LOCUS       NM_175210               8323 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family A member 12 (Abca12),
            mRNA.
ACCESSION   NM_175210 XM_001002308 XM_987225
VERSION     NM_175210.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8323)
  AUTHORS   Ford,N.C., Benedeck,R.E., Mattoon,M.T., Peterson,J.K., Mesler,A.L.,
            Veniaminova,N.A., Gardon,D.J., Tsai,S.Y., Uchida,Y. and Wong,S.Y.
  TITLE     Hair follicles modulate skin barrier function
  JOURNAL   Cell Rep 43 (7), 114347 (2024)
   PUBMED   38941190
REFERENCE   2  (bases 1 to 8323)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8323)
  AUTHORS   Cottle,D.L., Ursino,G.M.A., Jones,L.K., Tham,M.S., Zylberberg,A.K.
            and Smyth,I.M.
  TITLE     Topical Aminosalicylic Acid Improves Keratinocyte Differentiation
            in an Inducible Mouse Model of Harlequin Ichthyosis
  JOURNAL   Cell Rep Med 1 (8), 100129 (2020)
   PUBMED   33294854
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8323)
  AUTHORS   Teramura,T. and Nomura,T.
  TITLE     Acute skin barrier disruption alters the secretion of lamellar
            bodies via the multilayered expression of ABCA12
  JOURNAL   J Dermatol Sci 100 (1), 50-57 (2020)
   PUBMED   32873425
  REMARK    GeneRIF: Acute skin barrier disruption alters the secretion of
            lamellar bodies via the multilayered expression of ABCA12.
REFERENCE   5  (bases 1 to 8323)
  AUTHORS   Ursino,G.M., Fu,Y., Cottle,D.L., Mukhamedova,N., Jones,L.K.,
            Low,H., Tham,M.S., Gan,W.J., Mellett,N.A., Das,P.P., Weir,J.M.,
            Ditiatkovski,M., Fynch,S., Thorn,P., Thomas,H.E., Meikle,P.J.,
            Parkington,H.C., Smyth,I.M. and Sviridov,D.
  TITLE     ABCA12 regulates insulin secretion from beta-cells
  JOURNAL   EMBO Rep 21 (3), e48692 (2020)
   PUBMED   32072744
  REMARK    GeneRIF: ABCA12 regulates insulin secretion from beta-cells.
REFERENCE   6  (bases 1 to 8323)
  AUTHORS   Yanagi,T., Akiyama,M., Nishihara,H., Ishikawa,J., Sakai,K.,
            Miyamura,Y., Naoe,A., Kitahara,T., Tanaka,S. and Shimizu,H.
  TITLE     Self-improvement of keratinocyte differentiation defects during
            skin maturation in ABCA12-deficient harlequin ichthyosis model mice
  JOURNAL   Am J Pathol 177 (1), 106-118 (2010)
   PUBMED   20489143
  REMARK    GeneRIF: Results indicate that disrupted keratinocyte
            differentiation during the fetal development is involved in the
            pathomechanism of HI and, during maturation, Abca12(-/-) epidermal
            keratinocytes regain normal differentiation processes.
REFERENCE   7  (bases 1 to 8323)
  AUTHORS   Zuo,Y., Zhuang,D.Z., Han,R., Isaac,G., Tobin,J.J., McKee,M.,
            Welti,R., Brissette,J.L., Fitzgerald,M.L. and Freeman,M.W.
  TITLE     ABCA12 maintains the epidermal lipid permeability barrier by
            facilitating formation of ceramide linoleic esters
  JOURNAL   J Biol Chem 283 (52), 36624-36635 (2008)
   PUBMED   18957418
  REMARK    GeneRIF: ABCA12 activity is required for the generation of
            long-chain ceramide esters that are essential for the development
            of normal skin structure and function
REFERENCE   8  (bases 1 to 8323)
  AUTHORS   Yanagi,T., Akiyama,M., Nishihara,H., Sakai,K., Nishie,W., Tanaka,S.
            and Shimizu,H.
  TITLE     Harlequin ichthyosis model mouse reveals alveolar collapse and
            severe fetal skin barrier defects
  JOURNAL   Hum Mol Genet 17 (19), 3075-3083 (2008)
   PUBMED   18632686
  REMARK    GeneRIF: ABCA12 plays pivotal roles in lung and skin barrier
            functions in Harlequin ichthyosis disease midel.
REFERENCE   9  (bases 1 to 8323)
  AUTHORS   Smyth,I., Hacking,D.F., Hilton,A.A., Mukhamedova,N., Meikle,P.J.,
            Ellis,S., Satterley,K., Collinge,J.E., de Graaf,C.A., Bahlo,M.,
            Sviridov,D., Kile,B.T. and Hilton,D.J.
  TITLE     A mouse model of harlequin ichthyosis delineates a key role for
            Abca12 in lipid homeostasis
  JOURNAL   PLoS Genet 4 (9), e1000192 (2008)
   PUBMED   18802465
  REMARK    GeneRIF: Abca12 is a regulator of lipid transport and homeostasis.
            Erratum:[PLoS Genet. 2008 Oct;4(10). doi:
            10.1371/annotation/02a793a0-160f-46b9-abaa-4a3d3eecdde2. Slattery,
            Keith [corrected to Satterley, Keith]]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8323)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138589.16 and AC107789.7.
            
            On or before Mar 28, 2009 this sequence version replaced
            XM_987225.1, XM_001002308.2, NM_175210.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               AC138589.16        95961-96357         c
            398-491             AC138589.16        83098-83191         c
            492-645             AC138589.16        44048-44201         c
            646-737             AC138589.16        35117-35208         c
            738-835             AC138589.16        33155-33252         c
            836-1021            AC138589.16        30464-30649         c
            1022-1200           AC138589.16        28033-28211         c
            1201-1313           AC138589.16        22910-23022         c
            1314-1383           AC138589.16        17139-17208         c
            1384-1502           AC138589.16        11694-11812         c
            1503-1609           AC138589.16        10611-10717         c
            1610-1866           AC107789.7         236883-237139       c
            1867-1979           AC107789.7         236688-236800       c
            1980-2101           AC107789.7         235161-235282       c
            2102-2275           AC107789.7         232388-232561       c
            2276-2440           AC107789.7         229766-229930       c
            2441-2651           AC107789.7         229247-229457       c
            2652-2791           AC107789.7         227849-227988       c
            2792-2911           AC107789.7         225056-225175       c
            2912-3002           AC107789.7         222324-222414       c
            3003-3182           AC107789.7         218754-218933       c
            3183-3498           AC107789.7         217919-218234       c
            3499-3613           AC107789.7         216208-216322       c
            3614-3943           AC107789.7         210015-210344       c
            3944-4013           AC107789.7         208889-208958       c
            4014-4148           AC107789.7         208669-208803       c
            4149-4304           AC107789.7         207702-207857       c
            4305-4491           AC107789.7         206620-206806       c
            4492-4710           AC107789.7         203826-204044       c
            4711-4907           AC107789.7         201747-201943       c
            4908-5068           AC107789.7         200866-201026       c
            5069-5305           AC107789.7         199233-199469       c
            5306-5456           AC107789.7         198090-198240       c
            5457-5709           AC107789.7         195629-195881       c
            5710-5796           AC107789.7         194663-194749       c
            5797-5890           AC107789.7         194100-194193       c
            5891-6018           AC107789.7         191359-191486       c
            6019-6106           AC107789.7         189701-189788       c
            6107-6212           AC107789.7         187652-187757       c
            6213-6267           AC107789.7         183470-183524       c
            6268-6445           AC107789.7         182717-182894       c
            6446-6561           AC107789.7         181150-181265       c
            6562-6721           AC107789.7         180012-180171       c
            6722-6975           AC107789.7         178700-178953       c
            6976-7180           AC107789.7         176069-176273       c
            7181-7290           AC107789.7         175077-175186       c
            7291-7432           AC107789.7         174646-174787       c
            7433-7567           AC107789.7         173379-173513       c
            7568-7671           AC107789.7         165143-165246       c
            7672-7764           AC107789.7         163633-163725       c
            7765-7870           AC107789.7         162420-162525       c
            7871-8008           AC107789.7         160020-160157       c
            8009-8323           AC107789.7         158378-158692       c
FEATURES             Location/Qualifiers
     source          1..8323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 35.81 cM"
     gene            1..8323
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /note="ATP-binding cassette, sub-family A member 12"
                     /db_xref="GeneID:74591"
                     /db_xref="MGI:MGI:2676312"
     exon            1..397
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..8116
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /EC_number="7.6.2.1"
                     /note="ATP-binding cassette, sub-family A (ABC1), member
                     12"
                     /codon_start=1
                     /product="glucosylceramide transporter ABCA12"
                     /protein_id="NP_780419.2"
                     /db_xref="CCDS:CCDS48286.1"
                     /db_xref="GeneID:74591"
                     /db_xref="MGI:MGI:2676312"
                     /translation="MASQFHQLRILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITR
                     TKFPPTAKPTCYLAPRNLPSAGFFPFLQTLLCDTDSKCKDTPYGPRDLLRRKGIDGPL
                     FKESEILKKPSNPKRDSNLSLRSTQVPERSHTSLATVPPRPSYDLEGTGTENFNGSQL
                     LTRILGLEKLLKQNSTPEDIRRELCESYPGYTADYAFSWVTLGKNVFNKFCLSNMTLL
                     ESSLQELKYQVSQMSSDPDNQKRVFRGLVQVLSFFSQVQQQREVWQLLSSLPDVFQNG
                     TSLSSLFGVLQKANRVLLVVQKVYPRVQTDEGFSTLQKSVKHLLNTLDSPMQGDNSTH
                     AWSDDDEQTLSPSSLAAQLLILENFEDAILNISSNSPYSPYLACVRNMTDNLAKGSPD
                     NLKLLQSTIHFRKSFLQNGSSEDSFPPFLEILKSKLSQLRNLTELLCESETFSSIKKS
                     CQFSNMSFERLCEDHAFHVQLIEAAELGTDLTTGLLYHDNIISAKLRGLLTGDPSKIN
                     LNVDWLLEQALQMNYLENITRLIPTVEAMLHVNTSADASEKPGQLREMFKNIDLLKED
                     LRAIGMSNTSIDKLLAIPIPDNRAEIISRVFWLHSCDTNVTNPKLEDAMKEFCKLPLP
                     ERSHQSYLIGLTLLHYLDIYNFTYKVFFPRKDQKPMERMMELFIKLREILNQLASGTH
                     PLLDKMRSLRQMHLPRSVPLTQAMYRNTRMNSPAGSFSTISQALCSQGITTEYLTAML
                     PSSQKPKGNHTKDFLTYKLTKEEIASKYGIPLNATPFCFSLYKDIINMPAGPVIWAFL
                     KPMLLGKILYSPYNPTTKAIMEKSNVTLRQLAELREKSQEWMDKSPIFMNSFHLLNQT
                     IPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDDLDVLRLKLVNNIDIIDQLNTLSSL
                     TVNISSCVLYDRIQASDTVEEMETVAEQLYKSNELFGSVIFKLPSNGSLHRGFDPEKV
                     SLPPIVRYTIRMSLKTAQTTRSIRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAII
                     ELQTGRNSQEVAVQVQAVPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYE
                     KDLRLHEYMKMMGVNSCSHFFAWLIESIGFLLVTIAILIVILKFGNILPKTNGFILFL
                     YFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYVIAFFPFIVLVTVEDELSYVIKVF
                     MSLLSPTAFSYASQYIARYEEQGVGLQWENMYKSPVQDDTTSFGWLCCLILADSFIYF
                     FIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKHEKSNGLMFTNIMMQNTNP
                     SASKTSPDCAFPSNIEPEPKDLQVGVALHGVTKIYGSKTAVENLNLNFYEGHITSLLG
                     PNGAGKTTTISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTK
                     EHLLLYGSIKVPHWTKTQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALI
                     GGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQ
                     GGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLKE
                     DIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDS
                     QKSSNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSEKLEGFGLLL
                     KKIMAILIKRFHHTRRNWKGLIAQVILPIVFVATAMGLGTLRDSSNSYPEIMISPSIY
                     GTSEQTAFYANFDPSTSGLVSALWNFPGIDNVCLNTSDLQCLKKDDLGKWNTSGEAID
                     NFGVCSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTGKHMENYLITTANHFVQKRYGG
                     WSFGMKLTNDLRFDVTAVPDNRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSEYDA
                     ARHGIIMYSHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYIVREHQTKA
                     KQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGVIAIFKLPAFYSGNNLGAVSLLL
                     LLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPT
                     LELISETLKRIFLIFPQFCFGYGLIELSQQQAVLDFLKAYGVEYPSETFEMDKLGAMF
                     VALVSQGTMFFLLRLLINEWLIKKLRLFFRKFTSSPIMETVDEDEDVRAERFRVESGA
                     AEFDLVQLHRLTKTYQLIHKKIIAVNNISLGIPAGECFGLLGVNGAGKTTIFKMLTGD
                     IIPSSGNILIRNKSGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEK
                     DIKDTVHKLLRRLHLMAYKDRSTSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDP
                     KSKRHLWRIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGRFQCIGSLQHIKSRF
                     GRGFTVKVHLKNNKVSMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDL
                     LETNKTALNITNFLVSQTTLEEVFINFAKDQKSYENVDTSSQGSTISVDSQEDQLDS"
     exon            398..491
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            492..645
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            646..737
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            738..835
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1021
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1200
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1313
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1383
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1502
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1609
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1866
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1979
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2101
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2275
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2440
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2651
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2791
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2911
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3002
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3182
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3498
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3613
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3943
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4013
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4014..4148
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4304
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4305..4491
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4492..4710
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4711..4907
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4908..5068
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5069..5305
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..5456
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5457..5709
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5710..5796
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..5890
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5891..6018
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6019..6106
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6107..6212
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6213..6267
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6268..6445
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6446..6561
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6562..6721
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6722..6975
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6976..7180
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7181..7290
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7291..7432
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7433..7567
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7568..7671
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7672..7764
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7765..7870
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7871..8008
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            8009..8323
                     /gene="Abca12"
                     /gene_synonym="4832428G11Rik; 4833417A11Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attatctgaa tgatactcat tctctctgga gtgtggactt cgcacaagag gcagtatttt
       61 acaataagca caagccactg aaaggcactg agctggctcc tcattcctga agactttttg
      121 gttgagaaga gttaaggatt tactgaccgg aaaaacaaat ccattgggaa gagaagaact
      181 gtgggcttct taccccaggc cctacgaagc tatgccgtga aaaggctccc aacgcactgg
      241 catacagcat attagacggg acaccacttc tcttgaggac tggaggaaga gacaggaaca
      301 ttttgtttgt cttcagggtg tctgaaggat ggcttcccag tttcatcagc ttcggatcct
      361 ggtgtggaaa aattggctag gtgtcaaaag gcagccgctt tggacacttg tcttgatctt
      421 atggccagtc attattttca taattctggc tattacccgg acaaaattcc cgccaacagc
      481 aaaaccaact tgttacctcg cacctcgaaa ccttcccagt gctggattct tcccattcct
      541 acaaaccctg ctctgtgaca cagactctaa atgtaaagac acgccctatg gaccacgaga
      601 tctgctccgc aggaagggga ttgatggacc gctatttaaa gaaagcgaaa ttctgaaaaa
      661 gccgtccaac ccgaagaggg acagcaattt atcactccgg agcacccaag ttccagaaag
      721 aagtcacaca tcattggcca cagtacctcc aagaccaagc tatgatttgg aaggaacagg
      781 cacagaaaat ttcaatggta gccaattgct tacacgcatc cttggtttgg aaaagctgct
      841 gaagcaaaat tcaactccag aagacatacg aagagagctg tgtgagagct accctgggta
      901 cactgcggac tatgccttct cttgggtcac cctaggaaaa aacgttttta acaaattttg
      961 cctttcgaac atgacacttt tagagtcttc actccaggaa ctaaaatatc aagtctctca
     1021 gatgtcaagt gaccccgaca atcagaagag ggtgttccgg ggacttgtcc aggtgctgtc
     1081 ctttttctct caagtgcagc agcaaagaga agtgtggcaa cttctgtcga gcttaccaga
     1141 tgtgtttcag aatggcacct cattgagcag tctatttggt gttcttcaaa aggcaaacag
     1201 ggtgctgctg gtagtgcaga aggtttaccc acgtgttcaa actgatgaag gattcagcac
     1261 cctccagaag tctgttaaac atctgctgaa cactctggac tccccaatgc aaggtgacaa
     1321 ttcaacgcac gcatggagtg atgatgatga gcagacactg tccccgagca gtctggctgc
     1381 acagctcctg atcctggaaa actttgaaga tgccatcttg aacatatcat caaatagtcc
     1441 atattctcct tatttggcgt gtgtaaggaa catgactgac aacttggcta agggatcacc
     1501 agacaatcta aaacttctgc agtccacaat tcacttcaga aaatctttcc ttcaaaatgg
     1561 ctcctccgag gacagcttcc ctccatttct tgagatcctg aaatccaagc tgtctcaact
     1621 tcgaaatttg acggaacttc tctgcgaatc agagactttc agttcgatca agaagtcttg
     1681 ccagttctct aacatgagct tcgagaggct gtgtgaagac catgcctttc acgtgcaact
     1741 gattgaagcg gcagagctgg gcactgacct caccactggc ttactgtacc atgacaatat
     1801 aatatctgca aagctgaggg gtttgctcac tggagatccc agcaaaatta atctcaatgt
     1861 ggactggctc ctggaacagg cattgcaaat gaattacttg gagaatatca cacggctcat
     1921 accaaccgta gaggccatgc tgcatgtcaa caccagtgca gacgcttctg agaagccagg
     1981 tcaattaaga gaaatgttta aaaacataga tttgctgaaa gaagatctga gggcgatagg
     2041 gatgtccaac acaagtatcg acaagctgtt ggccattccc attccagaca atagagccga
     2101 gataatttct cgtgtattct ggttgcactc atgtgatacc aacgtcacca accccaaact
     2161 ggaagatgcc atgaaggagt tctgcaagct gcctcttcca gagagatcac atcagtccta
     2221 cctcatcgga ctcacccttc tgcactactt agacatttac aatttcacat acaaggtgtt
     2281 tttcccaagg aaggatcaaa agccaatgga aaggatgatg gagcttttca taaagctgag
     2341 agagattctc aatcagttgg cttccggcac acatccactg ctggacaaaa tgagatccct
     2401 gagacaaatg cacctgccca ggagtgttcc attaacacag gccatgtaca gaaacactcg
     2461 aatgaactcg ccagcaggat cgttcagtac tatctcccag gctctgtgct cccaggggat
     2521 caccaccgag tacttaactg ctatgctgcc ttcttcccag aagccaaaag gcaaccacac
     2581 caaggatttt ctcacttata aattaactaa agaagaaatt gcttcaaaat acgggattcc
     2641 tttaaatgct acaccatttt gcttctccct ttacaaagac atcattaaca tgcctgctgg
     2701 gcctgtgatt tgggccttct tgaaacccat gttgttggga aagattttat attcaccata
     2761 taacccaact acaaaggcca ttatggaaaa gtccaatgta actctaagac agctggcgga
     2821 attaagagaa aaatctcagg agtggatgga taagtcacca attttcatga attccttcca
     2881 cctgctaaac cagacgatcc caatgctcca gaatactcta cggaacccct ttgtgcaagt
     2941 ttttgtgaag ttctccgtgg gactcgatgc tgtcgaactc ctgaagcaga tagacgacct
     3001 tgatgttctc aggctgaaat tagtgaacaa cattgacatc attgatcagc tcaacacact
     3061 gtcttccctg actgtaaata tttcctcctg tgttctttac gaccgtattc aggcgtcaga
     3121 cactgtagag gagatggaga cggtggccga acaactctac aagagcaacg agctctttgg
     3181 aagtgtcatt tttaagcttc catctaacgg aagtttgcac agagggtttg accctgaaaa
     3241 agtgtctctt cctcctatcg taagatatac catccgcatg agtctgaaga cggcacagac
     3301 cacaaggagc ataagaacaa agatctgggc cccagggcca cacaactctc catcccataa
     3361 ccagatctat ggccgggctt tcatttatct gcaggatagc attgagagag caattattga
     3421 gttacaaaca ggaaggaact cacaggaagt cgccgtccag gttcaagcgg ttccttatcc
     3481 ctgcttcatg aaggacaatt tcctcaccag tgtctcctat tccctcccga ttgtgcttat
     3541 ggtcgcctgg gttgtattta tagctgcctt tgttaaaaag ctagtctacg agaaggacct
     3601 tcggctccat gagtacatga agatgatggg tgtcaactcc tgcagccatt tctttgcctg
     3661 gcttatagag agtattgggt tcttgctggt caccattgca atcctcatcg ttatcctcaa
     3721 gtttggcaat attcttccca agacaaacgg cttcattttg ttcctgtact tctcagacta
     3781 cagcttctca gtgattgcca tgagctatct catcagtgtc ttcttcaaca acaccaacat
     3841 tgcagctctg attggaagcc tcatctatgt catcgccttt ttcccattta ttgttctggt
     3901 tacagttgag gatgagctga gctacgttat taaagtattc atgagcctgc tgtccccgac
     3961 agcattcagc tatgcaagcc aatatattgc acggtatgaa gaacaaggcg ttggtcttca
     4021 gtgggaaaat atgtacaaat cccctgttca ggatgacacc acctcatttg gctggctgtg
     4081 ctgtctaatc ctagcagact ccttcattta tttctttatt gcttggtacg tcaggaatgt
     4141 tttcccaggg acatatggaa tggcagctcc atggtatttt cccatccttc cttcctattg
     4201 gaaagagcgc tttggatgcg cagaggtgaa gcatgagaaa agcaatggct taatgtttac
     4261 taatatcatg atgcagaaca ccaacccttc tgccagtaag acaagtcctg actgtgcatt
     4321 tccctccaac attgaacctg aacctaaaga tctccaagtt ggagttgccc ttcatggggt
     4381 cacaaagatc tatggctcaa aaacagctgt tgagaacctc aatctgaact tctacgaagg
     4441 gcacattaca tcactgttgg ggccaaacgg agctggcaaa accacaacaa tctccatgct
     4501 gactgggctg tttggtgcca cagcgggtac catttttgta tacggaaaag atatcaagac
     4561 agacctgaat actgttcgga aaaacatggg ggtctgcatg caacatgacg tcttgttcag
     4621 ttacctaacc accaaggaac accttctcct gtatggctcc atcaaagttc ctcactggac
     4681 caaaacacag ctccatgagg aggttaaaag gactttaaaa gacactggac tgtatagtca
     4741 tcgccataag agagttggaa cgttgtcggg aggaatgaag aggaagttgt ccatatccat
     4801 agctctcatc ggtggctcca gggtagtgat tttggatgaa ccatccacgg gcgttgaccc
     4861 atgttctcgc cgaagcatat gggatgtcat atccaagaac aaaactgcaa gaacaatcat
     4921 tctgtccaca caccacttgg atgaggccga agtgctgagt gaccgcatcg ccttcctgga
     4981 acagggtggg ctccggtgct gtggatctcc attttacctc aaggaagctt ttggggatgg
     5041 ttaccacctc acactcacca agaagaagag tccaaaccta gacacaaatg caatctgtga
     5101 cacagtggca gtgacagcaa tgatccagtc gcaccttcct gaagcctacc tcaaagagga
     5161 tattggggga gagcttgtat atgtgctccc tccattcagc acgaaagtct caggagctta
     5221 cctgtccctc ctgagagcac tggacaaggg catgggtaaa ctcaacatcg gctgctatgg
     5281 catttcagac accactgttg aagaggtctt cctgaacttg acaaaagatt cgcaaaaaag
     5341 tagtaatatg agtctggagc acttaacaca gaggaaagtt gggaacccca gtgccaacgg
     5401 gacctccact cctgacgacc tgtctgtgag cagcagcaac ttcaccgaca gagacgacaa
     5461 agtcctgaca agaagcgaga agctggaggg ctttggactc ttactgaaga agataatggc
     5521 tattctcatc aagaggttcc accacacccg ccggaactgg aaaggtctca ttgctcaggt
     5581 cattctcccc atcgtctttg tagccacggc catgggtctc ggcacactga gagattccag
     5641 caacagttac ccagagatca tgatctctcc gtccatttac ggcacctccg aacagacagc
     5701 cttctacgcg aattttgatc caagcaccag tggtctggtc tcagctctct ggaatttccc
     5761 tggcattgac aatgtgtgtt tgaatactag tgacttgcag tgtttaaaaa aagatgatct
     5821 gggaaagtgg aacacaagtg gagaagctat cgacaacttt ggtgtttgct cctgttccga
     5881 caatgtccag gaatgcccca aattcaacta tcatccacct catagaagaa cttactcttc
     5941 ccaagttatt tataacctca ctggaaaaca catggaaaat tatcttataa caactgcaaa
     6001 tcattttgtg cagaaaagat atggaggttg gagttttggg atgaaattga ctaacgacct
     6061 tcgttttgat gtgacagctg tccctgacaa tagaactctt gctaaggtgt ggtacgatcc
     6121 ggaaggctac cattccctcc cagcttacct caacagcctc aacaacttcc tcctgagggt
     6181 taacatgtca gagtacgatg ctgcccgaca cgggatcatc atgtatagcc acccttatcc
     6241 aggggtacaa gaccaggaac aagccacaat cagcagttta atcgatattt tagtggcgct
     6301 gtccatcctg atgggctact ctgtcaccac tgccagcttt gtcacctaca ttgtcaggga
     6361 acatcagacc aaagccaagc agttgcagca catttctggc atcggtgtga cgtgctactg
     6421 ggtgacaaat ttcatctatg acatggtctt ctatttggtt cctgtagcat tttcaattgg
     6481 tgtcatcgca attttcaagc ttcctgcctt ctacagtgga aacaatctag gcgctgtatc
     6541 cctcctactt ttgctgtttg gctatgcaac attttcttgg atgtacctgc tggctggcct
     6601 cttccacgaa acaggaatgg ccttcatcac ttatgtgtgt gtcaacctgt tctttggtat
     6661 caattccatc gtttccctgt cggtggtata cttcctttcc aaggaaaagc ctaatgaccc
     6721 gacgctagaa cttatttctg aaactctcaa gcggattttc ctgatcttcc cccaattctg
     6781 ttttggctac ggtttgattg aactttctca gcaacaggca gtcttggatt tcttaaaagc
     6841 ctacggtgtg gaatatccaa gcgagacctt tgagatggat aagctggggg caatgtttgt
     6901 ggccttggtt tctcagggca ccatgttttt cttgttgcga ctcctcatca atgagtggct
     6961 gataaagaag ctcaggctct tcttcaggaa atttacatct tcgcctatca tggagacagt
     7021 agatgaagat gaagatgtgc gggctgagag atttcgagtt gagagtggtg cagctgagtt
     7081 tgacctggtc cagctccatc gtctcacaaa gacctaccag ctgatccaca agaagattat
     7141 agctgtcaac aacatcagcc tggggatacc tgctggagag tgttttggcc tccttggtgt
     7201 gaacggagca gggaaaacca ctatatttaa gatgctgact ggagacataa ttccttccag
     7261 tggaaacatt ctgatcagaa acaagagcgg atccctggga catgtggatt ctcacagctc
     7321 tttggttggc tactgccctc aggaggacgc tttagatgac ctagtaactg tggaagagca
     7381 cttgtatttc tatgccagag tgcatgggat tccagagaag gacatcaaag acactgttca
     7441 taaactcctt aggagacttc acttgatggc ctacaaggac agatctacct ccatgtgcag
     7501 ttacggcaca aaaaggaagc tgtccactgc cctggccttg atagggaaac cgtccatcct
     7561 cctgctggat gagccaagct ctgggatgga tcccaagtca aaacgacacc tctggaggat
     7621 catttcagaa gaggtgcaga acaaatgctc tgtcatcctc acatctcaca gcatggaaga
     7681 atgtgaagct ctttgtaccc ggctggccat tatggtgaac ggaaggttcc agtgcattgg
     7741 gtctctgcaa cacataaaaa gcaggtttgg acgtggattt actgtcaagg ttcacttgaa
     7801 aaataataaa gtgagcatgg aaaccctcac gaagtttatg cagctacact ttccaaaaac
     7861 atacttaaaa gatcagcacc tgagcatgct ggagtaccac gtgccagtca cagcaggagg
     7921 ggtcgcaaac atctttgacc ttctggaaac caacaagact gctttaaata tcacaaattt
     7981 cctcgtgagc cagaccactt tggaggaggt tttcatcaac tttgccaaag accaaaaatc
     8041 ctacgaaaat gttgatacca gtagccaagg ttccaccata agtgtagact cacaggaaga
     8101 tcaactagat tcttagcacc tgcagcagat tcaacttcag caacaactga cggatgcttt
     8161 ctgaagaaga catcgatttt aaacatctct tccttataaa gtgttatact gcacggcaag
     8221 ggtacagcgt aagactgaca aatgataatg gacatccgtg aatgttactg ttcccaaaat
     8281 gattccctgt attcaacaca gtgagcacgc aacgtatatg ctg
//
