LOCUS       NM_011834               1780 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus aminoadipate aminotransferase (Aadat), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_011834
VERSION     NM_011834.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1780)
  AUTHORS   Balog,E., Jenei,G., Gellert,L., Ono,E., Vecsei,L., Toldi,J. and
            Kis,Z.
  TITLE     Species-specific neuronal localization of kynurenine
            aminotransferase-2 in the mouse cerebellum
  JOURNAL   Neurochem Int 142, 104920 (2021)
   PUBMED   33238153
  REMARK    GeneRIF: Species-specific neuronal localization of kynurenine
            aminotransferase-2 in the mouse cerebellum.
REFERENCE   2  (bases 1 to 1780)
  AUTHORS   Blanco-Ayala,T., Sathyasaikumar,K.V., Uys,J.D.,
            Perez-de-la-Cruz,V., Pidugu,L.S. and Schwarcz,R.
  TITLE     N-Acetylcysteine Inhibits Kynurenine Aminotransferase II
  JOURNAL   Neuroscience 444, 160-169 (2020)
   PUBMED   32768617
  REMARK    GeneRIF: N-Acetylcysteine Inhibits Kynurenine Aminotransferase II.
REFERENCE   3  (bases 1 to 1780)
  AUTHORS   Sathyasaikumar,K.V., Tararina,M., Wu,H.Q., Neale,S.A., Weisz,F.,
            Salt,T.E. and Schwarcz,R.
  TITLE     Xanthurenic Acid Formation from 3-Hydroxykynurenine in the
            Mammalian Brain: Neurochemical Characterization and Physiological
            Effects
  JOURNAL   Neuroscience 367, 85-97 (2017)
   PUBMED   29031603
REFERENCE   4  (bases 1 to 1780)
  AUTHORS   Heredi,J., Berko,A.M., Jankovics,F., Iwamori,T., Iwamori,N.,
            Ono,E., Horvath,S., Kis,Z., Toldi,J., Vecsei,L. and Gellert,L.
  TITLE     Astrocytic and neuronal localization of kynurenine
            aminotransferase-2 in the adult mouse brain
  JOURNAL   Brain Struct Funct 222 (4), 1663-1672 (2017)
   PUBMED   27568378
  REMARK    GeneRIF: This study demonstrates the presence of kynurenine
            aminotransferase-2 mRNA and protein throughout the adult C57Bl6
            mouse brain
REFERENCE   5  (bases 1 to 1780)
  AUTHORS   Pinto,J.T., Krasnikov,B.F., Alcutt,S., Jones,M.E., Dorai,T.,
            Villar,M.T., Artigues,A., Li,J. and Cooper,A.J.
  TITLE     Kynurenine aminotransferase III and glutamine transaminase L are
            identical enzymes that have cysteine S-conjugate beta-lyase
            activity and can transaminate L-selenomethionine
  JOURNAL   J Biol Chem 289 (45), 30950-30961 (2014)
   PUBMED   25231977
  REMARK    GeneRIF: human KAT III/CCBL2 possesses cysteine S-conjugate
            beta-lyase activity, as does mouse KAT II
REFERENCE   6  (bases 1 to 1780)
  AUTHORS   Sapko,M.T., Guidetti,P., Yu,P., Tagle,D.A., Pellicciari,R. and
            Schwarcz,R.
  TITLE     Endogenous kynurenate controls the vulnerability of striatal
            neurons to quinolinate: Implications for Huntington's disease
  JOURNAL   Exp Neurol 197 (1), 31-40 (2006)
   PUBMED   16099455
REFERENCE   7  (bases 1 to 1780)
  AUTHORS   Yu,P., Di Prospero,N.A., Sapko,M.T., Cai,T., Chen,A.,
            Melendez-Ferro,M., Du,F., Whetsell,W.O. Jr., Guidetti,P.,
            Schwarcz,R. and Tagle,D.A.
  TITLE     Biochemical and phenotypic abnormalities in kynurenine
            aminotransferase II-deficient mice
  JOURNAL   Mol Cell Biol 24 (16), 6919-6930 (2004)
   PUBMED   15282294
  REMARK    GeneRIF: Results show that gene targeting of kynurenine
            aminotransferase II (KAT) in mice leads to early and transitory
            decreases in brain KAT activity and kynurenic acid levels with
            commensurate behavioral and neuropathological changes.
REFERENCE   8  (bases 1 to 1780)
  AUTHORS   Alkondon,M., Pereira,E.F., Yu,P., Arruda,E.Z., Almeida,L.E.,
            Guidetti,P., Fawcett,W.P., Sapko,M.T., Randall,W.R., Schwarcz,R.,
            Tagle,D.A. and Albuquerque,E.X.
  TITLE     Targeted deletion of the kynurenine aminotransferase ii gene
            reveals a critical role of endogenous kynurenic acid in the
            regulation of synaptic transmission via alpha7 nicotinic receptors
            in the hippocampus
  JOURNAL   J Neurosci 24 (19), 4635-4648 (2004)
   PUBMED   15140935
  REMARK    GeneRIF: Alpha7* nAChR and NMDA receptor functions were studied in
            kynurenine aminotransferase II null mice(mKat-2-/- mice). At 21
            postnatal days, mKat-2-/- mice had lower hippocampal kynurenic acid
            levels and more spontaneous locomotor activity than control mice
REFERENCE   9  (bases 1 to 1780)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1780)
  AUTHORS   Yu,P., Mosbrook,D.M. and Tagle,D.A.
  TITLE     Genomic organization and expression analysis of mouse kynurenine
            aminotransferase II, a possible factor in the pathophysiology of
            Huntington's disease
  JOURNAL   Mamm Genome 10 (9), 845-852 (1999)
   PUBMED   10441733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137514.2.
            
            On Nov 17, 2006 this sequence version replaced NM_011834.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF072376.1, AK075578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC137514.2         82031-82186         c
            157-325             AC137514.2         81053-81221         c
            326-458             AC137514.2         72198-72330         c
            459-533             AC137514.2         69704-69778         c
            534-743             AC137514.2         61530-61739         c
            744-809             AC137514.2         58869-58934         c
            810-892             AC137514.2         56562-56644         c
            893-989             AC137514.2         56015-56111         c
            990-1051            AC137514.2         53675-53736         c
            1052-1116           AC137514.2         52519-52583         c
            1117-1223           AC137514.2         48149-48255         c
            1224-1325           AC137514.2         44687-44788         c
            1326-1780           AC137514.2         42633-43087         c
FEATURES             Location/Qualifiers
     source          1..1780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 30.85 cM"
     gene            1..1780
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /note="aminoadipate aminotransferase"
                     /db_xref="GeneID:23923"
                     /db_xref="MGI:MGI:1345167"
     exon            1..156
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1367
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /EC_number="2.6.1.7"
                     /EC_number="2.6.1.39"
                     /EC_number="2.6.1.63"
                     /EC_number="2.6.1.4"
                     /EC_number="2.6.1.73"
                     /note="kynurenine aminotransferase II; KAT/AadAT;
                     2-aminoadipate transaminase; 2-aminoadipate
                     aminotransferase; alpha-aminoadipate aminotransferase;
                     kynurenine--oxoglutarate transaminase II;
                     kynurenine--oxoglutarate aminotransferase II;
                     kynurenine--oxoglutarate transaminase 2; glycine
                     transaminase AADAT; kynurenine--glyoxylate transaminase
                     AADAT; methionine--glyoxylate transaminase AADAT"
                     /codon_start=1
                     /product="kynurenine/alpha-aminoadipate aminotransferase,
                     mitochondrial"
                     /protein_id="NP_035964.1"
                     /db_xref="CCDS:CCDS22320.1"
                     /db_xref="GeneID:23923"
                     /db_xref="MGI:MGI:1345167"
                     /translation="MNYSRFLTATSLARKPSPIRTTADILSKAPKTLISLAPGSPNPS
                     MFPFKSAAFTVENGSTIRFEDDLIKRALQYSPSYGIPELLSWLKQFQVKLHNPPTVNY
                     PPNQGQMDLCITSGCQDGLCKAFEMLINPGDTILVNEPLFPGTLYAMKPLGCNIINVP
                     SDEHGIIPEGLKKILSQWKPEDSKDPTKKTPKFLYTVPNGNNPTGNSLTGDRKKEIYE
                     LARKYDFLIIEDDPYYFLQFSKPWEPTFLSMDVDGRVIRADTFSKTVSSGLRVGFMTG
                     PKTLIQNIVLHTQVSSVHACTLSQLMILQLLHQWGEEGFLAHIDRTIDFYKNQRDSIL
                     AAADKWLRGLAEWHVPKAGMFLWIKVKGISDTKQLIEEKAIEREVLLVPGNGFFIDGS
                     APTSFFRASFSLATPAQMDTAFQRLAQLIKESL"
     exon            157..325
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..458
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..533
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..743
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..809
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..892
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..989
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1051
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1116
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1223
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1325
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1780
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /note="hexamer: AATAAA"
     polyA_site      1433
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /note="hexamer: AATAAA"
     polyA_site      1654
                     /gene="Aadat"
                     /gene_synonym="Aadt; Kat2; KATII; Kyat2; mKat-2"
                     /note="major polyA site"
ORIGIN      
        1 gcagattggg tggcactaca cagggacagc taacagtgca tcccgagtga ctggctttct
       61 gaatcctgct ccacgcgacc agcagagaca tgaattactc acggttcctc actgcaacga
      121 gcctggccag aaagccatct cccatcagaa ctacagcgga catactgagc aaagcaccaa
      181 aaaccctcat ctccctggct cctggatctc caaacccgag catgttcccc tttaagtcag
      241 ctgccttcac tgtggaaaac ggaagcacca tccggtttga agacgacttg atcaaaaggg
      301 ccctccaata ctctccaagc tatggaattc cagaacttct gtcctggcta aaacagtttc
      361 aagtaaaatt gcataatccc cccactgtca actacccacc caatcaagga cagatggatc
      421 tctgcatcac atctggctgc caagatggtc tctgtaaggc atttgaaatg ctcatcaatc
      481 ctggagacac tatcctggtc aatgaaccac tgtttccagg aaccctttat gctatgaaac
      541 cactaggctg caacattatt aatgtcccca gtgatgagca tgggattatt ccagagggtc
      601 tcaaaaaaat cctttcccag tggaaaccag aagattccaa ggatcccaca aaaaagactc
      661 caaaatttct gtatactgta ccaaatggca acaaccctac aggcaactcc ttgacaggtg
      721 accgcaagaa ggaaatctat gagcttgcaa gaaaatatga tttcctcata atagaagatg
      781 acccttacta ttttcttcag tttagcaagc cttgggagcc aacttttctc tccatggatg
      841 ttgatgggag agtcatcaga gctgacacct tttcaaaaac cgtctcctca gggttgagag
      901 tagggtttat gactggccct aagaccttga tacagaatat tgttctccac acacaagtct
      961 catcagtaca tgcctgtact ctctcacagc tcatgatact acagcttcta caccaatggg
     1021 gagaagaggg tttcctggct catattgaca gaactattga tttctacaag aaccagaggg
     1081 attccatatt ggcagctgca gacaagtggt tacgtggctt ggcagagtgg catgttccca
     1141 aagctggcat gtttctatgg attaaagtta agggaatctc cgatacaaaa caactgattg
     1201 aagaaaaggc tattgaaaga gaggtcttac ttgttcctgg aaatggtttc ttcattgatg
     1261 gttcagctcc tacctccttc ttcagagcat ccttctctct ggctactcca gcacagatgg
     1321 atacagcctt ccagagattg gcccaactga taaaagagtc tttatgaaga aatcaaactc
     1381 agcattggac tcataatttt taaataaatt acttctgtac tttgcagaag aaatggttgt
     1441 tgctgtttga ctgacaggat ggatccaggt tgtgaaacat ctgtagcaat ttccctgaac
     1501 cactttaaag tccccttaaa tccatcacat tgccaaatag ctttctgatc tacttttgcc
     1561 ctttgattaa tttgcaactg acaaagcatt aaattttatt gtaaagagct ctatagctgc
     1621 tttataatat ccaataaatt tttctcaaaa ctaacatatt atactgaatt atttacaaat
     1681 tgcaagaaaa ttagttaaaa tggcctataa tatgcagggt ttttctattt gaaggaaatt
     1741 tcatgaaccc tcagtgcaaa atttgctata acttgagagt
//
