LOCUS       NM_025112               3377 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ZXD family zinc finger C (ZXDC), transcript variant 1,
            mRNA.
ACCESSION   NM_025112 XM_371661
VERSION     NM_025112.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3377)
  AUTHORS   Liu,Y., Huang,Y., Zhang,X., Ma,X., He,X., Gan,C., Zou,X., Wang,S.,
            Shu,K., Lei,T. and Zhang,H.
  TITLE     CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation
            via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease
  JOURNAL   Cells 11 (23), 3792 (2022)
   PUBMED   36497052
  REMARK    GeneRIF: CircZXDC Promotes Vascular Smooth Muscle Cell
            Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya
            Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3377)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3377)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3377)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3377)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 3377)
  AUTHORS   Suter,B., Fontaine,J.F., Yildirimman,R., Rasko,T., Schaefer,M.H.,
            Rasche,A., Porras,P., Vazquez-Alvarez,B.M., Russ,J., Rau,K.,
            Foulle,R., Zenkner,M., Saar,K., Herwig,R., Andrade-Navarro,M.A. and
            Wanker,E.E.
  TITLE     Development and application of a DNA microarray-based yeast
            two-hybrid system
  JOURNAL   Nucleic Acids Res 41 (3), 1496-1507 (2013)
   PUBMED   23275563
REFERENCE   7  (bases 1 to 3377)
  AUTHORS   Aleksandrova,A., Galkin,O., Koneni,R. and Fontes,J.D.
  TITLE     An N- and C-terminal truncated isoform of zinc finger X-linked
            duplicated C protein represses MHC class II transcription
  JOURNAL   Mol Cell Biochem 337 (1-2), 1-7 (2010)
   PUBMED   19777325
  REMARK    GeneRIF: Role of ZXD proteins in regulating MHC II transcription.
REFERENCE   8  (bases 1 to 3377)
  AUTHORS   Jambunathan,S. and Fontes,J.D.
  TITLE     Sumoylation of the zinc finger protein ZXDC enhances the function
            of its transcriptional activation domain
  JOURNAL   Biol Chem 388 (9), 965-972 (2007)
   PUBMED   17696781
  REMARK    GeneRIF: study found sumoylation does not appear to disrupt or
            modulate interaction of ZXDC with binding partners; sumoylation of
            ZXDC is required for full activity of transcriptional activation
            domain; study suggests sumoylation is an important regulator of
            ZXDC
REFERENCE   9  (bases 1 to 3377)
  AUTHORS   Al-Kandari,W., Koneni,R., Navalgund,V., Aleksandrova,A.,
            Jambunathan,S. and Fontes,J.D.
  TITLE     The zinc finger proteins ZXDA and ZXDC form a complex that binds
            CIITA and regulates MHC II gene transcription
  JOURNAL   J Mol Biol 369 (5), 1175-1187 (2007)
   PUBMED   17493635
  REMARK    GeneRIF: ZXDA and ZXDC form an important regulatory complex for MHC
            II gene transcription.
REFERENCE   10 (bases 1 to 3377)
  AUTHORS   Al-Kandari,W., Jambunathan,S., Navalgund,V., Koneni,R., Freer,M.,
            Parimi,N., Mudhasani,R. and Fontes,J.D.
  TITLE     ZXDC, a novel zinc finger protein that binds CIITA and activates
            MHC gene transcription
  JOURNAL   Mol Immunol 44 (4), 311-321 (2007)
   PUBMED   16600381
  REMARK    GeneRIF: ZXDC is an important regulator of both MHC class I and
            class II transcription
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024558.21 and DQ079590.1.
            
            On Nov 24, 2018 this sequence version replaced NM_025112.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ079590.1, AY936556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389709.8/ ENSP00000374359.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AC024558.21        36143-36520         c
            379-3377            DQ079590.1         407-3405
FEATURES             Location/Qualifiers
     source          1..3377
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..3377
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /note="ZXD family zinc finger C"
                     /db_xref="GeneID:79364"
                     /db_xref="HGNC:HGNC:28160"
                     /db_xref="MIM:615746"
     exon            1..933
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2603
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein ZXDC; SERH2790; ZXD-like zinc finger
                     protein"
                     /codon_start=1
                     /product="zinc finger protein ZXDC isoform 1"
                     /protein_id="NP_079388.3"
                     /db_xref="CCDS:CCDS43145.1"
                     /db_xref="GeneID:79364"
                     /db_xref="HGNC:HGNC:28160"
                     /db_xref="MIM:615746"
                     /translation="MDLPALLPAPTARGGQHGGGPGPLRRAPAPLGASPARRRLLLVR
                     GPEDGGPGARPGEASGPSPPPAEDDSDGDSFLVLLEVPHGGAAAEAAGSQEAEPGSRV
                     NLASRPEQGPSGPAAPPGPGVAPAGAVTISSQDLLVRLDRGVLALSAPPGPATAGAAA
                     PRRAPQASGPSTPGYRCPEPQCALAFAKKHQLKVHLLTHGGGQGRRPFKCPLEGCGWA
                     FTTSYKLKRHLQSHDKLRPFGCPVGGCGKKFTTVYNLKAHMKGHEQESLFKCEVCAER
                     FPTHAKLSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQELFSCSFPG
                     CSKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHRRKHDDDRRFTCPV
                     EGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSKKHVQDVGAPK
                     SRCPVSTCNRLFTSKHSMKAHMVRQHSRRQDLLPQLEAPSSLTPSSELSSPGQSELTN
                     MDLAALFSDTPANASGSAGGSDEALNSGILTIDVTSVSSSLGGNLPANNSSLGPMEPL
                     VLVAHSDIPPSLDSPLVLGTAATVLQQGSFSVDDVQTVSAGALGCLVALPMKNLSDDP
                     LALTSNSNLAAHITTPTSSSTPRENASVPELLAPIKVEPDSPSRPGAVGQQEGSHGLP
                     QSTLPSPAEQHGAQDTELSAGTGNFYLESGGSARTDYRAIQLAKEKKQRGAGSNAGAS
                     QSTQRKIKEGKMSPPHFHASQNSWLCGSLVVPSGGRPGPAPAAGVQCGAQGVQVQLVQ
                     DDPSGEGVLPSARGPATFLPFLTVDLPVYVLQEVLPSSGGPAGPEATQFPGSTINLQD
                     LQ"
     exon            934..1086
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1165
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1296
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1467
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..2153
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2238
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2420
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2516
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..3377
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /note="hexamer: TATAAA"
     polyA_site      3377
                     /gene="ZXDC"
                     /gene_synonym="ZXDL"
                     /note="major polyA site"
ORIGIN      
        1 gctccgacgc cgtcgctggg accaagatgg acctcccggc gctgctcccc gccccgactg
       61 cgcgcggagg gcaacatggc ggcggccccg gcccgctccg ccgagcccca gcgccgctcg
      121 gcgcgagccc cgcgcgccgc cgcctgctac tggtgcgggg ccctgaagat ggcgggcccg
      181 gggcgcggcc cggggaggcc tccgggccaa gcccgccgcc cgccgaggac gacagcgacg
      241 gcgactcttt cttggtgctg ctggaagtgc cgcacggcgg cgctgccgcc gaggctgccg
      301 gatcacagga ggccgagcct ggctcccgtg tcaacctggc gagccgcccc gagcagggcc
      361 ccagcggccc ggccgccccc cccggccctg gcgtagcccc ggcgggcgcc gtcaccatca
      421 gcagccagga cctgctggtg cgtctcgacc gcggcgtcct cgcgctgtct gcgccgcccg
      481 gccccgcaac cgcgggcgcc gccgctcccc gccgcgcgcc ccaggcctcc ggccccagca
      541 cgcccggcta ccgctgcccc gagccgcagt gcgcgctggc cttcgccaag aagcaccagc
      601 tcaaggtgca cctgctcacg cacggcggcg gtcagggccg gcggcccttc aagtgcccac
      661 tggagggctg tggttgggcc ttcacaacgt cctacaagct caagcggcac ctgcagtcgc
      721 acgacaagct gcggcccttc ggctgtccag tgggcggctg tggcaagaag ttcactacgg
      781 tctataacct caaggcgcac atgaagggcc acgagcagga gagcctgttc aagtgcgagg
      841 tgtgcgccga gcgcttcccc acgcacgcca agctcagctc ccaccagcgc agccacttcg
      901 agcccgagcg cccttacaag tgtgactttc ccggctgtga gaagacattt atcacagtga
      961 gtgccctgtt ttcccataac cgagcccact tcagggaaca agagctcttt tcctgctcct
     1021 ttcctgggtg cagcaagcag tatgataaag cctgtcggct gaaaattcac ctgcggagcc
     1081 atacaggtga aagaccattt atttgtgact ctgacagctg tggctggacc ttcaccagca
     1141 tgtccaaact tctaaggcac agaaggaaac atgacgatga ccggaggttt acctgccctg
     1201 tcgagggctg tgggaaatca ttcaccagag cagagcatct gaaaggccac agcataaccc
     1261 acctaggcac aaagccgttc gagtgtcctg tggaaggatg ttgcgcgagg ttctccgctc
     1321 gtagcagtct gtacattcac tctaagaaac acgtgcagga tgtgggtgct ccgaaaagcc
     1381 gttgcccagt ttctacctgc aacagactct tcacctccaa gcacagcatg aaggcgcaca
     1441 tggtcagaca gcacagccgg cgccaagatc tcttacctca gctagaagct ccgagttctc
     1501 ttactcccag cagtgaactc agcagcccag gccaaagtga gctcactaac atggatcttg
     1561 ctgcactctt ctctgacaca cctgccaatg ctagtggttc tgcaggtggg tcggatgagg
     1621 ctctgaactc cggaatcctg actattgacg tcacttctgt gagctcctct ctgggaggga
     1681 acctccctgc taataatagc tccctagggc cgatggaacc cctggtcctg gtggcccaca
     1741 gtgatattcc cccaagcctg gacagccctc tggttctcgg gacagcagcc acggttctgc
     1801 agcagggcag cttcagtgtg gatgacgtgc agactgtgag tgcaggagca ttaggctgtc
     1861 tggtggctct gcccatgaag aacttgagtg acgacccact ggctttgacc tccaatagta
     1921 acttagcagc acatatcacc acaccgacct cttcgagcac cccccgagaa aatgccagtg
     1981 tcccggaact gctggctcca atcaaggtgg agccggactc gccttctcgc ccaggagcag
     2041 ttgggcagca ggaaggaagc catgggctgc cccagtccac gttgcccagt ccagcagagc
     2101 agcacggtgc ccaggacaca gagctcagtg caggcactgg caacttctat ttggaaagtg
     2161 ggggctcagc aagaactgat taccgagcca ttcaactagc caaggaaaaa aagcagagag
     2221 gagcggggag caatgcagga gcctcacagt ctactcagag aaaaataaaa gaaggcaaaa
     2281 tgagtcctcc ccatttccat gcaagccaga acagttggtt gtgtgggagc ctcgtggtgc
     2341 ccagcggagg acggccagga ccagctccag cagctggggt gcagtgcggg gcgcagggcg
     2401 tccaggtcca gctggtgcag gatgacccct ccggcgaagg tgtcctgccc tcggcccgcg
     2461 gcccagccac cttcctcccc ttcctcactg tggacctgcc cgtctacgtc ctccaggagg
     2521 tgctcccctc atctggaggc cctgctggac cggaggccac ccagttccca ggaagcacta
     2581 tcaacctgca ggatctgcag tgacggcagc ctcggcctgg gcaggcccaa ggccacggtc
     2641 taggacacac cttccctgag actcatgaca tgagcctggg gagacctcat ttggtttccg
     2701 ttcagaagac cagcgtagcc cttttgagac ttttgggtac atttatcaaa aatgttttcc
     2761 ttttgtttta ccaggaatga gttcgggcta tactctttga aactgccttt gtgagcaaag
     2821 tgctttggca aggcaagggt ctccctcagc agggctaggt gcactacagc ctctttcccc
     2881 gtgtcccgtt ggatctgagc tgtgtagcac ttgttgcatt acaaagaaaa agacttctgc
     2941 aggaaatagg gtagagaaca ggctgtctag tcagatgcag cttgatctgt ggcaaaacca
     3001 agtgtggtct ttcagcttca gtgtgttagc atcccagcac ctgggatggg gtttgtgggc
     3061 aagttgattt tgccacactg tagggcccag gtggtcccat tgccaccgtg aagccaaatt
     3121 ctagcccaag tctggtagag cagtcgggca gctagttttc gggggaggat gatgtggtgg
     3181 gacagaggac ctcagtggcc tattacggag ccctcttccc agactaaatt catagccgag
     3241 agctcggggg gatggtagag ttaaaattta aaataatttt ctaaattctg tatttggata
     3301 ttagtgttta agtggtaatt tggcaacagt ttataaagtg atgttctgaa taccataaat
     3361 tatgtgtagg actgtga
//
