LOCUS       NM_001004339            4445 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zyg-11 family member A, cell cycle regulator (ZYG11A),
            transcript variant 1, mRNA.
ACCESSION   NM_001004339 XM_001133615 XM_496365
VERSION     NM_001004339.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4445)
  AUTHORS   Achlaug,L., Somri-Gannam,L., Meisel-Sharon,S., Sarfstein,R.,
            Dixit,M., Yakar,S., Hallak,M., Laron,Z., Werner,H. and Bruchim,I.
  TITLE     ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates
            With Low Grade Disease
  JOURNAL   Front Endocrinol (Lausanne) 12, 688104 (2021)
   PUBMED   34220714
  REMARK    GeneRIF: ZYG11A Is Expressed in Epithelial Ovarian Cancer and
            Correlates With Low Grade Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4445)
  AUTHORS   Charoensuk,C., Thamtarana,P.J., Chanprasert,C., Tangjittipokin,W.,
            Shirakawa,J., Togashi,Y., Orime,K., Songprakhon,P., Chaichana,C.,
            Abubakar,Z., Ouying,P., Sujjitjoon,J., Doria,A., Plengvidhya,N. and
            Yenchitsomanus,P.T.
  TITLE     Autosomal dominant diabetes associated with a novel ZYG11A mutation
            resulting in cell cycle arrest in beta-cells
  JOURNAL   Mol Cell Endocrinol 522, 111126 (2021)
   PUBMED   33321115
  REMARK    GeneRIF: Autosomal dominant diabetes associated with a novel ZYG11A
            mutation resulting in cell cycle arrest in beta-cells.
REFERENCE   3  (bases 1 to 4445)
  AUTHORS   Balachandran,R.S., Heighington,C.S., Starostina,N.G.,
            Anderson,J.W., Owen,D.L., Vasudevan,S. and Kipreos,E.T.
  TITLE     The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in
            a conserved pathway that facilitates mitotic slippage
  JOURNAL   J Cell Biol 215 (2), 151-166 (2016)
   PUBMED   27810909
  REMARK    GeneRIF: the ubiquitin ligase CRL2(ZYG-11) redundantly targets the
            degradation of cyclin B1 in Caenorhabditis elegans and human cells.
REFERENCE   4  (bases 1 to 4445)
  AUTHORS   Wang,X., Sun,Q., Chen,C., Yin,R., Huang,X., Wang,X., Shi,R., Xu,L.
            and Ren,B.
  TITLE     ZYG11A serves as an oncogene in non-small cell lung cancer and
            influences CCNE1 expression
  JOURNAL   Oncotarget 7 (7), 8029-8042 (2016)
   PUBMED   26771237
  REMARK    GeneRIF: Over-expression of ZYG11A is associated with non-small
            cell lung cancer.
REFERENCE   5  (bases 1 to 4445)
  AUTHORS   Feral,C., Wu,Y.Q., Pawlak,A. and Guellaen,G.
  TITLE     Meiotic human sperm cells express a leucine-rich homologue of
            Caenorhabditis elegans early embryogenesis gene, Zyg-11
  JOURNAL   Mol Hum Reprod 7 (12), 1115-1122 (2001)
   PUBMED   11719588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY271826.1, BC119815.1, AC099677.2 and AI638616.1.
            
            On May 17, 2019 this sequence version replaced NM_001004339.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371528.2/ ENSP00000360583.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AY271826.1         241-587
            348-1143            BC119815.1         171-966
            1144-1702           AY271826.1         632-1190
            1703-1709           AC099677.2         38568-38574
            1710-2466           AY271826.1         1198-1954
            2467-4018           AC099677.2         53870-55421
            4019-4022           AI638616.1         16-19               c
            4023-4445           AC099677.2         55426-55848
FEATURES             Location/Qualifiers
     source          1..4445
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..4445
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /note="zyg-11 family member A, cell cycle regulator"
                     /db_xref="GeneID:440590"
                     /db_xref="HGNC:HGNC:32058"
                     /db_xref="MIM:618675"
     exon            1..214
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2404
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein zyg-11 homolog A; ZYG-11A early embryogenesis
                     protein"
                     /codon_start=1
                     /product="protein zyg-11 homolog A isoform 1"
                     /protein_id="NP_001004339.2"
                     /db_xref="CCDS:CCDS44148.1"
                     /db_xref="GeneID:440590"
                     /db_xref="HGNC:HGNC:32058"
                     /db_xref="MIM:618675"
                     /translation="MVHFLHPGHTPRNIVPPDAQKDALGCCVVQEEASPYTLVNICLN
                     VLIANLEKLCSERPDGTLCLPEHWSFPQEVAERFLRVMTWQGKLTDRTASIFRGNQMK
                     LKLVNIQKAKISTAAFIKAFCRHKLIELNATAVHADLPVPDIISGLCSNRWIQQNLQC
                     LLLDSTSIPQNSRLLFFSQLTGLRILSVFNVCFHTEDLANVSQLPRLESLDISNTLVT
                     DISALLTCKDRLKSLTMHYLKCLAMTKSQILAVIRELKCLLHLDISDHRQLKSDLAFH
                     LLQQKDILPNVVSLDISGGNCITDEAVELFIRLRPAMQFVGLLATDAGSSDFFTTKQG
                     LRVAGGASMSQISEALSRYRNRSCFVKEALHRLFTETFSMEVTMPAILKLVAIGMRNH
                     PLDLRVQFTASACALNLTRQGLAKGMPVRLLSEVTCLLFKALKNFPHYQQLQKNCLLS
                     LTNSRILVDVPFDRFDAAKFVMRWLCKHENPKMQTMAVSVTSILALQLSPEQTAQLEE
                     LFMAVKELLAIVKQKTTENLDDVTFLFTLKALWNLTDGSPAACKHFIENQGLQIFIQV
                     LETFSESAIQSKVLGLLNNIAEVRELSSKLVTEDVLKHINSLLCSREMEVSYFAAGII
                     AHLTSDRQLWISRDFQRRTLLQDLHATIQNWPSSSCKMTALVTYRSFKTFFPLLGNFS
                     QPEVQLWALWAMYHVCSKNPSKYCKMLVEEEGLQLLCDIQEHSEATPKAQQIAASILD
                     DFRMHFMNYQRPTLCQMPF"
     exon            215..380
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1132
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1273
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1450
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1515
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1615
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1666
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1828
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1873
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2068
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2130
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2228
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..4445
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3994..3999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /note="hexamer: AATAAA"
     regulatory      4000..4005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /note="hexamer: AGTAAA"
     polyA_site      4019
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
                     /note="major polyA site"
     polyA_site      4030
                     /gene="ZYG11A"
                     /gene_synonym="ZYG11"
ORIGIN      
        1 gctagctccg tgtgcctcgc aggcgtggtg ggcgcgtcct ggcagccgcc cgcttggttc
       61 tcgcgggatc cgggctccgg ctcgacgccg gctctctttt tgacgccccg ccgccggggt
      121 tgccatggtt catttcttgc acccgggcca cacgccccgg aacatcgtcc ctcctgacgc
      181 tcagaaggat gccctgggct gctgcgtggt acaggaagag gcatctccct acactttggt
      241 caacatctgc ctgaatgtcc tgattgctaa cctggagaaa ttgtgttctg aaagacctga
      301 tggaacactg tgccttccgg agcattggag tttccctcag gaagtagccg agcgatttct
      361 cagggtgatg acttggcaag gcaagctgac tgacagaaca gccagcattt tccgaggcaa
      421 ccaaatgaaa ctgaagctgg tcaatatcca aaaagctaaa atctctacag ctgcattcat
      481 aaaagccttc tgccgtcata agctcattga actgaatgct actgcagtgc acgctgacct
      541 cccagttcca gacatcataa gtggactctg cagcaatagg tggatccagc aaaacctcca
      601 gtgtctcctg ttagactcga caagcatccc tcaaaattca agattactgt tctttagtca
      661 gctcactggt cttcgcattt taagtgtttt taatgtttgt tttcatactg aagacctggc
      721 taatgtttct cagttaccaa gactggaaag cttagatatc tctaatactc tagtcactga
      781 tatttctgca ctgcttacct gtaaggatcg attgaagtct ctcacaatgc actatctgaa
      841 atgcctggcc atgaccaaat cacaaattct tgcagtcatt agagaactta aatgtctgct
      901 tcaccttgat atttctgatc acaggcaact caaatcagac ctagcttttc atttgctaca
      961 gcagaaggat atcctgccca atgttgtgtc attggatatt tctgggggca attgcatcac
     1021 tgatgaagct gtagaactgt ttatacgact gcggcctgcc atgcaatttg tgggactatt
     1081 ggccacggat gctggctctt ctgacttctt tactacaaag caaggcttga gggttgctgg
     1141 aggagccagt atgagtcaga tttcagaagc actgagccga tacaggaaca gatcatgttt
     1201 tgtgaaggaa gccctccaca ggctgttcac agagacattt tcaatggagg taaccatgcc
     1261 tgctatttta aagcttgtgg ctataggaat gaggaatcac ccattggatt tgcgagtgca
     1321 gttcacagcc agtgcttgcg ctctcaacct aacacgccag ggcctggcca aggggatgcc
     1381 tgttcgcctg ttgtcagagg tcacctgtct acttttcaag gctctgaaaa atttccccca
     1441 ttaccagcag ttacagaaga attgtcttct ctccttaacc aattccagga ttcttgtgga
     1501 tgttccattt gacaggtttg atgctgccaa gtttgtcatg agatggctct gtaagcatga
     1561 aaaccccaag atgcaaacaa tggcagtgag tgtcacctct attctggctc tgcagctctc
     1621 acctgagcaa acggcacagc ttgaagagct tttcatggca gttaaggaac ttctagcaat
     1681 agtaaaacaa aagactactg agaatttaga tgatgtcacc ttcttgttta ctttgaaagc
     1741 actttggaat cttacagatg ggtctccagc tgcctgcaag cacttcattg aaaatcaagg
     1801 attgcaaatc ttcatccaag tcttggagac cttttcagag tcagcaatac aaagcaaagt
     1861 acttggtctt ttgaacaaca tagcagaagt cagagagctc tcttccaagc tggtgaccga
     1921 agatgtgctg aagcatatca acagtttact ctgtagcagg gaaatggaag tcagctattt
     1981 tgctgcaggt atcatagccc acctgacatc tgacagacag ctttggatat cccgtgactt
     2041 ccagaggcgt actcttctcc aagatctgca tgcaaccata cagaattggc caagttcaag
     2101 ttgtaagatg acagcattgg tgacctatag atctttcaag acatttttcc cgctccttgg
     2161 caacttctct caaccagagg ttcagctctg ggcactatgg gctatgtatc atgtctgcag
     2221 taaaaatccc agcaaatact gcaaaatgtt agttgaagaa gaaggattgc agcttttgtg
     2281 tgatatccag gagcacagtg aggcaacccc caaagcacag cagattgcag cctccattct
     2341 ggatgacttc agaatgcatt tcatgaatta tcagaggccc actctgtgtc aaatgccctt
     2401 ctgaacctaa ggaatttcag aggtgtgtgc tcttcctcaa tgtcaggtgt tctgccctgg
     2461 cagtaattgc acatcagttg tcattggagt ttgtgagttg gctgtctcat tggcctttga
     2521 ttgttgattt tatatatgtt acaaaaggtt ggatttgtat gatagctgta atcccaagtc
     2581 aagttggact cattctgcag cctttcagca gcaattttga agactcaaac cgtggactct
     2641 gggaaggcct gggagcttgt gttggaacag ctatgcaagt tacttttctc tagccttgga
     2701 caattttttc cctttgggag cttgtcatgg gagtgggacc tgttcactag aagagaaagg
     2761 aaacctacag ggagactttg atatttatat taaatttcct ttgttgttat cgtcatgtga
     2821 agctatgaga aaagcttggg aagcatatgc ttcaaaatgt agtgtttaga aggcagaacc
     2881 cctgttggag agcggggaaa agaatttatt tatttattta tttatctatg gctgggtatg
     2941 gtggctcacg cctgtaatcc cagcactttg ggaggccaag gcaggtggat tgtctgaact
     3001 caggagttcg agatcagcct tgccaacgtg gtaaaactcc gtctctacca aaaaatacaa
     3061 aaattagctg agcgtggtgg tgtgcacctt tactcctagc tacttggagg ctgaggtggg
     3121 aggaccactt gagcccagga ggcagaggtt gcagtgagct gagattgcac cactgcactc
     3181 cagcctggat gacagagtga gacctcatct caaatgaata gaggggtgga gaaaagagaa
     3241 atatattttt ttaccttttt tttttttttt ttttttgtga cggaatctcg ctctgtcgcc
     3301 caggctggag tgcagtggca caatctcggc tcactgcaac ctctgcctcc caggttccag
     3361 caattctcct gcctcagcct cctgagtagc tgggactaca ggcacatgcc gccacgcccg
     3421 gctaattttt gtatttttta gtagagacag ggtttcacca tattggtcag gctggtctcg
     3481 acctcctgac ctcgtgatcc acccgtctcg gcctcccaaa gtgctgggat tacaggtgtg
     3541 agtcactgca cctggccttt ttacaatttt gggtgtctat ctttggcatg tttcctgtta
     3601 tgtgagcatg acatgctgtg tatgtgagtg agcttgtagg gcgtggtggg acttaggcat
     3661 ttgcagacag tgtttagatg aaagattaca tgtaatgata aatctgaatc cctccatttt
     3721 atttgggtgg aaccatgacc aaaaatggta ggaagacgaa aggccagaaa gagactttgc
     3781 cagagagttc acggagtttt cttaccccgc atgctgacta aagaaaacat gggcttttct
     3841 gaaaccagct tcaactacag tataaactat atcagaagct tacttgataa gccttgcgga
     3901 gctgctctga ggaatagtgt gaattccttc cttgccttat tgttgactgt taatgaacat
     3961 gttttgtcat ttatctgttt aagtttttca gaaaataaaa gtaaatttct gttagcacat
     4021 tttaggatta gatttttgtg cttttggctg gcttggttca gattcttaac tagagtacca
     4081 tgtactgtct ttggaaatca aatgaggaag aagctcattc tcttactcta aaccatgttc
     4141 caaactatta ccagagtcca accagataag cagaatttgt aaccttactt ccttccatag
     4201 tccttaaact gtactgtatt ttttcacact cttgcatgat tccaaaagga tatcttcctg
     4261 acctgggttc tagtacctca gagcattgtt atcagatgct agcttattct aatgtgagga
     4321 tgtgttaggg gaactagtgt gttaagtcca attctgtaca agacatcctt tcaagttctg
     4381 tgtcattcac aacaatcctc acgggtaggt gagttttatt ttcctcactt aacagatgag
     4441 aaaaa
//
