LOCUS       NM_015113              11466 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger ZZ-type and EF-hand domain containing 1
            (ZZEF1), mRNA.
ACCESSION   NM_015113 XM_001127649 XM_001719617 XM_001723898
VERSION     NM_015113.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11466)
  AUTHORS   Yu,Y., Tencer,A., Xuan,H., Kutateladze,T.G. and Shi,X.
  TITLE     ZZEF1 is a Histone Reader and Transcriptional Coregulator of
            Kruppel-Like Factors
  JOURNAL   J Mol Biol 433 (2), 166722 (2021)
   PUBMED   33227311
REFERENCE   2  (bases 1 to 11466)
  AUTHORS   McGrath,L.M., Cornelis,M.C., Lee,P.H., Robinson,E.B., Duncan,L.E.,
            Barnett,J.H., Huang,J., Gerber,G., Sklar,P., Sullivan,P.,
            Perlis,R.H. and Smoller,J.W.
  TITLE     Genetic predictors of risk and resilience in psychiatric disorders:
            a cross-disorder genome-wide association study of functional
            impairment in major depressive disorder, bipolar disorder, and
            schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (8), 779-788 (2013)
   PUBMED   24039173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087292.14, AB007859.4, AK127482.1, BC047285.1 and BC067099.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015113.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151836.1, AB007859.4 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381638.7/ ENSP00000371051.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC087292.14        130011-130081       c
            72-1613             AB007859.4         1-1542
            1614-1850           AK127482.1         1604-1840
            1851-3010           AB007859.4         1780-2939
            3011-3369           AK127482.1         3004-3362
            3370-5000           AB007859.4         3299-4929
            5001-5018           BC047285.1         322-339
            5019-6049           AB007859.4         4948-5978
            6050-7347           BC047285.1         1241-2538
            7348-11466          BC067099.1         35-4153
FEATURES             Location/Qualifiers
     source          1..11466
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..11466
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /note="zinc finger ZZ-type and EF-hand domain containing
                     1"
                     /db_xref="GeneID:23140"
                     /db_xref="HGNC:HGNC:29027"
                     /db_xref="MIM:619459"
     exon            1..489
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..9021
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /note="zinc finger, ZZ-type with EF hand domain 1"
                     /codon_start=1
                     /product="zinc finger ZZ-type and EF-hand
                     domain-containing protein 1"
                     /protein_id="NP_055928.3"
                     /db_xref="CCDS:CCDS11043.1"
                     /db_xref="GeneID:23140"
                     /db_xref="HGNC:HGNC:29027"
                     /db_xref="MIM:619459"
                     /translation="MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPAL
                     PPAAALLEPARLREAAAALLPTPPCESLVSRHRGALFRWLEERLGRGEESVTLEQFRE
                     LLEARGAGCSSEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQ
                     ACSLVPGFTDIFSESKEGLDIHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSV
                     LKESLDQLVQKEKESPGDLTRSPEMDKLKSVAKCYAYIETSSNSADIDKMTNGETSSY
                     WQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDV
                     HIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVS
                     DASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALRHMPPLSLSPGSTDFSTFLSP
                     NVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASS
                     LILSMASVRQNLLLKYGKPLQLTLQACDVKGKEDKSGPENLLVEPWTRDGFLTETGKT
                     RASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYNSSSDKFCAEEHFKRFEKYD
                     KWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFL
                     CTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCRKDTEESVCGATLLLRTLQFI
                     QQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQNPREECVSAQTLLLQLLQ
                     SCFSVLQGDVLAASEEEKAPIQSPKGVEAAKELYTHLCDVVDKVDGDSVPMEILKQEV
                     RNTLLNGAAIFFPNRQTRRNHLFTMMNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLL
                     LPEKNDLAKMNISEVLAVMDTLVSVAARECELLMLSGAPGEVGSVLFSLFWSVQGSLL
                     SWCYLQLKSTDSGAKDLAVDLIEKYVGQFLASMRAILESLFSQYSGKTIVERLCNSVF
                     SMAARQLVIFLLDFCTLDIPHCVLLREFSVLTELLKKLCSGPEGGLRKLDVETWQQEQ
                     PVVLHTWTKESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEFTDARGR
                     KTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGLPDVAVSWGL
                     DLQLLVSRLMGRLASQCMALKSVRQLGSNMVVPQAKMALVLSSPLWKPVFRHQVCPEL
                     ELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRK
                     QAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALSEEFAQVYSLA
                     DGIRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPESLAKECIEKSLLLLKFLPTGIS
                     SKESCEKLETADETSHLQPLNKRQRTSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQ
                     PKLPSSSGLPAADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKE
                     KYPVLKDVMDFIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQHCAESLGQPHCFHP
                     PFILFLLELLTCQKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDR
                     SLLPALSCVQTALLHLLDMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSE
                     EDELADAKQNSEWMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCD
                     GCDEIAPWHRYRCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGR
                     RMNCNVCDDFDLCYGCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSW
                     LLFAALALYSAHLASAEDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKA
                     LALLGVLPDGDSSLEDQALPVTVPTGASEEQLEKKAVQGAELSEAGNGKRAVHEEIRP
                     VDFKQRNKADKGVSLSKDPSCQTQISDSPADASPPTGLPDAEDSEVSSQKPIEEKAVT
                     PSPEQVFAECSQKRILGLLAAMLPPLKSGPTVPLIDLEHVLPLMFQVVISNAGHLNET
                     YHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDSSIVPDGWKTTHLLFSLGA
                     VCLDSRVGLDWACSMAEILRSLNSAPLWRDVIATFTDHCIKQLPFQLKHTNIFTLLVL
                     VGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQK
                     GGGQECGDSRAQLSQYSQHFAFIASHLLQSSMDSHCPEAVEATWVLSLALKGLYKTLK
                     AHGFEEIRATFLQTDLLKLLVKKCSKGTGFSKTWLLRDLEILSIMLYSSKKEINALAE
                     HGDLELDERGDREEEVERPVSSPGDPEQKKLDPLEGLDEPTRICFLMAHDALNAPLHI
                     LRAIYELQMKKTDYFFLEVQKRFDGDELTTDERIRSLAQRWQPSKSLRLEEQSAKAVD
                     TDMIILPCLSRPARCDQATAESNPVTQKLISSTESELQQSYAKQRRSKSAALLHKELN
                     CKSKRAVRDYLFRVNEATAVLYARHVLASLLAEWPSHVPVSEDILELSGPAHMTYILD
                     MFMQLEEKHEWEKILQKVLQGCREDMLGTMALAACQFMEEPGMEVQVRESKHPYNNNT
                     NFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSGSQQKWKDFEL
                     PGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVPHLPLAKIW
                     EWLVGVACRQTGHQRLKAIHLLLRIVRCCGHSDLCDLALLKPLWQLFTHMEYGLFEDV
                     TQPGILLPLHRALTELFFVTENRAQELGVLQDYLLALTTDDHLLRCAAQALQNIAAIS
                     LAINYPNKATRLWNVEC"
     exon            490..634
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            635..829
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1001
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1201
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1412
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1529
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1708
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1807
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1899
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2048
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2160
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2376
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2477
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2647
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2781
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2849
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2964
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3124
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3246
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3369
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3536
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3618
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3820
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3969
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..4210
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4290
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4384
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            4385..4853
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            4854..5018
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            5019..5138
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            5139..5300
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            5301..5430
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            5431..5569
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            5570..5735
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            5736..5998
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            5999..6150
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            6151..6301
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            6302..6441
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            6442..6719
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            6720..6894
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            6895..7027
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            7028..7227
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            7228..7347
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            7348..7539
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            7540..7640
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            7641..7776
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            7777..8136
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            8137..8280
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            8281..8449
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            8450..8548
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            8549..8714
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            8715..8868
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            8869..8940
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     exon            8941..11466
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9870..9875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /note="hexamer: AGTAAA"
     polyA_site      9891
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /note="major polyA site"
     regulatory      11435..11440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /note="hexamer: AATATA"
     polyA_site      11466
                     /gene="ZZEF1"
                     /gene_synonym="ZZZ4"
                     /note="major polyA site"
ORIGIN      
        1 aggaagccgg aagccgcagg ggccgccgtc gtctcctccg cgtccccgcc cgccagctgc
       61 tgtcggaggt tgacaggtcg aggcggggag gcggcggcgg cggctgcaga gccaggcgcc
      121 caagacggag accccatggg gaacgctccg agtcacagca gtgaagacga agcggcagct
      181 gccggtggcg agggctgggg cccacaccag gactgggccg cggtctcggg cacgaccccc
      241 ggcccgggcg tcgcggctcc agcgctacca cccgccgcgg cgctgctgga gccggccagg
      301 ctgcgagagg ctgctgcagc gttgctgccc acacccccct gcgagtcgct ggtgtcgagg
      361 catcgcggcg cgttgtttcg ctggctggaa gagcggctgg gccgcggcga agagtctgtc
      421 actctggagc agttccggga gctgctggag gctcgcggcg ccggctgctc tagcgagcag
      481 ttcgaggagg cctttgccca gtttgatgct gagggtgatg ggacagttga tgccgagaac
      541 atgttggagg ccctcaagaa ttccagtgga gctaatcttc agggggagct gagccacatc
      601 atcagacaac tacaggcctg ctctctggtt ccaggtttca cagacatatt ttcagagtcg
      661 aaggagggcc ttgatattca ctcgtcaatg atactgcgct tcctgcaccg caatcggctc
      721 tccagcgcgg tgatgcccta cccgatgctg gagcactgca ataacatgtg caccatgcgg
      781 tcttccgtcc tgaaggagtc tctggatcag ctggtacaaa aggaaaagga aagccctgga
      841 gatctaacta gaagtccaga gatggataaa ctcaagtcag tagcaaagtg ctatgcttat
      901 atagaaacat cctccaactc ggcagacatt gacaagatga caaatggaga aacctcatcc
      961 tactggcagt cagatggcag tgcctgttca cactggattc gtttaaaaat gaagccagat
     1021 gttgtgctta ggcacctgtc cattgcagtg gctgccactg accagagcta catgccacag
     1081 caggtgacag tagctgtagg gaggaatgcc agcgatcttc aggaagtccg agatgtgcac
     1141 atccccagca atgtcactgg ctatgtgacg ctgctggaaa atgccaacgt cagtcagctc
     1201 tatgtccaga ttaacataaa gcgttgtctt agcgatggct gcgacactag aattcatggt
     1261 ctcagggctg ttggctttca gagagttaag aagtctgggg tctcagtctc agatgcttct
     1321 gcaatatggt attggtctct gctgacatct ctggtgacgg cttctatgga gacaaatccc
     1381 gcctttgtcc agacagtgct gcacaatact cagaaggcgc tgcggcacat gcctccactc
     1441 tctctctcac caggatctac agatttctca actttcctct cccctaatgt gctggaagaa
     1501 gtggacagtt tcctcataag gataactagc tgctgttcta ccccagaggt agaactgact
     1561 cttctggctt ttgctctcgc aagaggaagt gttgccaaag tcatgagctc tctatgcacc
     1621 atcactgacc atctggacac gcagtatgat gcctcatccc tcatcttgtc catggcgtca
     1681 gtcagacaga acctgctcct caaatatggt aaacctctcc agttgactct tcaggcatgt
     1741 gatgtcaaag gaaaagaaga taagtctgga cccgaaaacc tccttgttga accgtggaca
     1801 agggatggtt ttcttacgga aactggaaaa accagagcca gcactatttt ttctaccgga
     1861 actgaatctg ccttccaagt tacacagata agaattatgg ttcgacgtgg tggcattggt
     1921 gcccagtgtg ggttggtgtt tgcctataac tcatcttcag ataaattttg tgcggaagaa
     1981 cacttcaaaa ggtttgaaaa atatgacaaa tggaagcttc aggagctcag gcaatttgta
     2041 aaaagcagga ttggttgctc atctgatgac cttggagagg atgatcctat tggctggttt
     2101 gaactggaag aagaatggga tgaagcagat gtgaagctgc aacagtgcag agttgccaaa
     2161 tatttgatgg tgaagttcct ctgcacccgt caggagtcag cagagcgctt gggagtgcaa
     2221 ggcttgacca tcagtgggta cctccggcct gcaagagcag aagcagaaca gagcgtcacc
     2281 tgtgcacact gcagaaagga cacagaggag agtgtctgtg gggccacgtt gctcctcagg
     2341 acccttcagt ttatccagca gctcgcccat gacctggtgc agcagaagga aagtggctta
     2401 aaatataaat cttttctgga cttcgcgggt cttgatttgc agatcttctg gaatttttac
     2461 agtaaattaa agcaaaaccc gagggaagaa tgcgtctctg cccaaaccct gcttctgcag
     2521 ctactccaga gctgcttctc tgtgctgcag ggagatgtac tggctgcttc tgaggaggaa
     2581 aaggctccaa tccaaagccc taaaggagta gaggctgcca aggagctgta cacacacttg
     2641 tgtgatgtgg tggacaaggt ggatggagac tctgtgccca tggagatact aaaacaagaa
     2701 gtcaggaata cccttctcaa tggggctgcc atcttctttc ctaatcgaca gacccgacgg
     2761 aaccatctct tcaccatgat gaatgtcacc gagcaggagc acaagcagtc cctgcagctc
     2821 actttccgtt cactgtgcac gtattttagt gacaaggatc caggcggcct tcttctttta
     2881 cctgagaaga acgacctggc caagatgaac atcagtgaag tcctggcggt catggacact
     2941 ctcgtctctg ttgctgctcg agagtgcgag ctgttaatgc tcagtggggc cccaggggag
     3001 gtgggctctg tgctcttctc cctgttctgg tccgtccaag gcagcctgct atcctggtgc
     3061 tacctgcagc tgaagagcac ggactctgga gccaaagatc ttgccgtgga ccttattgaa
     3121 aaatatgtgg gccagtttct ggcaagcatg agagcgattt tggaatccct tttctcacag
     3181 tacagtggaa aaaccatagt agaaagatta tgtaactcag tgttttcaat ggcagctcgt
     3241 caactggtta tcttcctgct ggacttctgc actttagaca tcccacactg cgtgctcttg
     3301 agagagttca gcgtcctcac agaactcctg aagaagctct gtagtggccc cgaaggagga
     3361 ctgaggaagc tggatgttga gacctggcaa caggaacagc ctgtggtgtt acatacgtgg
     3421 acgaaggaat ctgcccacaa ctatgaaaat aattgccatg aggtatccgt ctttgttagc
     3481 ccaggggcaa cctattttga agtggaattc gatgacaggt gtgaaactga aaaaaggtat
     3541 gattatctgg aatttaccga cgctagaggt cggaaaacac gctatgacac aaaagttggc
     3601 actgataaat ggcccaagaa agtgaccttc aaggccggtc ctcggttgca gttcctcttt
     3661 cactctgaca gcagtcacaa cgaatggggc tacaaattca ctgtcactgc ctgtgggctg
     3721 cccgatgttg ccgtgtcttg ggggctggat ttacagctcc tcgtctcccg gctgatggga
     3781 cgcctggctt cccagtgcat ggcgctcaag tctgtgcgcc agttaggaag taacatggta
     3841 gtacctcagg caaaaatggc attagtccta agctccccac tgtggaaacc tgtcttcagg
     3901 catcaggttt gtccagagtt ggaattagaa gcaagctggc ccactcaccc acaccggaat
     3961 agtaaggagg ttaagaacat tcctgacgac ccctgccgcc attttcttct tgattttgcc
     4021 cagtcagagc ctgctcagaa cttctgtggg ccatattcag aacttttcaa aggattcata
     4081 caggcatgta gaaaacaggc cccaaagaca gatatagttg ctggttccac tattgatcaa
     4141 gctgtgaacg ccacctttgc tgctctggtg tatcgcactc cagatttata tgagaagctg
     4201 caaaaatatg tcaacagtgg gggcaaaata gccctgagtg aagagtttgc ccaggtttat
     4261 tccttggcag atgggattcg aatatggatg ttagagatga agcagaagtc cctgatgagc
     4321 ctggggaatg aagcagaaga aaaacatagt tcagaagcta ctgaggtgaa ccctgagagc
     4381 ctggcaaaag agtgcattga gaagagtctt ctattactaa aatttctgcc cacgggcata
     4441 agttcaaaag aaagctgcga aaagttggag actgctgatg aaaccagtca tctccagcca
     4501 ctcaacaagc gtcagaggac aagctctgtg gtggaagagc atttccaagc ctcagtatct
     4561 cccactgaag ccgcaccccc tgccacagga gaccagagtc ctggcctggg cacccagcca
     4621 aagctgccat ccagcagtgg ccttcctgct gcagacgtgt cccctgccac agctgaagag
     4681 cccttgtcac cttccacacc cacccgccgg cctcccttca cccgagggcg actccggctg
     4741 ctctcctttc gatccatgga ggaggccaga ctggtgccca cagtgaaaga gaaataccct
     4801 gtgctgaagg acgtcatgga cttcattaag gatcagtcgc tctcgcacag gagtgttgtg
     4861 aaggttcttt ccctgaggaa agcccaggcc cagagcatcc tggaagtcct gaagataact
     4921 cagcactgtg cagaatccct tgggcagccc cactgcttcc atccaccttt catacttttc
     4981 ctgttggaac ttctgacctg tcagaaagat tttaccaatt attttggaca cctggaaggc
     5041 tgtggtgctg atctacacaa agaaattcga gacacttact atcaacttgt tctgtttttg
     5101 gtcaaagcag ttaaaggatt tagtagccta aatgacaggt ccttgctccc tgccttatcc
     5161 tgtgttcaga cagccctgct tcatcttttg gatatgggct gggaacccaa tgatctcgcc
     5221 ttctttgttg atattcagtt accagatctc ctcatgaaaa tgtcacagga gaatataagt
     5281 gtccatgaca gtgtgatcag ccaatggagt gaagaagatg agcttgctga tgccaagcag
     5341 aattcagaat ggatggatga gtgtcaggat ggcatgtttg aggcctggta tgaaaaaata
     5401 gcccaggaag atccagagaa gcagaggaaa atgcacatgt tcattgctcg ctactgtgac
     5461 ctgttaaatg tggacatctc ttgtgatggg tgtgatgaga ttgccccctg gcatcgatac
     5521 cgctgtctgc agtgcagcga catggatctc tgcaaaactt gcttcctagg tggggtgaag
     5581 cctgagggcc acggagacga ccatgaaatg gtcaacatgg agtttacctg tgaccactgc
     5641 cagggtttga tcataggccg gaggatgaac tgcaatgttt gcgatgactt tgatctttgc
     5701 tacggatgct atgcagcgaa gaaatactcc tacggccatt tgcctaccca cagcatcacg
     5761 gcccacccaa tggtaaccat tcggatcagt gaccggcaga ggctcatcca gccatatatc
     5821 cataactact cctggctgct ctttgctgcc ctggctctct atagcgccca cctggccagt
     5881 gcagaggatg tggatgggga gaagctggac ccccagacgc gcagcagtgc caccaccctg
     5941 cggagccagt gcatgcagct cgtcggggac tgtctgatga aggctcatca gggaaaaggc
     6001 cttaaagctc tagctttgct gggtgtattg ccagatgggg actcgagcct agaagatcag
     6061 gccctaccag tcactgtgcc caccggagcg tcagaggagc agctagagaa gaaagctgtc
     6121 cagggtgctg agctgtcaga agcaggcaat ggaaagagag ctgttcatga ggaaatcaga
     6181 cctgtagatt tcaagcagag aaataaggca gataaaggtg tatcattatc gaaggatcct
     6241 tcatgccaga cccaaatttc agattcacct gcagatgcta gcccacctac aggacttcca
     6301 gatgctgaag attcagaagt gtcatctcag aagcccatag aggaaaaagc agttactcca
     6361 agccctgagc aagtgtttgc tgagtgttcc cagaagagga ttttgggatt actagcagcc
     6421 atgttacctc ccttaaagtc gggccccacg gttcccctga tagacctgga gcacgtcctt
     6481 ccactcatgt ttcaggttgt catctcaaac gcaggccacc tgaatgaaac ctaccatctc
     6541 accctgggtc ttctcggcca gttaattatc cgtcttttgc cagcagaggt agacgccgca
     6601 gtgatcaaag tcctctcagc caaacacaac ctgtttgctg caggggacag ttccattgtg
     6661 ccagatggct ggaaaaccac ccacctgctc tttagcctgg gagctgtgtg tctggacagc
     6721 cgggtgggct tggactgggc gtgctccatg gcagagatcc tgcggtcact caacagtgcc
     6781 ccactgtggc gtgatgtcat tgccaccttc acagaccact gcatcaagca gctgccattc
     6841 cagctgaagc acaccaacat cttcaccctg ctcgtgctgg ttggcttccc ccaggtcctc
     6901 tgtgtgggaa cccgctgcgt ttatatggat aatgccaatg aaccccataa tgtgatcatc
     6961 ttgaagcact ttactgagaa gaacagggct gtgattgttg atgtcaaaac tcggaagagg
     7021 aaaacagtga aggactacca gctggtccag aagggaggag gacaagagtg tggtgactct
     7081 cgggcccagc tgagccagta ctcccagcac tttgccttta tcgccagtca ccttctgcaa
     7141 agcagcatgg acagccattg tcccgaggca gtagaagcaa cttgggtcct gtccctggcc
     7201 ctgaaaggat tgtataaaac actaaaggct cacggttttg aggagatccg tgctactttc
     7261 cttcagaccg atttgctgaa gttgctggtg aaaaagtgca gcaaagggac tggctttagt
     7321 aaaacgtggc tcctccggga cctggaaatt ttgtccatca tgctgtactc ctcaaaaaag
     7381 gagatcaacg ctttggctga gcacggagac ctagagctgg atgagcgagg ggaccgagag
     7441 gaagaggtgg aacggccagt cagcagccct ggcgacccag agcagaaaaa gctggacccc
     7501 cttgagggcc tggatgagcc caccagaata tgtttcttga tggctcatga tgccctcaat
     7561 gcccctctgc acattctccg ggccatatac gaactgcaga tgaaaaagac cgattatttc
     7621 ttcctggagg ttcagaagag gtttgatggt gatgagctca ccacagatga aaggatacgg
     7681 tccctggctc agcggtggca gcccagtaag agtctgaggc tggaagaaca gagcgccaaa
     7741 gctgtggata cagacatgat tatcctgcca tgcttgtccc ggcctgcacg ctgtgaccaa
     7801 gccactgctg aatcgaaccc tgtgacccag aagctgatct ccagcacaga gagcgaactg
     7861 cagcagagct atgccaagca gcgccgtagc aagagcgccg ccctcctgca caaggagctg
     7921 aactgcaaga gtaagagggc tgtccgggac tacctcttcc gagtgaacga ggccacagct
     7981 gtcctgtacg cccgccacgt gcttgcatcc ctgctcgccg agtggcctag ccacgtgcca
     8041 gtgagcgagg acatcctgga gctcagtggc cctgcccata tgacctacat tttggatatg
     8101 ttcatgcagc tggaagaaaa gcatgagtgg gagaagatcc tgcagaaagt gctccagggc
     8161 tgccgagagg acatgctggg gaccatggcc ctggctgcat gccagttcat ggaggagcca
     8221 ggaatggagg tgcaagtgag ggagtcgaaa cacccgtata acaacaacac caacttcgag
     8281 gataaagttc acattcctgg tgccatctac ctctcaatca aattcgactc tcagtgcaac
     8341 acagaggagg gctgtgacga gttagccatg tccagcagca gtgacttcca gcaagaccga
     8401 cacagcttca gcgggtctca gcagaagtgg aaagattttg aacttccagg agacactctg
     8461 tattaccgct tcacctccga catgagcaac accgagtggg gctacagatt caccgtgacg
     8521 gccggacacc tggggcggtt ccagacagga ttcgagattt tgaagcagat gttgtcagaa
     8581 gaaagggtcg tgcctcatct cccattggca aaaatttggg aatggctggt gggcgtggcc
     8641 tgtcgccaga ctggccatca acgattaaaa gccatccact tacttctgag gattgtgcga
     8701 tgctgcggcc acagtgacct gtgtgacctt gcgctgttga agcccctgtg gcagctcttt
     8761 acccacatgg agtacggcct gtttgaggac gtgacgcagc ccggcatcct ccttcccctg
     8821 catcgtgccc tcactgagct cttcttcgtc accgagaacc gtgcccagga gcttggcgtg
     8881 ctgcaggatt acctgctggc cctaaccacg gacgaccacc ttctccgctg tgcggcacag
     8941 gctctgcaga acattgctgc catcagcctg gccatcaact acccaaacaa ggccacccgc
     9001 ctctggaatg tggagtgtta gcccttggtg gggcgtgcat gggactagtt catctgccac
     9061 agggatttta gagcagacat ctaacctcat tcaggaaaac tcctgtagcg ccagtgccca
     9121 gctctccttg agctgaccac tccagttagg atgccaagca gccacgtctc caagagctcc
     9181 cgtgcgtagg ctggacacaa gcacaggctg tagcatggtg aaaataagcc aagcagtgca
     9241 gaatgcctca gaaagggtgg gcagggggcc cttaagaagg ttcagagacc agccttctcc
     9301 agaggctgtc actgcaggag ccgtgggcct gggaagactt ggaagcggcc tctctcaact
     9361 ggtttctgtc tccgtggagc tggaactgcc tgcacttgcc ttcagaggga ggcacagtcc
     9421 acccagatcc acctttccag caagaccccc agtggctgcc cagcctggga gcacctcttt
     9481 gcttttcaca ccaaaccaaa actggcgaga gcccctccta gccaccagtg atccccaagc
     9541 atccagtaca gaaccaggca tcgagctagc tccctgcacg gccgcaccct cccagagaac
     9601 tccttgagga gaacaagtgc ccttggggac agccggcagg cgcccctgta cgtctgctca
     9661 tgcaccaggc agcacagccg cagttcctca gttgttgttt tgacatattt cagtttccac
     9721 ctcacgtttt tagagcagaa ccacactgtc tccctggagg ggctcgaggg catgaccggg
     9781 gactgaccat tctgtgaaag gagcagaatg tgaggagcac gcgtgagctt atgtaccgtg
     9841 aagatgatca gaggatatct tattttaaga gtaaaaaccc acataatttt atttctgctt
     9901 gatagtcatg gtagtctgtc atacccacct ctgggactct gcgtggctgt ttggctgtca
     9961 cttgtagcaa taacgacatt agttctagtc agtgctgttt tacatttttc ttttgatggg
    10021 tttagtcttg ccctggagtg ccgatgatga ttctccctcc agagccacgc ttgggaacat
    10081 gaagcaagtc tggcgtgtgg gctgcgtgcc ggccttagtg ggacccgtgg ggttggagca
    10141 tgcctttagg ggcagtgtct gggccgaagc acgtcccacc acacagtgcc agagccagag
    10201 aaggggcccc accaccaagg ccaagcttga ccaggtcagc attgccatgg cccagtgtgc
    10261 cccgtggcct ctgaagatcc ctctgtgcag ggtctgcagg gatctggatt gcaagggccc
    10321 aagtctgcag gtctggaagc atcttcctat aagagcactt tcgccttctg ggtcaggact
    10381 ccaaggtgca gcgggcttca cagccctaca attgggttct cagctaagcc ccagagttct
    10441 ggtagaacca tcccggggcg ggtggagggt gggatttaag ggagacggga acacatgggg
    10501 caggtcctgg aacttggtgg cctgaggact gaggccattg ccctggtgga aaggcctggc
    10561 ctggttcctg tggcttggga cctgaatagg caggtgctgc tggctccgta gaaacccttt
    10621 tcccatcttt tgctctttgc caaacctacc ttgctttggg agctgcctgc accaccccag
    10681 agaaggcccc accttcttca tccctcagac ccgaggaggc ctcccagtaa ggagtttccc
    10741 aagaggggac tcacaggaaa caagtcttag tgcttgggag ggaggccccg ctgcgtgctc
    10801 agactcacag ccaacctgga aggtagacga gatagcgcca cccacgcccc tccacacccc
    10861 agactccgag taaagcgggc ggtagggccg gagtcacctc ccctatggca gtggccgccg
    10921 ctgtactcca tcctcccgtc aggaagatca gctgtaaata aacgctgggc tccccagagc
    10981 acctgtccgc ccactgccct tgctgttctg ggatcttcgc tgcagttcac gggaaacaag
    11041 cctgagtccg ctcgcacccg cggctgctct cccggctcgg cccggccgcc tctgtctccg
    11101 gccaccgggt ggcgctgccg agccagagcc gccgcgtccc ggcgctttcc aggagcccca
    11161 ggcccggagg aggcgaagcc cgcagagcaa aggtggaaac acgtgcctac gctgtaaaga
    11221 aatcctgttc cagagcatac ctgttgtaca aacagacact gttcctaacg agaggagtga
    11281 cgtattttca tcaccgtttt taatttgttt tcttacgggt ttacgatttt gaatttttct
    11341 tatttggttg aaagaatttt gattctatca gcctgagtga gttcagcctg taaaaaggat
    11401 gttaagctgt gggtaaaata tgcaaacgaa aagaaatata ttgtacaaat tctatataat
    11461 aaggta
//
