LOCUS       NM_144829               1346 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus alanyl-tRNA synthetase domain containing 1 (Aarsd1),
            mRNA.
ACCESSION   NM_144829
VERSION     NM_144829.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1346)
  AUTHORS   Echeverria,P.C., Briand,P.A. and Picard,D.
  TITLE     A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel
            Cochaperone Aarsd1 Is Required for Muscle Differentiation
  JOURNAL   Mol Cell Biol 36 (8), 1310-1321 (2016)
   PUBMED   26884463
  REMARK    GeneRIF: Artificially maintaining Hsp90alpha or knocking down
            Aarsd1L expression interferes with the differentiation of C2C12
            myotubes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1346)
  AUTHORS   Nawaz,M.H., Merriman,E., Yang,X.L. and Schimmel,P.
  TITLE     p23H implicated as cis/trans regulator of AlaXp-directed editing
            for mammalian cell homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 108 (7), 2723-2728 (2011)
   PUBMED   21285375
REFERENCE   3  (bases 1 to 1346)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   4  (bases 1 to 1346)
  AUTHORS   Beebe,K., Mock,M., Merriman,E. and Schimmel,P.
  TITLE     Distinct domains of tRNA synthetase recognize the same base pair
  JOURNAL   Nature 451 (7174), 90-93 (2008)
   PUBMED   18172502
  REMARK    GeneRIF: Deacylates mischarged tRNA(Ala) (AlaXp activity)
REFERENCE   5  (bases 1 to 1346)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC005711.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005711.1, AK136332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.95 cM"
     gene            1..1346
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /note="alanyl-tRNA synthetase domain containing 1"
                     /db_xref="GeneID:69684"
                     /db_xref="MGI:MGI:1916934"
     exon            1..84
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1284
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /note="alanyl-tRNA synthetase domain-containing protein 1;
                     alanyl-tRNA deacylase alaX"
                     /codon_start=1
                     /product="alanyl-tRNA editing protein Aarsd1"
                     /protein_id="NP_659078.1"
                     /db_xref="CCDS:CCDS25467.1"
                     /db_xref="GeneID:69684"
                     /db_xref="MGI:MGI:1916934"
                     /translation="MAFLCQRDSYAREFTTTVVSCSPAELQTDASGGKKEVLSGFHVV
                     LEDTLLFPEGGGQPDDRGTINDISVLRVTRRGAQADHFTESPLSPGSQVQVRVDWERR
                     FDHMQQHSGQHLITAVADLLFGLKTTSWELGRLRSVIELDSPSVTAEQVAAIEQSVNQ
                     KIRDRLPVSVRELSLDDPEVEQVRGRGLPDDHAGPIRVVTIEGVDSNMCCGTHVSNLS
                     DLQVIKILGTEKGKKNKSNLIFLAGNRVLKWMERSHGSEKALTSLLKCGVEDHVEAVK
                     KLQNATKLLQKNNLNLLRDLAVHTAHSLRSSPAWGGVVTLHRKEGDSEFMNIIANEIG
                     SEETLLFLTVGDEKGAGLFLLAGPAEAVETLGPRVAEVLEGKGAGKKGRFQGKATKMS
                     RRAEAQALLQDYVSTQSAEE"
     exon            85..216
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            217..376
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            377..434
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            435..591
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            592..708
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            709..839
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            840..906
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            907..998
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1053
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1148
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1334
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1314..1319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /note="hexamer: AGTAAA"
     polyA_site      1334
                     /gene="Aarsd1"
                     /gene_synonym="1110069E20Rik; 2310044P18Rik; AlaX;
                     AlaXp-II"
                     /note="major polyA site"
ORIGIN      
        1 ccggcttttc tgcgcgcgcg ggtctctccg gcctaggaga ccgcgatggc gttcctgtgt
       61 cagcgcgaca gctacgcacg ggagttcacc accaccgtgg tctcctgtag tcccgccgag
      121 ctgcagacgg acgcgagcgg cggcaagaaa gaagtgttga gcggattcca tgtggttctg
      181 gaagacacgc tgcttttccc cgagggcggg ggacagcctg atgaccgtgg taccatcaat
      241 gacatctctg tgctgagggt gacccgtcgt ggggcccagg ccgatcactt cacggagtca
      301 cctctgtccc ctgggagtca agtccaggtc cgggtggact gggagcggag gtttgaccac
      361 atgcagcagc attcagggca acatctcatc accgcggttg ctgaccttct cttcgggctg
      421 aagacaacgt catgggagtt agggagactc cggagtgtga ttgagttgga cagcccttct
      481 gtgactgctg agcaggtggc tgctatcgag cagagtgtca atcagaaaat cagagaccgg
      541 ctgcctgtga gtgttcgaga gctgagcctg gatgaccctg aggtggagca ggtgaggggt
      601 cggggtttgc ccgatgatca tgctgggccc attcgagttg ttaccatcga aggtgtagac
      661 tccaacatgt gctgtgggac gcacgtgagc aatctcagtg accttcaggt cattaagatt
      721 ctggggactg agaaagggaa aaagaacaaa agcaacctga tatttctggc tgggaatcgg
      781 gtactgaagt ggatggagcg aagtcatgga agtgaaaagg ccttgacctc actacttaag
      841 tgtggcgttg aggatcatgt ggaagcagta aaaaagctcc agaatgccac caagctcctg
      901 cagaagaaca acctgaacct ccttagagac ctggctgtgc acactgccca cagcctcagg
      961 agcagcccag cctggggtgg tgtggtcaca ctacacagga aagagggtga ttctgaattc
     1021 atgaatatca ttgctaatga gattggatcg gaggagaccc tcctgttctt aactgtgggg
     1081 gatgagaagg gtgctgggct cttcttactg gcaggcccgg cagaggctgt ggaaaccctg
     1141 gggcccaggg tggctgaagt cttggaaggc aaaggagcag ggaagaaggg ccgcttccag
     1201 ggcaaagcca ccaagatgag ccgccgggca gaggcgcagg cgcttctgca ggactatgtc
     1261 agcacacaga gtgctgagga gtgaggggcc aggacgtcgt ccctgtgacc aacagtaaaa
     1321 tattgtgact caaaaaaaaa aaaaaa
//
