LOCUS       NM_015534               6412 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger ZZ-type containing 3 (ZZZ3), transcript
            variant 1, mRNA.
ACCESSION   NM_015534
VERSION     NM_015534.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6412)
  AUTHORS   Lo Conte,M., Lucchino,V., Scalise,S., Zannino,C., Valente,D.,
            Rossignoli,G., Murfuni,M.S., Cicconetti,C., Scaramuzzino,L.,
            Matassa,D.S., Procopio,A., Martello,G., Cuda,G. and Parrotta,E.I.
  TITLE     Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway in human
            embryonic stem cells homeostasis
  JOURNAL   Stem Cell Reports 19 (5), 729-743 (2024)
   PUBMED   38701777
  REMARK    GeneRIF: Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway
            in human embryonic stem cells homeostasis.
REFERENCE   2  (bases 1 to 6412)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6412)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6412)
  AUTHORS   Mi,W., Zhang,Y., Lyu,J., Wang,X., Tong,Q., Peng,D., Xue,Y.,
            Tencer,A.H., Wen,H., Li,W., Kutateladze,T.G. and Shi,X.
  TITLE     The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated
            histone acetylation and gene activation
  JOURNAL   Nat Commun 9 (1), 3759 (2018)
   PUBMED   30217978
  REMARK    GeneRIF: Study identifies the ZZ domain of ZZZ3 as a histone H3
            reader that is required for the ATAC complex-mediated maintenance
            of histone acetylation and gene activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6412)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 6412)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   7  (bases 1 to 6412)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 6412)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 6412)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   10 (bases 1 to 6412)
  AUTHORS   Guelman,S., Suganuma,T., Florens,L., Swanson,S.K., Kiesecker,C.L.,
            Kusch,T., Anderson,S., Yates,J.R. 3rd, Washburn,M.P., Abmayr,S.M.
            and Workman,J.L.
  TITLE     Host cell factor and an uncharacterized SANT domain protein are
            stable components of ATAC, a novel dAda2A/dGcn5-containing histone
            acetyltransferase complex in Drosophila
  JOURNAL   Mol Cell Biol 26 (3), 871-882 (2006)
   PUBMED   16428443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX641001.1, AC093575.2, BX640658.1 and CA448091.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015534.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX641001.1, SRR1803614.222290.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370801.8/ ENSP00000359837.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4323              BX641001.1         2-4324
            4324-5411           AC093575.2         14472-15559
            5412-5729           BX640658.1         3501-3818
            5730-6412           CA448091.1         18-700              c
FEATURES             Location/Qualifiers
     source          1..6412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..6412
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="zinc finger ZZ-type containing 3"
                     /db_xref="GeneID:26009"
                     /db_xref="HGNC:HGNC:24523"
                     /db_xref="MIM:619892"
     exon            1..74
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            75..208
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..271
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..425
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..1981
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..3188
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger, ZZ domain containing 3; ATAC component 1 homolog;
                     ZZ-type zinc finger-containing protein 3"
                     /codon_start=1
                     /product="ZZ-type zinc finger-containing protein 3 isoform
                     1"
                     /protein_id="NP_056349.1"
                     /db_xref="CCDS:CCDS677.1"
                     /db_xref="GeneID:26009"
                     /db_xref="HGNC:HGNC:24523"
                     /db_xref="MIM:619892"
                     /translation="MAASRSTRVTRSTVGLNGLDESFCGRTLRNRSIAHPEEISSNSQ
                     VRSRSPKKRPEPVPIQKGNNNGRTTDLKQQSTRESWVSPRKRGLSSSEKDNIERQAIE
                     NCERRQTEPVSPVLKRIKRCLRSEAPNSSEEDSPIKSDKESVEQRSTVVDNDADFQGT
                     KRACRCLILDDCEKREIKKVNVSEEGPLNSAVVEEITGYLAVNGVDDSDSAVINCDDC
                     QPDGNTKQNSIGSYVLQEKSVAENGDTDTQTSMFLDSRKEDSYIDHKVPCTDSQVQVK
                     LEDHKIVTACLPVEHVNQLTTEPATGPFSETQSSLRDSEEEVDVVGDSSASKEQCKEN
                     TNNELDTSLESMPASGEPEPSPVLDCVSAQMMSLSEPQEHRYTLRTSPRRAAPTRGSP
                     TKNSSPYRENGQFEENNLSPNETNATVSDNVSQSPTNPGEISQNEKGICCDSQNNGSE
                     GVSKPPSEARLNIGHLPSAKESASQHITEEEDDDPDVYYFESDHVALKHNKDYQRLLQ
                     TIAVLEAQRSQAVQDLESLGRHQREALKNPIGFVEKLQKKADIGLPYPQRVVQLPEIV
                     WDQYTHSLGNFEREFKNRKRHTRRVKLVFDKVGLPARPKSPLDPKKDGESLSYSMLPL
                     SDGPEGSSSRPQMIRGRLCDDTKPETFNQLWTVEEQKKLEQLLIKYPPEEVESRRWQK
                     IADELGNRTAKQVASRVQKYFIKLTKAGIPVPGRTPNLYIYSKKSSTSRRQHPLNKHL
                     FKPSTFMTSHEPPVYMDEDDDRSCFHSHMNTAVEDASDDESIPIMYRNLPEYKELLQF
                     KKLKKQKLQQMQAESGFVQHVGFKCDNCGIEPIQGVRWHCQDCPPEMSLDFCDSCSDC
                     LHETDIHKEDHQLEPIYRSETFLDRDYCVSQGTSYNYLDPNYFPANR"
     exon            1982..2120
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2268
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2384
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2456
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2558
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2654
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2807
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2942
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3043
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..6412
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4291..4296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="hexamer: AATAAA"
     polyA_site      4323
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="major polyA site"
     regulatory      6333..6338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="hexamer: GATAAA"
     polyA_site      6353
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
     regulatory      6389..6394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="hexamer: TATAAA"
     polyA_site      6412
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
ORIGIN      
        1 gttggcagag cagttgtcct ggatggcgga gccttgggtt ccgggggcct gggacctgca
       61 actctttcta caagatatca agttattcta gtacaaccat ataaataaat aatacctgaa
      121 gtctcagtgt aacatggaca attaacagtg atgacagata aatacagacg catggggatc
      181 aaatactagg caaaacgctt tttaaaagtg tatcaggctt ttaagaaaca ctgcaggatc
      241 ctgtctatct taatgctgat agagctcagc taaaaattta ggaggttcta gtattcttca
      301 tggctgaagc tgagagagtc tgaaaccctg atgcttaagc tccattctag atcatagctc
      361 caactccttc aggatataag gaaaagagat tatatttcca caatgataga tctttggttg
      421 tacaggtttc ccaatgagtg gatcatgatg accgtattgt agggacttgc catagtatgg
      481 ctgcttcccg atctactcgt gttacaagat caacagtggg gttaaacggc ttggatgaat
      541 ctttttgtgg tagaacttta aggaatcgta gcattgcgca tcctgaagaa atctcttcta
      601 attctcaagt acgatcaaga tcaccaaaga agagaccaga gcctgtgcca attcagaaag
      661 gaaataataa tgggagaacc actgatttaa aacagcagag tacccgagaa tcatgggtaa
      721 gccctaggaa aagaggactt tcttcttcag aaaaggataa catagaaagg caggctatag
      781 aaaattgtga gagaaggcaa acagaacctg tttcaccagt tttaaaaaga attaagcgtt
      841 gtcttagatc tgaagcacca aacagttcag aagaagattc tcctataaaa tcagacaagg
      901 agtcagtaga acagaggagt acagtagtgg acaatgatgc agattttcaa gggactaaac
      961 gagcttgtcg atgtcttata ctggatgatt gtgagaaaag ggaaattaaa aaggtgaatg
     1021 tcagtgagga agggccactt aattctgcag tagttgaaga aatcacaggc tatttggctg
     1081 tcaatggtgt tgatgacagt gattcagctg ttataaactg tgatgactgt cagcctgatg
     1141 ggaacactaa acaaaatagc attggttcct atgtgttaca ggaaaaatca gtagctgaaa
     1201 atggggatac ggatacccaa acttcaatgt tccttgatag taggaaggag gacagttata
     1261 tagaccataa ggtgccttgc acagattcac aagtgcaggt caagttggag gaccacaaaa
     1321 tagtaactgc ctgcttgcct gtggaacatg ttaatcagct gactactgag ccagctacag
     1381 ggcccttttc tgaaactcag tcatctttaa gggattctga ggaggaagta gatgtggtgg
     1441 gagatagcag tgcctcaaaa gagcagtgta aagaaaacac caataacgaa ctggacacaa
     1501 gtcttgagag tatgccagcc tccggagaac ctgaaccatc tcctgttcta gactgtgttt
     1561 cagctcaaat gatgtcttta tcagaacctc aagaacatcg ttatactctg agaacctcac
     1621 cacgaagggc agcccctacc agaggtagtc ccactaaaaa cagttctcct tacagagaaa
     1681 atggacaatt tgaggagaat aatcttagtc ctaatgaaac aaatgcaact gttagtgata
     1741 atgtaagtca atctcctaca aatcctggtg aaatttctca aaatgaaaaa gggatatgtt
     1801 gtgactctca aaataatgga agtgaaggag taagtaaacc accctcagag gcaagactca
     1861 atattggaca tttgccatct gccaaagaga gtgccagtca gcacattaca gaagaggaag
     1921 atgatgatcc tgatgtttat tactttgaat cagatcatgt ggcactgaaa cacaacaaag
     1981 attatcagag actattacag acgattgctg tactcgaggc tcagcgttct caagcagtcc
     2041 aagaccttga aagtttaggc aggcaccaga gagaagcact gaaaaatccc attggatttg
     2101 tggaaaaact ccagaagaag gctgatattg ggcttccata tccacagaga gttgttcaat
     2161 tgcctgagat cgtatgggac caatataccc atagccttgg gaattttgaa agagaattta
     2221 aaaatcgtaa aagacatact agaagagtta agctagtttt tgataaagta ggtttacctg
     2281 ctagaccaaa aagtccttta gatcctaaga aggatggaga gtccctttca tattctatgt
     2341 tgcctttgag tgatggtcca gaaggctcaa gcagtcgtcc tcagatgata agaggacgct
     2401 tgtgtgatga taccaaacct gaaacattta accagttgtg gactgttgaa gaacagaaaa
     2461 agctggaaca gctactcatc aaataccctc ctgaagaagt agaatctcga cgctggcaga
     2521 agatagcaga tgaattgggc aacaggacag caaaacaggt tgccagccga gtacagaagt
     2581 atttcataaa gctaactaaa gctggcattc cagtaccagg cagaacacca aacttatata
     2641 tatactccaa aaagtcttca acaagcagac gacagcaccc tcttaataag catctcttta
     2701 agccttccac tttcatgact tcacatgaac cgccagtgta tatggatgaa gatgatgacc
     2761 gatcttgttt tcatagccac atgaacactg ctgttgaaga tgcatcagat gacgaaagta
     2821 ttcctatcat gtataggaat ttacctgaat ataaagaact attacagttt aaaaagttaa
     2881 agaagcagaa acttcagcaa atgcaagctg aaagtggatt tgtgcaacat gtgggcttta
     2941 agtgtgataa ctgtggcata gaacccatcc agggtgttcg gtggcattgc caggattgtc
     3001 ctccagaaat gtctttggat ttctgtgatt cttgttcaga ctgtctacat gaaacagata
     3061 ttcacaagga agatcaccaa ttagaaccta tttataggtc agagacattc ttagacagag
     3121 actactgtgt gtctcagggc accagttaca attaccttga cccaaactac tttccagcaa
     3181 acagatgaca tggaagagaa catcatttac tagtcctctt caacacatag caatggtatc
     3241 attgttaatt atgtgcacag tttggaaaga ttctctgctt tcccagaaat gacactcaca
     3301 gcatgagagc ttcctgagtg ttctcgtcaa gtacagctct gcaccgttgt ggctctagat
     3361 cactgttcag cagctgaaca ttcctggtga gcaaaggttt ccctggtgaa tttttcacca
     3421 ctgcgtttta ggtggtgatc ttaaatgggt gagatggaac gagagcacac attaaagaga
     3481 gagtaaattc caaaggtttc aaagaacttg gtcataaata tgataatgag aagacaaagt
     3541 atttatatta aaacagttta gtagccttca gttttgtgaa aatagttttc agcacagaaa
     3601 ctgacttctt tagacaaagt tttaaccaat gatggtgttt gcttctagga tatacacttt
     3661 aaaagaactc actgtcccag tggtggtcat tgatggcctt tagtaaattg gagctgctta
     3721 atcatattga tatctaattt cttttaacca caatgaattg tccttaatta ccaacagtga
     3781 agcactacag gaggcaactg tggcattgct tccttaacca gctcatggtg tgtgaatgtt
     3841 ataaaattgt cactcagata tattttttaa atgtaatgtt atataagatg atcatgtgat
     3901 gtgtacaaac tatggtgaaa agtgccagtg gtagtaactg tgtaaagttt ctaattcaca
     3961 acattaattc ctttaaaata cacagccttc tgcctctgta tttggagttg tcagtacaac
     4021 tcatcaaaga aaactgccta atataaaaat catatatatg gtaataattt ccctcttttg
     4081 tagtctgcac aagatccata aaagattgta tttttattac tatttaaaca agtgattaaa
     4141 tttagtctgc acagtgagca agggttcaca tgcattcttt tatactgctg gattttgttg
     4201 tgcatcattt aaaacatttt gtatgtttct tcttatctgt gtatacagta tgttcttgaa
     4261 tgatgttcat ttgtcaggag aactgtgaga aataaactat gtggatactg tctgtttata
     4321 ttatagaatg cttgttgtga cttccttttg gttagatttt ggattttttt ttttaccagt
     4381 gttaaaacca gaaattggta ttttttaaaa tggtttgctt cacatattta agagttttct
     4441 ttctgtcatt tatgaagaat aaggaatgta ttatggaaaa gagggtgatc ttaagcaacc
     4501 ctgtaaaaaa tggtaaagat ttttactcag tgtgtgctga aacactaaat taaactagct
     4561 tacaaaaagg aaacacggac catggttaaa gaaaaaggca attattaatg ctcaggtgtg
     4621 aaaactaaag ttgaaaattt tttttctagt tgtgtctcat gaagataagc ccccatgtat
     4681 ttaaacagat ggcttttgaa aaatcacctt gtttcctgga aattactatt aactatagga
     4741 aaagatagta taaatattct aagattgatt gttatatttg acccaatttt tagaatcacc
     4801 tgttttttcc tattttaaat caagggaaca ttatttacta gttctcttca gtacatagca
     4861 gggtactaaa atcataccct gaattttttt taattgagaa aagtaataga attttaaata
     4921 tagaaatatg agaattttaa agtaatatat tgattaaaga tcactgatga tatagatata
     4981 atatatcata acagaaggaa agtaaatgga cttgagctta acttctcacc ctggaattat
     5041 tagtgggtga agaggggaat cattagcatt ctgggcgttt ttatattaaa tgttttgtga
     5101 atatgccaga agatctgcct tcaacttgta attaggcaag atagtaatgc ttgatggtaa
     5161 cttctatgtt tgtgtagaaa taataccagt tagttttgga aagccattca gatccattca
     5221 aaaattccat aaagtatgat gtatgctttg gaagagggat atgagtgata caattgttat
     5281 ataaatggaa tagacaaacc atttgaatgc atttttctag ggcaaacatt ttttgagatt
     5341 tttgagttaa gaagattttt cggcttgagc agaagatgtg tttgttttgc atttttcagc
     5401 tccaaggaaa cagcccccat ggctttaaaa ggccctgaag ttcagatagt agtaggtagt
     5461 gttttgttat tgttttaatt tgagagttgc aggaataatg ggcagagctg tcatttgccg
     5521 gtaggctacc atctgcctac atagaattat tggactgtaa gctaaaacag actgtaaaag
     5581 acctacttgc taaagcattg cttattcagt ggtattcagt agataagatc tatttcctga
     5641 tatattgtgc tcaagttatt tgcacatctt aagaaacttt taatatctaa aaccattgtt
     5701 gtaagattta ggtagaggag gtttcctttt gtgtgatgca taataataga aaacactgat
     5761 acagtgttta ctatgtgcca agcaagcata tgataactaa ttcttaacaa ctctatgagg
     5821 cagggtcatt tattatcctg ttgtcatatg aggaaatctc gccagagaga agttaattaa
     5881 cctgcccaag gtcgtatagt tagtaaagtg gtcatgcttg gattttaacc taggcagatt
     5941 acttcagagt cagcgtctgc cttactatcc tgtttcctga gcaggaattt ccccttgtgt
     6001 caggcaacac taggtgttag gagtggaggt gtgcagatgt tgccttacat tctgttttcc
     6061 tgatgtggtg tgcttcctaa gagtacaaac ctgagcatat gtccaggctt gcaaagtctc
     6121 aggcaaagct gggactaagg cttgtgtttc ctgccttggg taggattttc ttctatgcat
     6181 gttgggtgct tctcacttaa cctaatagta tgccttgtct gttttccccc cttccccttt
     6241 ttgtttaaat tgattcacag aacacaaaaa tttactaggt atgaacattt gaaaaaatgg
     6301 aatagagaaa atggtacatc acatgtaata aagataaata ttgttttgtg aaatgtcttt
     6361 ttcaatcata aatatgtgtt gtgtgctata taaaactatt tcttattgtg ga
//
