LOCUS       NP_084486                672 aa            linear   ROD 02-MAY-2024
DEFINITION  acetoacetyl-CoA synthetase [Mus musculus].
ACCESSION   NP_084486
VERSION     NP_084486.1
DBSOURCE    REFSEQ: accession NM_030210.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 672)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 672)
  AUTHORS   Hasegawa,S., Imai,M., Yamasaki,M., Takahashi,N. and Fukui,T.
  TITLE     Transcriptional regulation of acetoacetyl-CoA synthetase by Sp1 in
            neuroblastoma cells
  JOURNAL   Biochem Biophys Res Commun 495 (1), 652-658 (2018)
   PUBMED   29137983
  REMARK    GeneRIF: These results suggest that Sp1 regulates gene expression
            of AACS in Neuro-2a cells and ketone body utilization affects the
            balance of histone acetylation.
REFERENCE   3  (residues 1 to 672)
  AUTHORS   Hasegawa,S., Inoue,D., Yamasaki,M., Li,C., Imai,M., Takahashi,N.
            and Fukui,T.
  TITLE     Site-specific cleavage of acetoacetyl-CoA synthetase by legumain
  JOURNAL   FEBS Lett 590 (11), 1592-1601 (2016)
   PUBMED   27129883
  REMARK    GeneRIF: Cleavage of AACS by legumain is critical for the
            regulation of enzymatic activity and results in gain-of-function
            changes.
REFERENCE   4  (residues 1 to 672)
  AUTHORS   Hasegawa,S., Noda,K., Maeda,A., Matsuoka,M., Yamasaki,M. and
            Fukui,T.
  TITLE     Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is
            controlled by SREBP-2 and affects serum cholesterol levels
  JOURNAL   Mol Genet Metab 107 (3), 553-560 (2012)
   PUBMED   22985732
  REMARK    GeneRIF: Acetoacetyl-CoA synthetase, a ketone body-utilizing
            enzyme, is controlled by SREBP-2 and affects serum cholesterol
            levels.
REFERENCE   5  (residues 1 to 672)
  AUTHORS   Hasegawa,S., Kume,H., Iinuma,S., Yamasaki,M., Takahashi,N. and
            Fukui,T.
  TITLE     Acetoacetyl-CoA synthetase is essential for normal neuronal
            development
  JOURNAL   Biochem Biophys Res Commun 427 (2), 398-403 (2012)
   PUBMED   23000407
  REMARK    GeneRIF: These results suggest that AACS is regulated by SREBP-2
            and involves in the normal development of neurons.
REFERENCE   6  (residues 1 to 672)
  AUTHORS   Hasegawa,S., Ikeda,Y., Yamasaki,M. and Fukui,T.
  TITLE     The role of acetoacetyl-CoA synthetase, a ketone body-utilizing
            enzyme, in 3T3-L1 adipocyte differentiation
  JOURNAL   Biol Pharm Bull 35 (11), 1980-1985 (2012)
   PUBMED   23123469
  REMARK    GeneRIF: Knockdown of AACS inhibits differentiation of 3T3-L1
            adipocytes and suppresses expression of the adipocyte markers,
            peroxisome proliferator-activated receptor gama and CCAAT/enhancer
            binding protein alpha.
REFERENCE   7  (residues 1 to 672)
  AUTHORS   Hasegawa,S., Yamasaki,M., Inage,T., Takahashi,N. and Fukui,T.
  TITLE     Transcriptional regulation of ketone body-utilizing enzyme,
            acetoacetyl-CoA synthetase, by C/EBPalpha during adipocyte
            differentiation
  JOURNAL   Biochim Biophys Acta 1779 (6-7), 414-419 (2008)
   PUBMED   18514076
  REMARK    GeneRIF: AACS promoter activity was controlled mainly by C/EBPalpha
            during adipogenesis.
REFERENCE   8  (residues 1 to 672)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (residues 1 to 672)
  AUTHORS   Ohgami,M., Takahashi,N., Yamasaki,M. and Fukui,T.
  TITLE     Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone
            body-utilizing enzyme, in human brain
  JOURNAL   Biochem Pharmacol 65 (6), 989-994 (2003)
   PUBMED   12623130
REFERENCE   10 (residues 1 to 672)
  AUTHORS   Gu,T., Orita,S. and Han,M.
  TITLE     Caenorhabditis elegans SUR-5, a novel but conserved protein,
            negatively regulates LET-60 Ras activity during vulval induction
  JOURNAL   Mol Cell Biol 18 (8), 4556-4564 (1998)
   PUBMED   9671465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119268.12.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044017.1, AK165418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 64.24 cM"
     Protein         1..672
                     /product="acetoacetyl-CoA synthetase"
                     /EC_number="6.2.1.16"
                     /calculated_mol_wt=75069
     Region          16..671
                     /region_name="ac_ac_CoA_syn"
                     /note="acetoacetyl-CoA synthase; TIGR01217"
                     /db_xref="CDD:273507"
     CDS             1..672
                     /gene="Aacs"
                     /gene_synonym="2210408B16Rik; SUR5"
                     /coded_by="NM_030210.2:105..2123"
                     /db_xref="CCDS:CCDS19687.1"
                     /db_xref="GeneID:78894"
                     /db_xref="MGI:MGI:1926144"
ORIGIN      
        1 msklarlere eimecqvmwe pdskkdtqmd rfraavgtac glalgnyndl yhwsvrsymd
       61 fwaefwkfsg ivysrmydev vdtskgiadv pewfrgsrln yaenllrhke ndrvalyvar
      121 egreeivkvt feelrqqval faaamrkmgv kkgdrvvgyl pnsahaveam laaasigaiw
      181 sstspdfgvn gvldrfsqiq pklifsveav vyngkehghl eklqrvvkgl pdlqrvvlip
      241 yvlprekidi skipnsvfld dflasgtgaq apqlefeqlp fshplfimfs sgttgapkcm
      301 vhsaggtliq hlkehmlhgn mtssdillyy ttvgwmmwnw mvsalatgas lvlydgsplv
      361 ptpnvlwdlv drigitilgt gakwlsvlee kdmkpvethn lhtlhtilst gsplkaqsye
      421 yvyrcikssv llgsisggtd iiscfmgqns sipvykgeiq arnlgmavea wdeegkavwg
      481 asgelvctkp ipcqpthfwn dengskyrka yfskfpgvwa hgdycrinpk tggiimlgrs
      541 dgtlnpngvr fgsseiyniv eafdevedsl cvpqynrdge ervvlflkma sghtfqpdlv
      601 krirdairlg lsarhvpsli letrgipytl ngkkvevavk qvmagrtveh rgafsnpetl
      661 dlyrdipelq df
//
