LOCUS       NM_175628               4687 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus alpha-2-macroglobulin (A2m), mRNA.
ACCESSION   NM_175628 XM_001005276
VERSION     NM_175628.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4687)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4687)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4687)
  AUTHORS   Koo,H.Y., Kim,M.A., Min,H., Hwang,J.Y., Prajapati-DiNubila,M.,
            Kim,K.S., Matzuk,M.M., Park,J.W., Doetzlhofer,A., Kim,U.K. and
            Bok,J.
  TITLE     Follistatin regulates the specification of the apical cochlea
            responsible for low-frequency hearing in mammals
  JOURNAL   Proc Natl Acad Sci U S A 120 (1), e2213099120 (2023)
   PUBMED   36577057
REFERENCE   4  (bases 1 to 4687)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4687)
  AUTHORS   Moon,K.H., Ma,J.H., Min,H., Koo,H., Kim,H., Ko,H.W. and Bok,J.
  TITLE     Dysregulation of sonic hedgehog signaling causes hearing loss in
            ciliopathy mouse models
  JOURNAL   Elife 9, e56551 (2020)
   PUBMED   33382037
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4687)
  AUTHORS   Umans,L., Serneels,L., Hilliker,C., Stas,L., Overbergh,L., De
            Strooper,B., Van Leuven,F. and Van den Berghe,H.
  TITLE     Molecular cloning of the mouse gene coding for alpha
            2-macroglobulin and targeting of the gene in embryonic stem cells
  JOURNAL   Genomics 22 (3), 519-529 (1994)
   PUBMED   7528166
REFERENCE   7  (bases 1 to 4687)
  AUTHORS   Lorent,K., Overbergh,L., Delabie,J., Van Leuven,F. and Van den
            Berghe,H.
  TITLE     Distribution of mRNA coding for alpha-2-macroglobulin, the
            murinoglobulins, the alpha-2-macroglobulin receptor and the
            alpha-2-macroglobulin receptor associated protein during mouse
            embryogenesis and in adult tissues
  JOURNAL   Differentiation 55 (3), 213-223 (1994)
   PUBMED   7514554
REFERENCE   8  (bases 1 to 4687)
  AUTHORS   van Leuven,F., Torrekens,S., Overbergh,L., Lorent,K., de
            Strooper,B. and van den Berghe,H.
  TITLE     The primary sequence and the subunit structure of mouse
            alpha-2-macroglobulin, deduced from protein sequencing of the
            isolated subunits and from molecular cloning of the cDNA
  JOURNAL   Eur J Biochem 210 (1), 319-327 (1992)
   PUBMED   1280217
REFERENCE   9  (bases 1 to 4687)
  AUTHORS   Hilliker,C., Overbergh,L., Petit,P., Van Leuven,F. and Van den
            Berghe,H.
  TITLE     Assignment of mouse alpha-2-macroglobulin gene to chromosome 6 band
            F1-G3
  JOURNAL   Mamm Genome 3 (8), 469-471 (1992)
   PUBMED   1379499
REFERENCE   10 (bases 1 to 4687)
  AUTHORS   Hudson,N.W. and Koo,P.H.
  TITLE     Subunit and primary structure of a mouse alpha-macroglobulin, a
            human alpha 2-macroglobulin homologue
  JOURNAL   Biochim Biophys Acta 704 (2), 290-303 (1982)
   PUBMED   6179545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY785372.1, BC072642.1, CN701262.1 and AI850558.1.
            
            On May 23, 2007 this sequence version replaced NM_175628.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY185125.1, BC072642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY785372.1         2-61
            61-2510             BC072642.1         1-2450
            2511-2913           CN701262.1         228-630
            2914-4655           BC072642.1         2854-4595
            4656-4687           AI850558.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..4687
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.49 cM"
     gene            1..4687
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /note="alpha-2-macroglobulin"
                     /db_xref="GeneID:232345"
                     /db_xref="MGI:MGI:2449119"
     exon            1..223
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..4541
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /note="alpha-2-macroglobulin-P"
                     /codon_start=1
                     /product="alpha-2-macroglobulin-P precursor"
                     /protein_id="NP_783327.2"
                     /db_xref="CCDS:CCDS39617.1"
                     /db_xref="GeneID:232345"
                     /db_xref="MGI:MGI:2449119"
                     /translation="MGKRWLPSLALLPLPPPLLLLLLLLLPTNASAPQKPIYMVMVPS
                     LLHAGTPEKGCLLFNHLNETVTVKVSMESVRGNQSLFTDLVVDKDLFHCASFIVPQSS
                     SNEVMFLTVQVKGPTHEFRRRSTVLIKTKESLVFAQTDKPIYKPGQMVRFRVVSLDEN
                     FHPLNELIPLLYIQDSKKNRIAQWQNFRLEGGLKQLSFPLSSEPTQGSYKVVIRTESG
                     RTVEHPFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPGHVTVNICR
                     KYSNPSSCFGEESLAFCEKFSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLDVNAKIQE
                     EGTGVEETGKGLTKITRTITKLSFVNVDTHFRQGIPFVGQVLLVDGRGTPIPYEMIFI
                     GADEANQNINTTTDKNGLARFSINTDDIMGTSLTVRAKYKDSNVCYGFRWLTEENVEA
                     WHTANAVFSPSRSFVHLESLPYKLRCEQTLAVQAHYILNDEAVLERKELVFYYLMMAK
                     GGIVRAGTHVLPVTQGHKKGHFSILISMETDLAPVARLVLYTILPNGEVVGDTVKYEI
                     EKCLANKVDLVFHPNIGLPATRAFLSVMASPQSLCGLRAVDQSVLLTKPEAELSASLV
                     YDLLPVKDLTGFPKGVNQQEEDTNGCLKQNDTYINGILYSPVQNTNEEDMYGFLKDMG
                     LKVFTNLNIRKPKVCERLGVNKIPAAYHLVSQGHMDAFLESSESPTETTRSYFPETWI
                     WDLVIVDSTGVAEMEVTVPDTITEWKAGAFCLSNDTGLGLSPVIDFQAFQPFFVDLTM
                     PYSVIRGEAFTLKATVLNYLQTCIRVGVQLEASPDFLATPEEKEQKSHCICMNERHTM
                     SWAVIPKSLGNVNFTVSAEALDSKELCRNEVPVVPERGKKDTIIKSLLVEPEGLENEV
                     TFNSLLCPTGAEVSEQISLKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGC
                     GEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFGD
                     KPGRSHANTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLN
                     NAMKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARRGASGNHVYT
                     KALLAYAFALAGNQDTKKEILKSLDEEAVKEDNSVHWTRAQKPRVPADLWYQPQAPSA
                     EVEMTAYVLLAYLTTELVPTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALS
                     KYGAATFTRAKKAAHVTIQSSGAFYTKFQVNNDNQLLLQRVTLPTVPGDYTAKVAGEG
                     CVYLQTSLKYSVLPREKEFPFALVVQTLPGTCEDLKAHTTFQISLNISYIGSRSDSNM
                     AIADVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQMLTLFFMVQQD
                     IPVRDLKPAIVKVYDYYEKDEFAVAKYSAPCSAGYGNA"
     exon            224..407
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            408..564
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            565..617
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            618..638
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            639..807
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            808..892
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1013
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1128
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1238
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1400
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1628
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1692
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1835
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1985
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2153
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2229
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2356
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2585
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2712
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2834
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2886
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2970
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3147
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3235
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3392
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3467
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3648
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3872
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4091
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..4219
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4310
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            4311..4379
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4482
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4524
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4671
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4631..4636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /note="hexamer: AATAAA"
     polyA_site      4653
                     /gene="A2m"
                     /gene_synonym="A2mp"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgggtgg aacccgctgt ttgcataaag cctagctgct cctcagcacg ttcaggacca
       61 gatctctggc ggggagcagg gtgcaaggca gccaggtctc cagtcctctc tgcagcatgg
      121 ggaagcgctg gctcccaagc ctggccctgc tgccgctgcc gccaccgctg ctgctgctgc
      181 tgttgctgct gctgcccaca aatgcctcag caccacagaa accaatctac atggtgatgg
      241 ttccctccct gctccacgct ggcacccctg agaagggctg cctcctgttc aaccacctaa
      301 acgagacagt aacagtgaaa gtatccatgg agtctgtccg tgggaaccaa agcctcttca
      361 ctgaccttgt tgttgacaag gacttattcc actgtgcctc cttcatcgtc ccacagtctt
      421 catccaatga ggtgatgttt ctcactgtcc aagtaaaagg accaactcat gagttcagga
      481 ggaggagcac ggtgctgatc aagactaaag agagcctggt ctttgctcag actgacaagc
      541 ccatctacaa accaggacag atggtgagat ttcgtgttgt ctcattggac gaaaatttcc
      601 acccccttaa tgaattgatt cctctactgt acattcagga ttcaaaaaaa aatcgcattg
      661 cacagtggca gaatttccgc ttagagggtg gcctcaaaca gctgtccttc cccctctcct
      721 cagagcccac tcagggctcc tacaaggtgg tgatacgtac agaatcaggc aggaccgtcg
      781 agcacccctt ctctgtgaag gaatttgtgc ttcccaagtt tgaagtcaaa gttgcagtac
      841 cagagacaat caccatcctg gaggaagaga tgaatgtgtc cgtgtgtggc atatacacct
      901 atgggaagcc tgttccagga cacgtgactg tgaacatttg cagaaagtac agtaatcctt
      961 ctagctgctt tggtgaagaa tcgctggctt tctgtgagaa attcagtcaa cagctagatg
     1021 gccgtggctg cttctcacag ctagtgaaaa ccaagtcttt ccagctaaag aggcaagagt
     1081 atgagatgca gcttgatgtg aatgccaaga tccaagaaga aggaacaggt gtggaagaaa
     1141 ccggtaaagg gctcactaag atcacaagaa ctataacaaa actatcattt gtgaacgtgg
     1201 atacacattt cagacaagga attcctttcg ttgggcaggt gctcctggtg gatgggagag
     1261 gcacccctat tccatatgaa atgatcttca ttggagctga tgaagcaaac cagaacataa
     1321 atactaccac tgataagaat ggcctggcac ggttctccat caacactgat gacatcatgg
     1381 gcacgtccct aactgtcagg gccaaataca aagatagcaa tgtctgctat ggatttagat
     1441 ggttgacaga agagaacgta gaggcttggc acactgccaa cgctgtcttc tcaccgagca
     1501 gaagcttcgt gcacctggaa tccctgccct ataaactgcg ctgtgagcaa accctggcgg
     1561 tccaggctca ttatattcta aatgacgagg ctgtgctgga gcggaaggag ttggtcttct
     1621 attatctgat gatggcaaag ggaggcattg ttcgggcagg gactcacgtt ctgcctgtga
     1681 cgcagggaca caagaaaggc catttctcca tcctcatctc gatggagaca gacctggctc
     1741 ctgtagctcg actggtcctt tataccattc tgcccaatgg agaagtggtt ggagatactg
     1801 ttaaatatga gattgaaaag tgcctggcca acaaggtgga tttggtcttc cacccaaata
     1861 tcggtcttcc ggccacacgt gccttcctca gtgtcatggc ttctcctcag tctctctgtg
     1921 gcctgcgagc tgtggaccaa agcgtactgc tcacaaagcc tgaggccgaa ctctctgcat
     1981 ccctggttta tgatctgcta ccagtgaaag acctcactgg cttccctaag ggtgtgaatc
     2041 aacaggaaga agacactaat ggctgcctta agcaaaatga cacttacatt aatggaatcc
     2101 tgtactcccc agtacagaat acaaatgaag aggacatgta tggcttccta aaggatatgg
     2161 gcttaaaggt attcaccaac ttgaacatcc gtaaacccaa agtctgtgaa cgccttggag
     2221 tcaataaaat accagctgca taccaccttg taagccaagg ccacatggat gcttttctag
     2281 agtcttcaga gtctcccaca gagactacac gaagctactt ccctgagacg tggatctggg
     2341 acttggtgat cgtggactca acaggagtgg ctgaaatgga agtgacagtc cctgacacca
     2401 tcactgaatg gaaggctggg gccttctgcc tgtccaatga cactgggttg ggcctctctc
     2461 ctgtgatcga tttccaagcc ttccagccct tcttcgtgga tctcacaatg ccctactccg
     2521 tgatccgtgg agaggccttc acgctcaagg ccactgtgct gaactacctc cagacatgca
     2581 tccgggttgg tgtacagctg gaggcctctc ctgatttcct agctacccca gaggagaagg
     2641 aacaaaagtc tcactgcatc tgtatgaacg agcggcatac catgtcctgg gcggtgatcc
     2701 ccaagtcatt aggaaatgtg aatttcacag tgagtgcaga ggcactggac tctaaggagc
     2761 tgtgtaggaa tgaggtgcca gtggttcctg aacgtggaaa gaaagacacg atcatcaagt
     2821 ccctgctggt tgaacctgaa ggtctagaga atgaagtgac attcaacagt ttgctttgtc
     2881 caacaggtgc tgaggtatcg gaacagatat ctctgaaact gccatcagat gtggtagagg
     2941 aatctgcccg agcttctgtc acagttttgg gagatatatt gggttctgct atgcagaaca
     3001 cacaggatct ccttaagatg ccctatggct gtggagaaca gaacatggtt ctgtttgctc
     3061 ctaatatcta tgtcctggac tatctgaatg aaacagagca gctgacacag gagatcaaga
     3121 ccaaggccat tacctatctc aatacgggtt accaaagaca attaaactac aagcaccggg
     3181 atggctccta cagtactttt ggggataaac ctggtaggag tcatgccaat acctggctca
     3241 cagcctttgt actgaagagt tttgctcagg ctcgaagata tatcttcatc gatgaatcac
     3301 acatcaccca agccctcacc tggctctccc agcagcagaa ggacaatggc tgcttcagga
     3361 gctccgggtc actgctcaac aatgccatga agggaggagt agaagatgaa gtcactttgt
     3421 ctgcctacat caccattgct ctcctggaga tgtctcttcc tgtcactcat cctgttgtcc
     3481 gaaatgccct cttttgcctg gacacagcct ggaagtcagc gaggagagga gccagcggca
     3541 accatgtcta cactaaggca ctgttggcct atgcatttgc ccttgctggt aaccaggaca
     3601 cgaagaagga gatactgaaa tcactcgatg aggaggcggt aaaagaagac aattctgtcc
     3661 actggaccag agctcagaaa cccagagtgc cagcagatct ctggtaccaa ccccaggctc
     3721 cctcggctga ggtagagatg accgcttatg tgctcctggc ttatcttacc actgagctgg
     3781 ttccaacccg agaggacctg actgctgcaa tgctcattgt gaagtggctc acaaagcagc
     3841 agaattccca cggtggcttc tcctccaccc aggacacggt agtggctctc catgctttgt
     3901 ccaaatacgg agcagctact ttcacaagag cgaagaaagc tgcacatgtg accatccagt
     3961 cttctggcgc attttataca aaattccaag tgaacaacga caaccagtta ttattacaga
     4021 gagtcacatt gccaactgtg cctggggatt acaccgcaaa ggtagctgga gaagggtgtg
     4081 tctacctcca gacatccttg aaatatagtg ttctcccgag ggagaaggag tttccatttg
     4141 ctttggtggt gcagactctg cctgggactt gtgaggatct caaagctcac accaccttcc
     4201 agatctcact caatatcagt tacattggaa gccgttctga ctccaacatg gcaattgctg
     4261 atgtgaagat ggtgtctggc ttcatcccct tgaaaccaac agtgaaaatg cttgaaagat
     4321 ctgtgcatgt gagccggacg gaagtcagca ataaccatgt cttgatttac ttggataagg
     4381 tgtcaaatca gatgctgacc ttgttcttca tggtgcagca agatattcca gtgagagacc
     4441 tgaagccagc catagtgaaa gtctatgatt actacgagaa agatgagttt gcagttgcaa
     4501 aatacagtgc tccctgcagt gcaggttatg gaaatgcctg aagacactgt gaataagaag
     4561 tgtttcacca gagccctgtt cttaggactt ctcaagaaaa agtggttttt gtatttccag
     4621 agatttgata aataaagcat tctttcatat ctatccatca ccattccttc aaaaaaaaaa
     4681 aaaaaaa
//
