LOCUS       NM_019816               1844 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus apoptosis antagonizing transcription factor (Aatf),
            mRNA.
ACCESSION   NM_019816 XM_914034
VERSION     NM_019816.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Caforio,M., Tumino,N., Sorino,C., Manni,I., Di Giovenale,S.,
            Piaggio,G., Iezzi,S., Strimpakos,G., Mattei,E., Moretta,L.,
            Fanciulli,M., Vacca,P., Locatelli,F. and Folgiero,V.
  TITLE     AATF/Che-1 RNA polymerase II binding protein overexpression reduces
            the anti-tumor NK-cell cytotoxicity through activating receptors
            modulation
  JOURNAL   Front Immunol 14, 1191908 (2023)
   PUBMED   37435061
  REMARK    GeneRIF: AATF/Che-1 RNA polymerase II binding protein
            overexpression reduces the anti-tumor NK-cell cytotoxicity through
            activating receptors modulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Fratini,E., Cervelli,M., Mariottini,P., Kanamori,Y., Amendola,R.
            and Agostinelli,E.
  TITLE     Link between spermine oxidase and apoptosis antagonizing
            transcription factor: A new pathway in neuroblastoma
  JOURNAL   Int J Oncol 55 (5), 1149-1156 (2019)
   PUBMED   31545418
  REMARK    GeneRIF: High AATF expression is associated with neuroblastoma.
REFERENCE   5  (bases 1 to 1844)
  AUTHORS   Jain,M., Kaiser,R.W.J., Bohl,K., Hoehne,M., Gobel,H., Bartram,M.P.,
            Habbig,S., Muller,R.U., Fogo,A.B., Benzing,T., Schermer,B.,
            Hopker,K. and Slaats,G.G.
  TITLE     Inactivation of Apoptosis Antagonizing Transcription Factor in
            tubular epithelial cells induces accumulation of DNA damage and
            nephronophthisis
  JOURNAL   Kidney Int 95 (4), 846-858 (2019)
   PUBMED   30770218
  REMARK    GeneRIF: Study in Aatf conditional knockout mice found that Aatf
            suppressed RNA:DNA hybrid formation and enabled DNA double strand
            break repair in vitro. Results suggest that Aatf is a regulator of
            primary cilia and a modulator of the DNA damage response,
            connecting two pathogenetic mechanisms in nephronophthisis and
            related ciliopathies.
REFERENCE   6  (bases 1 to 1844)
  AUTHORS   Guo,Q. and Xie,J.
  TITLE     AATF inhibits aberrant production of amyloid beta peptide 1-42 by
            interacting directly with Par-4
  JOURNAL   J Biol Chem 279 (6), 4596-4603 (2004)
   PUBMED   14627703
  REMARK    GeneRIF: AATF is an endogenous antagonist of Par-4 activity and an
            effective inhibitor of aberrant amyloid beta 1-42 production and
            secretion under apoptotic conditions.
REFERENCE   7  (bases 1 to 1844)
  AUTHORS   Monaco,L., Passananti,C. and Fanciulli,M.
  TITLE     Genomic structure and transcriptional regulation of Che-1, a novel
            partner of Rb
  JOURNAL   Gene 321, 57-63 (2003)
   PUBMED   14636992
REFERENCE   8  (bases 1 to 1844)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1844)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 1844)
  AUTHORS   Thomas,T., Voss,A.K., Petrou,P. and Gruss,P.
  TITLE     The murine gene, Traube, is essential for the growth of
            preimplantation embryos
  JOURNAL   Dev Biol 227 (2), 324-342 (2000)
   PUBMED   11071758
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF222801.1.
            
            On Dec 7, 2005 this sequence version replaced XM_914034.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF222801.1, BC025080.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.3 cM"
     gene            1..1844
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /note="apoptosis antagonizing transcription factor"
                     /db_xref="GeneID:56321"
                     /db_xref="MGI:MGI:1929608"
     exon            1..210
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1700
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /note="traube protein; rb-binding protein Che-1"
                     /codon_start=1
                     /product="protein AATF"
                     /protein_id="NP_062790.1"
                     /db_xref="CCDS:CCDS25186.1"
                     /db_xref="GeneID:56321"
                     /db_xref="MGI:MGI:1929608"
                     /translation="MAAPQPLALQLEQLLNPRPREADPEADPEEATRARVIDRFDEGE
                     EEKDDLAVSSIRKLAPVSLLDTDKRYSGKTTSRKAWKEDHWEQALPSSSDNEASDEGG
                     SEDGDSEGLGLEEISEDVDEDLEDNKISDEGGSEDGDSEGLGLEEFSEDVEEDLEGED
                     EEDREEDRNSEDDGVVAAFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTT
                     NQLPQPDVFPVFKDKGGPEFASALKNSHKALKALLRSLVDLQEELLFQYPDTRHIVNG
                     AKPNTESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRFADFTIYRNHTLQ
                     KWHDKTKLASGKLGKGFGAFERSILTQIDHIMMDKERLLRRTQTKRSAYRVLGKPEPV
                     PEPVAETLPGEPETLPQGPANAHLRDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQ
                     VAMGRQWLAIQKLRSKIRKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMSDDARTE
                     LFRSLFGQLNPPDADRGK"
     exon            211..399
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            400..495
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            496..714
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            715..852
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            853..967
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1166
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1331
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1415
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1483
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1564
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1636
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1800
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /note="hexamer: AATAAA"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /note="hexamer: AATAAA"
     polyA_site      1791
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
     polyA_site      1794
                     /gene="Aatf"
                     /gene_synonym="4933415H02Rik; 5830465M17Rik; Che-1; Trb"
                     /note="major polyA site"
ORIGIN      
        1 tccgccttga gttgccaagt agagtctggg ccgtagcgcc actgctgcga gtgtcgggcc
       61 ggggggctcg ggctgcagtg caggttcacg agcgcagcgc cggcagtgac ctggtgacca
      121 tggcggcgcc gcagcccttg gctctgcagc tggaacagtt gctgaatccg agaccgcgtg
      181 aggcggatcc tgaggccgac ccggaggagg ccactagagc cagagtgatt gacaggtttg
      241 atgaagggga agaggagaaa gatgatctgg cagtgagtag cattagaaag ttggcaccag
      301 tctccctctt ggacaccgac aaaaggtatt ctggcaagac cacttctagg aaagcttgga
      361 aagaagacca ttgggagcag gctctgccaa gttcatctga taacgaagca tctgatgagg
      421 gaggatctga agatggggat tcagagggcc tgggcctgga ggagatctca gaagatgttg
      481 acgaagactt agaagacaac aaaatatctg atgagggagg atctgaagat ggggattcag
      541 agggcctggg cctggaagag ttctcagaag atgttgagga ggacttagaa ggtgaggatg
      601 aggaagacag agaagaagac aggaacagtg aagatgatgg tgtggtggca gccttctcca
      661 gtgtcaaagt ttctgaggaa gtggaaaaag gaagagctgt gaagaatcag atagcattgt
      721 gggaccagct cttggaagga aggatcaagc tacaaaaagc tctcttgact accaatcagt
      781 tgcctcaacc agatgttttc cctgtcttca aggacaaagg tggcccagaa tttgccagtg
      841 ctctgaaaaa tagtcacaaa gcacttaaag ccttgttaag gtcattggtg gatcttcagg
      901 aagagttgct tttccagtac ccagacacga gacatatagt aaatggggcg aaacccaata
      961 cagagagtga ggagatttcc agtgaagatg atgagctagt gggagagaag aagaaacaac
     1021 gaaaggcccc acccaagagg aagctagaga tggaggacta tcccagcttc atggcaaagc
     1081 gctttgctga cttcaccatc tataggaatc acacactaca gaaatggcat gataaaacca
     1141 agcttgcttc tggaaaactg ggcaagggtt ttggtgcctt cgaacgctcg atcttgactc
     1201 agatcgatca tatcatgatg gacaaagaaa gattgcttcg gaggacacag accaagcgct
     1261 ctgcctaccg agttcttggc aaaccggagc cagtccctga gcctgttgca gagaccttgc
     1321 caggagaacc agagacgctt cctcagggcc ctgccaatgc ccacctgagg gacttggatg
     1381 aggagatatt tgatgatgat gacttttacc accagctcct tcgagaactc atagagcgga
     1441 aaaccagctc tttggatcca aatgatcagg tggccatggg aaggcagtgg cttgcaatcc
     1501 agaaactacg aagcaaaatc cgcaagaagg tagatagaaa agccagcaaa ggaaggaaac
     1561 ttcggttcca tgtccttagc aagctcctga gtttcatggc acctattgac cacaccgcaa
     1621 tgagtgatga tgccaggacg gagttgtttc gatctctttt cggccagctc aaccctcctg
     1681 atgcagaccg tgggaagtga cagtagcatc ctctcaggcc cgacctcagc acaggaccca
     1741 cctgctgcct ccaataaaat gatcaaaaac tacaataaac cttttttttt ttaatctgtt
     1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
