LOCUS       NM_001163378            5763 bp    mRNA    linear   ROD 04-DEC-2023
DEFINITION  Mus musculus RIKEN cDNA 2700049A03 gene (2700049A03Rik), transcript
            variant 1, mRNA.
ACCESSION   NM_001163378 XM_126944 XM_916714
VERSION     NM_001163378.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5763)
  AUTHORS   Martinez-Heredia V, Blackwell D, Sebastian S, Pearson T, Mok GF,
            Mincarelli L, Utting C, Folkes L, Poeschl E, Macaulay I, Mayer U
            and Munsterberg A.
  TITLE     Absence of the primary cilia formation gene Talpid3 impairs muscle
            stem cell function
  JOURNAL   Commun Biol 6 (1), 1121 (2023)
   PUBMED   37925530
  REMARK    GeneRIF: Absence of the primary cilia formation gene Talpid3
            impairs muscle stem cell function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5763)
  AUTHORS   Wang S, Tanaka Y, Xu Y, Takeda S and Hirokawa N.
  TITLE     KIF3B promotes a PI3K signaling gradient causing changes in a Shh
            protein gradient and suppressing polydactyly in mice
  JOURNAL   Dev Cell 57 (19), 2273-2289 (2022)
   PUBMED   36220081
REFERENCE   3  (bases 1 to 5763)
  AUTHORS   Bashford AL and Subramanian V.
  TITLE     Hippocampals neurogenesis is impaired in mice with a deletion in
            the coiled coil domain of Talpid3-implications for Joubert syndrome
  JOURNAL   Hum Mol Genet 31 (19), 3245-3265 (2022)
   PUBMED   35470378
REFERENCE   4  (bases 1 to 5763)
  AUTHORS   Wang J, Li T, Wang JL, Xu Z, Meng W and Wu QF.
  TITLE     Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor
            Delamination to Sustain Neurogenesis by Stabilizing Adherens
            Junctions
  JOURNAL   Cell Rep 33 (11), 108495 (2020)
   PUBMED   33326788
REFERENCE   5  (bases 1 to 5763)
  AUTHORS   Bashford AL and Subramanian V.
  TITLE     Mice with a conditional deletion of Talpid3 (KIAA0586) - a model
            for Joubert syndrome
  JOURNAL   J Pathol 248 (4), 396-408 (2019)
   PUBMED   30924151
  REMARK    GeneRIF: Findings in a mouse model reveal a role for Talpid3 in
            granule precursor cell migration in the cerebellum (either direct
            or indirect) which together with defective Hedgehog signaling
            underlies the Joubert syndrome phenotype.
REFERENCE   6  (bases 1 to 5763)
  AUTHORS   Kobayashi T, Kim S, Lin YC, Inoue T and Dynlacht BD.
  TITLE     The CP110-interacting proteins Talpid3 and Cep290 play overlapping
            and distinct roles in cilia assembly
  JOURNAL   J Cell Biol 204 (2), 215-229 (2014)
   PUBMED   24421332
REFERENCE   7  (bases 1 to 5763)
  AUTHORS   Bangs F, Antonio N, Thongnuek P, Welten M, Davey MG, Briscoe J and
            Tickle C.
  TITLE     Generation of mice with functional inactivation of talpid3, a gene
            first identified in chicken
  JOURNAL   Development 138 (15), 3261-3272 (2011)
   PUBMED   21750036
  REMARK    GeneRIF: Data show that talpid3-/- mouse embryos lack primary cilia
            and, like talpid(3) chicken embryos, have face and neural tube
            defects but also defects in left/right asymmetry.
REFERENCE   8  (bases 1 to 5763)
  AUTHORS   Yin Y, Bangs F, Paton IR, Prescott A, James J, Davey MG, Whitley P,
            Genikhovich G, Technau U, Burt DW and Tickle C.
  TITLE     The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is
            essential for primary cilia formation
  JOURNAL   Development 136 (4), 655-664 (2009)
   PUBMED   19144723
REFERENCE   9  (bases 1 to 5763)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 5763)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC043104.1.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_001163378.2.
            
            On or before Jul 22, 2009 this sequence version replaced
            XM_916714.2, XM_126944.6.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043104.1, BC150744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5763              BC043104.1         1-5763
FEATURES             Location/Qualifiers
     source          1..5763
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 29.39 cM"
     gene            1..5763
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /note="RIKEN cDNA 2700049A03 gene"
                     /db_xref="GeneID:76967"
                     /db_xref="MGI:MGI:1924217"
     exon            1..1191
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     CDS             993..5555
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein TALPID3"
                     /codon_start=1
                     /product="protein TALPID3 isoform 1"
                     /protein_id="NP_001156850.1"
                     /db_xref="CCDS:CCDS49081.1"
                     /db_xref="GeneID:76967"
                     /db_xref="MGI:MGI:1924217"
                     /translation="MKNVEFSLERGQRLKMPARKLREIVSPNQGNKLAVVEDELPRVP
                     PALAANKRLAVETRTSSNGTLCGSLDLTSARLYHQPLLESPPASKKSDFSKDAVVRQL
                     PLNKTEENNAPKANDIFISQYTMGQKDALRTVLKQKAQSMPVFKAVKVHLFEDTSTEK
                     NTVAQETETPPNRIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNCVGELLTKLQET
                     DKQLQRVTEHQASVQSKQEKVHCHDHDKQMNAFMEQHIRHLEKLQQQQIDIQTHFIDA
                     ALKASSLQLGMSTSRAVGKYSGKLGSPSVGSSVFSHNTFVSKRVPLSEDTDFDGQKSP
                     LETPAPRRFAPVPVSRDGKITKRESPTEEKENMEMNSPKGNVRLLEQVLNSNECLTRK
                     TESSDITSLTQPKMGWNLEKRDSTETLHSQIFPSSEERGTAQVPVPKYNDVVHDLGQK
                     KQASDMLQIKQSPVTLRLSDHPHNPALLQTTNTRSVLKDAAKILRGVQNNKKVLEENL
                     EAIVRAKDGAAMYSFINALATNREMSEKIRIRKQVDEWIKIISAEIQDELMRKDYEQK
                     RFDPKNQRNKKALTMSRDIKANNQEKTVNRSVIPRSHYQKQTQEQFTSPPVRNLPASG
                     PQKERSGLLKSATTLQDEDYMLQIYGKPVYQGHRSTLKKGPYLRFSSPSPKAKPQRPR
                     VIELVKGTKVKSAKTQTDFHAASRMKMDSKIQHPITALPHADQQYMVSPSREMPTVSG
                     TLEGHLIPMAILLGQTQSNSDSMPPAGVTVNKPRPVTVTTSIPPASRKGNAGVKKPNV
                     AIVEMKSEKKDPPQLSVQILPSVDIDSVSYSSTDGASSPPSPKEASLPPLHTWIQTPD
                     FMKVDEEEVPLPGTNFDEVIDVIQEEEKRDEIPECSAPMLEFNRSVKVVPTKYNGPSF
                     PPVVSAYHPTTDILDKVIERKETLENSLIQWVEQEIMSRIISGLFPLQQQARLDASVS
                     VSEASEPSASDIVAGTSSGALQRMVDARVPVNSDMVSHFVNEALTETIAVMLADREAE
                     RQRAAATSVPGDLSGTETNLLARVCAPVATPQPTPPCSPSPVREHVRVKTPDSSPCES
                     DPDAASSIKEIRVEKGSDMPAVMLVSTPTRTPVATPPPAAALTPTLSETSIDKLKLSS
                     PELPKPWDSGDLPLDEENPNSLQELPHPRAVVMSVANEEPESVDFSAQPAPPEPAPSA
                     PLPEGTKAPSLQRVPSSGSSTLENTLSTVTETETLDRHISEGEILFSCGQNLATKRPG
                     DLFLMNINDSLSSTLQDALEMEDDPPSEGQVIRRPHKKRHEDAIVALLTKQQRELLVS
                     QQEEDLDNSVGELSEGQRLVLKAAEDISAGPSGQMLPPTSPAEPSYQHADPRLVLQQS
                     DMASGNICEDLCASHGPMSLRELELQPDSNLILPITHTTTAVSDGNLPEAAEDFSQYQ
                     QKQDSDIKQVEHKPIQRHLTSVRNKPDSTLSQHQGGPADLLLIAHVSPARMSVTLPSA
                     NLEDCSQSLSTSSMHGGTESSGTDTF"
     exon            1192..1265
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1335
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1405
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1580
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1802
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1950
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2112
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2236
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2366
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2584
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2657
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2882
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3057
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3252
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3440
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3551
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3632
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3826
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            3827..3945
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4145
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4302
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4522
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            4523..4770
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            4771..4841
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            4842..4964
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            4965..5139
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            5140..5294
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            5295..5403
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
     exon            5404..5763
                     /gene="2700049A03Rik"
                     /gene_synonym="mKIAA0586; Ta3; Talpid3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcaacgga atctgtcgaa atttctagaa agcctaatat gcttaaccta ctaggtttct
       61 aacggtctgc agttcctaca gtgtaaataa cccttgataa acaaaagtgt ttatgggcta
      121 atcgagaatt cgccattcct ctaggaatac ttagtactgt gtccaaacat aaaggcgata
      181 ttctgccttt aaaaaaaaaa agtcacatct cctggcagtc ttttatgttg ggagtttgtt
      241 tccacccgga cacgaatgga agagcaccag agcactcccg ttccggtcgg gggggggggg
      301 gttggatctt tgcgcgcatg cgtgctgacg ctcaagggcg ggttttcggg gaagacggta
      361 ttgacccgcg aacaaccgaa gctgttattc tatcaaaatc aagacggcgt gtgtgccgga
      421 ctctgtggag actctgaaga ctaagttgag gtgtccgaaa ttgcgtcctg actcgtagaa
      481 agaaatctac taagctctta tgagggtggt gttttaaaaa acacgatttt aacgttgcct
      541 gctcgtctgg gtctccttaa caaatcctaa ccccgcctcc acgtctgttg gggttttcag
      601 ctgcagctct gggtttggag gagtgcgttt ttattacggt tcccgtggct tctcttttgc
      661 tcttggcata attcctttga aatttatttc ttcgatgcat taacagactc agtgggatca
      721 agactttttg ttttgttttg ttttttgttt ttgtcgtatt tagccctgga ttaaatgtca
      781 aaatcgaaat ttacagcttt atggatattt tgcctataga ctttctaagt taatgactgc
      841 ttcataatta tttttggaac tcaggtgttt ttcaaattca cttccaccat tacttctttt
      901 cctggtactc aaggagaaac tgcgtcctta agttttgaga agctagaatt ccctctgtta
      961 agaacggcgg gacttgattt gtgactaacc agatgaaaaa cgttgagttt agcctggaaa
     1021 gggggcaaag gcttaaaatg ccagcgagga aactgcgaga gattgtttct ccaaaccaag
     1081 ggaataaatt ggctgtggtg gaagatgagc tgccccgtgt tcctccagcc ctggctgcaa
     1141 ataaacgtct tgctgttgaa acgaggacta gttctaatgg aacgttatgt ggctccttgg
     1201 atttaacttc tgcaagactg tatcaccagc ctctgttaga aagtcctcct gcgtccaaga
     1261 aaagtgattt ttctaaagat gctgtagttc ggcagttacc tttgaataaa acagaagaga
     1321 acaacgcacc aaaagcaaat gacatcttta tttctcagta caccatggga cagaaagatg
     1381 ctctgagaac tgttttaaag caaaaagctc aaagcatgcc tgtttttaag gcggtgaaag
     1441 tacatctttt tgaagacacg agtacagaaa agaatactgt tgctcaggag actgaaactc
     1501 cacccaatag aattgattca gctacaactg tggctgcggc aactgccgct gccatcgcaa
     1561 cagcagctcc tttgatcaag gtacagagtg atttggaggc aaaggttaat tgtgttggag
     1621 agttacttac taagttacag gagactgata aacagttaca gcgcgtgaca gagcaccaag
     1681 ccagcgttca gagtaagcaa gagaaagtgc actgtcatga ccacgacaag cagatgaacg
     1741 cgttcatgga gcagcatatc aggcaccttg aaaaactaca gcaacagcag atagacattc
     1801 agacccattt tattgatgct gcactcaagg ctagcagtct tcaacttggc atgtccacgt
     1861 ccagagcagt ggggaagtat tctggaaaac tgggaagccc tagtgttggg agcagtgttt
     1921 tttcacacaa cacatttgtt tctaaacgag tgcctttaag tgaagacaca gattttgatg
     1981 ggcagaaatc tcctttagag accccagcac ctcgcaggtt tgcccctgta cctgtttcaa
     2041 gggatggaaa aataacaaaa agggaaagcc ctacagaaga aaaagaaaat atggaaatga
     2101 acagtcctaa aggaaatgta agactgttgg aacaagtact gaatagtaat gagtgtttga
     2161 caagaaagac tgaatcatca gatataacct cactaactca gccaaaaatg ggatggaatt
     2221 tagagaaaag agacagcact gaaactctac attcacaaat atttccttcc tctgaagagc
     2281 ggggaacagc tcaagtaccc gtgccgaagt ataatgatgt tgttcatgat cttggccaga
     2341 agaaacaagc aagtgacatg ctccagataa agcaatctcc agttaccttg aggctttcag
     2401 atcatccgca taatcctgcc ttgctccaga caaccaatac aaggtctgtc ttgaaagatg
     2461 ctgcgaagat tctgagagga gtacaaaaca ataaaaaagt actagaagaa aacctggaag
     2521 ctatcgttcg tgcaaaggat ggagctgcta tgtattcatt tatcaatgct ttagctacca
     2581 atagagagat gtcagagaaa attaggatca gaaagcaggt agatgaatgg attaaaatca
     2641 tttcagcaga aatccaggat gaacttatga gaaaagatta tgaacaaaag agatttgatc
     2701 caaagaatca aagaaacaag aaagctctaa ctatgagtag agatattaaa gccaataacc
     2761 aagaaaaaac ggtgaacaga tctgtaattc caagaagcca ttatcaaaag caaacccagg
     2821 agcagtttac aagtccacct gtgaggaact tgcctgcctc cggcccgcag aaagagagga
     2881 gtggcctctt gaagtcagcc acaacgttgc aagacgagga ttatatgtta cagatatatg
     2941 ggaagccagt ttatcagggc caccgcagca ctcttaagaa aggaccgtat ctcagattca
     3001 gttctccgtc tcctaaggcc aagccacaga ggccaagggt gatagagcta gtgaaaggca
     3061 ctaaagtcaa gtcagcaaaa acacaaactg actttcatgc tgcatcacgt atgaaaatgg
     3121 attctaaaat acagcatccc atcaccgcac tacctcatgc tgatcagcag tatatggtca
     3181 gcccaagcag agaaatgcct actgtttcag gtaccctgga aggtcatcta attcctatgg
     3241 caatcctctt aggacaaacc caaagcaata gtgactccat gccacctgct ggagtcactg
     3301 taaacaagcc acgccccgtg actgtgacca cttctattcc tccggcatct cgaaaaggga
     3361 acgctggagt caagaaaccc aacgtagcca ttgtagagat gaaatcagag aagaaggacc
     3421 ctccccagct ctctgtacag atattaccta gtgtggatat tgatagcgtt tcatacagca
     3481 gtactgacgg ggcttcctct ccaccaagtc ccaaagaagc ctctcttcct ccactgcaca
     3541 cctggatcca gactccagac tttatgaagg tggatgaaga agaggtgccc cttccaggaa
     3601 ctaactttga tgaagtaatc gatgttattc aggaagaaga aaaacgtgat gaaattcctg
     3661 aatgctctgc accaatgttg gagtttaaca gaagtgttaa agttgttcct acaaaatata
     3721 atggtccttc atttcctcct gtagtttctg cttaccatcc cactactgat attttagata
     3781 aagtaattga gagaaaagaa acattggaaa atagtttaat tcagtgggta gaacaagaaa
     3841 taatgtcaag aattatctct gggctctttc cactccagca acaggccaga cttgatgcca
     3901 gtgtctcagt aagtgaggcg agcgaaccgt cagcttctga cattgttgca ggaacaagca
     3961 gtggagcgct ccagcgtatg gttgatgcca gagttcctgt gaactcggac atggtcagcc
     4021 attttgtcaa tgaagctctg actgagacca ttgctgtcat gttagctgac agagaagcag
     4081 agaggcaaag ggctgctgcc acaagtgttc ctggtgatct ttcaggaact gaaactaacc
     4141 tgttggcaag agtttgtgct ccagtagcga cgccgcagcc cactcccccc tgctcaccat
     4201 cacctgtgag ggagcacgtg cgagtgaaaa cgccagactc ttctccctgt gaatccgatc
     4261 cagatgcggc ttcttctata aaagagatac gcgttgaaaa aggaagtgat atgcctgctg
     4321 tcatgcttgt tagtacacca acacgcactc ctgtcgctac ccctcctcca gcagcagctc
     4381 ttaccccaac tttgtccgaa acttccattg acaagttgaa gttatcaagc cctgaacttc
     4441 ccaagccatg ggacagtgga gacctgccac tggatgaaga gaatcctaac tctcttcaag
     4501 agcttcctca cccaagagcg gttgtaatgt ctgtggctaa tgaagaacct gagagtgtgg
     4561 acttttctgc tcagcctgca cctccggagc cagctccctc agcaccactt cctgagggca
     4621 ccaaggcccc ttccctccag cgagtaccaa gttcaggttc atccaccctg gagaacactc
     4681 tgagcactgt cactgaaaca gaaacgctag acaggcatat atctgaaggg gagatcttat
     4741 ttagctgtgg tcaaaacttg gctaccaaga gacctgggga cttgtttctg atgaacataa
     4801 atgacagctt atccagcact ctgcaggatg cccttgaaat ggaagatgac cctcccagtg
     4861 aagggcaggt gattaggagg ccccacaaaa agcgtcatga agatgccatc gttgcccttc
     4921 ttactaagca acaacgggag ttattagttt cacagcaaga ggaggacttg gataacagcg
     4981 tgggtgagct tagtgaagga cagaggctcg tgctgaaagc agcagaggac atctcagcag
     5041 gaccgtccgg ccaaatgctg ccgcccactt ctcctgcaga gccctcctat cagcacgcag
     5101 accctcggct ggtattgcag cagtctgaca tggcctcagg taatatttgt gaagatttat
     5161 gtgccagtca tggtccaatg agcttaaggg agctggagtt gcagcctgat tctaacctta
     5221 ttcttcccat aacacacact acaacagcag tcagcgatgg taatttacca gaagcagctg
     5281 aagatttttc tcagtaccaa caaaagcaag attcagacat taaacaagtt gaacacaagc
     5341 caatacaaag acatctaacc agtgtaagaa ataaacctga cagtacactt tcacagcatc
     5401 aaggtggccc ggcagatctg ctcctcattg cacatgtgtc acccgccagg atgtctgtga
     5461 ctctaccctc tgcgaacctt gaggactgct ctcagtccct gagcaccagc tccatgcatg
     5521 gcggcaccga atcctcaggg acagacacct tctgagcagg aggagagcag cacaaggttc
     5581 atgaagactc atgaaggctt acaaggttca tgaagacatg tcactctggc tgcagaccat
     5641 gtctgtatac tgttggcctt tgaacatatt tttaggggaa atatttctaa tatattatta
     5701 agacaaaagt gtcctttgaa tatttagtaa ggcttttaaa taaagtagat ataactcaac
     5761 taa
//
