LOCUS       NM_029444               1910 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RIKEN cDNA 4930447C04 gene (4930447C04Rik), mRNA.
ACCESSION   NM_029444
VERSION     NM_029444.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Li,Y., Wu,Y., Khan,I., Zhou,J., Lu,Y., Ye,J., Liu,J., Xie,X.,
            Hu,C., Jiang,H., Fan,S., Zhang,H., Zhang,Y., Jiang,X., Xu,B., Ma,H.
            and Shi,Q.
  TITLE     M1AP interacts with the mammalian ZZS complex and promotes male
            meiotic recombination
  JOURNAL   EMBO Rep 24 (2), e55778 (2023)
   PUBMED   36440627
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Fan,S., Jiao,Y., Khan,R., Jiang,X., Javed,A.R., Ali,A., Zhang,H.,
            Zhou,J., Naeem,M., Murtaza,G., Li,Y., Yang,G., Zaman,Q., Zubair,M.,
            Guan,H., Zhang,X., Ma,H., Jiang,H., Ali,H., Dil,S., Shah,W.,
            Ahmad,N., Zhang,Y. and Shi,Q.
  TITLE     Homozygous mutations in C14orf39/SIX6OS1 cause non-obstructive
            azoospermia and premature ovarian insufficiency in humans
  JOURNAL   Am J Hum Genet 108 (2), 324-336 (2021)
   PUBMED   33508233
  REMARK    Erratum:[Am J Hum Genet. 2022 Jul 7;109(7):1343. doi:
            10.1016/j.ajhg.2022.06.006.. PMID: 35803236]
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Sanchez-Saez,F., Gomez-H,L., Dunne,O.M., Gallego-Paramo,C.,
            Felipe-Medina,N., Sanchez-Martin,M., Llano,E., Pendas,A.M. and
            Davies,O.R.
  TITLE     Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1
            interactions that are disrupted in cases of human infertility
  JOURNAL   Sci Adv 6 (36) (2020)
   PUBMED   32917591
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Felipe-Medina,N., Caburet,S., Sanchez-Saez,F., Condezo,Y.B., de
            Rooij,D.G., Gomez-H,L., Garcia-Valiente,R., Todeschini,A.L.,
            Duque,P., Sanchez-Martin,M.A., Shalev,S.A., Llano,E., Veitia,R.A.
            and Pendas,A.M.
  TITLE     A missense in HSF2BP causing primary ovarian insufficiency affects
            meiotic recombination by its novel interactor C19ORF57/BRME1
  JOURNAL   Elife 9, e56996 (2020)
   PUBMED   32845237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Zhang,Q., Ji,S.Y., Busayavalasa,K. and Yu,C.
  TITLE     SPO16 binds SHOC1 to promote homologous recombination and
            crossing-over in meiotic prophase I
  JOURNAL   Sci Adv 5 (1), eaau9780 (2019)
   PUBMED   30746471
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Zhang,Q., Shao,J., Fan,H.Y. and Yu,C.
  TITLE     Evolutionarily-conserved MZIP2 is essential for crossover formation
            in mammalian meiosis
  JOURNAL   Commun Biol 1, 147 (2018)
   PUBMED   30272023
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1910)
  AUTHORS   Gomez-H,L., Felipe-Medina,N., Sanchez-Martin,M., Davies,O.R.,
            Ramos,I., Garcia-Tunon,I., de Rooij,D.G., Dereli,I., Toth,A.,
            Barbero,J.L., Benavente,R., Llano,E. and Pendas,A.M.
  TITLE     C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and
            is essential for mouse fertility
  JOURNAL   Nat Commun 7, 13298 (2016)
   PUBMED   27796301
  REMARK    GeneRIF: SIX6OS1 is essential for the appropriate processing of
            intermediate recombination nodules before crossover formation
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1910)
  AUTHORS   Trivedi,C.M., Zhu,W., Wang,Q., Jia,C., Kee,H.J., Li,L.,
            Hannenhalli,S. and Epstein,J.A.
  TITLE     Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic
            cardiac myocyte proliferation
  JOURNAL   Dev Cell 19 (3), 450-459 (2010)
   PUBMED   20833366
REFERENCE   10 (bases 1 to 1910)
  AUTHORS   Alfano,G., Vitiello,C., Caccioppoli,C., Caramico,T., Carola,A.,
            Szego,M.J., McInnes,R.R., Auricchio,A. and Banfi,S.
  TITLE     Natural antisense transcripts associated with genes involved in eye
            development
  JOURNAL   Hum Mol Genet 14 (7), 913-923 (2005)
   PUBMED   15703187
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK015397.1.
            
            On Apr 5, 2007 this sequence version replaced NM_029444.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015397.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1910              AK015397.1         1-1910
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.3 cM"
     gene            1..1910
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /note="RIKEN cDNA 4930447C04 gene"
                     /db_xref="GeneID:75801"
                     /db_xref="MGI:MGI:1923051"
     exon            1..58
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            59..115
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1791
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /note="Six6 antisense; six6 opposite strand transcript 1
                     homolog"
                     /codon_start=1
                     /product="protein SIX6OS1"
                     /protein_id="NP_083720.1"
                     /db_xref="CCDS:CCDS25971.1"
                     /db_xref="GeneID:75801"
                     /db_xref="MGI:MGI:1923051"
                     /translation="MNDNLFVSLDRLLLEFVFQYEQDISIKEDTIQRINKCLESIKEN
                     KANVSKLREAINKVDEDIAFHYKHSKEIKDSCSNWKPTCDVFHKHEDYIKDQLTAYQE
                     TNEKDKKMYHDYICQYEDVLKQYQLKYSETRFSCKYYEKKKEHEEIKNRVLACTEQLQ
                     LNETILMKFLVPAPFPSLTKWTLYVVNLRYRTQDILKRANNFTKRSFELEKEADDMEI
                     EINSLNKMARLFESKTFSEALDEKNKNTEKRKEFEERIFEKDEQVSNRSSQNSQLLLP
                     CESQKFVRNMNSSEARVTDKKEESSANQSKFVRSDVRQKENNPQIFNDSGMDSNSKSS
                     HIPAVKSSQGFMQFRLNQPNYNQRIEKEHIDAECGDKETVRQVRESKCSTQALYIEHF
                     GKSIENNSVEEERDENFPQTPETPSFLRTPEALKTPESMEKMQFPKSPFFEITKNATS
                     EGHKQKDSPGFSFLMSYTSRSPGLNLFDSSVSDSEISSDQFNEHYSAVNLNPSSSQQG
                     IGNLFGKSEGEDAFTFSFSSDSSHTFGAGKDDFSFPFSFEQDPSTMTSSSSKDFSSSQ
                     NKTQFMFF"
     exon            116..172
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..299
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..389
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..577
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..620
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..741
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..830
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..949
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1026
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1112
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1159
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1221
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1397
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1536
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1594
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1910
                     /gene="4930447C04Rik"
                     /gene_synonym="4921504I02Rik; A930035O15Rik; Six6as;
                     Six6OS; Six6os1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgctggtg gaagagcggt ctgaggagaa agctgcgggt ctgaggagga ggcagcagtg
       61 tccaagatga atgataatct gtttgtcagt ttggacaggc ttttgttgga atttgttttc
      121 cagtatgagc aagacataag tattaaagaa gatacgattc aaagaattaa taaatgcctt
      181 gaaagtatta aagaaaataa agcaaatgtt tctaagctac gtgaagctat aaacaaagta
      241 gatgaggaca ttgcttttca ctataaacat agtaaagaaa tcaaagacag ctgtagtaac
      301 tggaagccaa catgtgatgt ttttcataaa catgaagatt atataaaaga ccagcttact
      361 gcttaccaag aaaccaatga gaaagacaaa aaaatgtatc atgattatat atgtcagtat
      421 gaagatgttt tgaaacaata ccaactaaaa tactcagaaa cacgtttttc atgtaaatat
      481 tatgagaaga aaaaagaaca tgaagaaatt aaaaatagag tgttggcatg tactgaacaa
      541 ctacaattga atgaaactat tcttatgaaa tttctagtgc ctgctccttt cccatctctg
      601 actaaatgga cattatacgt agttaatttg agatacagaa cacaagatat tcttaaacgt
      661 gccaacaatt ttaccaaaag atcatttgaa ttggagaaag aagcagatga tatggaaata
      721 gaaattaatt ctttaaataa gatggcaaga ctttttgaaa gtaaaacatt ttcagaagct
      781 ctagacgaaa agaacaaaaa tacagaaaag agaaaagaat ttgaagagag aatttttgaa
      841 aaagatgagc aagtatcaaa cagaagctct caaaatagcc aattgttact gccatgtgag
      901 tctcagaaat ttgtaagaaa tatgaattct tcagaagcaa gagttacaga taaaaaagaa
      961 gaaagttcag ccaatcagtc aaagtttgtt agaagtgatg tgagacaaaa agaaaataat
     1021 ccacagatat ttaatgactc tggtatggat agtaattcaa aatcttcaca tattccagct
     1081 gttaaaagtt cacaaggttt tatgcaattc agattgaatc aaccaaatta caatcaacgg
     1141 attgaaaaag aacatataga tgctgaatgt ggagataaag agacagtaag acaagtaaga
     1201 gaatcaaaat gtagtacaca ggccctatac attgaacact ttggaaagtc catagaaaat
     1261 aatagtgttg aagaggaaag agatgagaat tttcctcaaa ctcctgaaac tccttcattt
     1321 ctaagaactc ctgaagcgct gaagacacct gaatctatgg agaaaatgca gttccctaaa
     1381 agccccttct ttgaaataac taaaaatgca acatctgaag gacataaaca aaaggattct
     1441 cctggatttt catttcttat gagttacacc tctagatcac ctggactaaa tttatttgat
     1501 tcttctgtat ctgattcaga aatctcatcg gatcagttta atgaacatta ctctgcggta
     1561 aatctaaatc cttcttcatc acaacaagga attggaaact tatttggaaa atcagaagga
     1621 gaagatgcct tcacattttc tttttcatca gactcttctc acacatttgg agctggaaaa
     1681 gatgacttta gttttccatt ttcttttgaa caggatccaa gcacaatgac ttcttcttcc
     1741 tcaaaagatt tttcatcctc acaaaataaa acacaattta tgtttttttg agttattatt
     1801 tttgaactat ttaatgctat ttaactattt gaactattta atatctgtaa aattttgtat
     1861 tatcactgaa tgtaagatat atttttgtca attaaagtag aaattgttcc
//
