LOCUS       NM_001001179            4698 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus alpha-2-macroglobulin like 1 (A2ml1), mRNA.
ACCESSION   NM_001001179 XM_132895
VERSION     NM_001001179.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4698)
  AUTHORS   Elling,C.L., Gomez,H.Z., Lee,N.K., Hirsch,S.D. and
            Santos-Cortez,R.L.P.
  TITLE     The A2ml1-Knockout mouse as an animal model for non-syndromic
            otitis media
  JOURNAL   Int J Pediatr Otorhinolaryngol 181, 111980 (2024)
   PUBMED   38759260
  REMARK    GeneRIF: The A2ml1-Knockout mouse as an animal model for
            non-syndromic otitis media.
REFERENCE   2  (bases 1 to 4698)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4698)
  AUTHORS   Huang,H.L., Li,S.C. and Wu,J.F.
  TITLE     A complex of novel protease inhibitor, ovostatin homolog, with its
            cognate proteases in immature mice uterine luminal fluid
  JOURNAL   Sci Rep 9 (1), 4973 (2019)
   PUBMED   30899053
  REMARK    GeneRIF: A complex of novel protease inhibitor, ovostatin homolog,
            with its cognate proteases in immature mice uterine luminal fluid.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4698)
  AUTHORS   Santos-Cortez,R.L., Chiong,C.M., Reyes-Quintos,M.R., Tantoco,M.L.,
            Wang,X., Acharya,A., Abbe,I., Giese,A.P., Smith,J.D., Allen,E.K.,
            Li,B., Cutiongco-de la Paz,E.M., Garcia,M.C., Llanes,E.G.,
            Labra,P.J., Gloria-Cruz,T.L., Chan,A.L., Wang,G.T., Daly,K.A.,
            Shendure,J., Bamshad,M.J., Nickerson,D.A., Patel,J.A.,
            Riazuddin,S., Sale,M.M., Chonmaitree,T., Ahmed,Z.M., Abes,G.T. and
            Leal,S.M.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Rare A2ML1 variants confer susceptibility to otitis media
  JOURNAL   Nat Genet 47 (8), 917-920 (2015)
   PUBMED   26121085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138836.1, AK161068.1 and AU044180.1.
            
            On Nov 28, 2009 this sequence version replaced NM_001001179.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161184.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3473              AK138836.1         2-3474
            3474-4691           AK161068.1         1824-3041
            4692-4698           AU044180.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..4698
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.05 cM"
     gene            1..4698
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /note="alpha-2-macroglobulin like 1"
                     /db_xref="GeneID:232400"
                     /db_xref="MGI:MGI:3039594"
     exon            1..159
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..4465
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /note="ovostatin homolog; alpha-2-macroglobulin-like
                     protein 1"
                     /codon_start=1
                     /product="alpha-2-macroglobulin-like protein 1 precursor"
                     /protein_id="NP_001001179.2"
                     /db_xref="CCDS:CCDS39651.1"
                     /db_xref="GeneID:232400"
                     /db_xref="MGI:MGI:3039594"
                     /translation="MVPTILLSALLLHFTDVVAAEPRYILWVSSVVQRFSSEKACLHL
                     LNLNESVSLSVTLEYDGSSTTIFDQPVDEGNFYACADFKVSQMSSEQLAFVALLVQGN
                     TLKISERRSVAIAAEENATFVQTDTPVHKPGDTVHFRVVTLNIWLKPVDDLYPLITVQ
                     DPQSNVIFQWINVTTFRNITQLSFQLTPEPILGDYTIVIKTQSGTTVMDHFTVNRDVL
                     PKFEVELTAPETITIADSQFQMVTCAKYTYGQPVQGKAQIKVCRELFSPAHCESNENE
                     ICEQFTVQLKDGCASHIINTKVFQLDRSGLFMTLNVNEVVTESGTGVQMSKTHSVFIT
                     SVLGTVSFENMDPFYRRGITYFGTLKFSGPNNTPLVDKLLQLELDGKPVGNYTTDENG
                     EARFSINTSEIFGAQISLKAVYVRPRSCHRSSWLSPEYLDAYFSASRFYSQTSSFTKI
                     ILEPKQLPCDQEKMFSVLYSLNPEAYKEASDVTFFYLVMVRGGISRSGQKQVRVQAWN
                     GNFSFPISINADLAPSADLFVYTLHPSGEIVADNVRLQIEKCFKNKVSINFSRDKDLP
                     GSNTSVHLQAAPDSFCALRAVDKSALLLNHGQEMTPESVYFTLPYIHQYGYFYNGLNL
                     DDQQAEPCIPQKDLFYNGLYYTPTGNIWDGDLSNLLSNMGLKIFTNLHYRKPEVCSSQ
                     ENQPLLRTFDHPNERIMMYGGGAPPSSAFHDSVDSISHAKVAIKETVRTNFPRTWIWN
                     LVSVDSSGTANVSFLVPDTITQWEASAFCVNGNAGFGISPKVSLQISQPFFVEVTSPF
                     SVVRSEQSDMVVTVFNYLTTCVEISVQLEASENYEASINTQRNTDSEVLQAGEQKTYV
                     WTIIPKTLGKVNVTVVATSKQSRACPNDASKEQDVHWKDTVVKTMLVEAEGIEKEATQ
                     SFLICPKGTKASKQTLLELPSNVVEGSVRSFVTIVGDILGVAMQNLESLLQMPYGCGE
                     QNIAQLASDVYILDYLKATDQLTEELKSKAQRLLSNGYQNHLSFKNYDGSYDVFCQSN
                     QEGSTWLSALSFKTVEKMKEYIFIEETVPKQTLIWLVKKQKSNGCFRRDEKHVDTAQE
                     GREGDQEDIALTAYVVGVFLEVGLNASFPALRNGLYCLEEAFSNGVTNGYTQAILAYV
                     FALAGKEQQAKSLLSILDKSATKTNNMIYWERDEKPETDNSPSFIPSALSGETEKTCY
                     VLLAVLSQDTQDLDYASKIVQWLAQRMNSHGGFSAMQDTTVCLLALTQYMKLTGSNPQ
                     NTITLSSEESEEVFYVNRNKRLLVQHSKVSKGHQQYTVDVEGDGCSFIQATLRYNVPL
                     PKEASGFSLSVKTGKSNSSDEFQTKFELTVTLTYTGARESSVTVLVDVKMLSGFTPVV
                     SSTEELKFNSQVTKTDIKNGHVLFYLENVPKEATSLTFSIEQTNHVANIQPAPVTVYS
                     YEKGEYAFDSYNINSISDSQ"
     exon            160..343
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..500
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            501..553
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..574
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..743
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..828
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..946
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1058
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1168
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1327
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1555
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1610
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1756
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1906
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2077
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2225
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2328
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2557
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2687
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2806
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2858
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2942
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3119
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3201
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3358
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3439
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3605
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3817
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..4027
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..4152
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4243
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4312
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            4313..4412
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4500
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4698
                     /gene="A2ml1"
                     /gene_synonym="Ovos; Ovos2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggaaag aaagtgggat gcctaagaaa ctggccagta agaggaggga aaagacaact
       61 tcttctaaag tcaccctcca ggtgctggga caacatggtg cctaccatct tgctcagtgc
      121 cctcctgctt catttcactg atgttgtggc tgcagaaccg cgatacatcc tgtgggtttc
      181 ttccgtggta cagcgatttt cctcagaaaa agcctgtctt catcttttaa acctcaacga
      241 atctgtgtcc ttgagcgtca ccctagaata tgatggatcc agtactacta tttttgacca
      301 gcccgtggac gaggggaact tctacgcttg tgcagatttc aaagtgtctc agatgtcctc
      361 agagcagttg gcctttgtgg cattacttgt tcagggaaac actcttaaaa tctctgagag
      421 aagatctgtg gccatcgctg ctgaggagaa cgccactttt gtgcagacag acacaccggt
      481 ccataaacct ggagacacag ttcactttcg cgttgtgaca ctgaacatct ggctgaagcc
      541 tgttgatgac ttgtatccct tgatcaccgt tcaggatccc caaagcaatg tgatttttca
      601 gtggatcaat gtgaccactt tcagaaacat tacccagctc tccttccaac tgacgccgga
      661 accaatattg ggggattaca caatcgtcat aaaaacacaa tcgggaacga cagtgatgga
      721 tcatttcact gttaaccgag acgttttgcc caaatttgaa gtcgagctca ctgcaccaga
      781 gacaataacc attgcggaca gtcaatttca aatggttaca tgtgcaaagt acacctatgg
      841 ccagcctgtg cagggaaaag cccagataaa agtgtgcaga gagctcttct ccccggcaca
      901 ttgtgagagc aatgagaatg aaatctgtga gcagttcact gtgcagctga aagatggctg
      961 tgcttctcac attatcaaca caaaagtctt ccagttggac cgctctggat tgttcatgac
     1021 cttgaatgtt aacgaagtgg ttacagaatc tggaacaggt gtgcagatga gtaaaacaca
     1081 ctcggttttt atcacttccg tgcttggcac tgtcagcttc gagaacatgg accctttcta
     1141 caggagaggg atcacttatt ttggaactct taaattttct ggtcccaata acacaccact
     1201 ggtggacaaa cttttgcaac tggaactcga cggcaaacct gtaggaaatt acaccacaga
     1261 tgagaacggg gaagctcgat tttccattaa cacttcagag atattcggtg cacagattag
     1321 cttgaaggcc gtctacgtcc gacctagaag ctgccatcgt tccagctggc tgtcccctga
     1381 gtatttggac gcttacttct cggcctcgcg cttttactcc cagaccagca gcttcacgaa
     1441 gatcattctc gagcccaagc agcttccgtg cgatcaagag aagatgttct cagtacttta
     1501 ctccctaaac cccgaggcct acaaggaggc ctcagatgtg accttcttct atttggtgat
     1561 ggtgagagga ggtatctccc gcagcggaca gaagcaagtc agagttcaag cctggaatgg
     1621 gaacttctct ttcccaatca gcatcaatgc tgatctggcg ccatcggctg acctgttcgt
     1681 ctacaccctc caccctagcg gggaaatcgt tgcggataat gtcaggctcc agatcgagaa
     1741 gtgctttaaa aacaaggtta gcataaactt ctcacgggat aaggatctac cgggctctaa
     1801 caccagtgtt catcttcaag cggcccctga ctccttctgt gccctgcgag cagtggacaa
     1861 aagtgccctt ctactgaacc acggacaaga aatgacacct gagagcgtgt acttcacact
     1921 cccgtatatc catcaatatg gctatttcta caatggcctc aacttggatg atcagcaagc
     1981 agaaccatgc attcctcaga aggacttatt ctacaatgga ctgtattata cacctacagg
     2041 caatatttgg gatggagacc tctctaatct tctcagtaac atgggtctga aaatctttac
     2101 aaatctccat taccggaaac cggaagtgtg ttcatcccag gaaaaccagc ccttgctgag
     2161 gacgttcgat cacccaaatg aacggataat gatgtacggt ggtggcgccc caccttcttc
     2221 tgcctttcat gactctgtgg acagcatcag ccatgcaaaa gtggccatca aagagacagt
     2281 gaggacaaac ttccccagga catggatatg gaaccttgtc agtgtagatt cctcaggcac
     2341 agcaaatgtc tcgttcctgg tccctgatac catcacccag tgggaggcca gcgccttctg
     2401 tgtcaatggc aatgctgggt ttggcatttc acccaaagtg tccctacaga tctcccagcc
     2461 cttcttcgtg gaagttacct cacccttttc cgttgttcga agtgaacaga gtgacatggt
     2521 tgtcactgtc ttcaactacc tgactacatg tgtagagatt tctgttcagt tagaagcatc
     2581 tgagaattat gaagcaagca tcaacaccca gcgtaacacc gacagtgaag tcctccaggc
     2641 tggagaacag aaaacatatg tctggaccat tattcctaag acactgggta aagtaaatgt
     2701 cactgtagtg gctacatcca aacagagcag ggcttgccca aatgacgcca gtaaggagca
     2761 agatgtccac tggaaagaca ctgtcgtcaa aaccatgctg gtagaggctg aaggtattga
     2821 aaaagaagca actcaaagtt tcctcatctg tccaaaaggt accaaagcct caaaacaaac
     2881 acttctggaa ttgccaagca atgtagtaga aggttcagtc agatcttttg tcaccattgt
     2941 gggggacatt ctgggagtcg caatgcagaa tctggagagc cttctccaaa tgccctatgg
     3001 gtgtggtgaa cagaacattg cccagctagc atctgacgtt tacatactgg actacctgaa
     3061 agctaccgac cagctgacag aagaactcaa atctaaggct cagcgtctct tatccaatgg
     3121 ttaccaaaat cacttgtctt tcaaaaacta tgatgggtcc tacgatgtgt tctgccagag
     3181 caaccaggaa gggagcacat ggctcagtgc cctttctttc aagacagttg agaaaatgaa
     3241 ggaatatatt ttcatcgaag agacagtccc caaacagacg ttaatctggc ttgtaaagaa
     3301 acagaaatca aatggatgct ttagaaggga cgagaagcat gtcgacacgg ctcaggaggg
     3361 ccgtgagggt gaccaggaag atattgcgct cactgcgtac gtcgtcgggg tgttccttga
     3421 agttggactc aatgccagct ttcctgccct ccgcaatggt ctctattgcc tggaagaggc
     3481 attttcgaat ggtgtcacca atggctacac gcaagctatt ctggcttatg tatttgcatt
     3541 agctgggaaa gaacagcaag cgaaatcctt actctcaatc ctggacaaat ctgctacaaa
     3601 aacaaataat atgatatact gggagagaga tgagaaaccc gagacagaca actctccatc
     3661 attcattcct tcggcacttt ctggtgagac agagaagacg tgctatgtgc tgctggctgt
     3721 cctttcccag gacactcagg accttgatta tgccagcaag attgtgcagt ggcttgccca
     3781 gcggatgaac tcccatggag gcttctctgc catgcaggac accacagtgt gccttctcgc
     3841 tctaacccaa tacatgaagt taaccggctc taaccctcaa aacaccatca cgctgagctc
     3901 agaggagtct gaggaggttt tctatgttaa cagaaataaa cgccttctgg tccagcactc
     3961 aaaagtatcc aaaggccacc aacaatacac agtggatgta gaaggagatg gatgctcatt
     4021 tatccaggcc accctcaggt acaacgtgcc acttcctaag gaggcctcag gattttccct
     4081 ttccgtgaaa actggaaaaa gcaactcttc agatgaattc cagaccaagt ttgaactcac
     4141 ggtgaccctc acctacactg gagctcgtga aagctcagtt acagtccttg tggatgtgaa
     4201 gatgctctct ggctttactc ctgtcgtctc atccaccgag gagcttaaat tcaatagtca
     4261 agtaacgaag acggacataa agaatggcca cgttctgttc tacttggaaa atgttcccaa
     4321 ggaagcaacc agcctcacct tctccattga acaaactaac catgtggcca atatccagcc
     4381 agccccagtc acggtctaca gctatgaaaa aggtgaatat gcttttgatt cttacaacat
     4441 caatagcatt tcggattccc aataaaacaa agaagcgcac agaaaaaaag aaaaaaaaaa
     4501 gtatgagact atttctttga ataaactgtt ctcctggtca ccatcctacc aagagcctga
     4561 tcaagcacct cccatcctga agactctccc atcacaatga cttcttgtca gcttcacttc
     4621 cttccttcct tctttccttc cttccttcct tccttccttc cttccttcct tccattaaat
     4681 ggcatcattt taagtctg
//
