LOCUS       NM_198655               2682 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RIKEN cDNA 4921509C19 gene (4921509C19Rik), mRNA.
ACCESSION   NM_198655 XM_355354
VERSION     NM_198655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2682)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2682)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2682)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   4  (bases 1 to 2682)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2682)
  AUTHORS   Caenepeel,S., Charydczak,G., Sudarsanam,S., Hunter,T. and
            Manning,G.
  TITLE     The mouse kinome: discovery and comparative genomics of all mouse
            protein kinases
  JOURNAL   Proc Natl Acad Sci U S A 101 (32), 11707-11712 (2004)
   PUBMED   15289607
  REMARK    GeneRIF: First described as a mouse-specific duplication of the
            MARK kinase family, and named MarkmE1
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL928719.6.
            
            On Nov 17, 2006 this sequence version replaced NM_198655.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL928719.6         38733-38895         c
            164-2096            AL928719.6         34612-36544         c
            2097-2170           AL928719.6         34027-34100         c
            2171-2682           AL928719.6         33286-33797         c
FEATURES             Location/Qualifiers
     source          1..2682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..2682
                     /gene="4921509C19Rik"
                     /gene_synonym="Gm1005"
                     /note="RIKEN cDNA 4921509C19 gene"
                     /db_xref="GeneID:381393"
                     /db_xref="MGI:MGI:2685851"
     exon            1..163
                     /gene="4921509C19Rik"
                     /gene_synonym="Gm1005"
                     /inference="alignment:Splign:2.1.0"
     exon            164..2096
                     /gene="4921509C19Rik"
                     /gene_synonym="Gm1005"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2130
                     /gene="4921509C19Rik"
                     /gene_synonym="Gm1005"
                     /EC_number="2.7.11.1"
                     /note="MarkmE1"
                     /codon_start=1
                     /product="sperm motility kinase X"
                     /protein_id="NP_941057.1"
                     /db_xref="CCDS:CCDS38271.1"
                     /db_xref="GeneID:381393"
                     /db_xref="MGI:MGI:2685851"
                     /translation="MKRWQACQDLRSNTFEDAALTEHYEILTTLGQGTFGEVKLASHL
                     VTQTKVAIKILPKSRKNSLVQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGG
                     ELMSRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTD
                     FGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATGCLPFN
                     GYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWLKPDNE
                     ASPASLGENIESHPDPSIMVLMGVMGYNPGEIRESLREKKFDQVMATYLMLKQQSAWE
                     NKTTKKPDPRLCDRMLRSTEPTIKNQTSVRRASSVPTHSTFSLPNESESLEKGKRTTM
                     SHSMPPTRNCFNEETTPLHSICPQLVQKAHYRRSIWGETEISDTSEESSTGESLEHPS
                     LKIHTLQTSMGVSKAGSTYSKSKGSSQCVSSHHTSVEEDQCEGTNISREINPPLSPVS
                     PQENLMGQLHIVTTAGSMDIMNTQVTSPPFSRKEAKGEGPALQQRESRPSSPNTLQGH
                     LHGRRQTVPQAPFQRRVWRTLRNGLIRGLRTLCCCLPIERRVHPTNNRDLAVSQKSHG
                     GSHGIRAFRGTVLPEK"
     exon            2097..2170
                     /gene="4921509C19Rik"
                     /gene_synonym="Gm1005"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2682
                     /gene="4921509C19Rik"
                     /gene_synonym="Gm1005"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagtggt ttggtggtgg tttgggagac gtggactgtg gtgataattt tggacttgga
       61 tactggtaac gttttggact cggattctgg caacggtttt ggactcggat tctggagaag
      121 gtttggactc ggatattggt gaacctgctt ggactttgac acggtgttgt ggccattgac
      181 cacaaaccaa ctgacctatc agtgaagatg aagagatggc aagcgtgtca ggacctcagg
      241 tctaacacct ttgaagacgc tgccttaaca gaacactatg aaatattaac aacccttggc
      301 caaggaacat ttggggaagt aaaactggcg agccatctcg tcacccagac taaggtagca
      361 ataaaaatcc tccccaaaag caggaaaaac tcccttgtcc aacccgaaat tgaaatcatg
      421 aaatctcttg accatcccca tattattaaa cttttacaca taatcgacac caccagaaac
      481 attttcatcg ttctggagca tgctgtggga ggagagctga tgagcagaat tgaagagttt
      541 ggctatctag cagaggtgga gtgccacagg ctgtttaaac agctggtcta tgccctccag
      601 tattgtcatg agaaagggat tgtccacagg gatttaaagc cagaaaacat tttattggac
      661 cacagaggaa atgtaaagct tactgatttt ggattgggca ccaagataat catgggccag
      721 aagctggtca cgttctgtgg aaccctccct tactgtgccc cagaactgtt tgaagataga
      781 gggtatgatg gccgggccac tgatgtctgg agcttggggg ttgtgcttta ttttatggcc
      841 acagggtgcc ttcctttcaa tggatatagc tatgaagcaa taaagcagaa gatcattgca
      901 ggaaagtacc ctaggagttt cagtctgtca ccagaacttt gggaggtgat agccaagttg
      961 ctaactgtca accctggaga gaggccaaca gtccatgaca ttgccagatt taagtggcta
     1021 aagcctgaca acgaagcttc tcccgcttct ttgggagaga acattgagag tcacccggac
     1081 ccctctataa tggtgctcat gggtgtcatg ggatacaatc caggagagat aagagaaagt
     1141 ttgcgggaga aaaaattcga ccaggtgatg gctacttatt taatgctcaa acaacagtca
     1201 gcctgggaaa ataagacaac aaaaaaacca gatccaaggc tatgtgatag aatgttgaga
     1261 agcacagagc caaccataaa aaaccaaaca tctgtaagga gggcatctag tgtgcctaca
     1321 cattccacct tcagtttgcc caatgaatca gaaagtcttg aaaagggaaa gagaactaca
     1381 atgagccact ctatgccacc cacgaggaac tgcttcaacg aggagacaac tccactccac
     1441 agtatctgcc cccagcttgt ccagaaggct cactacagga ggagcatctg gggggagaca
     1501 gagatcagtg acacttcaga agaaagctct actggagagt ctttggaaca tccatcactg
     1561 aaaatccaca ccctccagac atccatgggt gtgtccaaag ctggatctac ctattcaaag
     1621 agcaaggggt cttcacagtg tgtttcttct catcatacct ctgtggaaga agaccagtgt
     1681 gagggcacca acatatccag agagatcaac ccacctcttt caccagtctc gcctcaggag
     1741 aacctcatgg gacagctcca cattgtgact acagctgggt caatggacat catgaacaca
     1801 caagttacat cacctccatt ctccaggaag gaggccaagg gtgagggtcc tgctctacaa
     1861 cagagagagt ccagaccatc ctccccaaat acactccagg gacacctcca tggcaggcgt
     1921 cagactgtgc cccaggcccc ctttcaaaga cgggtctgga ggaccctgag gaacggttta
     1981 atcagaggcc tgcgaacttt atgttgctgc ctgccaatcg aaaggagagt gcacccgacc
     2041 aacaacagag acctggctgt gagtcaaaag agccatggag gtagccatgg tatcagagca
     2101 tttagaggca ctgtgctccc tgaaaaatga taccagagag tgaagagcag cctactgagg
     2161 atgcacacag gttggttcat gttggctggt gattccacag ttttgccagg caagcaaagt
     2221 actccataga tctcagtaat tctggaaaca aggtaccatg acatgcaggt catcattgga
     2281 aaaccaaacc tcagaggaac ttccaggcat gtagagatca tcagctgcct gtctccagat
     2341 gtacccatgg gacattagaa gagcaagtgg acactggaag cagagtagga ccccagagtg
     2401 tctgatctga tctacttgtg gttgtgttca agatgactgg tgcttaccag tttggagcca
     2461 gaaacagagc aaggagagtg cagggaatgt ccatcttgtg ctcataagca agatagagtg
     2521 ggcatgaaca gctaagccca ttgctcatgg tgcagttcat aaaaccatcc tggcttgcta
     2581 gacagcttga ttctaatcca ccattactca gataccctca aaactcaccc tatttggaca
     2641 gaaagggaca cacacacaca cacacacaca cacacacaca gc
//
