LOCUS       NP_001074543             595 aa            linear   ROD 12-JUN-2025
DEFINITION  APOBEC1 complementation factor isoform 1 [Mus musculus].
ACCESSION   NP_001074543 XP_129159
VERSION     NP_001074543.1
DBSOURCE    REFSEQ: accession NM_001081074.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 595)
  AUTHORS   Fuchs,M.A.A., Burke,E.J., Latic,N., Murray,S.L., Li,H.,
            Sparks,M.A., Abraham,D., Zhang,H., Rosenberg,P., Saleem,U.,
            Hansen,A., Miller,S.E., Ferreira,D., Hanzelmann,S., Hausmann,F.,
            Huber,T., Erben,R.G., Fisher-Wellman,K., Bursac,N., Wolf,M. and
            Grabner,A.
  TITLE     Fibroblast growth factor 23 and fibroblast growth factor receptor 4
            promote cardiac metabolic remodeling in chronic kidney disease
  JOURNAL   Kidney Int 107 (5), 852-868 (2025)
   PUBMED   39923962
REFERENCE   2  (residues 1 to 595)
  AUTHORS   Perelli,R.M., Dewars,E.R., Cope,H., Behura,A.S., Ponek,A.Q.,
            Sala,A.M., Zhang,Z., Muralidharan,P., Moya-Mendez,M.E., Berkman,A.,
            Monaco,G.G., Sullivan,M.C., Ezekian,J.E., Yang,Q., Sun,B.,
            Kurzlechner,L.M., Asokan,T., Breglio,A.M., Campbell,M.J.,
            Spector,Z.Z., Rehder,C.W., Tang,P.C., James,C.A., Calkins,H.,
            Shashi,V. and Landstrom,A.P.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     TAX1BP3 Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic
            Cardiomyopathy
  JOURNAL   Circ Res 136 (7), 667-684 (2025)
   PUBMED   39963794
REFERENCE   3  (residues 1 to 595)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   4  (residues 1 to 595)
  AUTHORS   Du,T., Han,Y., Han,H., Xu,T., Yan,Y., Wu,J., Li,Y., Liu,C.,
            Liao,X., Dong,Y., Chen,D., Ou,J., Lin,S. and Huang,Z.P.
  TITLE     The tRNA methyltransferase Mettl1 governs ketogenesis through
            translational regulation and drives metabolic reprogramming in
            cardiomyocyte maturation
  JOURNAL   Nat Cardiovasc Res 3 (12), 1438-1453 (2024)
   PUBMED   39587264
REFERENCE   5  (residues 1 to 595)
  AUTHORS   Dias,A.P., Rehmani,T., Salih,M. and Tuana,B.
  TITLE     Tail-anchored membrane protein SLMAP3 is essential for targeting
            centrosomal proteins to the nuclear envelope in skeletal myogenesis
  JOURNAL   Open Biol 14 (10), 240094 (2024)
   PUBMED   39378988
REFERENCE   6  (residues 1 to 595)
  AUTHORS   Dur,S., Krause,K., Pluntke,N. and Greeve,J.
  TITLE     Gene structure and expression of the mouse APOBEC-1 complementation
            factor: multiple transcriptional initiation sites and a spliced
            variant with a premature stop translation codon
  JOURNAL   Biochim Biophys Acta 1680 (1), 11-23 (2004)
   PUBMED   15451168
REFERENCE   7  (residues 1 to 595)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
REFERENCE   8  (residues 1 to 595)
  AUTHORS   Petrich,B.G., Molkentin,J.D. and Wang,Y.
  TITLE     Temporal activation of c-Jun N-terminal kinase in adult transgenic
            heart via cre-loxP-mediated DNA recombination
  JOURNAL   FASEB J 17 (6), 749-751 (2003)
   PUBMED   12594183
REFERENCE   9  (residues 1 to 595)
  AUTHORS   Sohal,D.S., Nghiem,M., Crackower,M.A., Witt,S.A., Kimball,T.R.,
            Tymitz,K.M., Penninger,J.M. and Molkentin,J.D.
  TITLE     Temporally regulated and tissue-specific gene manipulations in the
            adult and embryonic heart using a tamoxifen-inducible Cre protein
  JOURNAL   Circ Res 89 (1), 20-25 (2001)
   PUBMED   11440973
REFERENCE   10 (residues 1 to 595)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125019.6 and AC117816.11.
            
            On Feb 6, 2007 this sequence version replaced XP_129159.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY566862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19"
     Protein         1..595
                     /product="APOBEC1 complementation factor isoform 1"
                     /note="APOBEC-1 stimulating protein"
                     /calculated_mol_wt=65551
     Region          2..595
                     /region_name="hnRNP-R-Q"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; TIGR01648"
                     /db_xref="CDD:273732"
     Region          360..409
                     /region_name="Required for nuclear localization.
                     /evidence=ECO:0000250|UniProtKB:Q9NQ94"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5YD48.2)"
     CDS             1..595
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /coded_by="NM_001081074.2:93..1880"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS37959.1"
                     /db_xref="GeneID:69865"
                     /db_xref="MGI:MGI:1917115"
ORIGIN      
        1 mesnhksgdg lsgtqkeaal ralvqrtgys lvqengqrky ggpppgwdst ppergceifi
       61 gklprdlfed eliplcekig kiyemrlmmd fngnnrgyaf vtfsnkqeak naikqlnnye
      121 irtgrllgvc asvdncrlfv ggipktkkre eilsemkkvt egvvdvivyp saadktknrg
      181 fafveyeshr aaamarrrll pgriqlwghp iavdwaepev evdedtmssv kilyvrnlml
      241 stseemieke fnsikpgave rvkkirdyaf vhfsnredav eamkalngkv ldgspievtl
      301 akpvdkdsyv rytrgtggrn tmlqgeytyp lshvydpttt ylgapvfytp qayaaipslh
      361 fpatkghlsn ralirtpsvr eiymnvpvga agvrglggrg ylaytglgrg yhvkgdkred
      421 klydllpgme ltpmntvslk pqgiklapqi leeicqknnw gqpvyqlhsa igqdqrqlfl
      481 ykvtipalas qnpaihpfip pklsayvdea kryaaehtlq tlgipteggd agttaptats
      541 atvfpgyavp satapvstaq lkqavtlgqd laayttyevy ptfalttrgd aygtf
//
