LOCUS       NM_023383               1294 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus arylacetamide deacetylase (Aadac), mRNA.
ACCESSION   NM_023383
VERSION     NM_023383.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1294)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1294)
  AUTHORS   Huang,Z., Li,Y., Konishi,K., Sakai,Y., Tashiro,K., Fukami,T. and
            Borjigin,J.
  TITLE     In vitro deacetylation of N-acetylserotonin by arylacetamide
            deacetylase
  JOURNAL   J Pineal Res 75 (1), e12870 (2023)
   PUBMED   37002641
  REMARK    GeneRIF: In vitro deacetylation of N-acetylserotonin by
            arylacetamide deacetylase.
REFERENCE   3  (bases 1 to 1294)
  AUTHORS   Sun,R., Lin,Z., Wang,X., Liu,L., Huo,M., Zhang,R., Lin,J., Xiao,C.,
            Li,Y., Zhu,W., Lu,L., Zhang,J. and Chen,J.
  TITLE     AADAC protects colorectal cancer liver colonization from
            ferroptosis through SLC7A11-dependent inhibition of lipid
            peroxidation
  JOURNAL   J Exp Clin Cancer Res 41 (1), 284 (2022)
   PUBMED   36163032
  REMARK    GeneRIF: AADAC protects colorectal cancer liver colonization from
            ferroptosis through SLC7A11-dependent inhibition of lipid
            peroxidation.
            Erratum:[J Exp Clin Cancer Res. 2022 Oct 25;41(1):313. doi:
            10.1186/s13046-022-02508-w.. PMID: 36280883]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1294)
  AUTHORS   Nagaoka,M., Fukami,T., Kisui,F., Yamada,T., Sakai,Y., Tashiro,K.,
            Ogiso,T., Konishi,K., Honda,S., Hirosawa,K., Nakano,M. and
            Nakajima,M.
  TITLE     Arylacetamide deacetylase knockout mice are sensitive to
            ketoconazole-induced hepatotoxicity and adrenal insufficiency
  JOURNAL   Biochem Pharmacol 195, 114842 (2022)
   PUBMED   34798123
  REMARK    GeneRIF: Arylacetamide deacetylase knockout mice are sensitive to
            ketoconazole-induced hepatotoxicity and adrenal insufficiency.
REFERENCE   5  (bases 1 to 1294)
  AUTHORS   Sakai,Y., Fukami,T., Nagaoka,M., Hirosawa,K., Ichida,H., Sato,R.,
            Suzuki,K., Nakano,M. and Nakajima,M.
  TITLE     Arylacetamide deacetylase as a determinant of the hydrolysis and
            activation of abiraterone acetate in mice and humans
  JOURNAL   Life Sci 284, 119896 (2021)
   PUBMED   34450168
  REMARK    GeneRIF: Arylacetamide deacetylase as a determinant of the
            hydrolysis and activation of abiraterone acetate in mice and
            humans.
REFERENCE   6  (bases 1 to 1294)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   7  (bases 1 to 1294)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1294)
  AUTHORS   Lo,V., Erickson,B., Thomason-Hughes,M., Ko,K.W., Dolinsky,V.W.,
            Nelson,R. and Lehner,R.
  TITLE     Arylacetamide deacetylase attenuates fatty-acid-induced
            triacylglycerol accumulation in rat hepatoma cells
  JOURNAL   J Lipid Res 51 (2), 368-377 (2010)
   PUBMED   19654421
  REMARK    GeneRIF: Expression of AADA cDNA in McArdle-RH7777 cells
            significantly reduced intracellular triacylglycerol levels and
            apolipoprotein B secretion and increased fatty acid oxidation.
REFERENCE   9  (bases 1 to 1294)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   10 (bases 1 to 1294)
  AUTHORS   Trickett,J.I., Patel,D.D., Knight,B.L., Saggerson,E.D.,
            Gibbons,G.F. and Pease,R.J.
  TITLE     Characterization of the rodent genes for arylacetamide deacetylase,
            a putative microsomal lipase, and evidence for transcriptional
            regulation
  JOURNAL   J Biol Chem 276 (43), 39522-39532 (2001)
   PUBMED   11481320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF306788.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008244.1, BC054823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/SvEvTacfBr"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.17 cM"
     gene            1..1294
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /note="arylacetamide deacetylase"
                     /db_xref="GeneID:67758"
                     /db_xref="MGI:MGI:1915008"
     exon            1..154
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1216
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /EC_number="3.1.1.3"
                     /note="arylacetamide deacetylase (esterase)"
                     /codon_start=1
                     /product="arylacetamide deacetylase"
                     /protein_id="NP_075872.1"
                     /db_xref="CCDS:CCDS17375.1"
                     /db_xref="GeneID:67758"
                     /db_xref="MGI:MGI:1915008"
                     /translation="MGKTISLLISVVLVAYYLYIPLPDAIEEPWKVVWETAFVKIGTD
                     LASFGELLGISHFMETIQLLMSFQEVPPTSDEHVTVMETAFDSVPVRIYIPKRKSMAL
                     RRGLFYIHGGGWCLGSAAHFSYDTLSRWTAHKLDAVVVSTDYGLAPKHHFPRQFEDVY
                     RSLRWFLQEDVLEKYGVDPRRVGVSGDSAGGNLAAAVTQQLIQDPDVKIKLKVQALIY
                     PALQALDTNVPSQQEGSHFPVLTRSLMVRFWSEYFTTDRGLEKAMLLNQHVPMESSHL
                     LQFVNWSSLLPERYKKSPVYKNPTPGSSELAQKYPGFIDVKACPLLANDNILHHLPKT
                     YIITCQYDVLRDDGLMYVKRLQNVGVHVTHHHVEDGFHGTFSFPGLKLSERMKNQYLS
                     WLIKNL"
     exon            155..377
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /inference="alignment:Splign:2.1.0"
     exon            378..447
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /inference="alignment:Splign:2.1.0"
     exon            448..619
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /inference="alignment:Splign:2.1.0"
     exon            620..1294
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /note="hexamer: AATAAA"
     polyA_site      1282
                     /gene="Aadac"
                     /gene_synonym="5033417E09Rik; Aada"
                     /note="major polyA site"
ORIGIN      
        1 agaaagagca gaaggaaaca tggggaaaac catttctctt ctcatctctg tggtgcttgt
       61 agcttattat ctttatatac cgcttccaga tgctattgaa gagccttgga aggtagtatg
      121 ggaaactgcc tttgtaaaga taggaacaga tttggcttca tttggtgaac ttttgggaat
      181 cagtcatttc atggaaacga tacagttact tatgagtttt caagaagtcc cacccacgtc
      241 tgatgagcat gtcactgtga tggagacagc tttcgacagt gttcccgtcc gcatatacat
      301 acccaaaaga aagtcaatgg ctctcaggcg gggcttgttt tatattcatg gtggtggctg
      361 gtgtttgggg agtgctgctc acttctccta tgacactcta tcgagatgga cagcccataa
      421 acttgatgct gttgttgtgt caactgacta tggcttagcc ccaaaacacc attttccaag
      481 acagtttgaa gatgtgtatc gtagtttacg atggttctta caagaggacg tccttgaaaa
      541 atatggtgta gatcctagga gagtcggtgt gtctggagac agtgctggtg gaaacttagc
      601 cgcagctgtg acccaacagc ttatacaaga tccagatgtc aagatcaaac tcaaggtcca
      661 agccttaata tatcctgccc ttcaggctct tgatacgaat gtaccatcac aacaagaagg
      721 ttcccatttt ccagttttaa ccaggtcatt aatggtcagg ttctggagtg aatactttac
      781 tacagaccga ggcctggaaa aagccatgct tctcaaccaa catgtaccca tggaatctag
      841 ccacttgtta cagtttgtga attggagttc cttgctccct gagagataca agaaaagtcc
      901 cgtttacaaa aatcccactc ctggtagttc tgagctggct caaaagtatc cagggttcat
      961 agatgtgaag gcatgccctc tgttggccaa tgacaatata ttgcatcatt tacctaagac
     1021 ctatatcatc acttgccagt atgatgtcct aagagatgat ggactcatgt atgtcaagcg
     1081 gcttcagaat gttggagttc atgtgactca tcaccatgtg gaagatggat tccatggaac
     1141 gttttccttt cctggtttaa aactttcaga gaggatgaaa aatcagtact tgagttggct
     1201 tatcaaaaat ctgtaacaaa acctgcaaaa tgatttattg aagatataag caacaaaata
     1261 agaaataaac tattaaacat ggctttgagg tttc
//
