LOCUS       NM_026276               2870 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aminoadipate-semialdehyde
            dehydrogenase-phosphopantetheinyl transferase (Aasdhppt),
            transcript variant 1, mRNA.
ACCESSION   NM_026276
VERSION     NM_026276.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115802.10.
            
            On Apr 25, 2009 this sequence version replaced NM_026276.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144671.1, BC038013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC115802.10        157727-157967       c
            242-467             AC115802.10        157167-157392       c
            468-589             AC115802.10        151567-151688       c
            590-751             AC115802.10        150943-151104       c
            752-823             AC115802.10        147771-147842       c
            824-2870            AC115802.10        143266-145312       c
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..2870
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="aminoadipate-semialdehyde
                     dehydrogenase-phosphopantetheinyl transferase"
                     /db_xref="GeneID:67618"
                     /db_xref="MGI:MGI:1914868"
     exon            1..241
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..988
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /EC_number="2.7.8.7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     L-aminoadipate-semialdehyde
                     dehydrogenase-phosphopantetheinyl transferase;
                     alpha-aminoadipic semialdehyde
                     dehydrogenase-phosphopantetheinyl transferase;
                     4'-phosphopantetheinyl transferase"
                     /codon_start=1
                     /product="L-aminoadipate-semialdehyde
                     dehydrogenase-phosphopantetheinyl transferase isoform 1"
                     /protein_id="NP_080552.3"
                     /db_xref="CCDS:CCDS22794.1"
                     /db_xref="GeneID:67618"
                     /db_xref="MGI:MGI:1914868"
                     /translation="MVFPAKRLCVVPSMEGVRWAFSCGTWLPSRAEWLLAMRSIQPEE
                     KERIGKFVFARDAKAALAGRLMIRKLVAEKLNIPWDHIRLQRTSKGKPVLAKDSLNPY
                     PNFNFNISHQGDYAVLAAEPEVQVGIDIMKTSFPGRGSIPEFFHIMKRKFTKKEWETI
                     RSFNDEWTQLDMFYRHWALKESFIKAIGVGLGFEMQRLEFDVSPLNMDIGQVYKETCL
                     ILDGEEEKEWAFEESKIDEHHFVAVAVRKPDGSRHQNVSYQDDSKLSQRKFTILNFND
                     LVASAIPMTPEDPSFWDCFCFTEEILIRNGTKS"
     exon            242..467
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /inference="alignment:Splign:2.1.0"
     exon            468..589
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /inference="alignment:Splign:2.1.0"
     exon            590..751
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /inference="alignment:Splign:2.1.0"
     exon            752..823
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /inference="alignment:Splign:2.1.0"
     exon            824..2870
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1045..1050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="hexamer: AATAAA"
     polyA_site      1068
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="major polyA site"
     regulatory      1608..1613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="hexamer: GATAAA"
     polyA_site      1628
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="hexamer: AGTAAA"
     polyA_site      1706
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="major polyA site"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="hexamer: ATTAAA"
     polyA_site      2705
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
     regulatory      2709..2714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="hexamer: AGTAAA"
     polyA_site      2733
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
     regulatory      2821..2826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
                     /note="hexamer: AATAAA"
     polyA_site      2850
                     /gene="Aasdhppt"
                     /gene_synonym="2010309J24Rik; 2810407B07Rik; AASD-PPT;
                     CGI-80; LYS2; LYS5"
ORIGIN      
        1 gtggctacgt cagcgtctgc tctacctggc ttgaggatca gcggaccgag ccggtcgtat
       61 ggtgttcccc gctaagaggc tgtgcgtggt gccatccatg gagggcgttc gttgggcatt
      121 ctcctgcggt acctggctgc caagtcgagc cgaatggctt ctggcgatgc ggtctatcca
      181 gccggaggag aaggagcgca tcggcaagtt cgtgtttgcc cgcgacgcca aggcagcctt
      241 ggctggtcgt ttgatgataa ggaaattagt tgcagagaaa ttgaatatcc cttgggatca
      301 tatccgtctg cagagaactt caaagggaaa gccggttctt gcgaaagact cgttgaatcc
      361 atatcccaat ttcaacttta acatctctca ccaaggggac tatgcagttc ttgctgcaga
      421 acctgaggta caggttggca ttgatatcat gaagactagt tttccaggtc gtggttcaat
      481 tccagaattc tttcatatca tgaaaagaaa gtttaccaaa aaggagtggg aaacaatcag
      541 aagttttaat gatgaatgga ctcagctgga tatgttttac cggcactggg cactgaaaga
      601 aagcttcata aaagccattg gagttggatt gggatttgaa atgcagcggc ttgaatttga
      661 tgtatctcca ttaaacatgg acattggtca ggtttataag gaaacctgtt tgattttgga
      721 tggggaagaa gaaaaagaat gggcctttga ggaaagcaaa atagatgaac accattttgt
      781 tgcagtggct gttaggaagc ctgatggatc tagacatcaa aatgtttcat atcaagatga
      841 ttctaagcta tcccagagga agtttaccat tcttaatttt aatgatttgg tagcatctgc
      901 tattcctatg acacctgagg atccttcatt ttgggactgt ttttgcttca cagaagaaat
      961 tctaatacga aatggtacca agtcatgata ggattctctt agtaaggaaa ataaatgaaa
     1021 agggtgatct tgtgtattta ctgaaataaa ttgcctgatg tgatcaaatt ttatttaaca
     1081 aaacattttt aaagacacaa attctttcta agagcagatt tccagttcag tggctccatt
     1141 ggctccattg agtatgctca cttcttcctt ccagaactgt aattattaga aacaatgaca
     1201 gaatcttcca aggataaatg tgcatcttag aaagaaaaat gtaaacatgc ttaaggcaag
     1261 catttcacct tgtttttcag agaactctaa actttctgtt atctttccag agactttttt
     1321 tgcagagaac tctaaaattt ctgttatctt tccagaaact tgttgcaaat taatcgatat
     1381 ttacttttct aaaagtgggg acatgtattt tgtagttata agaaaatgcc cctgcctttc
     1441 ataactattc tgctgcataa gttactgtgc taagttactg tcttgtatga catctgttta
     1501 aggtatcaac attgcaacac tcattttgcc ttgactgtag taacacaaac tgctgttgag
     1561 acttccaggt ttatatcttc ataaagttgt aacatttatt ttatcttgat aaattatccc
     1621 cccaaagatt ccatcgactc agatgattct gatttttttt ttttttaacc actgtcaaaa
     1681 gtaaactatt gtagagaaaa aactaagtct gtcgtcttag ggtttcatta ctgcgaagag
     1741 acaccacaac catggcagct cttataaagg acatttaatt ggggctggct tacaggttca
     1801 gaggttcagt ccattatcat tatgcctgga aacatggtag cgtctaggca gtcatggccc
     1861 agaaggagcg gagagttgta tctcttgttc caaaagaagg taggagaaga ctggctccca
     1921 agtggttagg aggagggtct caaagcccat ccccacaatg acatacttcc tccaacaaga
     1981 ccatacctac tctaacaaag ccacacctaa tagtgccatt tcctgggcca agcatattca
     2041 aaccagttat acctggtatg gtttgggaga gtttcattga catcacacta ctgtggttga
     2101 ggaaaatcta ccagagggta ctcatttcca tgttaggagc tttcattatc tttgtcatta
     2161 ctgtaagcag tactacagtg aaaatgtggc attttgagag tcattgttat gtcctgcaga
     2221 caggagtgat tggttcaaag ggtttaaaca aatagcttta ggtattacct tattgctctt
     2281 tttaggtatt accttattgc tcttgaaaaa cttcagttta tgcttcagct agttgtgttt
     2341 tacctttctt ttacctgaag attggtttgt tggtttttgt tgtttccttg tattggataa
     2401 ctgtataact gaaaagtgat ttaaatttac atccttttat tacaagtaag gttaatatgg
     2461 cattgttact ggtaatttgc attttctttt tatgaaccta ttgctaatcc ccatttgttt
     2521 ttatttacta aatagattta aagtgaatat aatatattaa gataccaaga ccatcatatt
     2581 gatgagagaa tctatttatg gttatagtgc atgtcttcag gagttagtcc tgttagtgtt
     2641 aaatagcaag aagtagaata atatcgtttt tattactaac attaaatgct gtaagtgctc
     2701 aaaaattcag taaaagtttt tttttaaatt gaacatgctt aattatagaa agcatagaaa
     2761 atcttgaagc atatctaata gatgaagtga ttttttttcc ctatatgagt ataatactga
     2821 aataaaaaat catttgtctt atcattataa taaaataata ataattatgg
//
