LOCUS       NM_009591               1370 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus arylalkylamine N-acetyltransferase (Aanat), transcript
            variant 1, mRNA.
ACCESSION   NM_009591
VERSION     NM_009591.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1370)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 1370)
  AUTHORS   Callahan,J.W., Morales,J.C., Atherton,J.F., Wang,D., Kostic,S. and
            Bevan,M.D.
  TITLE     Movement-related increases in subthalamic activity optimize
            locomotion
  JOURNAL   Cell Rep 43 (8), 114495 (2024)
   PUBMED   39068661
REFERENCE   3  (bases 1 to 1370)
  AUTHORS   Sirbulescu,R.F., Nicholson,K., Kawai,K., Hilton,O.M., Sobell,D.,
            Jin,G., Verrill,D.E., Dwyer,L.J., Xiong,Y., Bachanova,P., Kim,S.E.,
            Gallup,S., Gelevski,D., Daley,H., Hernandez Rodriguez,D.E.,
            Negre,H., Sturtevant,O., Nikiforow,S., Ritz,J., Chen,Y.B.,
            Reeves,P.M., Sluder,A.E., Berry,J.D., Sadri-Vakili,G., Cudkowicz,M.
            and Poznansky,M.C.
  TITLE     Allogeneic B cell immunomodulatory therapy in amyotrophic lateral
            sclerosis
  JOURNAL   FASEB J 38 (13), e23796 (2024)
   PUBMED   38967302
REFERENCE   4  (bases 1 to 1370)
  AUTHORS   Dautan,D., Monai,A., Maltese,F., Chang,X., Molent,C., Mauro,D.,
            Galbusera,A., Vecchia,D., Antonelli,F., Benedetti,A., Drago,F.,
            Leggio,G.M., Pagani,M., Fellin,T., Gozzi,A., Schumann,G., Manago,F.
            and Papaleo,F.
  TITLE     Cortico-cortical transfer of socially derived information gates
            emotion recognition
  JOURNAL   Nat Neurosci 27 (7), 1318-1332 (2024)
   PUBMED   38769153
REFERENCE   5  (bases 1 to 1370)
  AUTHORS   Mao,R., Cavelli,M.L., Findlay,G., Driessen,K., Peterson,M.J.,
            Marshall,W., Tononi,G. and Cirelli,C.
  TITLE     Behavioral and cortical arousal from sleep, muscimol-induced coma,
            and anesthesia by direct optogenetic stimulation of cortical
            neurons
  JOURNAL   iScience 27 (6), 109919 (2024)
   PUBMED   38812551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1370)
  AUTHORS   Yoshimura,T., Nagabukuro,A., Matsuda,Y., Suzuki,T., Kuroiwa,A.,
            Iigo,M., Namikawa,T. and Ebihara,S.
  TITLE     Chromosomal mapping of the gene encoding serotonin
            N-acetyltransferase to rat chromosome 10q32.3 and mouse chromosome
            11E2
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 172-175 (1997)
   PUBMED   9605843
REFERENCE   7  (bases 1 to 1370)
  AUTHORS   Kelly,S.L. and Sim,E.
  TITLE     Arylamine N-acetyltransferase in Balb/c mice: identification of a
            novel mouse isoenzyme by cloning and expression in vitro
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 347-353 (1994)
   PUBMED   7545952
REFERENCE   8  (bases 1 to 1370)
  AUTHORS   Goto,M., Oshima,I., Hasegawa,M. and Ebihara,S.
  TITLE     The locus controlling pineal serotonin N-acetyltransferase activity
            (Nat-2) is located on mouse chromosome 11
  JOURNAL   Brain Res Mol Brain Res 21 (3-4), 349-354 (1994)
   PUBMED   8170356
REFERENCE   9  (bases 1 to 1370)
  AUTHORS   Ebihara,S., Hudson,D.J., Marks,T. and Menaker,M.
  TITLE     Pineal indole metabolism in the mouse
  JOURNAL   Brain Res 416 (1), 136-140 (1987)
   PUBMED   3620949
REFERENCE   10 (bases 1 to 1370)
  AUTHORS   Ebihara,S., Marks,T., Hudson,D.J. and Menaker,M.
  TITLE     Genetic control of melatonin synthesis in the pineal gland of the
            mouse
  JOURNAL   Science 231 (4737), 491-493 (1986)
   PUBMED   3941912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL607039.25 and CO040083.1.
            
            On Jan 13, 2010 this sequence version replaced NM_009591.2.
            
            Summary: The protein encoded by this gene belongs to the
            acetyltransferase superfamily. It is the penultimate enzyme in
            melatonin synthesis and controls the night/day rhythm in melatonin
            production in the vertebrate pineal gland. Melatonin is essential
            for the function of the circadian clock that influences activity
            and sleep. This enzyme is regulated by cAMP-dependent
            phosphorylation that promotes its interaction with 14-3-3 proteins
            and thus protects the enzyme against proteasomal degradation. This
            gene may contribute to numerous genetic diseases such as delayed
            sleep phase syndrome. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the shorter and
            protein-coding transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF004108.1, BC119139.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN01164131 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AL607039.25        21260-21347
            89-306              AL607039.25        23149-23366
            307-461             AL607039.25        23699-23853
            462-1217            AL607039.25        24362-25117
            1218-1370           CO040083.1         1-153               c
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.43 cM"
     gene            1..1370
                     /gene="Aanat"
                     /gene_synonym="AA-NAT; Nat-2; Nat4; Snat"
                     /note="arylalkylamine N-acetyltransferase"
                     /db_xref="GeneID:11298"
                     /db_xref="MGI:MGI:1328365"
     exon            1..88
                     /gene="Aanat"
                     /gene_synonym="AA-NAT; Nat-2; Nat4; Snat"
                     /inference="alignment:Splign:2.1.0"
     exon            89..306
                     /gene="Aanat"
                     /gene_synonym="AA-NAT; Nat-2; Nat4; Snat"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..767
                     /gene="Aanat"
                     /gene_synonym="AA-NAT; Nat-2; Nat4; Snat"
                     /EC_number="2.3.1.87"
                     /note="serotonin acetylase; aralkylamine
                     N-acetyltransferase"
                     /codon_start=1
                     /product="serotonin N-acetyltransferase"
                     /protein_id="NP_033721.1"
                     /db_xref="CCDS:CCDS25671.1"
                     /db_xref="GeneID:11298"
                     /db_xref="MGI:MGI:1328365"
                     /translation="MLNINSLKPEALHLPLGTSEFLGCQRRHTLPASEFRCLTPEDAT
                     SAFEIEREAFISVSGTCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERL
                     TQESLTLHRPGGRTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPAVRRAVLMCED
                     ALVPFYEKFGFQAVGPCAITVGSLTFTELQCSLRCHAFLRRNSGC"
     exon            307..461
                     /gene="Aanat"
                     /gene_synonym="AA-NAT; Nat-2; Nat4; Snat"
                     /inference="alignment:Splign:2.1.0"
     exon            462..1353
                     /gene="Aanat"
                     /gene_synonym="AA-NAT; Nat-2; Nat4; Snat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aanat"
                     /gene_synonym="AA-NAT; Nat-2; Nat4; Snat"
                     /note="hexamer: AATAAA"
     polyA_site      1353
                     /gene="Aanat"
                     /gene_synonym="AA-NAT; Nat-2; Nat4; Snat"
                     /note="major polyA site"
ORIGIN      
        1 ccttgcagtc aggagtctca gcttctccta gtcccagcac ccagtgacag cccccaggac
       61 aacacctgca ctccttctta aagttctgtt gctcagggag cacttctgaa gctggggaac
      121 ccctgggagg gttcagtggc cagacgccca tgttgaacat caactccctg aaacctgagg
      181 ccctgcacct gccacttggg acctcagagt tcctaggctg ccagcggcgc cacacactcc
      241 ctgccagtga gttccgctgc ctcacacctg aggatgccac cagtgcgttt gagattgagc
      301 gggaagcctt tatctctgtc tccggtacct gtcccctcta cttggatgag atccggcact
      361 tcctaaccct gtgtccagag ctgtcactgg gctggtttga ggaaggctgc cttgtggcct
      421 tcatcattgg ctcgctgtgg gacaaggaga gacttactca ggagtcgctg acactacaca
      481 ggcccggagg ccgcacagcc cacctgcacg tactggcggt gcacagaacc ttccggcagc
      541 agggcaaggg ctctgtcctc ctgtggagat accttcacca cctgggcagt cagccggccg
      601 tgcgccgggc tgtgctcatg tgtgaggatg ccctggtacc cttctatgag aaatttggct
      661 tccaggctgt gggcccatgt gccatcaccg tgggctctct caccttcacg gagctacagt
      721 gttccttacg atgccacgcc ttcctgcgca ggaacagcgg ctgctgaccc aagctgtgtg
      781 cttggccatg gcgagggtgg gagcagcagc tcggggcctc cggtccactt cccatgtcac
      841 agcctcctct gcctccagcc catccaacta gagctggcta gcatgaaggg agacagcggt
      901 tcccaactgg agtacagagg taagggccaa taaagaggac aggaggtggc ttcccttcag
      961 cagaggctgc tgtctgtccc cagaggacct cttgccttct gaactgtgca caaaggcaag
     1021 accaggatgg ggaagcagga acagaggggg tttgtctccg catttcctcc tctgcctgct
     1081 ctgtttactg tgctccagtg cagtgccctg gtccttggga gccctcactc ctggccaggc
     1141 tgacatccct tcctagctcc gaacgctggg gatgaggggc agccaggagc cgggacttgt
     1201 taatggtggc atccttgggg tagggacatg ctgcagagcc acaccaaact gcagtcagcc
     1261 accaatgtgc cggcccaccc ccctgcctcc ctggttcccc caccagccac aggactggca
     1321 cctctgccca cgaataaagt agctatgtcc ccaaaaaaaa aaaaaaaaaa
//
