LOCUS       NM_001368624            8140 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family A member 2 (Abca2),
            transcript variant 2, mRNA.
ACCESSION   NM_001368624 XM_006497612
VERSION     NM_001368624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8140)
  AUTHORS   Davis,W. Jr.
  TITLE     The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression
            Modulates Sphingosine Levels and Transcription of the Amyloid
            Precursor Protein (APP) Gene
  JOURNAL   Curr Alzheimer Res 12 (9), 847-859 (2015)
   PUBMED   26510981
  REMARK    GeneRIF: Study suggests that ABCA2 modulation of sphingolipid
            metabolism activates a signaling pathway that regulates amyloid
            precursor protein transcription
REFERENCE   3  (bases 1 to 8140)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 8140)
  AUTHORS   Haller,J.F., Cavallaro,P., Hernandez,N.J., Dolat,L., Soscia,S.J.,
            Welti,R., Grabowski,G.A., Fitzgerald,M.L. and Freeman,M.W.
  TITLE     Endogenous beta-glucocerebrosidase activity in Abca12/epidermis
            elevates ceramide levels after topical lipid application but does
            not restore barrier function
  JOURNAL   J Lipid Res 55 (3), 493-503 (2014)
   PUBMED   24293640
REFERENCE   5  (bases 1 to 8140)
  AUTHORS   Davis,W. Jr.
  TITLE     The ATP-binding cassette transporter-2 (ABCA2) regulates
            esterification of plasma membrane cholesterol by modulation of
            sphingolipid metabolism
  JOURNAL   Biochim Biophys Acta 1841 (1), 168-179 (2014)
   PUBMED   24201375
  REMARK    GeneRIF: control of ABCA2 expression level may be a key locus of
            regulation for esterification of plasma membrane-derived
            cholesterol through modulation of sphingolipid metabolism.
REFERENCE   6  (bases 1 to 8140)
  AUTHORS   Kasahara,M., Hayashi,M., Tanaka,K., Inoko,H., Sugaya,K., Ikemura,T.
            and Ishibashi,T.
  TITLE     Chromosomal localization of the proteasome Z subunit gene reveals
            an ancient chromosomal duplication involving the major
            histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 9096-9101 (1996)
   PUBMED   8799160
REFERENCE   7  (bases 1 to 8140)
  AUTHORS   Allikmets,R., Gerrard,B., Glavac,D., Ravnik-Glavac,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Modi,W. and Dean,M.
  TITLE     Characterization and mapping of three new mammalian ATP-binding
            transporter genes from an EST database
  JOURNAL   Mamm Genome 6 (2), 114-117 (1995)
   PUBMED   7766993
REFERENCE   8  (bases 1 to 8140)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   9  (bases 1 to 8140)
  AUTHORS   Luciani,M.F., Denizot,F., Savary,S., Mattei,M.G. and Chimini,G.
  TITLE     Cloning of two novel ABC transporters mapping on human chromosome 9
  JOURNAL   Genomics 21 (1), 150-159 (1994)
   PUBMED   8088782
REFERENCE   10 (bases 1 to 8140)
  AUTHORS   Higgins,C.F.
  TITLE     ABC transporters: from microorganisms to man
  JOURNAL   Annu Rev Cell Biol 8, 67-113 (1992)
   PUBMED   1282354
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ126415.1, AK169438.1, AL732557.4 and CJ263864.1.
            
            On Feb 12, 2019 this sequence version replaced XM_006497612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               CJ126415.1         2-382
            382-1106            AK169438.1         304-1028
            1107-1107           AL732557.4         107701-107701
            1108-1569           AK169438.1         1030-1491
            1570-1572           AL732557.4         108405-108407
            1573-4231           AK169438.1         1493-4151
            4232-4232           AL732557.4         114708-114708
            4233-6002           AK169438.1         4152-5921
            6003-7365           AK169438.1         5923-7285
            7366-7366           AL732557.4         120099-120099
            7367-8139           AK169438.1         7287-8059
            8140-8140           CJ263864.1         430-430
FEATURES             Location/Qualifiers
     source          1..8140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.25 cM"
     gene            1..8140
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /note="ATP-binding cassette, sub-family A member 2"
                     /db_xref="GeneID:11305"
                     /db_xref="MGI:MGI:99606"
     exon            1..237
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..7476
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ATP-binding cassette transporter 2; ATP-binding cassette
                     2; ATP-binding cassette, sub-family A (ABC1), member 2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family A member 2
                     isoform 2"
                     /protein_id="NP_001355553.1"
                     /db_xref="GeneID:11305"
                     /db_xref="MGI:MGI:99606"
                     /translation="MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQ
                     KKPTISVKEVSFYTAAPLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLHR
                     VVEEGNLFDPVRPSLGSELEALRQRLEALSSGPGTWESHSARPAVSSFSLDSVARDQR
                     ELWRFLMQNLSLPNSTAQALLAARVDPSEVYRLLFGPLPDLDGKLGFLRKQEPWSRLG
                     SNPLLQMEELLLAPALLEQLTCAPGSGELGRILTMPEGHQVDLQGYRDAVCSGQATAR
                     AQRFSDLAAELRNQLDTAKIAQQLGFDVPNGSDPQPQAPSPQSLPALLGDLLDAQKLL
                     QDVDVLSALALLLPQGACAGQASAPQASSLNGLANSTGIGANSGSNTTVEEGTQSPVS
                     PASPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSKEQRNLGLL
                     VHLMTSNPKILYAPVGSEADRVILKANETFAFVGNVTHYAQVWLNISTEIRSFLEQGR
                     LQQHLQWLQQYVADLQLHPEAMNLSLEELPPALRQDFSLPNGTALLQQLDTIDNAACG
                     WIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYK
                     IRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIINTFVGHDVVEP
                     GNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKT
                     MGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVLIIWLFLAVYAVATIM
                     FCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTT
                     AFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDTVVYGVLTWYIE
                     AVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWAHTPRLSVMEEDQACAMESRH
                     FEETRGMEEEPTHLPLVVCVDKLTKVYKNDKKMALNKLSLNLYENQVVSFLGHNGAGK
                     TTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFY
                     SRLKSMAQEEIRKETDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIIL
                     DEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGS
                     PLFLKGAYGDGYRLTLVKQPAEPGTSQEPGLASSPSGCPRLSSCSEPQVSQFIRKHVA
                     SSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSSFGLMDTTLEEVFLK
                     VSEEDQSLENSEADVKESRKDVLPGAEGLTAVGGQAGNLARCSELAQSQASLQSASSV
                     GSARGEEGTGYSDGYGDYRPLFDNLQDPDNVSLQEAEMEALAQVGQGSRKLEGWWLKM
                     RQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQY
                     HNYTQPRGNFIPYANEERQEYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSL
                     GPMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPVSPDEDSLQ
                     AWNMSLPPTAGPETWTSAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTG
                     DILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNVQKSIPASFGARVPPMVRKIAVRR
                     VAQVLYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSL
                     DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYV
                     WDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEV
                     PSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGL
                     MEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMTVEGFVGFFLTIMCQYNFLR
                     QPQRLPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRL
                     CLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKDLLQVQQSLGY
                     CPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVKWALEKLELTKYADKPAGTYSGG
                     NKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEE
                     CEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQNVKDVVRFFNRNFPE
                     AMLKERHHTKVQYQLKSEHISLAQVFSKMEQVVGVLGIEDYSVSQTTLDNVFVNFAKK
                     QSDNVEQQEAEPSSLPSPLGLLSLLRPRPAPTELRALVADEPEDLDTEDEGLISFEEE
                     RAQLSFNTDTLC"
     exon            238..331
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            332..334
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            335..446
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            447..610
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            611..738
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            739..849
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1068
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1436
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1596
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1725
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1890
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1987
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2161
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2264
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2379
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2570
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2721
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2926
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3091
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3272
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3485
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3682
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..3865
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..4050
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            4051..4171
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            4172..4408
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            4409..4615
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4718
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..5038
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..5252
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5358
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            5359..5470
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..5531
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            5532..5706
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            5707..5822
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            5823..5970
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            5971..6094
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            6095..6227
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            6228..6345
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            6346..6524
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            6525..6666
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            6667..6801
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            6802..6905
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            6906..6998
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            6999..7101
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            7102..7239
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            7240..7440
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     exon            7441..8140
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8122..8127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /note="hexamer: AATAAA"
     polyA_site      8140
                     /gene="Abca2"
                     /gene_synonym="Abc2; D2H0S1474E; mKIAA1062"
                     /note="major polyA site"
ORIGIN      
        1 gagtctctgt agctgcggcc gccggggcgg agcctgcgag cagcaggtcc tggactctcg
       61 agcgccccgc ccccgcgcgg gcgatgccga gcggcgcggc cggcagcggg gcccggcggg
      121 gcgcgcagag gacagggccg cggcgctgaa gcggcggagc gcggcccggc catgggcttc
      181 ctgcaccagc tgcagctgct gctctggaag aacgtgacgc tgaagcgccg gagcccgtgg
      241 gtcctggctt ttgagatctt catcccgctt gtcctcttct tcatcctgtt gggactgcgg
      301 cagaagaagc ccaccatctc tgtgaaggaa gtctctttct acaccgcagc accgctgaca
      361 tcagccggca tcctgcccgt catgcagtcg ctttgccctg atggccagcg tgatgagttt
      421 ggcttcctgc aatatgccaa ctccacggtc acccagcttc tggaacgcct ccaccgtgta
      481 gtggaggagg gcaatttgtt cgacccagtg cgacccagcc tgggctcaga gctcgaggct
      541 ctgcgccaac gtctggaggc cctcagctca ggccctggca cctgggagag tcactcagcc
      601 agacctgcag tttcatcctt ctctctggac tcggtggcca gggaccagag agagctttgg
      661 cgtttcctga tgcagaacct gtcactgccc aacagcacgg cccaagccct cctagctgcc
      721 cgtgtggacc cttccgaggt ctatcgcttg ctttttggtc ctttgcctga cctggatgga
      781 aagttgggtt tccttaggaa gcaggagccc tggagccgcc tgggtagcaa tcctctgctc
      841 caaatggagg agctgctgct ggctcctgcc cttttggaac agctcacatg tgctccaggt
      901 tctggggaac tgggccggat tcttaccatg cctgagggtc atcaggtaga ccttcagggc
      961 taccgggatg ctgtgtgcag tgggcaggct acagctcgtg cccagcgctt cagcgatttg
     1021 gccgctgagc tcaggaacca gctggacaca gccaagattg ctcagcagct gggcttcgat
     1081 gtccccaacg gctcagatcc ccagccacag gcaccgtccc cacagagcct gccggcactc
     1141 ttaggggacc tgctggatgc ccagaaactt ctgcaggatg tggatgtcct atcagccctt
     1201 gccctgctgc tgcctcaagg tgcctgtgct ggccaggcct ctgcacctca agccagcagc
     1261 ctgaatggcc tggccaacag caccgggata ggtgcaaatt caggttccaa caccactgtt
     1321 gaggagggca cccagtcacc tgtcagccca gcctctcctg acactctgca agggcagtgc
     1381 tcagcctttg tgcagctctg ggctggcttg caacccatct tgtgtggcaa caaccgcacc
     1441 atcgagcctg aagcgcttcg gagaggcaac atgagctccc tgggttttac aagcaaggaa
     1501 cagcggaact tgggccttct agtgcacctc atgaccagca accccaaaat cctgtacgca
     1561 ccagtgggct ctgaagcgga ccgcgttatc ctcaaggcaa atgagacctt tgcctttgtg
     1621 ggcaacgtta cacactacgc ccaggtctgg ctcaacatct ccacagagat ccgaagcttc
     1681 ttggagcaag gcaggctgca gcagcatctg cagtggttac agcagtatgt agctgatctt
     1741 cagctacacc ctgaagcaat gaacctgtcc ctggaggagc tgccacctgc tctgcgccag
     1801 gacttctcac tgcctaatgg cacagccctc ctgcaacagc ttgacacaat agacaacgca
     1861 gcctgtggct ggatccagtt catgtccaag gtgagtgtgg acatcttcaa gggatttcct
     1921 gatgaggaga gcatcgtgaa ctacactctc aatcaggcct accaggacaa tgtcacagtg
     1981 tttgccagcg tgatcttcca gacacggaag gacggctccc tccctccaca tgtacattac
     2041 aagattcgcc agaattcaag cttcactgag aaaaccaatg agatccgccg tgcttattgg
     2101 cgtccagggc ccaacaccgg tggtcgcttc tacttcctct atggcttcgt ctggatccag
     2161 gacatgatgg agcgcgccat catcaacaca tttgtggggc atgacgtggt cgaacctggc
     2221 aactacgtgc agatgttccc atacccctgc tacacccgtg acgacttcct gtttgtcatt
     2281 gaacacatga tgccattgtg catggtgatc tcctgggtct actctgtggc catgaccatc
     2341 cagcatattg tggcagagaa agagcacagg ctcaaggagg tgatgaagac gatgggcctg
     2401 aacaacgccg tgcactgggt ggcctggttc atcacgggct ttgtgcagct gtctatctcc
     2461 gtgacagctc tgaccgccat cctcaagtac ggccaggtgc tcatgcacag ccacgtgctc
     2521 attatctggc tcttccttgc cgtctacgct gtggccacta tcatgttttg cttcctggtg
     2581 tctgtgctgt actctaaggc taagttggcc tcagcctgtg gcggtatcat ctacttcctg
     2641 agctacgttc cctacatgta tgtagcgatc cgcgaggagg tagcccatga caagatcact
     2701 gccttcgaga agtgcattgc gtccctgatg tccacaacag cctttggcct gggttccaag
     2761 tactttgcac tgtatgaagt ggcaggagtg ggcatccagt ggcacacgtt cagccagtcc
     2821 ccagtggaag gagatgactt caatctgctc cttgctgtca ccatgcttat ggtggacacg
     2881 gtggtctacg gcgtgctcac ttggtacatt gaggctgtgc acccaggtat gtatgggctg
     2941 ccccggccct ggtacttccc gctacagaag tcctattggc tgggcagtgg gcggacagaa
     3001 gcctgggagt ggagctggcc atgggcacac acaccgcgcc tcagcgttat ggaggaggac
     3061 caggcctgtg ccatggagag ccggcacttc gaggagaccc gcggcatgga ggaggagccc
     3121 acccacctgc ccttggtcgt ctgtgtggac aagctcacca aggtctataa gaatgacaag
     3181 aagatggcct taaacaaact gagcctcaat ctgtatgaga atcaggtggt ctctttccta
     3241 ggccacaacg gggccggcaa gaccacgacc atgtcgatcc tgactggact gttcccaccc
     3301 acgtcgggct cagccactat ctatgggcac gacatccgca ccgagatgga tgagatccgc
     3361 aagaacctgg gcatgtgccc acagcacaac gtgctctttg accggctcac ggtggaggag
     3421 cacctctggt tctactcacg cctcaaaagc atggcacagg aggagatccg caaagagacg
     3481 gacaagatga ttgaggacct ggaactctct aacaagcggc actcactggt gcagacgttg
     3541 tctggaggca tgaagcgcaa gctttcggta gccattgcct ttgtgggtgg ctctagagcc
     3601 attatcttag acgagcccac ggctggcgtg gacccctatg ctcgccgtgc catctgggac
     3661 ctcattctga agtacaagcc gggccgcact atcctcctgt ctacccatca catggatgag
     3721 gctgacctgc tgggggatcg cattgccatc atctcccatg ggaagctcaa atgctgtggc
     3781 tctcccctct tcctcaaggg agcctatggc gatgggtacc gcctcacatt ggtcaagcag
     3841 cctgcagaac ctggcacctc ccaagagcca gggctggctt ccagcccctc aggttgtcct
     3901 cggctgagca gctgctcgga gccgcaagtg tcccagttca tccgcaagca tgtggcttcc
     3961 tccctgctgg tctcagacac gagcaccgag ctctcctaca tcctgcccag cgaggccgtc
     4021 aagaaggggg ccttcgagcg cctctttcag caactggaac acagcctgga tgcgctccat
     4081 ctgagcagtt ttgggctgat ggacacaact ctggaggagg tgttcctcaa ggtgtctgaa
     4141 gaagatcagt cactggagaa cagcgaggct gatgtgaagg agtcccggaa ggatgtgctg
     4201 cctggggcag agggcctgac agctgtgggg ggtcaagctg gcaacctggc tcggtgctca
     4261 gagctggcac agtcacaggc atcgctgcag tctgcatcct ctgtgggctc tgcccgtggg
     4321 gaggagggca ccggctactc tgatggctac ggtgactacc gtcccctctt tgacaacttg
     4381 caggacccag acaatgtcag cttacaagag gcagagatgg aggccctggc tcaggtgggc
     4441 cagggcagcc gcaaactcga gggctggtgg ctgaagatgc ggcagttcca tgggctcctg
     4501 gtgaagcgct tccactgtgc tcgtcggaac tccaaagctc tctgctctca gattctgctg
     4561 cctgccttct ttgtctgtgt ggccatgact gtggcgttgt ctgtccctga gattggtgac
     4621 ctacctccac tggtcctgtc accctctcag taccacaact acacccagcc ccgtggcaac
     4681 tttatccctt atgccaatga ggaacgccag gagtaccgat tacggctgtc acctgatgcc
     4741 agcccccagc agctggtgag cacattccgg ctgccctctg gtgtgggtgc cacttgtgtg
     4801 ctcaagtctc ctgccaacgg ctccctggga cccatgctga acttaagcag tggagagtcc
     4861 cgcctgctgg cggcacggtt cttcgacagt atgtgcctgg agtccttcac acaggggctg
     4921 ccactgtcca acttcgtgcc acctccgccc tcacccgccc cttctgactc acccgtgtcc
     4981 ccagatgagg attcactgca agcctggaac atgtccctgc cacctactgc tgggccagag
     5041 acgtggacgt cggcgccttc tctgccacgc ctagtgcatg agccagtccg ctgtacctgc
     5101 tctgcacagg gcacggggtt ctcatgcccc agcagtgtgg gtggacaccc accccagatg
     5161 agagtggtca caggtgacat cctgactgac atcactggcc acaatgtttc tgagtacctg
     5221 ctcttcacct ctgaccgttt ccgactacac cgatatggag ccatcacctt tggtaatgtt
     5281 cagaagtcta tcccagcatc ctttggtgcc cgggtccctc ctatggtgcg gaagattgca
     5341 gtgcggaggg tggctcaggt gctctacaat aacaagggct accacagcat gcccacctac
     5401 ctcaacagcc tcaacaatgc cattctgcgt gcaaacctac ccaaaagcaa gggcaatcca
     5461 gcagcctatg gcatcaccgt caccaaccac cccatgaaca agaccagtgc tagcctctcc
     5521 ctggattacc tactgcaggg cacagatgtg gtcatcgcca tcttcatcat tgtggccatg
     5581 tccttcgtgc cagccagctt tgtggtcttc cttgtggcag agaaatccac caaggccaaa
     5641 cacctgcagt tcgtcagcgg gtgcaaccct gtcatctact ggctggccaa ctacgtgtgg
     5701 gacatgctca attacctggt cccagccacc tgctgcgtga tcatcctctt tgtctttgac
     5761 ttacctgcct acacatcacc caccaacttc cccgcggtgc tctccttgtt cctgctctat
     5821 gggtggtcca tcacacccat catgtaccca gcctccttct ggtttgaggt ccctagctca
     5881 gcctacgtgt tcctcatcgt catcaacctc ttcatcggca tcacagccac ggtggccact
     5941 ttccttctgc agctttttga gcatgacaag gatctgaagg ttgtcaacag ttacctgaaa
     6001 agctgcttcc tcatcttccc caactacaac ctgggccacg ggctcatgga gatggcctac
     6061 aatgagtaca tcaacgaata ctacgccaag attggccagt ttgacaagat gaagtccccg
     6121 ttcgagtggg acattgtcac acgtggactg gtggccatga cagtcgaggg cttcgtggga
     6181 ttcttcctca ccatcatgtg ccagtataac ttcctacggc agccacaacg cctgcctgtg
     6241 tctactaaac ctgtggaaga cgatgtggat gtggctagtg agcgacagag agtgctccgt
     6301 ggcgatgctg acaatgacat ggtcaagatt gagaacctga ccaaggtgta caagtctcgg
     6361 aagattggcc ggatcctggc agtggaccgc ctttgcctgg gtgtgcgccc tggagagtgc
     6421 tttgggctcc ttggtgtcaa tggtgcaggg aagaccagca ccttcaagat gctgactgga
     6481 gatgagagca caactggggg agaggccttt gtcaatggac acagcgtgct caaggacctg
     6541 ctccaggtac agcagagcct tggctactgc ccgcagtttg atgccctgtt tgatgagctc
     6601 acggctcgtg aacacctgca gctgtacacg cggctgcgtg gcatcccctg gaaggatgag
     6661 gcacaggtag tgaagtgggc cctagagaag ctggaactga caaagtatgc agacaagcca
     6721 gctggcacct acagtggagg caacaaacgg aagctttcca cagccattgc cctcattggg
     6781 taccctgcct tcatctttct agatgagccc accactggca tggaccctaa ggcccggcgc
     6841 ttcctgtgga acctcattct ggacctcatc aagacgggac gttcggtggt gctgacgtca
     6901 cacagcatgg aggagtgtga ggctctgtgc acacgcttgg ccatcatggt gaacgggcgg
     6961 ctgcgctgcc tgggcagcat ccagcacctt aagaacaggt ttggggatgg ctacatgatt
     7021 actgtaagga ccaaaagcag ccagaacgtg aaggacgtgg tgcggttctt caacaggaac
     7081 ttcccagagg ccatgctcaa ggaaagacac catacgaagg tgcagtatca gctcaagtca
     7141 gagcacatct cgctggctca ggtgttcagc aagatggagc aggtggtggg tgtgctgggc
     7201 atcgaggatt actcagtcag ccagaccacc ctggataacg tgtttgtgaa ctttgcgaag
     7261 aagcagagtg ataatgtgga gcagcaagag gctgagccct cgtccttgcc gtcccccctt
     7321 ggactgctca gcctgctgag gccccgcccc gcacccacag agctccgggc attggtggct
     7381 gatgagccag aggacctgga cacagaggat gaaggcctca tcagcttcga ggaagagcgg
     7441 gcccagctct ccttcaacac tgatacgctc tgctgaccat caagagccac atcagggatg
     7501 cagctgtgtg gggcagatgt caggcggtgg ccgtggcccc tagtcacaca tgccaggccc
     7561 tggaaaggca ggttcaggac caaagggctc ctgccctcct cccaactacc atcctccccg
     7621 aattgtgcca aaggctggcc tggccctggg ctgcacatac cctcaccctg ctttgcctta
     7681 aagccttggg tcctggccca gccccttacc ctgcccagca ccatccacct tcccagggtg
     7741 acatgggctg ccccaagtat cctgtgactc ttctctgcag cggccgcaag tctacccagg
     7801 ccagcatctt gcacagatgt cttttcatgg acacccttga ctgcagttgg ggatggggca
     7861 gcttgcctat ttattttgct ttaagagcct ccctcacttg gctgtggtac agaagttagg
     7921 ctaccatggg aagccgtgaa tgtggctgcc tcagccctgg tggaatgaca ggaacggaga
     7981 agctgggctt gctggctagg ggaggggcca ctgttccctc cctaccccct caatctgcct
     8041 ttgctctccc gtccagcttg gcccttcctg ccacccacat gggagcagga ctttgtatat
     8101 agcacacaga tgtttgtttt caataaataa gcaaaaagca
//
