LOCUS       NP_666222                435 aa            linear   ROD 30-APR-2024
DEFINITION  angio-associated migratory cell protein isoform 2 [Mus musculus].
ACCESSION   NP_666222
VERSION     NP_666222.2
DBSOURCE    REFSEQ: accession NM_146110.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 435)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 435)
  AUTHORS   Mugford,J.W., Yu,J., Kobayashi,A. and McMahon,A.P.
  TITLE     High-resolution gene expression analysis of the developing mouse
            kidney defines novel cellular compartments within the nephron
            progenitor population
  JOURNAL   Dev Biol 333 (2), 312-323 (2009)
   PUBMED   19591821
REFERENCE   3  (residues 1 to 435)
  AUTHORS   Hayes,C., Rump,A., Cadman,M.R., Harrison,M., Evans,E.P., Lyon,M.F.,
            Morriss-Kay,G.M., Rosenthal,A. and Brown,S.D.
  TITLE     A high-resolution genetic, physical, and comparative gene map of
            the doublefoot (Dbf) region of mouse chromosome 1 and the region of
            conserved synteny on human chromosome 2q35
  JOURNAL   Genomics 78 (3), 197-205 (2001)
   PUBMED   11735226
REFERENCE   4  (residues 1 to 435)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   5  (residues 1 to 435)
  AUTHORS   Ramamoorthy,S., Leibach,F.H., Mahesh,V.B., Han,H., Yang-Feng,T.,
            Blakely,R.D. and Ganapathy,V.
  TITLE     Functional characterization and chromosomal localization of a
            cloned taurine transporter from human placenta
  JOURNAL   Biochem J 300 (Pt 3) (Pt 3), 893-900 (1994)
   PUBMED   8010975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101182.1, AK162750.1 and AV170929.1.
            
            On Nov 18, 2005 this sequence version replaced NP_666222.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146470.1, AK162750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.53 cM"
     Protein         1..435
                     /product="angio-associated migratory cell protein isoform
                     2"
                     /calculated_mol_wt=46764
     Region          87..387
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(91,110,114,120..121,133..134,152,156,162..163,191,
                     196,202..203,215,232,237,243..244,259..260,278,282,
                     288..289,301..302,334,339,345..346,358,376,380,386..387)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          96..133
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          138..176
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          177..214
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          219..255
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          265..301
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          308..353
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          362..398
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          390..428
                     /region_name="WD40"
                     /note="WD40 repeats; smart00320"
                     /db_xref="CDD:197651"
     Region          404..428
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..435
                     /gene="Aamp"
                     /gene_synonym="Aamp-rs"
                     /coded_by="NM_146110.3:116..1423"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS15043.1"
                     /db_xref="GeneID:227290"
                     /db_xref="MGI:MGI:107809"
ORIGIN      
        1 mesesesgaa adtppletls fhgdeeiiev veldpgppdp ddlaqemedv dfeeeeeeee
       61 gndegwvlep qegvvgsmeg pddsevtfal hsasvfcvsl dpktntlavt ggeddkafvw
      121 rlgdgellfe caghkdsvtc agfshdstlv atgdmsgllk vwqvdtkeev wsfeagdlew
      181 mewhprapvl lagtadgntw mwkvpngdck tfqgpncpat cgrvlpdgkr avvgyedgti
      241 riwdlkqgnp ihvlkgtegh qgpltcvatn qdgsliltgs vdcqaklvsa ttgkvvgvfr
      301 petvasqpsl gegeesesns veslgfcsvm plaavgyldg tlaiydlstq tlrhqcqhqs
      361 givqllweag tavvytcsld gvvrlwdart grlltdyrgh taeildfals kdaslvvtts
      421 gdhkakvfcv qrpdr
//
