LOCUS       NM_007157               5467 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger X-linked duplicated B (ZXDB), mRNA.
ACCESSION   NM_007157 XM_372226
VERSION     NM_007157.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5467)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5467)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   3  (bases 1 to 5467)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 5467)
  AUTHORS   Greig,G.M., Sharp,C.B., Carrel,L. and Willard,H.F.
  TITLE     Duplicated zinc finger protein genes on the proximal short arm of
            the human X chromosome: isolation, characterization and
            X-inactivation studies
  JOURNAL   Hum Mol Genet 2 (10), 1611-1618 (1993)
   PUBMED   8268913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031115.2.
            
            On Jul 1, 2020 this sequence version replaced NM_007157.3.
            
            Summary: The ZXDB gene is one of a pair of duplicated zinc finger
            genes on chromosome Xp11.21 (Greig et al., 1993 [PubMed 8268913]);
            see also ZXDA (MIM 300235).[supplied by OMIM, Jul 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK289766.1, SRR1660807.227046.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374888.3/ ENSP00000364023.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5467              AL031115.2         41242-46708         c
FEATURES             Location/Qualifiers
     source          1..5467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..5467
                     /gene="ZXDB"
                     /gene_synonym="dJ83L6.1; ZNF905"
                     /note="zinc finger X-linked duplicated B"
                     /db_xref="GeneID:158586"
                     /db_xref="HGNC:HGNC:13199"
                     /db_xref="MIM:300236"
     exon            1..5467
                     /gene="ZXDB"
                     /gene_synonym="dJ83L6.1; ZNF905"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2450
                     /gene="ZXDB"
                     /gene_synonym="dJ83L6.1; ZNF905"
                     /codon_start=1
                     /product="zinc finger X-linked protein ZXDB"
                     /protein_id="NP_009088.1"
                     /db_xref="CCDS:CCDS35313.1"
                     /db_xref="GeneID:158586"
                     /db_xref="HGNC:HGNC:13199"
                     /db_xref="MIM:300236"
                     /translation="MEIPKLLPARGTLQGGGGGGIPAGGGRVHRGPDSPAGQVPTRRL
                     LLLRGPQDGGPGRRREEASTASRGPGPSLLAPRTDQPSGGGGGGGDDFFLVLLDPVGG
                     DVETAGSGQAAGPVLREEAEEGPGLQGGESGANPAGPTALGPRCLSAVPTPAPISAPG
                     PAAAFAGTVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPGCLIAPQAGFPHA
                     AHPGDCPELPPDLLLAEPAEPAPAPAPEEEAEGPAAALGPRGPLGSGPGVVLYLCPEA
                     QCGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPF
                     GCPAEGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLSAHQRSHFEPERP
                     YQCAFSGCKKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTG
                     ERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITH
                     LGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCPISSCNKLFTSKHSMKT
                     HMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLD
                     TALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFG
                     TAATGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQALTPSSKLTVDTDALTPS
                     STLCENSVSELLTPTKAEWNVHPDSDFFGQEGETQFGFPNAAGNHGSQKETDLITVTG
                     SSFLV"
     regulatory      5443..5448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZXDB"
                     /gene_synonym="dJ83L6.1; ZNF905"
                     /note="hexamer: AATAAA"
     regulatory      5451..5456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZXDB"
                     /gene_synonym="dJ83L6.1; ZNF905"
                     /note="hexamer: TATAAA"
     polyA_site      5462
                     /gene="ZXDB"
                     /gene_synonym="dJ83L6.1; ZNF905"
                     /note="major polyA site"
     polyA_site      5467
                     /gene="ZXDB"
                     /gene_synonym="dJ83L6.1; ZNF905"
                     /note="major polyA site"
ORIGIN      
        1 ctcggctctg gttccagccg agcctctcgg acgcagagat ggaaatcccg aagctgctcc
       61 cggctcgcgg gacactacag ggcggcggcg gcggcggtat ccccgcgggt ggcggccgag
      121 tccaccgagg ccctgactcg ccggctggcc aggtccccac gcgccgcctc ctgctgctcc
      181 ggggccccca agatggcggg cccgggcggc ggcgcgagga ggccagcacg gcatcacggg
      241 gccctggccc aagcctgttg gcgccgagga ccgatcaacc tagcggcggc ggcggcggcg
      301 gcggcgacga cttcttcctg gtgctgcttg acccggtggg tggcgacgtg gagaccgcgg
      361 gctccggtca ggccgcaggg cctgtgttga gggaggaggc cgaggagggc ccggggctcc
      421 aggggggcga gagcggcgcg aatcccgcgg ggcccactgc gctaggcccc cgctgcctgt
      481 ccgcggttcc cactccggcc ccgatctccg cccccggccc cgccgcggcc ttcgcgggca
      541 cagtcactat ccacaaccag gacctgctgt tgcgctttga gaacggcgtc ctcaccctgg
      601 ccacgccccc accacacgcc tgggagccag gggccgctcc tgcccagcag cccgggtgtc
      661 tgatcgcccc gcaagctggg ttcccgcatg ccgcgcaccc gggtgactgc ccagagctgc
      721 cgccagacct cctgctagct gagccggccg aacccgcgcc agctccggcg cctgaggagg
      781 aggcggaggg cccggccgcc gccctgggcc cccgcggacc gctgggctcc ggcccaggcg
      841 tggtgctgta cttgtgcccc gaggcgcagt gcgggcaaac cttcgccaag aagcaccagc
      901 tgaaggtgca cctgctgacg cacagcagca gccagggcca gaggcccttc aaatgccccc
      961 tgggtggctg cggctggacc ttcaccacct cttacaagct caagaggcac ctgcagtcgc
     1021 acgacaaact gcggcccttt ggctgcccgg cagagggctg tggcaagagc ttcaccacag
     1081 tgtacaacct caaggcgcac atgaagggcc atgagcagga gaactcattc aaatgcgagg
     1141 tgtgcgagga gagcttcccc acgcaggcca aactcagcgc ccaccagcgc agccacttcg
     1201 aaccggagag gccttaccag tgcgcgtttt ctggctgcaa gaagacattt atcacagtga
     1261 gtgctctgtt ttcccataac cgcgcccatt tcagggaaca ggaactgttt tcctgctctt
     1321 ttcctggctg cagcaaacaa tatgacaagg cttgtaggct gaaaattcac ctgcggagtc
     1381 acaccggcga gagacctttc ctttgtgact ttgatggctg tggctggaac ttcactagca
     1441 tgtccaaact cttaaggcac aaaagaaagc acgacgatga ccggaggttc atgtgccctg
     1501 tggaaggctg tgggaaatct ttcacgaggg cggaacatct gaaaggccac agcataaccc
     1561 acctgggcac aaagcctttc gtgtgtcctg tggcaggctg ctgtgccagg ttctctgctc
     1621 gcagtagcct ctacattcac tccaagaaac acctgcagga tgtggacact tggaaaagcc
     1681 gttgcccgat ctcctcttgt aataaactct tcacatccaa gcacagcatg aagacgcaca
     1741 tggttaaaag gcataaggtg ggccaggatc tcttagctca gctagaagca gcaaattctc
     1801 tcacacccag cagtgaactt accagccaga gacagaatga tctcagtgat gcagagatag
     1861 tgtctctctt ctctgatgta cctgacagta cttctgctgc attgctggac acagcattgg
     1921 tgaactctgg aatcttgact attgatgtgg cttctgtgag ctcgactctg gcagggcacc
     1981 tccctgctaa taataataat tccgtagggc aggctgtgga ccctccgtcc ttgatggcca
     2041 ccagcgaccc tcctcaaagt ctggatacct ctctcttttt tggaacggcg gccactggtt
     2101 ttcagcagag ctccttaaat atggatgagg tctcaagtgt aagtgtgggg ccattgggat
     2161 ctctggactc tttggccatg aaaaactcca gtccagagcc tcaggctttg acacccagca
     2221 gtaagctaac agtggacaca gatgctctga ctccttcgag caccctttgt gaaaacagtg
     2281 tctcagaact actgacacca accaaagcgg agtggaacgt acatcctgac tctgacttct
     2341 ttggacagga gggagaaacc cagtttggat tccccaatgc agcaggaaac catggttctc
     2401 agaaagaaac agatcttatc actgtgactg gcagctcatt tttggtatga accaactcta
     2461 ttcattcctc atcatgtggc ttacttttat tacagtcaat tttgaggata ttctggacta
     2521 aatatttaag tgcagtcatt tctttttggt ttgcaaaaag agcacagccc tggactacaa
     2581 gtttggagat ttaaattctg atcttgagtt tggaactgac aagttgtgtg accctgagca
     2641 agtcagttaa cctatctgag ccttaatttc cttatttata aattgaggtg gtttgaatag
     2701 attgctttta aggtctttct gctctgtgat tccttgataa tacatttctt tccttgaaaa
     2761 atatgaggac gtttttcagt gatgtggcat gcgttttttt ttaactgccc ccccagccct
     2821 gacatgttct ttttttggca aacatacata atgttacatc atactatgat gaacatccat
     2881 gtacttttca ctcaatttca gcaattatga atccatgaac aatctttttt aacttagcct
     2941 cactcactcc ccatgttcta gtattatttt gtaacaaata gcagacatct gatcatttta
     3001 tccataaata ttctttatat atctctgaaa gctatgggat gatatggaaa aaaatgataa
     3061 ttccattatc gcaagtgata tttacagtaa ttctttaata tcagtaaata tccagtgagg
     3121 gttcaaactt ccaattgcct cataaatgct acttgtttta ttatttttaa ttagtagaat
     3181 cccgtaaatc tcctaagtgt cttcttaatc cgtatgtttc cctttcatct ttcttttttt
     3241 ccttgcgatt ttgtttatga aatgaggttg tttcacatgt agcatttgcc acaatttaag
     3301 ttttgctaat tgcatcccta tggtaatgtt tgctttcctc tatcctctgt ttctttaatt
     3361 tgctagttat gtctagagac ttgatgagat tgaaacatgg cttttggcat gaatgtttca
     3421 taggttatgt tgtgttcatt tagtaggtgg cgcataatct gtggttttct ctctttttgt
     3481 ggtattagca gctgctgcag ataaatgcat taattcatga tgcttctgat atgatgagtc
     3541 atctttgtag agttactaag cattagcaaa ggaggaaatg ctatgtaata gaaatattat
     3601 tcaatgccaa aatattttct taaatagtca tagaactaac aagaaaaaat agatagcaaa
     3661 aaaatgtgtt ggctgttctc actgtttatc ttcctaactt cttttgatga tggaaggcag
     3721 ttttgtggaa attgccagcc aggactttga catgaaacag acccagggct aaattttggc
     3781 tctgtggtgt tggataagtg gccttgaata aattagttat taagcttcag ttttctagct
     3841 tttaactgat tataacaatg cacacacata cctgacacac tgttaaattt tcttctcttc
     3901 ctgtttctta tgttaaggaa agatactctg tgttttggca tatgttggtg aatttgtacc
     3961 atttttatcc tctcagtcct tccttttata agacaataat tggagtagtt taatcttatt
     4021 catgtgcaga taaaagaggt ttatgaagtt tagggtgaag taggcaaggg aatctgttta
     4081 ctccctcttc cctctactga ataattttcc ctctactgaa taattttccc tctaagaatt
     4141 gctgtgggta ataccaggag tggggacatt gcccacatgc ataagagcgt atctctccat
     4201 tcgatcagtt tgtcaccatc tttgctctgt tttgaaagtc aggcttctct gtgactgtga
     4261 agcctgctgt tccctgaaaa tctgataatg gagcagtgga ggtttttttc tttctgtgct
     4321 ctgtagatct cattgtttgc acttgtaatt tcccagagtt gaaaggaaag attgaactgg
     4381 aatattgtgt aaactatctg tcttacatta gtgtagcatt ttgcaatttg gggaacatct
     4441 tcacaatttg tgtctcgttg ttcagaacaa ccctgtgaag tagttttggc aatgtctgtg
     4501 ttacatttca tgtaatttag ccaactccca ttccaactag gctttggcta aatctgacaa
     4561 ttttatatat agcttaaaac aaagaatata cattcttttc acccctccca gtctacccat
     4621 ccagccttca tgattcattc ctgtgtcaag gttagtcgct gttttccatt tgaattggtt
     4681 tcttttatgg tcagtttact ttcttccctc tcccctccct ttcctgcaca tccccatcct
     4741 tgctatgcct ttctgtcctc ttttataatg gatatatctt tttcctgcca ttatccctca
     4801 gacattctcc tcatggcaca ttttcttcaa atgctaacat ttactgagtg tacattgaag
     4861 ttctgtgcat acaggaagaa gttattttct gagcttagat aatactatgt gtatatgtga
     4921 ttaaaatgaa gattattttc taaagccttc aaattagaag tggatttctg tttcattact
     4981 tccgttttaa aagtttttgc cagagagttt tgctaaatac tctcttattt gctctagtgt
     5041 actagtccag tagtgtttgc atgtggatgt ctgtggatga cagttattgt agcactttgg
     5101 cagtgcacta aaattttgcc actatgaaat gtttctttat tgtgtgtgcg tgtgtgtttt
     5161 gaaatacgca cacagccaca cccacatata tattaaaagt ggttgtattc atttagtgaa
     5221 aaacaaaaag tagatgtact tctgtaaatc agataaatgc ttggaatttg attgtctacc
     5281 caatcaacag ttttccctct ttgctctgga aatatttgta ctcatatagc atatttcaaa
     5341 aatgttgtca ttcattaagg cctcttaaat agaccactat tttttgtgtc tggcagatga
     5401 gtatgtcaag gattgagatg aacacataag tcttggaaat taaataaatt tataaacata
     5461 aagataa
//
