LOCUS       NM_001009819            3390 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus alpha 1,3-galactosyltransferase 2 (A3galt2), mRNA.
ACCESSION   NM_001009819 XM_144044
VERSION     NM_001009819.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Porubsky,S., Speak,A.O., Salio,M., Jennemann,R., Bonrouhi,M.,
            Zafarulla,R., Singh,Y., Dyson,J., Luckow,B., Lehuen,A., Malle,E.,
            Muthing,J., Platt,F.M., Cerundolo,V. and Grone,H.J.
  TITLE     Globosides but not isoglobosides can impact the development of
            invariant NKT cells and their interaction with dendritic cells
  JOURNAL   J Immunol 189 (6), 3007-3017 (2012)
   PUBMED   22875802
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   De Santo,C., Salio,M., Masri,S.H., Lee,L.Y., Dong,T., Speak,A.O.,
            Porubsky,S., Booth,S., Veerapen,N., Besra,G.S., Grone,H.J.,
            Platt,F.M., Zambon,M. and Cerundolo,V.
  TITLE     Invariant NKT cells reduce the immunosuppressive activity of
            influenza A virus-induced myeloid-derived suppressor cells in mice
            and humans
  JOURNAL   J Clin Invest 118 (12), 4036-4048 (2008)
   PUBMED   19033672
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Sorensen,D.B., Dahl,K., Ersboll,A.K., Kirkeby,S., d'Apice,A.J. and
            Hansen,A.K.
  TITLE     Aggression in cataract-bearing alpha-1,3-galactosyltransferase
            knockout mice
  JOURNAL   Lab Anim 42 (1), 34-44 (2008)
   PUBMED   18348765
  REMARK    GeneRIF: A study evaluating aggressive behavior associated with
            cataract formation in mice with a knockout at this enzyme site is
            reported.
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Porubsky,S., Speak,A.O., Luckow,B., Cerundolo,V., Platt,F.M. and
            Grone,H.J.
  TITLE     Normal development and function of invariant natural killer T cells
            in mice with isoglobotrihexosylceramide (iGb3) deficiency
  JOURNAL   Proc Natl Acad Sci U S A 104 (14), 5977-5982 (2007)
   PUBMED   17372206
  REMARK    GeneRIF: Invariant natural killer T cells with A3galt2 deficiency
            had normal development and function.
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   Okuda,T., Tokuda,N., Numata,S., Ito,M., Ohta,M., Kawamura,K.,
            Wiels,J., Urano,T., Tajima,O., Furukawa,K. and Furukawa,K.
  TITLE     Targeted disruption of Gb3/CD77 synthase gene resulted in the
            complete deletion of globo-series glycosphingolipids and loss of
            sensitivity to verotoxins
  JOURNAL   J Biol Chem 281 (15), 10230-10235 (2006)
   PUBMED   16476743
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   Milland,J., Christiansen,D., Lazarus,B.D., Taylor,S.G., Xing,P.X.
            and Sandrin,M.S.
  TITLE     The molecular basis for galalpha(1,3)gal expression in animals with
            a deletion of the alpha1,3galactosyltransferase gene
  JOURNAL   J Immunol 176 (4), 2448-2454 (2006)
   PUBMED   16456004
REFERENCE   7  (bases 1 to 3390)
  AUTHORS   Zhou,D., Mattner,J., Cantu,C. 3rd, Schrantz,N., Yin,N., Gao,Y.,
            Sagiv,Y., Hudspeth,K., Wu,Y.P., Yamashita,T., Teneberg,S., Wang,D.,
            Proia,R.L., Levery,S.B., Savage,P.B., Teyton,L. and Bendelac,A.
  TITLE     Lysosomal glycosphingolipid recognition by NKT cells
  JOURNAL   Science 306 (5702), 1786-1789 (2004)
   PUBMED   15539565
  REMARK    GeneRIF: Molecular cloning and functional analysis of mouse iGb3
            synthase in mouse thymus, with its enzyme-synthesized product
            verified by NMR spectrum.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132334.1.
            
            On Nov 1, 2005 this sequence version replaced NM_001009819.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132334.1, AY491982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3390              AK132334.1         2-3391
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.23 cM"
     gene            1..3390
                     /gene="A3galt2"
                     /gene_synonym="Gm433; iGb3; iGb3S"
                     /note="alpha 1,3-galactosyltransferase 2"
                     /db_xref="GeneID:215493"
                     /db_xref="MGI:MGI:2685279"
     exon            1..764
                     /gene="A3galt2"
                     /gene_synonym="Gm433; iGb3; iGb3S"
                     /inference="alignment:Splign:2.1.0"
     CDS             652..1764
                     /gene="A3galt2"
                     /gene_synonym="Gm433; iGb3; iGb3S"
                     /EC_number="2.4.1.87"
                     /note="iGb3 synthase; alpha 1,3-galactosyltransferase 2
                     (isoglobotriaosylceramide synthase)"
                     /codon_start=1
                     /product="alpha-1,3-galactosyltransferase 2"
                     /protein_id="NP_001009819.1"
                     /db_xref="CCDS:CCDS18675.1"
                     /db_xref="GeneID:215493"
                     /db_xref="MGI:MGI:2685279"
                     /translation="MALGTELGVSWPGSHGSCREQEGQRQRGPGKPTWGLSRAKKRLL
                     WRFFLSAFGFLGLYHYRFIIIRLIEGSIPMGTCPTAIMPLPRDNFTGVLHHWARPEVL
                     TCTSWGAPIIWDGTFDPHVAQQEARRRNLTIGLTVFAVGRYLEKYLEHFLVSAEQHFM
                     VGQNVVYYVFTDRPEAVPYVALGQGRLLRAKPVQRERRWQDVSMARMPTLHEALGGQL
                     GQEADFVFCLDVDQYFTGNFGPEVLADLVAQLHAWHYRWPRWLLPYERDKRSAAALSL
                     SEGDFYYHAAVFGGSVAALLKLTAHCATGQQLDHKRGIEALWHDESHLNKFFWLNKPT
                     KLLSPEFCWAEEIIWRREIHHPRLLWAPKEYTLVRN"
     exon            765..848
                     /gene="A3galt2"
                     /gene_synonym="Gm433; iGb3; iGb3S"
                     /inference="alignment:Splign:2.1.0"
     exon            849..938
                     /gene="A3galt2"
                     /gene_synonym="Gm433; iGb3; iGb3S"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1076
                     /gene="A3galt2"
                     /gene_synonym="Gm433; iGb3; iGb3S"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..3390
                     /gene="A3galt2"
                     /gene_synonym="Gm433; iGb3; iGb3S"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctggctt acaggtcagc aactccagga agtctctgaa agcctcctgc ccactcccat
       61 tccctcccag gctcattaac catattcctt gtgtgtcgcc tcctcttctg ggttcactgt
      121 gcagagccct gctcttactc cacctgcctc aatcttcact ccgcatcctg aagacaggtt
      181 ttgtctttcc atctcactta ccttgatgtc ttggacccag cacaaggctt ggtgccacaa
      241 tgtgaccaag agcagggccg aacagacctt ggcaagcatc ttgatgtatg gccatcttct
      301 atacaaaaag gcatcttctt ccaacggatg gacagaggct ggggctgttg gacatcagag
      361 gacaagtacc gaaagctaag cagctcccta aaaggccaag atagttccca ggagacggct
      421 tctcacactg tatgctggca acctgtctat ttttgccata gctctttttt ttttttaagg
      481 cgatcttttt ataaacaaaa cctgccggtg ggttctaatt tgtatgtctt tgcctactag
      541 tgaggtgaac atttttccat ttatttgcct actaaataca tccccccctc ttctagaatt
      601 aagcttctgg tttgccatag gcactgttaa aggaggttgg tctcttagga gatggctctg
      661 gggacagagt tgggagtgag ctggccaggg tcacatggaa gttgccgaga acaagaagga
      721 cagagacaaa gaggcccagg gaagccaacc tggggacttt cacgggccaa gaagagactc
      781 ctgtggcggt tcttcctgtc tgcatttggt ttcttaggcc tgtaccatta caggttcatt
      841 attatcaggc tcatagaagg ctccatcccc atgggcacct gccctacagc cataatgcct
      901 ctgccgaggg acaatttcac aggagtactg caccactggg cccggcctga agtcctgacc
      961 tgtacctctt ggggagcacc aattatttgg gatggcactt tcgaccctca tgtagcccag
     1021 caagaggcga gacggcggaa cctcaccatc gggctgactg tgtttgctgt aggcaggtac
     1081 ctggagaagt acctggaaca cttcctggta tcggcagagc agcacttcat ggtcggccag
     1141 aacgtggtgt actatgtgtt tacggatcgc ccggaagcag tgccctatgt ggctctaggc
     1201 cagggtcgcc tgctgcgggc aaaacccgtg cagcgagaga ggcgctggca ggacgtgtcc
     1261 atggcacgca tgcccacgct acacgaggct ctgggagggc agctgggcca agaagctgac
     1321 tttgtgttct gcctggacgt ggaccagtac ttcaccggta acttcgggcc tgaggtgctg
     1381 gcagatttgg tggcacagct gcacgcctgg cactaccgct ggccgcggtg gctgctgccc
     1441 tacgagaggg acaagcgatc ggctgctgcg ctgtcgttaa gcgaaggcga tttctactac
     1501 cacgctgcgg tgtttggcgg cagtgtggct gcactgctca agctgacggc ccactgtgcg
     1561 actggccaac agctggacca taagcgcggc attgaggcac tctggcacga cgaaagccac
     1621 cttaacaagt tcttctggct gaacaagccc accaagctgc tgtcgcctga gttctgctgg
     1681 gcagaggaaa ttatctggag gagagagatc catcacccac gcctgctctg ggcacccaag
     1741 gaatatacgc tggtgcgaaa ctagcagccc ttccctggcc aagcaggcgc caacatcttt
     1801 ggcactacct taagtcagag ccacttatag cgcctctggg aagggggact ttggaactca
     1861 gagatattga aaagagatcc tgtacctggg gcctgtagac cctttgtcag ctgacaggag
     1921 agcctttttg ctccaaccag aagcaaatta tggaaaggca agaattctgg cagcttttgt
     1981 atcccaggtg cttgtcagca ggggggcgtg cagcaagtac cacctaccag gattaaagct
     2041 tttgcagagg ccttggggac aaggccttcc ttagcccttg gcagtggcta gtgtctcagc
     2101 ttctgagtgg acctaggtat tggggttccc acaccttgac aatgaccagt gttgctccta
     2161 ttggagcctt tagtatctga ggcttgacaa ctgtctgaag ccattcctgt gaccaggatc
     2221 tgcagtttct catctcttgg tcctcaccga cttcagcctc agctctccgt cctgtctgcc
     2281 tctgctggcc ctcttgttcg tatgcaggtc cctgcctgcg tttatttgtt tgactgcctc
     2341 ttcttccacc gtcaagcagg cttctcctgt ctggagcatg gctggctccc tgccccatgg
     2401 gcacttcccc ttcaattccc ttgccgttgt tgtgtggccg gcaggtcacg cggttgtcat
     2461 tgcctctgcc accaccactg ctatgctggc tcttccttca tgttaccgga cagccctcac
     2521 tgttggccat tcaagggaag cctctcatgg gacctaacag cgcggtgtca ggagagcagc
     2581 aggagagtgt cagcccttct cccctccgaa acccctgcat gctggctcat aagggcagct
     2641 gagcatccag tgtagtagcc ataagtgaga tgtttgaacc gaccgagcct catctctctg
     2701 ggatgctccc aggtagccct tctgctagac ctcttctctg tatggtgatg ggtatggagt
     2761 cttctggagt tctcaaaggc tttggcagca gaaggtctgt ttcaaataac catggtttta
     2821 tggctgtgcc ttaaggagct ctgattgttg tgtgggactc tcaaggtgtc catgggctgt
     2881 gcaagacaag gggtgccagc atgggggtag tccaacacct gctggcatgg gagtcaagtt
     2941 gacagtgctt acttccagga cagtgcgctc cagggggaat gttaacagta gggggttgaa
     3001 ggacttattg ttaacacgtg ttctaattgt gagagatttt caacactgct taacaccacc
     3061 cagggcccca ggaagggatg agacccttcc cctagcccct ttcacctctg accttactga
     3121 gtgcttcttt tgacgtgata tttttaacat gaggagactg gggcacaaag agcgaccaaa
     3181 ctgcccagac acaggaccat ttcgagccct tgtgatcatc agcagcggaa gaatgagagt
     3241 tagatcttcc ttccagccca actcccttta ggagggagcc actgagaaag gcaagcagac
     3301 gttccagtca tatattatct ctgctctatt atctcccgtg gccgcagcag cttgtgcata
     3361 tttgaggaat gctataacaa gcaagtaatt
//
