LOCUS       NM_024646               8143 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zyg-11 family member B, cell cycle regulator (ZYG11B),
            mRNA.
ACCESSION   NM_024646 XM_038291
VERSION     NM_024646.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8143)
  AUTHORS   Duan,B., Zhang,H., Zhu,Z., Yan,X., Ji,Z. and Li,J.
  TITLE     LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes
            the chemoresistance of colorectal cancer cells by inducing
            autophagy
  JOURNAL   Anticancer Drugs 34 (7), 827-836 (2023)
   PUBMED   36847071
  REMARK    GeneRIF: LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B
            promotes the chemoresistance of colorectal cancer cells by inducing
            autophagy.
REFERENCE   2  (bases 1 to 8143)
  AUTHORS   Zhang,B., Li,Y., Feng,Q., Song,L., Dong,C. and Yan,X.
  TITLE     Structural insights into ORF10 recognition by ZYG11B
  JOURNAL   Biochem Biophys Res Commun 616, 14-18 (2022)
   PUBMED   35636250
  REMARK    GeneRIF: Structural insights into ORF10 recognition by ZYG11B.
REFERENCE   3  (bases 1 to 8143)
  AUTHORS   Fonseca,B.F. and Chakrabarti,L.A.
  TITLE     A close shave: How SARS-CoV-2 induces the loss of cilia
  JOURNAL   J Cell Biol 221 (7) (2022)
   PUBMED   35695891
  REMARK    GeneRIF: A close shave: How SARS-CoV-2 induces the loss of cilia.
REFERENCE   4  (bases 1 to 8143)
  AUTHORS   Yan,X., Li,Y., Wang,G., Zhou,Z., Song,G., Feng,Q., Zhao,Y., Mi,W.,
            Ma,Z. and Dong,C.
  TITLE     Molecular basis for recognition of Gly/N-degrons by CRL2ZYG11B and
            CRL2ZER1
  JOURNAL   Mol Cell 81 (16), 3262-3274 (2021)
   PUBMED   34214466
  REMARK    GeneRIF: Molecular basis for recognition of Gly/N-degrons by
            CRL2(ZYG11B) and CRL2(ZER1).
REFERENCE   5  (bases 1 to 8143)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 8143)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 8143)
  AUTHORS   Timms,R.T., Zhang,Z., Rhee,D.Y., Harper,J.W., Koren,I. and
            Elledge,S.J.
  TITLE     A glycine-specific N-degron pathway mediates the quality control of
            protein N-myristoylation
  JOURNAL   Science 365 (6448) (2019)
   PUBMED   31273098
REFERENCE   8  (bases 1 to 8143)
  AUTHORS   Balachandran,R.S., Heighington,C.S., Starostina,N.G.,
            Anderson,J.W., Owen,D.L., Vasudevan,S. and Kipreos,E.T.
  TITLE     The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in
            a conserved pathway that facilitates mitotic slippage
  JOURNAL   J Cell Biol 215 (2), 151-166 (2016)
   PUBMED   27810909
  REMARK    GeneRIF: the ubiquitin ligase CRL2(ZYG-11) redundantly targets the
            degradation of cyclin B1 in Caenorhabditis elegans and human cells.
REFERENCE   9  (bases 1 to 8143)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   10 (bases 1 to 8143)
  AUTHORS   Vasudevan,S., Starostina,N.G. and Kipreos,E.T.
  TITLE     The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a
            conserved family of CUL-2 complex components
  JOURNAL   EMBO Rep 8 (3), 279-286 (2007)
   PUBMED   17304241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099784.2, AK296460.1, AB051517.1 and AL139255.9.
            
            On Nov 22, 2018 this sequence version replaced NM_024646.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.209888.1,
                                           SRR1660803.11859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294353.7/ ENSP00000294353.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC099784.2         97052-97057         c
            7-62                AK296460.1         6-61
            63-63               AC099784.2         96995-96995         c
            64-3996             AB051517.1         8-3940
            3997-4316           AC099784.2         1-320               c
            4317-8143           AL139255.9         2001-5827
FEATURES             Location/Qualifiers
     source          1..8143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..8143
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /note="zyg-11 family member B, cell cycle regulator"
                     /db_xref="GeneID:79699"
                     /db_xref="HGNC:HGNC:25820"
                     /db_xref="MIM:618673"
     exon            1..231
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2436
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /note="zyg-11 homolog B"
                     /codon_start=1
                     /product="protein zyg-11 homolog B"
                     /protein_id="NP_078922.1"
                     /db_xref="CCDS:CCDS30717.1"
                     /db_xref="GeneID:79699"
                     /db_xref="HGNC:HGNC:25820"
                     /db_xref="MIM:618673"
                     /translation="MPEDQAGAAMEEASPYSLLDICLNFLTTHLEKFCSARQDGTLCL
                     QEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKAF
                     CHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSR
                     LSGLRALSITNVLFYNEDLAEVASLPRLESLDISNTSITDITALLACKDRLKSLTMHH
                     LKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGR
                     KHVTDKAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRY
                     SERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMRNHPMNLPVQLAASACVFNLTK
                     QDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAK
                     LVMQWLCNHEDQNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQN
                     SVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESFPTESSIQQKVLGLLN
                     NIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSRSQR
                     NSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNP
                     SRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILDSLEKHIVRHGRPPPCKKQPQ
                     ARLN"
     exon            232..397
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            398..1152
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1293
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1470
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1535
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1635
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1686
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1848
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1896
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2094
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2147
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2245
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..8143
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8124..8129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /note="hexamer: AATAAA"
     polyA_site      8143
                     /gene="ZYG11B"
                     /gene_synonym="ZYG11"
                     /note="major polyA site"
ORIGIN      
        1 ggagtctgcg ctctggttcg ggctgcggct gcggctgcgg ctgcggctgc tactgctacg
       61 ctcctagctt gagggaaaga ggccgaggcc tgggccaagc ccggagccgc cgctcgccgg
      121 agcctcctgg agcctccgcg ccggctcagc ctgggggcgg gctccggtcc ggcccgccgc
      181 cgcacccagg acggaggctg catgcccgag gaccaggccg gcgcagccat ggaggaggcg
      241 tctccctatt ccttacttga tatctgcttg aatttcttga ctactcacct tgagaagttc
      301 tgttcagcca gacaagatgg aacattgtgt ctgcaggaac ctggagtatt cccacaggag
      361 gtggctgatc gactgcttcg gaccatggct tttcatggtc tattgaatga tggaactgtg
      421 ggtattttta ggggcaacca gatgcgctta aagcgagcct gcattcgcaa agcaaagatc
      481 tctgctgttg ctttccggaa agctttctgc caccacaagt tagtggaact tgatgccaca
      541 ggtgtgaatg ctgatatcac gattacagac attatcagtg ggcttggcag taacaaatgg
      601 atccagcaga atctccagtg cctggtgctg aattcattaa ctctctccct cgaggatcct
      661 tacgagcgct gcttcagccg gctttctggc cttcgagctt taagcatcac gaatgttctc
      721 ttttacaatg aagacctggc tgaagttgcc tcattgccaa gattagagag cttggatatt
      781 tctaacacct caatcacaga catcactgct ctactggcct gcaaagaccg actcaagtct
      841 ctaaccatgc accacttgaa atgtttaaaa atgacaacta cccagatact ggatgtagtt
      901 cgggaactca aacatctgaa tcatcttgat atctcagatg ataaacagtt tacatcagac
      961 atagctcttc gcttactaga acaaaaagac atcctaccta accttgtttc tctggatgtt
     1021 tctgggagaa agcacgtgac agataaagcc gttgaagcct ttatacaaca acgtccaagc
     1081 atgcaatttg taggtttgct ggctactgat gctggttact ctgaattcct cacaggcgaa
     1141 ggacatttga aggtgtctgg ggaagccaat gaaactcaga ttgcagaagc actgaagcgt
     1201 tacagtgaac gggcattctt tgttcgggaa gctctatttc atctttttag tctgactcat
     1261 gtgatggaaa aaacaaagcc agaaatttta aagcttgtgg ttactgggat gagaaaccac
     1321 cctatgaatt tgccagtgca actggctgca agcgcctgtg tatttaactt aaccaagcag
     1381 gatcttgctg cagggatgcc tgtccgactc ctggctgatg tgacccattt gctgctcaaa
     1441 gccatggaac attttcccaa tcaccagcag ttacagaaga attgcctcct ttcactttgc
     1501 agtgaccgga tccttcaaga tgttccattt aacaggtttg aagcagccaa gcttgtcatg
     1561 cagtggcttt gcaaccatga ggatcaaaac atgcaaagga tggcagttgc tatcatttct
     1621 atcctggctg ccaagctttc tacagaacaa actgcacagc ttggtactga gctcttcatt
     1681 gtcaggcaac ttcttcaaat agtgaagcag aaaaccaatc aaaattcagt ggacactaca
     1741 ttgaaattta ctttgagtgc actttggaac ctcacagatg aatctccaac cacttgtaga
     1801 cactttattg aaaaccaagg gttagaactc ttcatgaggg ttctagagtc tttcccaact
     1861 gagtcatcca ttcagcagaa agttctagga cttttgaaca atatagctga agtacaagaa
     1921 ttacattctg aattaatgtg gaaagatttt atagaccaca tcagtagtct cctacacagt
     1981 gtggaagtgg aagtcagtta ctttgcagct ggaattattg cccatttaat atccagaggt
     2041 gaacaagctt ggacattgag tcgtagccag aggaattctc tgctggatga tttgcattca
     2101 gctattttga aatggccaac tccagagtgt gagatggtag catacaggtc ctttaatcca
     2161 tttttcccat tacttggctg tttcacaaca ccaggagttc agctatgggc agtttgggcc
     2221 atgcaacatg tctgcagcaa gaatccttca aggtattgca gcatgctgat tgaagaagga
     2281 ggattgcagc atttatacaa catcaaagat catgaacata ctgatcccca tgtccaacag
     2341 attgctgtgg ccattctgga tagcttagaa aaacacattg tgcgccatgg gaggccacct
     2401 ccctgtaaaa aacagcccca agccagacta aattgatagc cataagtatt ggatagttga
     2461 atcacaggaa tcctttttgt gattggtcca tttggaatat cttaccctcc ctgatgtttt
     2521 gggggtttct atgacaagag tcataaaatc agtttgggat tgataatgtg tagtactgcc
     2581 catgtgaaca gtctctaatt tgtcttgtga ttttaaactt atgagtcaag aagggtctct
     2641 tcctttatca ttgcctttta ggaaattttc cacatctttc agtgtttgaa cttacttgtg
     2701 cttgagattc tacagtttta tggtaaagtt tgcacgaacc cttaggccag acttttctga
     2761 tctcagagtc ccttccaatc aatttgcagc ttcacataag ctgttgacct gatttctgac
     2821 actgcttcag ttgtaaattt tatactgctt ctgtataaaa tgcctttctt ctctatctgt
     2881 gtatatttta taagatgtcc ttcttagtgt gaaagaaggg aaatgtggat catcttgtgg
     2941 aagctaatca ctggcaggag cctggatggc tggcggaaag atatatgaga aagaaaaatt
     3001 atgaaggtag aacagagtgt aggaactggg aattggtttc atggtatagg ttttaaaatg
     3061 agacaggcta cccttcggga gtccacctct cttgaggcgg tgagcagaag cttgtcctcc
     3121 atatttatac ctagaagtgt ggactgctgg ttcctgcaca gactgccggt tattcactag
     3181 gaatatttcc ccaagcacca cagtataaaa tactacagca ctctgtgtta aagactaact
     3241 gtctacatct ccatatgttg tagtgttgtg aaaatgtgat tttaaaaaat tatcgccagt
     3301 taaaactggc tattcttttc ctctatttca aagtcatttt tgttcagtgg aatagagaca
     3361 gcaacatggt gttaacctct caattaaaat acaattgaca ccagtaaatt ttgccataaa
     3421 aagttaaaat ctcttgttca aaatatgtgt atcttcttaa tgtgttcatg ttagagaaag
     3481 tgtccccatc tcactgccaa aaatgaaaga aaataattaa actctttaaa tgattaaatg
     3541 taatgattct actcgcagtg cataacagca catatttttg acagattatt ttttaggcaa
     3601 ttacctttcc ttaaggtatc tgatacagta tagtaaagaa tcacttatat cagtaatagc
     3661 acttgagaga tagcaagtca ccaagaaact taattttcat ttaaaatttt attttgtgaa
     3721 taaggtcaat ctacaatccc agataactac attttttttc atagatggcc agtgttttca
     3781 acagagattt aaaatggaat attaaaatta tagtgattat tcagaagcat tttaatttag
     3841 aaaggagctg gtttgttagt tcactgatga cattttttga caaacatttt ataccattat
     3901 cacaataatc agacttgaat tttttttgga gttccttcat gtgaatgaaa actgagttaa
     3961 aagaaagtag gcatttaggt ctggatgcag tggctcatgc ttgtaatccc agcactttgg
     4021 gaagctgaag caggaggatt gcttgagccc agaagttcaa gactagcctg ggcaacatag
     4081 tgagactcgg tctctaccaa aaaaaaaaat tttttttttt taaattagct gggtgtggtg
     4141 gcacctggga aacagagcga gacgctgact caaataaata tctaaataga tatttagaat
     4201 cactgaaaac catattaaat gctgggttaa tgctgactta attggcttaa ggaattttta
     4261 taggcgtaag ataaattttc acagactaag tttatttcag acaaaataga gaattctttt
     4321 aaaagttttt tttttttttt tcctttttcg aatgttaatg tctaagacaa agttcagaaa
     4381 acgagatggc ctgtggtagt ttggaaattg ctagatatgt tgaccgtttc caggtctttt
     4441 atctagtgta gttaagggaa agcctattta agaagtttgg cttcaagttt ctgttttata
     4501 agacaaaagt gcatatttct ttacaggcta atgctaggtt tttgtcttta caaattattt
     4561 tcagaaatgg ctaaaagtgt acagaaaaca gtaaatccct tctttactca gaataacttc
     4621 ttaatagttg aagcatccaa aatatgtaaa agcaagggtg ggcgtagtgg ctcttgcctg
     4681 taatcccagc attctgggag gccgaggcgg gcagatcact tgagatcagg agttcgagac
     4741 caccctggcc aacgtggtga aaccccgtct ctactaaaaa tacaaaaact agctgggcat
     4801 ggtggctttt ttgcacgcct atagtcccag ctactcggga ggctgaggca cgagaatcac
     4861 ttgaacccag gaagtggagg ttgcagtgag ctaagatcgt gccactgcac tccagcctgg
     4921 acaacggagt gagactctgg ggaaaaaaaa aattaaactt cctacttttt ttctttttgt
     4981 agagacagag tttcactctg tcgcccaagc tggagtgcag tggcacaatc atacctcact
     5041 gcagcctctt gggcttatgt gatcttaccc cctcagcctc tggagtagct ggaactacag
     5101 gctaaatttc ctactttgta aacatcagta gtggccagat acttctgagt cttaaaagca
     5161 taataggccg ggcgcggtgg ctcacgcctg taatcccagc actttgggag gccgaggtgg
     5221 gtggatcaca aggtcaggag ttcaagacca gcctggccca aatggtgaaa ccctgtctct
     5281 actaaatata caaaaattag ctgggtgtgg tggcgggcac ctgtaatccc agctactcag
     5341 gaggctgagg caggagaatc gcttgaacct gggaggtgga ggttgtggtg agccaatatc
     5401 atgccactgc actccagcct gggtgacaga gtaagactcc gtctcaaaaa aaaaaaaagc
     5461 ataataattt attacatccc aaatatataa aaatttgagt gcctttgcag ttgggatggt
     5521 tcctaaaatt gcgtatagaa ttaaggcaca gaattgtgtg taaggtcctg aatctggcta
     5581 aaatacagtg gatgtatgta ttggaattat gaggcataag tagccagtat ctatagttag
     5641 aatctacaag gcctcctttt tgcacctgta gactagaata taactgttat tggtgccttt
     5701 gagtgttatc tctcagtggc tagaggtgct gtttcaagca caatttagac tagggttgaa
     5761 ccactcattg ttcaaatcat tggtgggctc caatgtaaaa tatcactaca tcagtccaca
     5821 agcaacatta aggaaatcta aaggaaatgg aatttgactt tttagagtat aatgatgttc
     5881 tagggcataa tgaggaaaat ttttaaaaaa tagattataa tgatacatat tggtatcatt
     5941 aagacaacag atttgagcaa atacaattaa ggtgtcttat tttttgcatc aagtaattat
     6001 tgctgtggtc tttctactcc acaaaataat tttttctttt tgcagttgaa aattaactgc
     6061 attattaact aattaataaa ataaatcaag tggtataagg gattagttta ccctcaagcc
     6121 gatgactcca tggctactga tattagttag tttaggattt ttaaaaagca tatcagaccc
     6181 ccagtttcag gaattgagta taaatattgc ttcttgtcac cctgggacag taatgcctta
     6241 tagtggcact agtcacctta agtagattac acatggttga ggtgaataaa gctgcatggg
     6301 aatttgcttt cgtgatatat ttcatttgca aacttctaca taatcaagtt ttatgtttaa
     6361 aaccatcggt tctatatatc tagctttagg aagttgccct tacaggtggg accttttgtg
     6421 ttaatctgtt ttctccccag tcatcttatt tggctatgtt aaaaaaaaaa aaaaaaaaaa
     6481 agcgagagag agagatggtg tctcactgtg ttgcccaggc tggtctcgaa ctcctggcct
     6541 caagtgactt tcccacctca gcttcccaaa gtgctggaat cacaggcatg agccacagtg
     6601 cctggtctta gctgtgtttt taattatgcc atgcatcaac ataacaccgg gccatcttcc
     6661 tatcccttcc tatcccatat gtttaatgaa aacatatttt atgtgctaaa ttaggttaat
     6721 ttaccagaga tttagcttag tgtttttaaa ctatagaaca atacccctat agaacaatgt
     6781 acagctgcac ccaaggttaa aaagaggtag cagggaaaac aaacttaaac tctttgtata
     6841 tggtgaaacc catccctctc ctgccctcta atggtatgtt tacattattt cgttattata
     6901 caatgtagtg gtataaacag tattattaaa ctgaaggcat aagttaaagg aagtatgtta
     6961 ctttgagctg atgtaggctc ttccactttt atctgtattt tacttatttg gggactttgt
     7021 attgctaggg cttcagaata ctaactttga cacagctccc agagaggttt gcaaactttt
     7081 ggtttccctc tcaaatccat ggtagtagtt tcaaatgagt ttgtggataa tggatgttta
     7141 gtccttatca tttgctgtgt tttgacagtt tttaatttgc agtattcact cacgaactgt
     7201 tttattttag gaataatgca aaaccaacct tcgtccggtg atgagaatag ccgtatgata
     7261 agagaatttg ctcatcgtgc tttaaatgat taactgtttt accttattta gtatttcata
     7321 gactttgcat gatatggtac actcctaatt atgcattctt tggtttccaa atcttaatct
     7381 aagatacttt gttaactgac tggtagccta agaaagagac ttttcttcct gtttttctct
     7441 ctccccattt tttggggtaa gttttgcaaa gatcagtgct gcttctcatg actctaaagt
     7501 aaagctcttt tggatagcac agcctaactt tacagctaga cagaatggcc attaagaata
     7561 tttccaaaat ccaagtttat caaaattatt ttgtgggaaa tcatcaatct attttattaa
     7621 tgttatgtgt ttaattttgg acttattttg ggaaaaactg ttcaaattgg gtccttttaa
     7681 gcttatttta agcagcctag aaggaagaag ctacttagct aatgaaagct gagacacttt
     7741 attaaaagca ggatcttaag agcattgttt ttccttaaaa actttatact ctcagataat
     7801 ctgcaacaac aaaaattaag aaatccctga cttttgtaga attcccactg tcaaattctc
     7861 actgacttat gagtgtgaga gaagttatct tttgtttgaa ttctgataga acagtttaac
     7921 tcctttctaa ggatataaaa aattcattgg aaagtgtgta tatttcaaag actctcaatt
     7981 atctggactg aaggcactgt tctcactatg gccagatgaa tgggagtatt ctgtacatga
     8041 atcatgctgt attttaaatc aggacatcac ttaagtatta atgttgtgtg tacagatttt
     8101 tgttttggga ttttttttgc ctaaataaat gttataaatt tta
//
