LOCUS       NM_001081074            6735 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus APOBEC1 complementation factor (A1cf), transcript
            variant 1, mRNA.
ACCESSION   NM_001081074 XM_129159
VERSION     NM_001081074.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6735)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   2  (bases 1 to 6735)
  AUTHORS   Dias,A.P., Rehmani,T., Salih,M. and Tuana,B.
  TITLE     Tail-anchored membrane protein SLMAP3 is essential for targeting
            centrosomal proteins to the nuclear envelope in skeletal myogenesis
  JOURNAL   Open Biol 14 (10), 240094 (2024)
   PUBMED   39378988
REFERENCE   3  (bases 1 to 6735)
  AUTHORS   Shi,Y., Tian,M., Zhao,X., Tang,L., Wang,F., Wu,H., Liao,Q., Ren,H.,
            Fu,W., Zheng,S., Jose,P.A., Li,L. and Zeng,C.
  TITLE     alpha-Ketoglutarate promotes cardiomyocyte proliferation and heart
            regeneration after myocardial infarction
  JOURNAL   Nat Cardiovasc Res 3 (9), 1083-1097 (2024)
   PUBMED   39223390
REFERENCE   4  (bases 1 to 6735)
  AUTHORS   Marrow,J.P., Alshamali,R., Edgett,B.A., Allwood,M.A.,
            Cochrane,K.L.S., Al-Sabbag,S., Ayoub,A., Ask,K., Hare,G.M.T.,
            Brunt,K.R. and Simpson,J.A.
  TITLE     Cardiomyocyte crosstalk with endothelium modulates cardiac
            structure, function, and ischemia-reperfusion injury susceptibility
            through erythropoietin
  JOURNAL   Front Physiol 15, 1397049 (2024)
   PUBMED   39011088
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6735)
  AUTHORS   Lam,N.T., Nguyen,N.U.N., Ahmed,M.S., Hsu,C.C., Rios Coronado,P.E.,
            Li,S., Menendez-Montes,I., Thet,S., Elhelaly,W.M., Xiao,F.,
            Wang,X., Williams,N.S., Canseco,D.C., Red-Horse,K., Rothermel,B.A.
            and Sadek,H.A.
  TITLE     Targeting calcineurin induces cardiomyocyte proliferation in adult
            mice
  JOURNAL   Nat Cardiovasc Res 1 (7), 679-688 (2022)
   PUBMED   39196243
REFERENCE   6  (bases 1 to 6735)
  AUTHORS   Dur,S., Krause,K., Pluntke,N. and Greeve,J.
  TITLE     Gene structure and expression of the mouse APOBEC-1 complementation
            factor: multiple transcriptional initiation sites and a spliced
            variant with a premature stop translation codon
  JOURNAL   Biochim Biophys Acta 1680 (1), 11-23 (2004)
   PUBMED   15451168
REFERENCE   7  (bases 1 to 6735)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
REFERENCE   8  (bases 1 to 6735)
  AUTHORS   Petrich,B.G., Molkentin,J.D. and Wang,Y.
  TITLE     Temporal activation of c-Jun N-terminal kinase in adult transgenic
            heart via cre-loxP-mediated DNA recombination
  JOURNAL   FASEB J 17 (6), 749-751 (2003)
   PUBMED   12594183
REFERENCE   9  (bases 1 to 6735)
  AUTHORS   Sohal,D.S., Nghiem,M., Crackower,M.A., Witt,S.A., Kimball,T.R.,
            Tymitz,K.M., Penninger,J.M. and Molkentin,J.D.
  TITLE     Temporally regulated and tissue-specific gene manipulations in the
            adult and embryonic heart using a tamoxifen-inducible Cre protein
  JOURNAL   Circ Res 89 (1), 20-25 (2001)
   PUBMED   11440973
REFERENCE   10 (bases 1 to 6735)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125019.6 and AC117816.11.
            
            On Jul 25, 2018 this sequence version replaced NM_001081074.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY566862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC125019.6         72126-72172         c
            48-191              AC125019.6         47787-47930         c
            192-326             AC125019.6         32059-32193         c
            327-457             AC125019.6         29749-29879         c
            458-696             AC125019.6         22863-23101         c
            697-861             AC125019.6         19999-20163         c
            862-959             AC125019.6         13780-13877         c
            960-1233            AC125019.6         8287-8560           c
            1234-1439           AC125019.6         6152-6357           c
            1440-1576           AC117816.11        66297-66433
            1577-1728           AC117816.11        67119-67270
            1729-6735           AC117816.11        68692-73698
FEATURES             Location/Qualifiers
     source          1..6735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19"
     gene            1..6735
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /note="APOBEC1 complementation factor"
                     /db_xref="GeneID:69865"
                     /db_xref="MGI:MGI:1917115"
     exon            1..47
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            48..191
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1880
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /note="isoform 1 is encoded by transcript variant 1;
                     APOBEC-1 stimulating protein"
                     /codon_start=1
                     /product="APOBEC1 complementation factor isoform 1"
                     /protein_id="NP_001074543.1"
                     /db_xref="CCDS:CCDS37959.1"
                     /db_xref="GeneID:69865"
                     /db_xref="MGI:MGI:1917115"
                     /translation="MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPP
                     PGWDSTPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRLMMDFNGNNRGYAFVT
                     FSNKQEAKNAIKQLNNYEIRTGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVT
                     EGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEP
                     EVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNR
                     EDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRNTMLQGEYTYPLSHV
                     YDPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVREIYMNVPVGAAG
                     VRGLGGRGYLAYTGLGRGYHVKGDKREDKLYDLLPGMELTPMNTVSLKPQGIKLAPQI
                     LEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFIPPKLSAYVD
                     EAKRYAAEHTLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVT
                     LGQDLAAYTTYEVYPTFALTTRGDAYGTF"
     exon            192..326
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            327..457
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            458..696
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            697..861
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            862..959
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1233
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1439
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1576
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1728
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..6735
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /note="hexamer: ACTAAA"
     polyA_site      4298
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /note="major polyA site"
     regulatory      6713..6718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /note="hexamer: AATAAA"
     polyA_site      6735
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /note="major polyA site"
ORIGIN      
        1 ataatcaagg aaccttttcc gggtggggaa cctcagaaat tgctcagtga gcaaccctaa
       61 ttaacctgat tttttgctga taatcactct caatggaatc aaatcacaaa tccggggatg
      121 gattgagcgg cacccagaag gaagcggcac tccgcgcact ggtccagcgc acaggatata
      181 gcttggtcca ggaaaatgga caaaggaagt atggtggccc tccaccaggc tgggattcta
      241 cacccccaga aaggggctgc gagattttca ttgggaaact tccccgggac ctctttgagg
      301 atgaactcat accattgtgt gaaaaaattg gtaaaattta tgaaatgaga ttgatgatgg
      361 attttaatgg taacaacaga ggctatgcat ttgtaacatt ctcaaataag caggaagcca
      421 agaatgcaat caagcaactt aataattatg aaattcggac tggccgtctc ttgggagtct
      481 gtgccagtgt ggacaattgc cgattgtttg tgggaggaat ccccaaaacc aaaaagaggg
      541 aagaaatctt atcagagatg aaaaaagtca cagaaggagt tgttgatgtc attgtctacc
      601 caagtgctgc tgataaaacc aaaaaccggg gatttgcctt tgtggaatat gagagtcacc
      661 gagcagccgc catggctagg cggaggctgc tgccaggaag aattcagttg tggggacatc
      721 ctattgcagt agactgggca gaaccagaag ttgaagttga tgaggacaca atgtcttccg
      781 tgaaaatcct gtacgtaagg aaccttatgc tgtctacctc ggaagaaatg attgaaaagg
      841 aattcaacag tattaaacca ggtgctgtgg aaagagtgaa gaagatccga gactacgctt
      901 ttgtgcactt cagtaaccga gaagatgcag ttgaagccat gaaggctttg aatggcaagg
      961 tgctggatgg ttccccaata gaagtgacct tggccaagcc agtggacaag gacagttatg
     1021 ttaggtacac ccggggcacc ggtggcagga acaccatgct gcaaggagaa tacacctacc
     1081 ctctgagcca tgtttatgac cctaccacaa cctaccttgg agctcctgtc ttctataccc
     1141 cccaagccta tgcagccatt ccaagtcttc atttcccagc tactaaagga catctcagca
     1201 acagggctct catcaggacc ccttctgtca gagaaattta catgaatgtc cctgtagggg
     1261 ctgcgggggt gagaggactg ggcggccgtg ggtatttggc atacacaggc ctgggtcgag
     1321 gataccacgt caaaggagac aagagagaag acaaactcta tgatcttctg cctgggatgg
     1381 agctcacccc gatgaatact gtctctttaa aaccacaagg aattaaactt gctcctcaga
     1441 tattagaaga aatctgtcag aaaaataact ggggacagcc agtgtaccaa ctgcattctg
     1501 ccattggaca agatcaaaga cagttattcc tctacaaagt aactatccca gcgctggcca
     1561 gccagaatcc tgcaatccac cctttcatac caccaaagct aagcgcctat gtggatgaag
     1621 cgaagaggta tgctgcagag cacactctac agacactagg catccccaca gaaggagggg
     1681 acgctgggac tacagcaccc acggccactt ctgccactgt gttcccagga tatgctgtcc
     1741 ccagtgccac cgctcctgtg tctacagccc agctcaagca agcagtgaca cttggacaag
     1801 acttagcagc atatacaacc tatgaggtct accctacttt tgcactgacc acccgaggcg
     1861 atgcatatgg aaccttctaa cgatccctgt cctctaagaa taagccttta tagaaggatc
     1921 tgtagaagat acgaacctct agccagatcc ctcatgacca caagtcatac cttcccccaa
     1981 agcaatgcct ttcctgagac cacaagattt attcgtcgta ttactcatga aatgtgaata
     2041 ttattcttca acaaaatcaa atgttaagca gaaacctgaa gatccacgga cagcaaaagt
     2101 tgttcttcca aggatcctga gtgtctcagg aagaggataa caccctgaca aattagcata
     2161 tgctcttagt acagagagct gggcagtccg tagtaaggca cagccagtaa aatgcccatc
     2221 ttagtcactg gctggcagct gcttcttcat tcacagaact tagacaccag aggaaagcag
     2281 gaagctctgt aagaggcctt cagcattgca tacagtgtgg agtatgatcc caggctgagc
     2341 tcagcaaaac tgtctgaaac attatagatt ccttctcact tttggtctgg acattccaca
     2401 ctgttcgcct gtcataggtc agcatcctcc tgtccctgca acctctgggg actttctaga
     2461 aatcagtaca atgtatttca gatatgcttg agacaaatcc aagccctgta tttattcaac
     2521 tctttaagcc actgttttcc ttcagaatcc tttccctgct caaggattcc caaatcacag
     2581 aaaccatgcc agtaccaagt tctagagtga aagatgactt tttttggggg gggggggtgt
     2641 caggaaattc tggcttgtcc atactcattt gctttcatct cagactcatt ttgctgatcc
     2701 caaaaactac aaagtaaatc agatctacat aaaaatcact atgatatttt cataatcaga
     2761 aacttgacca aaaagtcatt tcaaagagaa aagtgtttgg cttttgtctc gctgggtagc
     2821 ccaggctcac cttgatattg atcttgtgat cctcctgcct ctgctccccc catgctggtg
     2881 ttgtttacac acaacaccat actcatctcc aagaagttgc attaaaattg aggttacctt
     2941 tgagttctct acccagttca tattaatcta ccaaaaatca ctgtccatcc catcttttga
     3001 ttgtctttca atatgtgcag ctggctttac tatgactgag tcccttgata gtgaaactat
     3061 tccaggaaag ccttacaccc atcatggttg cttagagacc atccctttta gcattcagta
     3121 aaagtgttgc tttccaaaat gtcccaattt agaccatctg atagtgactg ggggagggag
     3181 gctatataca tgtaaaaagg atgtaatgtt ctgatacaaa ttagatataa ctccagcctt
     3241 attagggatt ttaggagata cggcacttga attcccatta aaacaaaaca aaaacaaaaa
     3301 agcttttggc ttttgtgaaa gtctgtagaa ctcaagagac aataaagaca aaagtacaga
     3361 aaatattgtc aactccttct tggaattctg gaatctaaaa tcaggccaaa ttccatccaa
     3421 tcaaagccag ggaaatgtca accagagttg aatacctcat aacctttagg ttctcataag
     3481 tctagctaga catctaaagt tgagaacccc agctgaaacg aaaggctctg gatttcctgg
     3541 attatgcctt ctttcgggtt attgtgttcc taagaacagg aactcccgag cttggcagca
     3601 tatccaaaac acctaaagag ctttcaatca gttaaggcca agctcacagg ccaaatatgt
     3661 cagagagtct tggcatgggg cctgacgtca gtgttttggg aagattcctg tgtggtttga
     3721 aaaagcagct tggagtggga atgttagagt ctttgtagat ccactccgct tctttcattc
     3781 tgtcctttct aattcagtct gcaccaaata cacaacacct atacattgtt ttagtcaaaa
     3841 acaagtaagt ggtcatgtgg ctgtcattat agtcatcaag cacatgctct gagcttgaac
     3901 gaagttcata ttggcttcaa actacttatt aagacaaact ttaaaaagaa aattcacctt
     3961 cccttaaagt aattcttata ttcaaattta tactcaccat aacctgtttt tattcagaga
     4021 gagagagaga gagagagaga gagagagaga attacattga cccacaaatg tcctctggcc
     4081 aggtaaattt ctcctcagcc tgaaaagaca tttcaaattc tacctgagga aaaccctcaa
     4141 aaataaatag cgaagggctc actatatgtt ttctcaagat agaagatgct gtggaagatt
     4201 gaaatccatt taacaggaaa agataagtgc ttcatacaga taataccatc atcgcccact
     4261 aaaagcatca gcaacataat accaaatgct acaaaaaaga aacaaagtgt gaagaagatt
     4321 accagtggga tactacatgc ttactttcca gagaaaacat aactaattaa tggcctgcct
     4381 ccctgtggct aatctatata ctactaaatg gatggatgga tgctgctgct gctgctgctg
     4441 ctgcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcttctt
     4501 cttcttcttc ttcttcttct ttctcttctt cttcttctcc tcctcctcct cctcttcttc
     4561 ctccttctcc tcctccttat tcttcttttt ctccctcttc ctcttcttct tcgtcctcct
     4621 ccctttccat cctattcttt cttcttctct tcctcctcct cctgctcctc ctcctcattc
     4681 attctattct tcctcctcct cttcttcctc ttcctcctca tcctccccat tcttcttttt
     4741 ggagggatgg ttctgaaatt ttactttatt ttggtaatat agagagggga atttgaattc
     4801 cgttgtaaca ttcgtagtct gtgtcagtgt gttactacca taacagacca atttttgggg
     4861 tactgggttt gactctaggg agaaaatgag ttgctatttt gggtggaggt gttgctattg
     4921 gatttagttt tggggtgttt gttttgttaa cagttttaag acattttctc cctatgcagt
     4981 ccaggctggc ctcaaactct tcaacctcct ctctcttcct cttaagtgct gggctcatag
     5041 gattgtacca ccacacatac ctcaaagata aactttgaga atatcaagtg tcaaatgaaa
     5101 ggttagtttt gcatagtgtt tatattttag atttagcaaa ttaggactaa taccttctga
     5161 ccttacaaat cacaaatcat aattcatctt ctctctcccc tgtgtgcttc ttagttcttc
     5221 atggaaaaac ttaaaatcat caacacaacc acatgatatt gacaagccac cctgggcaat
     5281 catttagaag catctaccaa attaggattt ggtttctaaa gtctgtcagt tgacagtttg
     5341 ttgatgaagt aatcccctct gcatttaact tcacagttcc tgttgctctt ccacttcctc
     5401 atccaaactc ttcagtttct cctatacaaa ggctttcgtc gctccctagt agaaagtagc
     5461 atcaacagct tatgcccctt ttcacgaaat tcttgcctat catttgttgc ctttactaat
     5521 gctgagaatt ttacaatcca tgttgattga cccacctgtt cattcatgac agaatgtgtc
     5581 tttgtctact gtgttctttg tttactatat accctctgtt actccagaaa tgggaaatac
     5641 aggcacacat atttctgttc ctctctgcaa cgggagcaca atccaagaag cgcattcttc
     5701 acttttgaaa actgaacata acgagatcag ctggtaactt tgtcacttcg tcaaaatccc
     5761 cagaataagc caattccatc ctaacccttg tatttccagc actaccaccc aacatgttct
     5821 tagagtgaaa tgaattttaa agtatttttt cccagaaaaa taccaagagc tatgtaaaaa
     5881 taaaaagcaa aggtttagtt agtcacaagc tttaaactta tggctataag gaatatgtac
     5941 ctgatttaag attttgatga gccccacaca ggcttattta cttgaaaaca ttttggtcat
     6001 taagtatttc tgtttgtgtt tataaaattc aaaactatat ttaacaagcc tttgccatat
     6061 ctccatgttt tgacagtaag tggtttacgg cgcagtcttt ttatcttcta caaatataca
     6121 atcttatttt caaacttgtt attttgtatt ataattccta ggagatattt gggagttcaa
     6181 actccaaata tatcgattta aatcaatctt cattatcttg ctttaactac ttaatcactg
     6241 gtatttttag tactattctc tcatagaaat catttttaat caatttttgt gactgctata
     6301 caatcaaata ttactttctc tttctctttt atcttttatt gaaaacaaag ctttaaacaa
     6361 actggatttc cagttcccag gtgttaaaac tcttggttct tttcttttta ttgttattta
     6421 tatggattta tctagagtac caaaagaaag ttatattaaa agaacagtat taaagaatgt
     6481 gcataaagca ttatttttgt acttagagta caatgttttg tagagctata tgatctagtt
     6541 atattaagta acattatatc attggattat taggaaaatg attattgctt tgaaaaatac
     6601 aaatatcctg gtcatatgat ttagggtcat aattcaaatg aaatgagaaa tgacacaatt
     6661 ttgtgagatt ttaggatggt gatatggctt taattgagtt ttcaagttcc gtaataaagt
     6721 tttagaaatt atcaa
//
