LOCUS       NM_001377503            5199 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus apoptosis-associated tyrosine kinase (Aatk),
            transcript variant 4, mRNA.
ACCESSION   NM_001377503
VERSION     NM_001377503.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5199)
  AUTHORS   Jin,R., Zhang,H., Lin,C., Guo,J., Zou,W., Chen,Z. and Liu,H.
  TITLE     Inhibition of miR338 rescues cleidocranial dysplasia in Runx2
            mutant mice partially via the Hif1a-Vegfa axis
  JOURNAL   Exp Mol Med 55 (1), 69-80 (2023)
   PUBMED   36599929
REFERENCE   2  (bases 1 to 5199)
  AUTHORS   Takahashi,M., Sugiyama,A., Wei,R., Kobayashi,S., Fukuda,K.,
            Nishino,H., Takahashi,R., Tsutsumi,K., Kita,I., Ando,K., Manabe,T.,
            Kamiguchi,H., Tomomura,M. and Hisanaga,S.I.
  TITLE     Hyperactive and impulsive behaviors of LMTK1 knockout mice
  JOURNAL   Sci Rep 10 (1), 15461 (2020)
   PUBMED   32963255
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5199)
  AUTHORS   Wei,R., Sugiyama,A., Sato,Y., Nozumi,M., Nishino,H., Takahashi,M.,
            Saito,T., Ando,K., Fukuda,M., Tomomura,M., Igarashi,M. and
            Hisanaga,S.I.
  TITLE     Isoform-dependent subcellular localization of LMTK1A and LMTK1B and
            their roles in axon outgrowth and spine formation
  JOURNAL   J Biochem 168 (1), 23-32 (2020)
   PUBMED   32044995
  REMARK    GeneRIF: Isoform-dependent subcellular localization of LMTK1A and
            LMTK1B and their roles in axon outgrowth and spine formation.
REFERENCE   4  (bases 1 to 5199)
  AUTHORS   Ding,L.Y., Hou,Y.C., Kuo,I.Y., Hsu,T.Y., Tsai,T.C., Chang,H.W.,
            Hsu,W.Y., Tsao,C.C., Tian,C.C., Wang,P.S., Wang,H.C., Lee,C.T.,
            Wang,Y.C., Lin,S.H., Hughes,M.W., Chuang,W.J., Lu,P.J., Shan,Y.S.
            and Huang,P.H.
  TITLE     Epigenetic silencing of AATK in acinar to ductal metaplasia in
            murine model of pancreatic cancer
  JOURNAL   Clin Epigenetics 12 (1), 87 (2020)
   PUBMED   32552862
  REMARK    GeneRIF: Epigenetic silencing of AATK in acinar to ductal
            metaplasia in murine model of pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5199)
  AUTHORS   Nishino,H., Saito,T., Wei,R., Takano,T., Tsutsumi,K., Taniguchi,M.,
            Ando,K., Tomomura,M., Fukuda,M. and Hisanaga,S.I.
  TITLE     The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine
            Formation via Endosome Trafficking
  JOURNAL   J Neurosci 39 (48), 9491-9502 (2019)
   PUBMED   31628178
REFERENCE   6  (bases 1 to 5199)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   7  (bases 1 to 5199)
  AUTHORS   Tomomura,M., Fernandez-Gonzales,A., Yano,R. and Yuzaki,M.
  TITLE     Characterization of the apoptosis-associated tyrosine kinase
            (AATYK) expressed in the CNS
  JOURNAL   Oncogene 20 (9), 1022-1032 (2001)
   PUBMED   11314040
REFERENCE   8  (bases 1 to 5199)
  AUTHORS   Baker,S.J., Sumerson,R., Reddy,C.D., Berrebi,A.S., Flynn,D.C. and
            Reddy,E.P.
  TITLE     Characterization of an alternatively spliced AATYK mRNA: expression
            pattern of AATYK in the brain and neuronal cells
  JOURNAL   Oncogene 20 (9), 1015-1021 (2001)
   PUBMED   11314039
REFERENCE   9  (bases 1 to 5199)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   10 (bases 1 to 5199)
  AUTHORS   Gaozza,E., Baker,S.J., Vora,R.K. and Reddy,E.P.
  TITLE     AATYK: a novel tyrosine kinase induced during growth arrest and
            apoptosis of myeloid cells
  JOURNAL   Oncogene 15 (25), 3127-3135 (1997)
   PUBMED   9444961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL953913.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.11778.1,
                                           SRR14995047.955744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               AL953913.5         25077-25503         c
            428-546             AL953913.5         24662-24780         c
            547-634             AL953913.5         24455-24542         c
            635-768             AL953913.5         23808-23941         c
            769-853             AL953913.5         21999-22083         c
            854-975             AL953913.5         21797-21918         c
            976-1125            AL953913.5         21072-21221         c
            1126-3718           AL953913.5         18183-20775         c
            3719-3866           AL953913.5         17956-18103         c
            3867-4067           AL953913.5         17624-17824         c
            4068-5199           AL953913.5         15662-16793         c
FEATURES             Location/Qualifiers
     source          1..5199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.96 cM"
     gene            1..5199
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /note="apoptosis-associated tyrosine kinase"
                     /db_xref="GeneID:11302"
                     /db_xref="MGI:MGI:1197518"
     exon            1..427
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            428..546
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..4108
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 4;
                     serine/threonine-protein kinase LMTK1;
                     apoptosis-associated tyrosine kinase 1B; lemur tyrosine
                     kinase 1; brain apoptosis-associated tyrosine kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LMTK1 isoform 3"
                     /protein_id="NP_001364432.1"
                     /db_xref="GeneID:11302"
                     /db_xref="MGI:MGI:1197518"
                     /translation="MQFLEEAQPYRALQHSNLLQCLAQCAEVTPYLLVMEFCPLGDLK
                     GYLRSCRVTESMAPDPLTLQRMACEVACGVLHLHRHNYVHSDLALRNCLLTADLTVKV
                     GDYGLSHCKYREDYLVTADQLWVPLRWIAPELVDEVHGNLLVVDQTKSSNVWSLGVTI
                     WELFELGAQPYPQHSDGQVLAYAVREQQLKLPKPQLQLALSDRWYEVMQFCWLQPEQR
                     PTAEEVHLLLSYLCAKGTTELEEEFERRWRSLRPGGSTGLGSGSAAPAAATAASAELT
                     AASSFPLLERFTSDGFHVDSDDVLTVTETSHGLNFEYKWEAGCGAEEYPPSGAASSPG
                     SAARLQELCAPDSSPPGVVPVLSAHSPSVGSEYFIRLEGAVPAAGHDPDCAGCAPSPQ
                     AVTDQDNNSEESTVASLAMEPLLGHAPPTEGLWGPCDHHSHRRQGSPCPSRSPSPGTP
                     MLPAEDIDWGVATFCPPFFDDPLGASPSGSPGAQPSPSDEEPEEGKVGLAAQCGHWSS
                     NMSANNNSASRDPESWDPGYVSSFTDSYRDDCSSLEQTPRASPEVGHLLSQEDPRDFL
                     PGLVAVSPGQEPSRPFNLLPLCPAKGLAPAACLITSPWTEGAVGGAENPIVEPKLAQE
                     AEGSAEPQLPLPSVPSPSCEGASLPSEEASAPDILPASPTPAAGSWVTVPEPAPTLES
                     SGSSLGQEAPSSEDEDTTEATSGVFTDLSSDGPHTEKSGIVPALRSLQKQVGTPDSLD
                     SLDIPSSASDGGCEVLSPSAAGPPGGQPRAVDSGYDTENYESPEFVLKEAHESSEPEA
                     FGEPASEGESPGPDPLLSVSLGGLSKKSPYRDSAYFSDLDAESEPTFGPEKHSGIQDS
                     QKEQDLRSPPSPGHQSVQAFPRSAVSSEVLSPPQQSEEPLPEVPRPEPLGAQGPVGVQ
                     PVPGPSHSKCFPLTSVPLISEGSGTEPQGPSGQLSGRAQQGQMGNPSTPRSPLCLALP
                     GHPGALEGRPEEDEDTEDSEESDEELRCYSVQEPSEDSEEEPPAVPVVVAESQSARNL
                     RSLLKMPSLLSEAFCDDLERKKKAVSFFDDVTVYLFDQESPTRETGEPFPSTKESLPT
                     FLEGGPSSPSATGLPLRAGHSPDSSAPEPGSRFEWDGDFPLVPGKAALVTELDPADPV
                     LAAPPTPAAPFSRFTVSPTPASRFSITHISDSDAQSVGGPAAGAGGRYTEA"
     exon            547..634
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            635..768
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            769..853
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            854..975
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1125
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..3718
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3866
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..4067
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..5199
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5199
                     /gene="Aatk"
                     /gene_synonym="AATYK; aatyk1; mKIAA0641"
                     /note="major polyA site"
ORIGIN      
        1 gttggttgct ctgctgtcct cccaggcctc ggcaccagct tcctgcctca tccaaacgcc
       61 tttccaggcc ctgctgtttg ggcttggctt ctccctgtgg ctctgctctg ggcatcccca
      121 ggctttgcct ggatggagac ttgaggtcca tagctctgct gacagcagcc accccagagc
      181 ctaagagaca ctggccctcg atgacagcgc tcaaacctgg cctccacttt attgaagctt
      241 ctttggctgg ggagcttggg aaagctctct gggctctgga gagcgtggtc gggaagatgg
      301 agagggagcg gtggctaagc tgtgtctgga tttctgttcc actctagtgc aacttctcaa
      361 gtccacggac ctgggccggc acagcctcct gtacttaaag gagattggcc acggctggtt
      421 tgggaaggtg tttttggggg aggtacactc gggcgtcagt ggcacgcagg tggtggtgaa
      481 ggagctgaag gtgagcgcca gcgtgcagga gcagatgcag ttcctggagg aggcgcagcc
      541 ctacagggcc ctgcagcaca gcaacctgct ccagtgcctg gcccagtgtg ctgaagtgac
      601 cccctacctg ctggttatgg agttctgtcc actgggggac ctcaaaggtt atctacggag
      661 ctgccgggtg acagagtcca tggcgcctga cccacttacc ttgcagcgca tggcgtgcga
      721 ggtggcgtgt ggcgtcttgc atctacatcg acacaactat gtacacagtg acctggccct
      781 gaggaactgc ctgcttacgg ctgacctgac agtgaaggtt ggtgattatg gcctgtcgca
      841 ttgcaaatac agggaagact atctcgtgac cgctgaccag ctgtgggtgc cgctgcgctg
      901 gatcgcgcca gagctggtgg acgaggttca cggcaacctg ctggtggtgg accagaccaa
      961 gagcagcaac gtgtggtccc tgggtgtgac catctgggag cttttcgagt tgggtgcgca
     1021 gccgtacccc cagcactcgg acgggcaggt gctggcttac gccgtccggg agcagcagct
     1081 taagttgccc aagccccagc tgcagctggc tctatctgat cgatggtacg aggtgatgca
     1141 gttctgctgg ctgcagccag agcagaggcc cacagctgaa gaggttcatc tactgctgtc
     1201 ctacttgtgt gctaagggca ccacagaatt ggaggaggag tttgagcggc gctggcgctc
     1261 cctgcggccc gggggcagca cgggcctggg ctcgggttct gcagccccag cagctgccac
     1321 cgccgcctcc gcggagctca ccgctgcctc gtctttcccg ctgctggagc ggttcaccag
     1381 cgacggcttt cacgtggaca gtgatgacgt gctgacggtc acggagacaa gccacggcct
     1441 caactttgaa tacaagtggg aggctggctg tggcgctgag gagtacccac cctcgggggc
     1501 tgcatcaagc ccaggctcgg cagcgcgcct gcaggagttg tgcgcgcctg acagttcacc
     1561 gccgggtgtg gtgccagtcc tcagtgccca cagcccctca gtgggtagcg agtacttcat
     1621 ccgcctggag ggggcagtgc ctgctgctgg ccacgatcca gactgtgccg gctgcgctcc
     1681 cagcccccag gctgtgactg accaggacaa taactctgag gagagcactg ttgcgtccct
     1741 tgccatggag ccattgctgg gccatgcacc cccaactgag ggtctgtggg gcccctgtga
     1801 ccaccattca cataggaggc aagggtcacc ctgtccctca cgctcaccct ctcctgggac
     1861 cccgatgttg ccagctgaag acatagactg gggtgtggct accttctgcc cgcccttctt
     1921 tgatgaccca ctgggtgcat ctccctcggg gagtcctggg gcccagccct cccccagtga
     1981 tgaggagcca gaggagggga aggtggggtt ggccgctcag tgtggacact ggagctctaa
     2041 catgtcagct aacaacaaca gtgccagtcg cgacccagaa tcctgggatc ctggctatgt
     2101 tagcagcttc acagacagct acagggacga ctgctccagc ttagagcaga cccctcgagc
     2161 ctcccctgag gtgggccatc tcctgtccca ggaggatccc agagattttc tccctgggct
     2221 agtagcagtc tcccctggtc aggagccaag ccgtcccttc aacctgctcc ccctgtgtcc
     2281 tgccaaaggc ctggcacctg ctgcctgcct catcacatcc ccttggacag agggagctgt
     2341 gggtggggct gagaacccca ttgtggaacc caaacttgcc caggaggctg agggatctgc
     2401 tgaaccccag ctaccccttc cttccgtccc ctccccatcc tgtgaaggag cctcacttcc
     2461 ctcggaggag gcaagcgctc ctgacatcct acctgcctca cccacacccg ctgctggcag
     2521 ctgggtgacc gtccctgagc cagcccccac cctggagagc agcggcagtt ctctggggca
     2581 agaggcaccc agcagcgagg acgaagacac gaccgaggca acatcaggag tcttcaccga
     2641 cctgtccagt gacggcccac acacggagaa gtcaggcata gtaccagcct tgcgcagtct
     2701 gcagaagcag gtggggaccc ctgactccct ggactctctg gacataccgt cctcagccag
     2761 tgatggtggc tgtgaggtct taagcccatc agctgctggt ccacctggcg ggcagccccg
     2821 tgccgtggac agtggctatg atacagagaa ctatgagtct cctgagtttg tgctcaagga
     2881 ggcccatgag tcgagtgagc ctgaggcctt tggggagcca gcctcagagg gtgagagccc
     2941 agggcccgat cctctgctct ctgtctccct tggtggcctc agcaagaaga gcccctaccg
     3001 agactctgcc tacttttcag acctggatgc cgagtccgaa cccacctttg gccctgagaa
     3061 gcacagtggg atccaggact cccaaaagga gcaagacctg aggagcccac ctagcccagg
     3121 gcatcagtct gtgcaggctt ttcccaggtc tgcagtgtcc agcgaggtgc tgtcccctcc
     3181 acagcagtca gaggagccct tgccagaagt ccccaggcca gagcctctcg gggctcaagg
     3241 cccagttgga gtgcagcctg tgcccggccc aagtcattcc aaatgtttcc cgctgacctc
     3301 cgttccactg atctcagaag gcagtggcac ggagccccag ggtccctcag gacagctgtc
     3361 agggcgagcc cagcaggggc agatgggcaa tcctagcaca cccagatccc cgctctgcct
     3421 ggccctgcct ggccaccccg gggctttgga gggccggccg gaggaggatg aggacaccga
     3481 ggacagcgag gagtctgatg aggagctccg gtgctacagc gtccaggagc ccagtgagga
     3541 cagcgaggag gagccgccag cggtgcccgt ggtggtggct gagagccaga gtgcccgaaa
     3601 tctacgcagc ctgctgaaga tgcccagcct gctgtcagag gccttctgtg acgacctgga
     3661 gcgcaagaag aaggctgtgt ccttcttcga tgatgtcacg gtctacctct ttgaccagga
     3721 aagccccacc cgagagactg gggagccctt tcccagcaca aaggaatcac tccctacgtt
     3781 cctggagggt ggccccagct cacccagtgc caccggcctg ccactgcggg ctggccactc
     3841 tcctgacagc tctgctcctg aaccaggcag taggttcgaa tgggatggtg atttcccgtt
     3901 ggtgcccggc aaggctgctt tggtgactga gctggatcct gctgaccctg tcctggcggc
     3961 gcctcccacg ccagctgcgc ccttctcacg cttcaccgtg tcacccacac ctgcctcccg
     4021 cttttccatc acccacatat ctgactcaga tgcccagtcc gtgggaggcc cagcagcagg
     4081 tgctgggggc cgatacacag aggcttgaga cccaggttat cccacccttc ggaggctggc
     4141 atcactggag cccctgccat cctgcccagg cagcgacaag gttggtgact gactgggaat
     4201 gaatggggac caccggcacc ctacagcatc ctggagaagc aggtggacaa gaggcctgta
     4261 tctagcccta gacgcattgg gctgtgtacc ttctctgtgc tgccctgatg acagaatgtg
     4321 tcccgagtgg atgctggggt ttgctgctag cccctggaga tacctgtagc ctgggggggt
     4381 ctatgggtgt ctgtaagcat atgtgtacac actcaagaag ggccccctga ctcttaggtg
     4441 actctccact cctgggaaga gcctccctcc ccaatatgtc tgttggtggt aaactggcct
     4501 caggccaggc caggaccagg cagtccaagg gcctgtatgc ccttgttggc taggtcctgc
     4561 catgtgttca aagggcactt ggccaggttt caggatggct ttaagcctgc aggtcccttt
     4621 tgggttcccc cacctttctt acctgggtct aggtttgctc agagcaaggt tggacctctg
     4681 ggctctaagc ccttatctca gagtccgtag ctatttcccc ttcactgcct ctgtggacgc
     4741 ccttccccac agggtcggtc tggattgttc tggcccaggt cctgcccagt agtaggggct
     4801 tccaggctgc ggctggctgc ctcagagatg ccctctgcag ggtagtgtgg gcagctctct
     4861 gttgcagggc agtgcctgcc ccacaccctg gtggctagag gagagtaggg ggtaccctac
     4921 agccactggg ggctcctgcc tgcaggcagg gctgggagaa aacagggctg gggtgggcag
     4981 tacagggaat atttttgtaa cttgctggag tgaatgaaaa tggggcgatt ctaagttatt
     5041 gttgccaaag acatgtaaag tatattgttg ctttgggggt gggggcaatg ttttctgttt
     5101 tgtttttgtt tctgttttta gtttgaggct taggatggac gctggtgcaa tgattttctt
     5161 gttccttgtt ttttaagaga aaccaagcta agaaaaaaa
//
