LOCUS       NM_001308237            4919 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger ZZ-type containing 3 (ZZZ3), transcript
            variant 2, mRNA.
ACCESSION   NM_001308237 XM_005270728
VERSION     NM_001308237.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4919)
  AUTHORS   Lo Conte,M., Lucchino,V., Scalise,S., Zannino,C., Valente,D.,
            Rossignoli,G., Murfuni,M.S., Cicconetti,C., Scaramuzzino,L.,
            Matassa,D.S., Procopio,A., Martello,G., Cuda,G. and Parrotta,E.I.
  TITLE     Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway in human
            embryonic stem cells homeostasis
  JOURNAL   Stem Cell Reports 19 (5), 729-743 (2024)
   PUBMED   38701777
  REMARK    GeneRIF: Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway
            in human embryonic stem cells homeostasis.
REFERENCE   2  (bases 1 to 4919)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4919)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4919)
  AUTHORS   Mi,W., Zhang,Y., Lyu,J., Wang,X., Tong,Q., Peng,D., Xue,Y.,
            Tencer,A.H., Wen,H., Li,W., Kutateladze,T.G. and Shi,X.
  TITLE     The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated
            histone acetylation and gene activation
  JOURNAL   Nat Commun 9 (1), 3759 (2018)
   PUBMED   30217978
  REMARK    GeneRIF: Study identifies the ZZ domain of ZZZ3 as a histone H3
            reader that is required for the ATAC complex-mediated maintenance
            of histone acetylation and gene activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4919)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 4919)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   7  (bases 1 to 4919)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 4919)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 4919)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   10 (bases 1 to 4919)
  AUTHORS   Guelman,S., Suganuma,T., Florens,L., Swanson,S.K., Kiesecker,C.L.,
            Kusch,T., Anderson,S., Yates,J.R. 3rd, Washburn,M.P., Abmayr,S.M.
            and Workman,J.L.
  TITLE     Host cell factor and an uncharacterized SANT domain protein are
            stable components of ATAC, a novel dAda2A/dGcn5-containing histone
            acetyltransferase complex in Drosophila
  JOURNAL   Mol Cell Biol 26 (3), 871-882 (2006)
   PUBMED   16428443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035079.2, BC035818.2, AC093575.2, BX640658.1 and CA448091.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001308237.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, lacks an alternate exon in the 5' coding region, and
            initiates translation at an alternate start codon, compared to
            variant 1. The encoded isoform (2) has a distinct N-terminus and is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.4035497.1, BC035079.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-769               BC035079.2         22-790
            770-2830            BC035818.2         1838-3898
            2831-3918           AC093575.2         14472-15559
            3919-4236           BX640658.1         3501-3818
            4237-4919           CA448091.1         18-700              c
FEATURES             Location/Qualifiers
     source          1..4919
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4919
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="zinc finger ZZ-type containing 3"
                     /db_xref="GeneID:26009"
                     /db_xref="HGNC:HGNC:24523"
                     /db_xref="MIM:619892"
     exon            1..137
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..271
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..334
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..488
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..1695
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger, ZZ domain containing 3; ATAC component 1 homolog;
                     ZZ-type zinc finger-containing protein 3"
                     /codon_start=1
                     /product="ZZ-type zinc finger-containing protein 3 isoform
                     2"
                     /protein_id="NP_001295166.1"
                     /db_xref="CCDS:CCDS76172.1"
                     /db_xref="GeneID:26009"
                     /db_xref="HGNC:HGNC:24523"
                     /db_xref="MIM:619892"
                     /translation="MIDLWLYSYQRLLQTIAVLEAQRSQAVQDLESLGRHQREALKNP
                     IGFVEKLQKKADIGLPYPQRVVQLPEIVWDQYTHSLGNFEREFKNRKRHTRRVKLVFD
                     KVGLPARPKSPLDPKKDGESLSYSMLPLSDGPEGSSSRPQMIRGRLCDDTKPETFNQL
                     WTVEEQKKLEQLLIKYPPEEVESRRWQKIADELGNRTAKQVASRVQKYFIKLTKAGIP
                     VPGRTPNLYIYSKKSSTSRRQHPLNKHLFKPSTFMTSHEPPVYMDEDDDRSCFHSHMN
                     TAVEDASDDESIPIMYRNLPEYKELLQFKKLKKQKLQQMQAESGFVQHVGFKCDNCGI
                     EPIQGVRWHCQDCPPEMSLDFCDSCSDCLHETDIHKEDHQLEPIYRSETFLDRDYCVS
                     QGTSYNYLDPNYFPANR"
     exon            489..627
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..775
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..891
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..963
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1065
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1161
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1314
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1449
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1550
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..4919
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2798..2803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="hexamer: AATAAA"
     polyA_site      2830
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="major polyA site"
     regulatory      4840..4845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="hexamer: GATAAA"
     polyA_site      4860
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
     regulatory      4896..4901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
                     /note="hexamer: TATAAA"
     polyA_site      4919
                     /gene="ZZZ3"
                     /gene_synonym="ATAC1"
ORIGIN      
        1 acctggaagc gccgcggcgc cgctatcgag cttcctgcag cggtggccac ccgagcaagt
       61 gccgtggcgg gggcggagag cggccacggc ggcggcgcct ccccaagtgg cccgttgcgt
      121 ccgaccccgc gtgaaagata tcaagttatt ctagtacaac catataaata aataatacct
      181 gaagtctcag tgtaacatgg acaattaaca gtgatgacag ataaatacag acgcatgggg
      241 atcaaatact aggcaaaacg ctttttaaaa gtgtatcagg cttttaagaa acactgcagg
      301 atcctgtcta tcttaatgct gatagagctc agctaaaaat ttaggaggtt ctagtattct
      361 tcatggctga agctgagaga gtctgaaacc ctgatgctta agctccattc tagatcatag
      421 ctccaactcc ttcaggatat aaggaaaaga gattatattt ccacaatgat agatctttgg
      481 ttgtacagtt atcagagact attacagacg attgctgtac tcgaggctca gcgttctcaa
      541 gcagtccaag accttgaaag tttaggcagg caccagagag aagcactgaa aaatcccatt
      601 ggatttgtgg aaaaactcca gaagaaggct gatattgggc ttccatatcc acagagagtt
      661 gttcaattgc ctgagatcgt atgggaccaa tatacccata gccttgggaa ttttgaaaga
      721 gaatttaaaa atcgtaaaag acatactaga agagttaagc tagtttttga taaagtaggt
      781 ttacctgcta gaccaaaaag tcctttagat cctaagaagg atggagagtc cctttcatat
      841 tctatgttgc ctttgagtga tggtccagaa ggctcaagca gtcgtcctca gatgataaga
      901 ggacgcttgt gtgatgatac caaacctgaa acatttaacc agttgtggac tgttgaagaa
      961 cagaaaaagc tggaacagct actcatcaaa taccctcctg aagaagtaga atctcgacgc
     1021 tggcagaaga tagcagatga attgggcaac aggacagcaa aacaggttgc cagccgagta
     1081 cagaagtatt tcataaagct aactaaagct ggcattccag taccaggcag aacaccaaac
     1141 ttatatatat actccaaaaa gtcttcaaca agcagacgac agcaccctct taataagcat
     1201 ctctttaagc cttccacttt catgacttca catgaaccgc cagtgtatat ggatgaagat
     1261 gatgaccgat cttgttttca tagccacatg aacactgctg ttgaagatgc atcagatgac
     1321 gaaagtattc ctatcatgta taggaattta cctgaatata aagaactatt acagtttaaa
     1381 aagttaaaga agcagaaact tcagcaaatg caagctgaaa gtggatttgt gcaacatgtg
     1441 ggctttaagt gtgataactg tggcatagaa cccatccagg gtgttcggtg gcattgccag
     1501 gattgtcctc cagaaatgtc tttggatttc tgtgattctt gttcagactg tctacatgaa
     1561 acagatattc acaaggaaga tcaccaatta gaacctattt ataggtcaga gacattctta
     1621 gacagagact actgtgtgtc tcagggcacc agttacaatt accttgaccc aaactacttt
     1681 ccagcaaaca gatgacatgg aagagaacat catttactag tcctcttcaa cacatagcaa
     1741 tggtatcatt gttaattatg tgcacagttt ggaaagattc tctgctttcc cagaaatgac
     1801 actcacagca tgagagcttc ctgagtgttc tcgtcaagta cagctctgca ccgttgtggc
     1861 tctagatcac tgttcagcag ctgaacattc ctggtgagca aaggtttccc tggtgaattt
     1921 ttcaccactg cgttttaggt ggtgatctta aatgggtgag atggaacgag agcacacatt
     1981 aaagagagag taaattccaa aggtttcaaa gaacttggtc ataaatatga taatgagaag
     2041 acaaagtatt tatattaaaa cagtttagta gccttcagtt ttgtgaaaat agttttcagc
     2101 acagaaactg acttctttag acaaagtttt aaccaatgat ggtgtttgct tctaggatat
     2161 acactttaaa agaactcact gtcccagtgg tggtcattga tggcctttag taaattggag
     2221 ctgcttaatc atattgatat ctaatttctt ttaaccacaa tgaattgtcc ttaattacca
     2281 acagtgaagc actacaggag gcaactgtgg cattgcttcc ttaaccagct catggtgtgt
     2341 gaatgttata aaattgtcac tcagatatat tttttaaatg taatgttata taagatgatc
     2401 atgtgatgtg tacaaactat ggtgaaaagt gccagtggta gtaactgtgt aaagtttcta
     2461 attcacaaca ttaattcctt taaaatacac agccttctgc ctctgtattt ggagttgtca
     2521 gtacaactca tcaaagaaaa ctgcctaata taaaaatcat atatatggta ataatttccc
     2581 tcttttgtag tctgcacaag atccataaaa gattgtattt ttattactat ttaaacaagt
     2641 gattaaattt agtctgcaca gtgagcaagg gttcacatgc attcttttat actgctggat
     2701 tttgttgtgc atcatttaaa acattttgta tgtttcttct tatctgtgta tacagtatgt
     2761 tcttgaatga tgttcatttg tcaggagaac tgtgagaaat aaactatgtg gatactgtct
     2821 gtttatatta tagaatgctt gttgtgactt ccttttggtt agattttgga tttttttttt
     2881 taccagtgtt aaaaccagaa attggtattt tttaaaatgg tttgcttcac atatttaaga
     2941 gttttctttc tgtcatttat gaagaataag gaatgtatta tggaaaagag ggtgatctta
     3001 agcaaccctg taaaaaatgg taaagatttt tactcagtgt gtgctgaaac actaaattaa
     3061 actagcttac aaaaaggaaa cacggaccat ggttaaagaa aaaggcaatt attaatgctc
     3121 aggtgtgaaa actaaagttg aaaatttttt ttctagttgt gtctcatgaa gataagcccc
     3181 catgtattta aacagatggc ttttgaaaaa tcaccttgtt tcctggaaat tactattaac
     3241 tataggaaaa gatagtataa atattctaag attgattgtt atatttgacc caatttttag
     3301 aatcacctgt tttttcctat tttaaatcaa gggaacatta tttactagtt ctcttcagta
     3361 catagcaggg tactaaaatc ataccctgaa ttttttttaa ttgagaaaag taatagaatt
     3421 ttaaatatag aaatatgaga attttaaagt aatatattga ttaaagatca ctgatgatat
     3481 agatataata tatcataaca gaaggaaagt aaatggactt gagcttaact tctcaccctg
     3541 gaattattag tgggtgaaga ggggaatcat tagcattctg ggcgttttta tattaaatgt
     3601 tttgtgaata tgccagaaga tctgccttca acttgtaatt aggcaagata gtaatgcttg
     3661 atggtaactt ctatgtttgt gtagaaataa taccagttag ttttggaaag ccattcagat
     3721 ccattcaaaa attccataaa gtatgatgta tgctttggaa gagggatatg agtgatacaa
     3781 ttgttatata aatggaatag acaaaccatt tgaatgcatt tttctagggc aaacattttt
     3841 tgagattttt gagttaagaa gatttttcgg cttgagcaga agatgtgttt gttttgcatt
     3901 tttcagctcc aaggaaacag cccccatggc tttaaaaggc cctgaagttc agatagtagt
     3961 aggtagtgtt ttgttattgt tttaatttga gagttgcagg aataatgggc agagctgtca
     4021 tttgccggta ggctaccatc tgcctacata gaattattgg actgtaagct aaaacagact
     4081 gtaaaagacc tacttgctaa agcattgctt attcagtggt attcagtaga taagatctat
     4141 ttcctgatat attgtgctca agttatttgc acatcttaag aaacttttaa tatctaaaac
     4201 cattgttgta agatttaggt agaggaggtt tccttttgtg tgatgcataa taatagaaaa
     4261 cactgataca gtgtttacta tgtgccaagc aagcatatga taactaattc ttaacaactc
     4321 tatgaggcag ggtcatttat tatcctgttg tcatatgagg aaatctcgcc agagagaagt
     4381 taattaacct gcccaaggtc gtatagttag taaagtggtc atgcttggat tttaacctag
     4441 gcagattact tcagagtcag cgtctgcctt actatcctgt ttcctgagca ggaatttccc
     4501 cttgtgtcag gcaacactag gtgttaggag tggaggtgtg cagatgttgc cttacattct
     4561 gttttcctga tgtggtgtgc ttcctaagag tacaaacctg agcatatgtc caggcttgca
     4621 aagtctcagg caaagctggg actaaggctt gtgtttcctg ccttgggtag gattttcttc
     4681 tatgcatgtt gggtgcttct cacttaacct aatagtatgc cttgtctgtt ttcccccctt
     4741 cccctttttg tttaaattga ttcacagaac acaaaaattt actaggtatg aacatttgaa
     4801 aaaatggaat agagaaaatg gtacatcaca tgtaataaag ataaatattg ttttgtgaaa
     4861 tgtctttttc aatcataaat atgtgttgtg tgctatataa aactatttct tattgtgga
//
