LOCUS       NM_013855               6515 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family A member 3 (Abca3),
            transcript variant 1, mRNA.
ACCESSION   NM_013855
VERSION     NM_013855.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6515)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6515)
  AUTHORS   Jones,M.R., Lingampally,A., Ahmadvand,N., Chong,L., Wu,J.,
            Wilhem,J., Vazquez-Armendariz,A.I., Ansari,M., Herold,S.,
            Ornitz,D.M., Schiller,H.B., Chao,C.M., Zhang,J.S., Carraro,G. and
            Bellusci,S.
  TITLE     FGFR2b signalling restricts lineage-flexible alveolar progenitors
            during mouse lung development and converges in mature alveolar type
            2 cells
  JOURNAL   Cell Mol Life Sci 79 (12), 609 (2022)
   PUBMED   36445537
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6515)
  AUTHORS   Yang,G., Lu,S., Jiang,J., Weng,J. and Zeng,X.
  TITLE     Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in
            Mice by the FGF Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (11), 6014 (2022)
   PUBMED   35682694
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6515)
  AUTHORS   He,H., Chen,J., Zhao,J., Zhang,P., Qiao,Y., Wan,H., Wang,J.,
            Mei,M., Bao,S. and Li,Q.
  TITLE     PRMT7 targets of Foxm1 controls alveolar myofibroblast
            proliferation and differentiation during alveologenesis
  JOURNAL   Cell Death Dis 12 (9), 841 (2021)
   PUBMED   34497269
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6515)
  AUTHORS   Stahlman,M.T., Besnard,V., Wert,S.E., Weaver,T.E., Dingle,S.,
            Xu,Y., von Zychlin,K., Olson,S.J. and Whitsett,J.A.
  TITLE     Expression of ABCA3 in developing lung and other tissues
  JOURNAL   J Histochem Cytochem 55 (1), 71-83 (2007)
   PUBMED   16982851
REFERENCE   7  (bases 1 to 6515)
  AUTHORS   Huls,M., van den Heuvel,J.J., Dijkman,H.B., Russel,F.G. and
            Masereeuw,R.
  TITLE     ABC transporter expression profiling after ischemic reperfusion
            injury in mouse kidney
  JOURNAL   Kidney Int 69 (12), 2186-2193 (2006)
   PUBMED   16612327
  REMARK    GeneRIF: showed for the first time expression and subcellular
            localization of abcb11 and abca3 in mouse kidney
REFERENCE   8  (bases 1 to 6515)
  AUTHORS   Salaun,B., de Saint-Vis,B., Pacheco,N., Pacheco,Y., Riesler,A.,
            Isaac,S., Leroux,C., Clair-Moninot,V., Pin,J.J., Griffith,J.,
            Treilleux,I., Goddard,S., Davoust,J., Kleijmeer,M. and Lebecque,S.
  TITLE     CD208/dendritic cell-lysosomal associated membrane protein is a
            marker of normal and transformed type II pneumocytes
  JOURNAL   Am J Pathol 164 (3), 861-871 (2004)
   PUBMED   14982840
REFERENCE   9  (bases 1 to 6515)
  AUTHORS   Mulugeta,S., Gray,J.M., Notarfrancesco,K.L., Gonzales,L.W.,
            Koval,M., Feinstein,S.I., Ballard,P.L., Fisher,A.B. and Shuman,H.
  TITLE     Identification of LBM180, a lamellar body limiting membrane protein
            of alveolar type II cells, as the ABC transporter protein ABCA3
  JOURNAL   J Biol Chem 277 (25), 22147-22155 (2002)
   PUBMED   11940594
  REMARK    GeneRIF: Identification of LBM180, a lamellar body limiting
            membrane protein of alveolar type II cells, as the ABC transporter
            protein ABCA3
REFERENCE   10 (bases 1 to 6515)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117577.16, AK165458.1, BC079617.1, CX563731.1, CV784401.1 and
            BC020183.1.
            
            On Nov 15, 2013 this sequence version replaced NM_013855.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154698.1, AY083616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC117577.16        559-623             c
            66-2895             AK165458.1         2-2831
            2896-3073           BC079617.1         2387-2564
            3074-3648           CX563731.1         193-767
            3649-4242           CV784401.1         128-721
            4243-6476           BC079617.1         2969-5202
            6477-6515           BC020183.1         579-617
FEATURES             Location/Qualifiers
     source          1..6515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.38 cM"
     gene            1..6515
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /note="ATP-binding cassette, sub-family A member 3"
                     /db_xref="GeneID:27410"
                     /db_xref="MGI:MGI:1351617"
     exon            1..229
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            230..302
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            303..504
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..614
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             561..5675
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.1"
                     /note="xenobiotic-transporting ATPase ABCA3; ATP-binding
                     cassette, sub-family A (ABC1), member 3"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase ABCA3"
                     /protein_id="NP_038883.2"
                     /db_xref="CCDS:CCDS37486.1"
                     /db_xref="GeneID:27410"
                     /db_xref="MGI:MGI:1351617"
                     /translation="MAVLRQLTLLLWKNYTLKKRKVLVTVLELFLPLLFSGILIWLRL
                     KIQSENVPNATVYPDQSIQELPLFFSFPPPGGTWELAYVPSHSDAARTITETVKREFM
                     IKMRVHGFSSEKDFEDYIRYDNHSSSVLAAVVFEHSFNHSQDPLPLAVKYHLRFSYTR
                     RNYMWTQTGNIFLKETEGWHTTSLFPLFPSPGPREPSSPDGGEPGYIREGFLAMQHAV
                     DKAIMRYHANTSAQQLFQKLMVITKRFPFPPYISDPFLIAIQYQLPLLLMLSFTYTSL
                     TIIRAVVQEKEKKLKEYMRMMGLNSWLHWSAWFLMFFLFFLIVVSFMTLLFCVKVKKD
                     IAVLSNSDPSLVLAFLLCFAISSISFSFMVSTFFSKANIAAAVGGFLYFFTYTPYFFV
                     APRYNWMTLSQKLLSCLLSNVAMAMGAQLIGKFEAKGTGIQWRDLLNPVNVDDNFCFG
                     QVLGMLLLDSALYGLVTWYVEAVFPGQFGVPQPWHFFLMPSYWCGNPRTVVGKEEEGS
                     DPEKALRNEYFEAEPEDLVAGIKIKHLSKVFQVGNKDKMGIRDLTLNLYEGQITVLLG
                     HNGAGKTTTMSLLTGLFPPTSGHAYIHGYEISQDMAQIRKSLGLCPQHDVLFDNLTVA
                     EHLYFYAQLKGLSLQKCPEEVKQMLHILSLEDKRDLRSKFLSGGMKRKLSIGIALIAG
                     SKVLMLDEPTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEADLLGDRIAILAKGE
                     LQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEGISQLVHHHVPNAMLESHAGAELSFIL
                     PKESTHRFESLFAKLEKKQKELGIASFGASVTTMEEVFLRVGKLVDTSMDIQAIQLPA
                     LQYQHERRASDWALDSNLCGVMDPTNGIGALIEEEEVLVKLNTGLALHCQQFWAMFLK
                     KAAYSWREWKMVAAQVLVPLTCLTLALLAIHYTSEIFDDPLLKLSLNEYGRTVVPFSV
                     PGTSRLAQQLSENLRDMLQAERQEPREVLGDLEEFLVFRASVEGGGFNERCLVATSFK
                     DRGELTVVTALFNNQAYHSPATALAIVDNLLFKLLCGPQASIEISNYPQPRNTLQVAK
                     DHFNEGRKGFDIALNLLIAMAFLASTFSILAVSERAVQAKHVQFVSGVHVATFWFSAL
                     LWDLISFLVPSLLLLVVFQAFNVHAFTRDGHMADLLLLLMLYGWAIIPLMYLMSFFFS
                     AASTAYTRLTIFNILSGIATFIMVTIMRIPAVKLEELSRTLDHVFLVLPNHCLGMAVS
                     NFYENYETRRYCTSSELAAHYCKKYNIQYQESFYAWSTPGVGKFVTSMAASGGIYLTL
                     LFLIETNLLWRLRTFICAFRRRWTLAELQNRTSVLPEDQDVAEERSRILVPSLDSMLD
                     TPLIINELSKVYDQRAPLLAVDRISLAVQKGECFGLLGFNGAGKTTTFKMLTGEETIT
                     SGDAFVGGYSISSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYARLRGIPERLINAC
                     VENTLRGLLLEPHANKLVKTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRL
                     LWDTVARARESGKAIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYS
                     LQAKVRSEGKQDALEEFKAFVDLTFPGSILEDEHQDMVHYHLPGCDLSWAKVFGILEK
                     AKEKYGVDDYSVSQISLEQVFLSFAHLQPPTTEDGR"
     exon            615..879
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1007
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1173
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1433
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1550
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1671
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1845
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2027
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2171
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2301
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2456
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2612
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2823
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2974
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3073
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3260
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3564
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3838
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..4043
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4263
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4264..4422
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4423..4595
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..4724
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4725..4919
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4920..5107
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..5278
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5279..5469
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..5543
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5544..6479
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6455..6460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /note="hexamer: AATAAA"
     polyA_site      6476
                     /gene="Abca3"
                     /gene_synonym="1810036E22Rik; ABC-C; Abc3"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcacg cgcgctccga cgcgcccccc caccccctcc aggagccgga gcttcctggt
       61 gcgttcttcc acccgcgcct gtcgcaggcg cctcctctct gccccgccgc ctcagttgtc
      121 agcttcggcc gcaaccgccc cagcaaggct ggagcaggac cgggagtcta agggagggaa
      181 cctggcgaga gagctgcgca gaccgccgcc accctggcgc tgagggtcga gaatacaaga
      241 aaattgctca ctatccctcc actgtgatgt actgtcttgt tcattctgct tggaaacaac
      301 tggtgccagc acatcatgcc cgtgagcccc aggtccctcc agatgtccct ggagatctca
      361 gcgttcctgc tccctagggc tgttgcttct gtccagggga ccactggctc caccccaggg
      421 tcatctgtgt agaactgctg acgccaggcg acttcacccg tagccttgca gtgacacctt
      481 cagccaacct ttcctggaac taagttgtcc atctttaagt cttgatctct ggttggtgtt
      541 ggcactgtgc cagcaagaag atggcagtgc tgcggcagct caccctccta ctctggaaga
      601 actataccct gaagaaacgg aaggttctag tgacagtcct ggagctcttc ctgcccctgc
      661 tgttttctgg gatcctgatt tggcttcgct tgaagatcca gtcggagaat gtgcccaatg
      721 ccactgttta cccggaccag tccatccagg agctgcccct gtttttctca ttccctccac
      781 ctggggggac ctgggagctc gcctatgtcc cttcccacag cgatgctgcc aggaccatca
      841 cggagacggt gaaaagggaa ttcatgatca agatgagagt gcacggcttc tcctctgaga
      901 aggacttcga ggactacatt cgctatgaca accactcctc cagcgtgctg gcagctgtgg
      961 tatttgagca cagcttcaac cacagccagg accccctgcc gctggcggtg aaataccacc
     1021 tgcgcttcag ttacacacga agaaattaca tgtggaccca aacaggaaat attttcctaa
     1081 aagagactga aggctggcat accacttcac tttttccact ttttccaagc cccggaccgc
     1141 gggaaccttc atcacctgat ggcggtgaac ctggatacat tcgggaaggc ttcctggcca
     1201 tgcaacatgc tgtagacaaa gccatcatgc gttaccatgc caacacctct gcacagcagc
     1261 tgttccagaa gctcatggtg atcaccaaaa ggttcccgtt cccaccatac atctcagatc
     1321 cattcctcat tgccatccag taccagcttc ctctgctgct catgctgagt ttcacctaca
     1381 cctccctcac catcatccgg gctgtggtgc aggagaagga gaaaaaacta aaggagtaca
     1441 tgcgcatgat ggggcttaac agctggctac actggagcgc ttggttcctc atgttcttcc
     1501 tattcttcct catcgtggtc tccttcatga ccctcctgtt ctgtgtcaaa gtgaagaagg
     1561 acatagcagt cctttccaac agcgacccct ccctggtcct ggcgttcctg ctgtgttttg
     1621 caatctcctc catttccttc agcttcatgg tcagcacctt cttcagtaaa gccaacatag
     1681 cagcagccgt gggtggcttc ctgtacttct tcacctatac cccctacttt ttcgtggctc
     1741 ctcggtacaa ctggatgaca ctgagtcaaa agctcttgtc ctgtctccta tctaatgttg
     1801 ccatggcaat gggagcccag ctcataggaa aattcgaagc caaaggcact ggcatccagt
     1861 ggcgggacct cctcaaccct gtcaacgtgg acgacaattt ctgctttgga caagtgctgg
     1921 ggatgctgct gctggactca gcactctatg gcctggtgac ctggtacgtg gaggctgtct
     1981 tcccaggcca gtttggcgta ccccagccct ggcacttctt ccttatgccc tcctactggt
     2041 gtgggaaccc aagaactgtc gtagggaagg aagaggaagg cagcgaccca gagaaagctc
     2101 tcaggaacga gtactttgaa gccgagccag aggacttggt agctggaatc aagatcaagc
     2161 atctctccaa ggtgttccaa gtgggcaata aggacaagat gggcatcaga gacctgaccc
     2221 tgaacctcta cgaaggacag ataacagtcc tcctgggcca caatggtgct gggaagacca
     2281 cgaccatgtc tctgctgaca ggcctcttcc cccctaccag tggacatgct tatattcatg
     2341 ggtacgaaat ttcccaagac atggctcaga tccgcaagag tttgggcctg tgtccccagc
     2401 atgatgtact gtttgacaac ctgacagttg ccgaacatct ttacttctat gcacagctga
     2461 aaggcctctc tctccagaag tgtcctgagg aagtcaagca gatgctacac atcctcagcc
     2521 tggaggacaa gcgtgactta cggtccaagt tcctgagtgg gggcatgaag cgcaagctct
     2581 ccattggcat cgccctcata gcgggctcta aggtgctgat gttagatgag cccacctcag
     2641 gcatggatgc agtgtccaga agggccatct gggaccttct ccagcagcag aagagtgacc
     2701 gcaccgtcct gctgaccact cacttcatgg acgaagctga cctgctggga gaccgcatcg
     2761 ccatcttggc caagggggag ctccagtgct gcgggtcttc actatttctc aagcagaaat
     2821 acggagctgg ctaccacatg acgctggtaa aagaaccgca ctgcaatcct gaaggaatct
     2881 ctcagctggt gcaccaccat gtccccaatg ccatgctgga gagccatgct ggggctgagc
     2941 tgtcctttat tcttcccaag gagagcacgc acaggtttga aagtctgttt gctaaactgg
     3001 aaaagaagca gaaggagttg ggcatcgcaa gcttcggggc ctcggtcacc accatggagg
     3061 aagtcttcct tcgggttggt aagctggtgg acaccagcat ggacattcaa gccattcagc
     3121 ttcctgctct gcagtaccag catgagaggc gggcaagcga ctgggctttg gacagtaacc
     3181 tgtgtggggt gatggaccca acgaatggca ttggagccct catagaggaa gaggaagttt
     3241 tggtcaagct caacacaggg cttgccctcc actgccagca gttctgggcc atgttcctga
     3301 agaaggctgc atacagctgg cgggaatgga agatggtggc agctcaggtc ctggtccccc
     3361 tgacctgcct caccctggcc ctcctggcta tccactacac ctcagagatc tttgatgacc
     3421 ctctcctgaa gctaagcctg aacgagtatg gtagaacggt tgtgcccttc tcggtcccag
     3481 gcacatccag gctggctcag cagctgtctg agaatctaag ggacatgctg caggctgaga
     3541 ggcaggagcc ccgggaagtg ctaggtgacc tagaggagtt cctggttttc agggcctcag
     3601 tggaaggagg cggctttaat gagcggtgcc tagtagcaac atccttcaaa gacagaggag
     3661 agctgaccgt ggtcactgcc ctgttcaaca accaggcata ccactcccca gccactgccc
     3721 tggccatcgt ggacaacctt ctgttcaagc tattgtgtgg ccctcaggcc tccattgaga
     3781 tctccaacta cccccagccc cggaacaccc tgcaggtcgc caaggaccac ttcaatgagg
     3841 gccggaaggg atttgacatt gccctcaatt tgctcatcgc catggcattt ctggccagca
     3901 ccttttccat cctggctgtc agtgagaggg ccgtccaggc caagcacgtt cagtttgtga
     3961 gcggtgtcca tgtggctact ttctggttct ccgctctgtt gtgggacctc atctccttcc
     4021 tcgttcccag tctactactt ctggtggtgt tccaagcctt caatgtgcac gccttcacga
     4081 gggatggtca catggctgac ctgctgctgc tgctcatgct ctacggctgg gccatcatcc
     4141 ccctcatgta cctcatgagc ttcttcttct cggctgcgtc cacagcttat accaggctga
     4201 ccatattcaa catcctgtcg ggcatcgcta ccttcatcat ggtcactatc atgcgtatcc
     4261 cagctgtgaa gttagaagaa ctttccagaa ccttagatca tgtgttcttg gtgctgccaa
     4321 accactgcct ggggatggcg gtcagcaact tctatgagaa ctatgagact cggcgatact
     4381 gcacttcctc agagcttgct gcccactact gcaagaagta caacatccag taccaggaga
     4441 gcttctatgc ctggagcacc ccaggcgtgg gcaagtttgt gacttccatg gctgcctcag
     4501 ggggcatcta cctcaccctg ctgttcctca ttgagaccaa cctgctgtgg cgactgagaa
     4561 ccttcatctg tgccttccgg aggaggtgga ctctggcaga actgcagaac cggacatcag
     4621 tgctgcccga ggaccaggat gtagctgagg agaggagccg aatcctggtc cctagcttgg
     4681 actccatgct cgacacacca ctgatcatca acgagctctc caaggtgtat gaccagcgag
     4741 caccgctcct tgccgtggac aggatctccc ttgcggtcca gaaaggggag tgcttcggcc
     4801 tgttgggttt caatggagct ggaaaaacca caacattcaa aatgctgact ggggaggaga
     4861 ccatcacctc aggggatgcc tttgttggtg gttacagcat cagttctgac atcgggaagg
     4921 tgcggcagcg gatgggctac tgcccccagt ttgatgcact gcttgatcac atgactggca
     4981 gggagatgct ggttatgtat gcacggctcc gaggcatccc agagcggctc atcaatgcct
     5041 gtgtggagaa tactctgcgg ggtctgctgc tggaaccgca cgccaacaaa ctagtcaaga
     5101 cttacagtgg tggtaacaaa cgcaagctaa gcactggcat tgccctcatt ggagagcctg
     5161 cagtcatctt cctggatgag ccatcgaccg gcatggaccc agtggcccgg cgtctactct
     5221 gggatactgt agcccgggcc cgagagtctg gcaaagccat tgtcatcacc tcccacagta
     5281 tggaggagtg tgaagcctta tgtaccaggc tggccatcat ggtacagggc cagttcaagt
     5341 gcctgggcag cccacagcac ctcaagagca agtttggcag cggctactcc ctgcaggcca
     5401 aggtccggag cgaggggaag caagacgcgc tagaggagtt caaggccttt gtggacctga
     5461 ccttcccagg cagcatccta gaagatgagc accaagacat ggtccattat catctgcctg
     5521 gctgtgacct cagctgggcc aaggtatttg gtatcctgga gaaagccaag gagaagtatg
     5581 gagtggatga ttactctgtg agccagatct ccctggagca ggtctttctg agctttgccc
     5641 acctacaacc ccccaccact gaggatggcc ggtgaggagc tctgctgcct ccagagcacc
     5701 aggcgtggaa ggggcaaatc gtgcttagcc gtgcgtcctc tccctcccag tttctccttt
     5761 ctttcatttt taatcactct tttctatgat ggacatgaaa aacaatcaag gtgatatgca
     5821 caaagtggac catgtgtgtc tgtcagtgcc tgcaggcagg agtcagcatg caggtttcca
     5881 ctcctgaagt caggtctctg gaaccacagt cccagacccc atcctgctgt gcacacagac
     5941 aggccttggt cccagctggt actgcagcta gcctggggga ttgagcttct ttccagtgct
     6001 tatccagaga gaccccaggg acctgtctat gtttacatat gacactaagc tcccctaggg
     6061 ggggaaagaa agccaacagg gttgagcagc aacaaggact tccaggctgc caggaatgag
     6121 cagcaaagtt gcaaatacct tcatgaaggg aagatactgg ctatgactag gtgctgagac
     6181 cattggctcc caatgcaact gcacaggcat ccttggatgt caatgttcct tccagtatgg
     6241 acagtggacc gggctgatct gatcctgagc cagatgtcat cccacagagc atcggcagca
     6301 caagagagag ctgtggccag acttgaagca catcctctgt tcctagctct gtgccttcaa
     6361 gaagtcactg gccacaggat tgtcagggac cactacaggg ctgagtagtg tcatctcttg
     6421 aggatacact taaacatatt gtgattctat aaaaaataaa ggataagggg acatgaccaa
     6481 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
