LOCUS       NM_146110               1817 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus angio-associated migratory protein (Aamp), transcript
            variant 2, mRNA.
ACCESSION   NM_146110
VERSION     NM_146110.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Mugford,J.W., Yu,J., Kobayashi,A. and McMahon,A.P.
  TITLE     High-resolution gene expression analysis of the developing mouse
            kidney defines novel cellular compartments within the nephron
            progenitor population
  JOURNAL   Dev Biol 333 (2), 312-323 (2009)
   PUBMED   19591821
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Hayes,C., Rump,A., Cadman,M.R., Harrison,M., Evans,E.P., Lyon,M.F.,
            Morriss-Kay,G.M., Rosenthal,A. and Brown,S.D.
  TITLE     A high-resolution genetic, physical, and comparative gene map of
            the doublefoot (Dbf) region of mouse chromosome 1 and the region of
            conserved synteny on human chromosome 2q35
  JOURNAL   Genomics 78 (3), 197-205 (2001)
   PUBMED   11735226
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Ramamoorthy,S., Leibach,F.H., Mahesh,V.B., Han,H., Yang-Feng,T.,
            Blakely,R.D. and Ganapathy,V.
  TITLE     Functional characterization and chromosomal localization of a
            cloned taurine transporter from human placenta
  JOURNAL   Biochem J 300 (Pt 3) (Pt 3), 893-900 (1994)
   PUBMED   8010975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101182.1, AK162750.1 and AV170929.1.
            
            On Jun 24, 2010 this sequence version replaced NM_146110.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146470.1, AK162750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                BY101182.1         1-72
            73-1810             AK162750.1         1-1738
            1811-1817           AV170929.1         285-291
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.53 cM"
     gene            1..1817
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /note="angio-associated migratory protein"
                     /db_xref="GeneID:227290"
                     /db_xref="MGI:MGI:107809"
     exon            1..236
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1423
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="angio-associated migratory cell protein isoform
                     2"
                     /protein_id="NP_666222.2"
                     /db_xref="CCDS:CCDS15043.1"
                     /db_xref="GeneID:227290"
                     /db_xref="MGI:MGI:107809"
                     /translation="MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLA
                     QEMEDVDFEEEEEEEEGNDEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDP
                     KTNTLAVTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLK
                     VWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCP
                     ATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNPIHVLKGTEGHQGPLTCVATNQDGSLI
                     LTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAA
                     VGYLDGTLAIYDLSTQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGR
                     LLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR"
     exon            237..392
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            393..512
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            513..652
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            653..797
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            798..881
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            882..997
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1101
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1192
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1347
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1817
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1794..1799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /note="hexamer: AATAAA"
     polyA_site      1811
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /note="major polyA site"
ORIGIN      
        1 gagtcaccta cgcctacttc ctcccgggag gaggggctcg agttccgcgt cgtcgcgcag
       61 agctgactct gggaggcgtt tgggcccaga gaagtggatc ggtagctttc gccgcatgga
      121 gtccgaatcg gagagcggag cggccgctga caccccgcct ctggagactc tgagctttca
      181 cggagatgaa gagatcattg aggtggtaga gctggatcca ggcccgccgg acccggatga
      241 tctggcccag gagatggaag acgtggactt tgaggaagag gaagaagaag aagagggcaa
      301 tgacgagggc tgggtcttgg aaccccagga aggggtggtc ggtagcatgg agggcccgga
      361 tgatagtgag gtcacctttg cattgcactc agcgtctgtg ttctgtgtga gcctggaccc
      421 caaaaccaac accttggcag tgacaggggg cgaagacgac aaggccttcg tgtggaggct
      481 cggtgatgga gagctgctct ttgagtgtgc aggccacaaa gactctgtga catgcgctgg
      541 tttcagtcac gattccaccc tagtggccac aggggacatg agtggtcttt tgaaagtatg
      601 gcaggtagac accaaggaag aagtctggtc ctttgaagca ggagacctgg agtggatgga
      661 gtggcaccct cgggctcctg tcctgttggc gggcacagcc gatggcaaca cttggatgtg
      721 gaaggtcccg aatggtgact gtaagacctt tcagggcccc aactgccctg caacctgtgg
      781 ccgcgtcctc cctgatggga agagagctgt ggtagggtat gaagatggta ccatcaggat
      841 ctgggacctc aagcaaggaa accccatcca tgtactaaaa gggactgagg gtcatcaggg
      901 ccctctgacc tgtgtagcca ccaaccagga tggcagtctg atcctgactg gctctgtaga
      961 ctgccaggcc aagctggtca gtgccaccac tggcaaggtg gtgggtgtgt tcagacctga
     1021 gacagtcgcc tcccagccca gcctgggaga gggggaggag agtgagtcta actccgtgga
     1081 gtccttgggc ttctgcagtg tcatgcctct ggccgctgtt ggctatctgg acggaacctt
     1141 ggccatctat gacctgtcta cgcagacact ccggcaccaa tgtcagcacc agtcgggcat
     1201 tgttcagctg ctgtgggagg ctggcactgc tgtggtgtac acctgtagcc tggatggtgt
     1261 tgtacgtctc tgggatgccc ggactggccg cctgcttact gactaccggg gccacactgc
     1321 tgagatcctg gactttgccc tcagcaaaga tgcttccctg gtggtgacca catcaggaga
     1381 ccacaaagca aaagtatttt gtgtccagag acctgaccgt taacagctgt agcctctggc
     1441 atggtgtctg gtgttaaggg ggataaaggg acgcccctgc ccccagcaga gttgcggggt
     1501 gcagagggaa gaggagggga gaccactgga ctgctttctg accccttcag ctgacctgct
     1561 tactccttgt ccttttcctc cctggagacc cgccttgcca ggccctccct cccctgccca
     1621 gccctggggc cttgtaggag gccgtgtctc tttgactttg attcgctggt gtgagccatg
     1681 gggtgcgtct ttgtatgttg gggttaggtc tttgaggttc ccgttctttc ccttcccaac
     1741 tctctgggaa aggaaaggag gaagagagac tagttacaga ttttaaaaat gtaaataaaa
     1801 tatacttccc attggca
//
