggaaccccgc tcttcctcaa gaactgcttt
     3541 ggcacaggct tctacttgac cttagttcgc aagatgaaaa acatccagag ccaaagaggt
     3601 ggctgtgagg gggtctgcag ctgtacatca aagggtttct ctaccaggtg tccaacccga
     3661 gtcgatgaga taacagaaga acaagtcctg gatggagatg tgcaggagct gatggatttg
     3721 gtataccacc atgtcccaga ggcaaagctg gtggaatgca ttggtcaaga acttatcttc
     3781 ctccttccaa acaagaattt caagcagaga gcatatgcca gccttttccg agagctggag
     3841 gagactctgg ctgacctggg gctcagcagc tttggaattt ctgacactcc cctggaagag
     3901 attttcctga aggtcacaga ggatgctgga gcgggctcta tgtttgtagg tggcgctcag
     3961 cagaaaagag aacaagccgg tctccggcac ccttgttcgg ctcccactga gaagctcagg
     4021 cagtatgccc aggccccaca tacctgttcc ccaggacaag tggatcctcc caagggccaa
     4081 ccttccccag agccagagga ccccggtgtc ccattcaaca caggtgctcg gctgattctt
     4141 caacatgtgc aggccctgct agtcaagcga ttccatcaca ccatccgcag ccgcaaggac
     4201 tttgtggctc agattgttct ccctgccact ttcgtgttct tggctctgat gctttcaatc
     4261 attgtgcctc cgtttggtga atttccagct ttgactcttc atccctggat gtatgggcat
     4321 caatatacct tcttcagcat ggacgaaccc aacaatgaac accttgaagt actggcagat
     4381 gtccttctga acaggccagg ctttggcaac cgttgtctaa aggaagagtg gcttccggag
     4441 tacccatgca ttaatgcaac ctcctggaag acgccctccg tgtccccgaa catcacccac
     4501 ctgttccaga agcagaaatg gacagcagcc cacccctctc cctcctgcaa gtgcagcacc
     4561 agagagaagc tcaccatgtt gcccgagtgc cccgagggtg ctggagggct cccaccccca
     4621 cagaggacac agcgcagcac tgaagtccta caagacctca cgaacaggaa catctccgac
     4681 tacttggtaa aaacgtaccc tgctctcata agaagcagct taaagagcaa attctgggtc
     4741 aatgaacaga ggtatggagg aatttccatc ggaggaaaac tccctgctat ccccatcagc
     4801 ggggaagcac ttgttggctt tctaagtggc cttggccaga tgatgaacgt gagcgggggt
     4861 cctgtcacca gggaggcctc caaagaaatg ttagatttcc tcaaacatct tgaaaccaca
     4921 gacaacatta aggtatggtt taacaacaag ggctggcatg ccctggtcag ctttctgaat
     4981 gtggctcaca acgccatctt acgggccagc ctgcccaggg acagggaccc tgaggagtat
     5041 ggaatcactg tcatcagcca gcctctgaac ctgaccaagg agcagctctc ggacatcaca
     5101 gtactgacta cttccgtgga tgccgtggtt gccatatgtg tgattttcgc catgtccttc
     5161 gttccagcca gctttgtcct ttacttgatc caggagaggg tgacgaaagc taaacatttg
     5221 cagtttatca gtggtgtgag ccccaccacc tactggctga ccaacttcct ctgggatatt
     5281 atgaattatg ctgtgagtgc gggattggtg gtgggcatct tcattggatt tcaaaagaaa
     5341 gcctacacat ccccagacaa ccttcctgct ctcgtctctc tgctcatgct gtatggatgg
     5401 gcagtcattc ctatgatgta tccagcatcc ttcctgtttg aagtccccag cacagcctat
     5461 gtggctttgt cctgtgctaa cctgttcatc ggcatcaaca gcagcgccat caccttcgtc
     5521 ctggaattat ttgagaataa ccggacgctg ctcaggttca atgccatgtt gaggaagttg
     5581 ctcattgtct tcccccactt ctgcctgggc aggggcctca ttgacctggc actgagccaa
     5641 gctgtgacag acgtctatgc ccagtttggt gaggagtact ctgcaaaccc attccagtgg
     5701 gacctgattg ggaagaacct ggttgctatg gcaatagaag gggtggtata cttccttctg
     5761 accctgctca tccaacacca ttttttcctc acccggtgga tcgctgagcc tgctagagag
     5821 cccgtttttg atgaagatga cgatgtggct gaagaaagac aaagagttat gagtggggga
     5881 aataaaaccg acatcttaaa gctaaacgaa ctaaccaagg tttactcagg ctcttccagt
     5941 ccagcagtag atcggttatg tgttggagtt cgacctggag agtgctttgg cctcctggga
     6001 gtgaatggtg caggcaaaac caccacattc aagatgctca ctggggacac cacagtgaca
     6061 tcgggggatg ctactgtggc aggcaagagc attttaacta gtatttctga tgtccatcaa
     6121 aacatgggct actgtcctca gtttgatgca atcgatgacc tgctcacagg cagagaacac
     6181 ctttacctct atgccaggct gcggggcgtg ccatcgaagg aaatcgagaa ggttgccaac
     6241 tggggtatcc agagcctggg cttgtctctc tacgctgacc gcctggcagg cacctacagt
     6301 ggaggcaata agaggaaact ctctacagcc atagctctca ctggctgccc tcccctgctg
     6361 ctgctggatg agcccacgac agggatggat ccccaggcac gccgcatgct gtggaacacc
     6421 attgtgagca tcatcagaga agggagagct gtggttctca cctcccacag catggaagaa
     6481 tgtgaagctc tgtgtacgcg gctggccatc atggtgaagg gcacctttca gtgtctgggt
     6541 accatccaac acctcaagta caagtttgga gacggctaca ttgtcacaat gaaaatcaaa
     6601 tctccaaagg acgacttgct tcccgatttg aatcctgtgg agcagttctt ccagggcaac
     6661 ttccctggca gcgtgcagag ggagagacac cacagcatgc tccagttcca ggtcccctcg
     6721 tcctccctgg ccaggatctt ccagctgctc atttcccaca aggacagcct gctcatcgag
     6781 gagtactcag tcacccagac cacgctggac caggtgtttg taaacttcgc taaacagcag
     6841 actgagacct atgacctccc tctgcacccc cgggctgctg gagccagctg gcaagccaag
     6901 cttgaagaga aatccggacg gctgcagaca caggagcctt tgcccgcagg atctgaacaa
     6961 ctggctaacg gaagcaaccc cacggcagca gaagataagc acaccaggag tccacagtga
     7021 gctggaggag actctttcag aaagaaacca aaattcactg gctcaccgga actcctgatg
     7081 gcaaaactga cctatcagaa tggtcacctg tttatccaga acccctgact ggtggctttg
     7141 gccttagcga tactttcatt ctgagtggat ctgcttttgt ggagtgggaa gggtatggat
     7201 gtgtgggtgt tatttgaggg gagaaataaa aaacagtctc ctgattaaaa aaaaaaaaaa
     7261 aaaaaaaa
//
