LOCUS       NM_029964               1078 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus RIKEN cDNA 6030468B19 gene (6030468B19Rik), mRNA.
ACCESSION   NM_029964 XM_126537 XM_911360
VERSION     NM_029964.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1078)
  AUTHORS   Catalan-Dibene,J., Vazquez,M.I., Luu,V.P., Nuccio,S.P.,
            Karimzadeh,A., Kastenschmidt,J.M., Villalta,S.A., Ushach,I.,
            Pone,E.J., Casali,P., Raffatellu,M., Burkhardt,A.M.,
            Hernandez-Ruiz,M., Heller,G., Hevezi,P.A. and Zlotnik,A.
  TITLE     Identification of IL-40, a Novel B Cell-Associated Cytokine
  JOURNAL   J Immunol 199 (9), 3326-3335 (2017)
   PUBMED   28978694
  REMARK    GeneRIF: these observations indicate that C17orf99 encodes a novel
            B cell-associated cytokine, which we have called IL-40, that plays
            an important role in humoral immune responses and may also play a
            role in B cell development.
REFERENCE   2  (bases 1 to 1078)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB843270.1, AK020081.1 and AL645856.5.
            
            On or before Nov 18, 2009 this sequence version replaced
            XM_911360.2, XM_126537.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020081.1, SRR5189673.52605.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BB843270.1         2-76
            76-912              AK020081.1         1-837
            913-913             AL645856.5         97786-97786
            914-1071            AK020081.1         839-996
            1072-1078           AL645856.5         97945-97951
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.96 cM"
     gene            1..1078
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /note="RIKEN cDNA 6030468B19 gene"
                     /db_xref="GeneID:77727"
                     /db_xref="MGI:MGI:1924977"
     exon            1..144
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..866
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /note="uncharacterized protein C17orf99 homolog;
                     interleukin-40; protein IL-40"
                     /codon_start=1
                     /product="protein IL-40 precursor"
                     /protein_id="NP_084240.1"
                     /db_xref="CCDS:CCDS48992.1"
                     /db_xref="GeneID:77727"
                     /db_xref="MGI:MGI:1924977"
                     /translation="MALLQLLLFAMLAACGFSEEQTEGITIAYKVLEVYPQSRRVLIT
                     CDAPEASQPITYSLLASRGILVAKKVVHDSVPASFNINITIKSSPDLLTYSCQATSNS
                     GTYGPSSRLQMYQELWAKPVSQLQADFVLRHGDSGPTVELSCLASSGSPPITYRLVGN
                     GGRVLAQQRPLHGKPANFSLPLSQTTGWFQCEAENDVGVDSSARIPLPRAEARAKLVT
                     TLAGELPLTPTCILAGSLVSIAVIASRMLSSTGL"
     exon            145..177
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /inference="alignment:Splign:2.1.0"
     exon            178..465
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /inference="alignment:Splign:2.1.0"
     exon            466..735
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /inference="alignment:Splign:2.1.0"
     exon            736..859
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1078
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /note="hexamer: AATAAA"
     polyA_site      1071
                     /gene="6030468B19Rik"
                     /gene_synonym="Il-40"
                     /note="major polyA site"
ORIGIN      
        1 tagctgcagg cagccacccg aggagcatcc aggggccttg gggtggagag gccagacagg
       61 aagctttgga cagcctgagc catacacagc cccaacctca cagacgcatg gcgctccttc
      121 agctgctcct ctttgccatg ctggctgcct gtggcttctc agaggagcag acagaaggca
      181 tcaccattgc ctacaaagta ctggaagttt atccccaaag ccggagggtg cttataacct
      241 gcgatgcccc tgaggcgtcc cagcccatca catactctct cctggctagc cgaggtatcc
      301 tggtggcaaa aaaggttgtg catgactccg tgccggcctc cttcaacatc aatatcacca
      361 tcaagtccag cccagacctg ctcacctact cctgccaggc aacctcgaac tctggcacct
      421 atggacccag cagcaggctc cagatgtacc aggaactgtg ggctaagcca gtgtctcagc
      481 tgcaggctga cttcgtccta cgccatgggg actcgggccc cactgtggag ctgtcctgcc
      541 tggcatcctc aggcagcccc cccatcacct accgcttggt ggggaatggt gggcgtgttc
      601 ttgcacagca aaggccactt catggaaaac cagccaactt ctccctcccg ctgtcccaga
      661 ccactggttg gttccagtgc gaagctgaaa acgatgtcgg tgtggacagc agtgcccgca
      721 tcccgctgcc ccgagcagag gcccgagcca agctggtgac caccctcgca ggggagctgc
      781 ccctgacacc cacctgtatt ctggctggca gcctcgtctc catagccgtt attgcttcca
      841 ggatgctgag ctcgaccggg ttgtgaccgg aagacagagc catgggcttg cctccctgcc
      901 ctgtacaaga acccaccaat ggagcaaaag agagcctgag gtgtgggggt agaaaagggg
      961 ggttcagggc tggagagatg gctcagttac agcactgact gttcttccag aggtcccgag
     1021 ttcaattccc ataatgtact tctacacata aaataaataa ttcttttttt gttttgtt
//
