LOCUS       NM_153416               1816 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus achalasia, adrenocortical insufficiency, alacrimia
            (Aaas), mRNA.
ACCESSION   NM_153416
VERSION     NM_153416.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1816)
  AUTHORS   Zhou,J., Wang,X., Wang,M., Chang,Y., Zhang,F., Ban,Z., Tang,R.,
            Gan,Q., Wu,S., Guo,Y., Zhang,Q., Wang,F., Zhao,L., Jing,Y.,
            Qian,W., Wang,G., Guo,W. and Yang,C.
  TITLE     The lysine catabolite saccharopine impairs development by
            disrupting mitochondrial homeostasis
  JOURNAL   J Cell Biol 218 (2), 580-597 (2019)
   PUBMED   30573525
REFERENCE   2  (bases 1 to 1816)
  AUTHORS   Juhlen,R., Peitzsch,M., Gartner,S., Landgraf,D., Eisenhofer,G.,
            Huebner,A. and Koehler,K.
  TITLE     Compensation for chronic oxidative stress in ALADIN null mice
  JOURNAL   Biol Open 7 (1) (2018)
   PUBMED   29362278
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1816)
  AUTHORS   Juhlen,R., Landgraf,D., Huebner,A. and Koehler,K.
  TITLE     Identification of a novel putative interaction partner of the
            nucleoporin ALADIN
  JOURNAL   Biol Open 5 (11), 1697-1705 (2016)
   PUBMED   27754849
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1816)
  AUTHORS   Carvalhal,S., Ribeiro,S.A., Arocena,M., Kasciukovic,T., Temme,A.,
            Koehler,K., Huebner,A. and Griffis,E.R.
  TITLE     The nucleoporin ALADIN regulates Aurora A localization to ensure
            robust mitotic spindle formation
  JOURNAL   Mol Biol Cell 26 (19), 3424-3438 (2015)
   PUBMED   26246606
REFERENCE   5  (bases 1 to 1816)
  AUTHORS   Huebner,A., Mann,P., Rohde,E., Kaindl,A.M., Witt,M., Verkade,P.,
            Jakubiczka,S., Menschikowski,M., Stoltenburg-Didinger,G. and
            Koehler,K.
  TITLE     Mice lacking the nuclear pore complex protein ALADIN show female
            infertility but fail to develop a phenotype resembling human triple
            A syndrome
  JOURNAL   Mol Cell Biol 26 (5), 1879-1887 (2006)
   PUBMED   16479006
REFERENCE   6  (bases 1 to 1816)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163291.3, AK087134.1, AK034591.1 and BB397636.1.
            
            On Jun 25, 2009 this sequence version replaced NM_153416.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018191.1, AK034591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC163291.3         184033-184058       c
            27-488              AK087134.1         2-463
            489-1806            AK034591.1         384-1701
            1807-1816           BB397636.1         282-291
FEATURES             Location/Qualifiers
     source          1..1816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.49 cM"
     gene            1..1816
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /note="achalasia, adrenocortical insufficiency, alacrimia"
                     /db_xref="GeneID:223921"
                     /db_xref="MGI:MGI:2443767"
     exon            1..264
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            265..392
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            393..448
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            449..540
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            541..587
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            588..686
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            687..830
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            831..951
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1076
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1137
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1228
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1322
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1390
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1472
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1557
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1816
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /note="hexamer: AATAAA"
     polyA_site      1807
                     /gene="Aaas"
                     /gene_synonym="AAA; ADRACALA; D030041N15Rik; GL003"
                     /note="major polyA site"
ORIGIN      
        1 ttccgttcag cttcgcgcag tcgtttgtcc tgtacggcta cccgtcctca cacgaatcta
       61 gcccgggaac taagattccg gggagcgcag tcgtcaccag ccgggagcct gtcgattcca
      121 gacgctctcc ggactggcaa gatgtgctcc ctggggttgt tccccccgcc gccgcctaga
      181 ggtcaagtca ccctgtatga gcacaataac gagctggtga ccggcaacag ctatgagagc
      241 ccgcctcccg actttcgggg ccagtggatc aatcttcctg tcctacacct gaccaaggat
      301 cccctaaaag ccccagggag gctggaccat ggtacaagaa ctgccttcat ccatcaccgt
      361 gagcaagtgt ggaagagatg catcaatgtt tggcatgatg tgggcctttt tggcgtcctg
      421 aatgaaattg cgaattcaga ggaagaagtg tttgagtggg taaagacagc ctgcagctgg
      481 gccctggctc tctgtggccg cgcctcctca ctccatggct ccctgtttcc acacctctct
      541 ctcaggagtg aagatctgat tgctgaattt gcccaagtaa ctaactggtc cagctgctgc
      601 ttacgggtct ttgcctggca tcctcacacc aacaagtttg cagtggccct gctggacgac
      661 tccatccgtg tttataatgc caacagcact atagttccct ccctgaagca ccgtctgcag
      721 cgaaatgtag cagccttggc ctggaagccc ctcagtgcct ctgtcttggc tgtggcctgc
      781 cagagctgta ttctcatctg gaccctagac cccacttcct tatctacgag accctcctct
      841 ggctgcgccc aggtgttgtc tcaccctggg cacacaccag tcactagctt ggcttgggcc
      901 cccaatgggg ggtggctgct ctcagcctca cctgtagatg ctgttattct ggtatgggac
      961 gtttcaacag agacttgtgt cccccttcct tggttccgag gaggaggggt taccaatctg
     1021 ctgtggtccc cagatggcag caaagtcctg gctactactc cttctgccgt ctttagagtc
     1081 tgggaggccc agatgtggac ttgtgaggcg tggccaactc tttcagggcg ctgccagact
     1141 ggctgctgga gtccagatgg aaaccgactg ctgttcactg tattggggga agcattaatt
     1201 tattccttgt cattcccaga acgatgtgga acagggaaag gacatgttgg aggtgcaaag
     1261 tcagcaacca tcgtagcaga tctttctgag acaacaattc agaccccaga tggagaggag
     1321 agactcgggg gagaggccca ctccatggtg tgggacccaa gtggtgaacg tctggctgtg
     1381 ctcatgaaag gaaacccaca ggttcaggac gggaatcctg tcatcctcct ttttcgaact
     1441 cgaaacagcc ccgtgtttga actgcttccc tgtggtatta ttcaggggga accaggagcc
     1501 caagctcagc tcatcacttt ccatccttcc ttcaacaaag gggccttgct tagtgtgtgc
     1561 tggtccacag gccgaatcac ccacatacct ctgtactttg tcaatgctca gtttccacgc
     1621 tttagcccag tacttggtcg agcccaggag cctccagctg gagggggagg ctctattcat
     1681 gaagtgccac tatttactga gacatcacca acctctgctc cttgggaccc tcttccagga
     1741 caatcatctg ctcaacccca ctcccctcat tcccacttgt aaataaagtt tttcttgttt
     1801 ccactcattt accagg
//
