LOCUS       NM_007156               5029 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger X-linked duplicated A (ZXDA), mRNA.
ACCESSION   NM_007156 XM_939033
VERSION     NM_007156.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5029)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   2  (bases 1 to 5029)
  AUTHORS   Aleksandrova,A., Galkin,O., Koneni,R. and Fontes,J.D.
  TITLE     An N- and C-terminal truncated isoform of zinc finger X-linked
            duplicated C protein represses MHC class II transcription
  JOURNAL   Mol Cell Biochem 337 (1-2), 1-7 (2010)
   PUBMED   19777325
  REMARK    GeneRIF: Role of ZXD proteins in regulating MHC II transcription.
REFERENCE   3  (bases 1 to 5029)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
REFERENCE   4  (bases 1 to 5029)
  AUTHORS   Jambunathan,S. and Fontes,J.D.
  TITLE     Sumoylation of the zinc finger protein ZXDC enhances the function
            of its transcriptional activation domain
  JOURNAL   Biol Chem 388 (9), 965-972 (2007)
   PUBMED   17696781
REFERENCE   5  (bases 1 to 5029)
  AUTHORS   Al-Kandari,W., Koneni,R., Navalgund,V., Aleksandrova,A.,
            Jambunathan,S. and Fontes,J.D.
  TITLE     The zinc finger proteins ZXDA and ZXDC form a complex that binds
            CIITA and regulates MHC II gene transcription
  JOURNAL   J Mol Biol 369 (5), 1175-1187 (2007)
   PUBMED   17493635
  REMARK    GeneRIF: ZXDA and ZXDC form an important regulatory complex for MHC
            II gene transcription.
REFERENCE   6  (bases 1 to 5029)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 5029)
  AUTHORS   Greig,G.M., Sharp,C.B., Carrel,L. and Willard,H.F.
  TITLE     Duplicated zinc finger protein genes on the proximal short arm of
            the human X chromosome: isolation, characterization and
            X-inactivation studies
  JOURNAL   Hum Mol Genet 2 (10), 1611-1618 (1993)
   PUBMED   8268913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034396.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 1, 2020 this sequence version replaced NM_007156.4.
            
            Summary: This gene encodes one of two duplicated zinc finger genes
            on chromosome Xp11. This gene is the telomeric copy; GeneID 158586
            ZXDB is the more centromeric copy. The two genes have 98%
            nucleotide sequence similarity, and the predicted proteins contain
            10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK292686.1, BC059356.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358697.6/ ENSP00000351530.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5029              AL034396.6         18534-23562         c
FEATURES             Location/Qualifiers
     source          1..5029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..5029
                     /gene="ZXDA"
                     /gene_synonym="ZNF896"
                     /note="zinc finger X-linked duplicated A"
                     /db_xref="GeneID:7789"
                     /db_xref="HGNC:HGNC:13198"
                     /db_xref="MIM:300235"
     exon            1..5029
                     /gene="ZXDA"
                     /gene_synonym="ZNF896"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2438
                     /gene="ZXDA"
                     /gene_synonym="ZNF896"
                     /note="zinc finger protein 896"
                     /codon_start=1
                     /product="zinc finger X-linked protein ZXDA"
                     /protein_id="NP_009087.1"
                     /db_xref="CCDS:CCDS14376.1"
                     /db_xref="GeneID:7789"
                     /db_xref="HGNC:HGNC:13198"
                     /db_xref="MIM:300235"
                     /translation="MEIPKLLPARGTLQGGGGGGIPAGGGRVHRGPDSPAGQVPTRRL
                     LLPRGPQDGGPGRRREEASTASRGPGPSLFAPRPHQPSGGGDDFFLVLLDPVGGDVET
                     AGSGQAAGPVLREEAKAGPGLQGDESGANPAGCSAQGPHCLSAVPTPAPISAPGPAAA
                     FAGTVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPRCLIAPQAGFPQAAHPG
                     DCPELRSDLLLAEPAEPAPAPAPQEEAEGLAAALGPRGLLGSGPGVVLYLCPEALCGQ
                     TFAKKHQLKMHLLTHSSSQGQRPFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPA
                     EGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLGAHQRSHFEPERPYQCA
                     FSGCKKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPF
                     LCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTK
                     PFVCPVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCPISSCNKLFTSKHSMKTHMVK
                     RHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDTALV
                     NSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAAT
                     GFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQALTPSSKLTVDTDTLTPSSTLC
                     ENSVSELLTPAKAEWSVHPNSDFFGQEGETQFGFPNAAGNHGSQKERNLITVTGSSFL
                     V"
     regulatory      5008..5013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZXDA"
                     /gene_synonym="ZNF896"
                     /note="hexamer: AATAAA"
     polyA_site      5029
                     /gene="ZXDA"
                     /gene_synonym="ZNF896"
                     /note="major polyA site"
ORIGIN      
        1 ctcggctctg gttccagccg agcctctcgg acgcagagat ggaaatcccg aagctgctcc
       61 cggctcgcgg gacactacag ggcggcggcg gcggcggtat ccccgcgggt ggcggccgag
      121 tccaccgagg ccctgactcg ccggctggcc aggtccccac gcgccgcctc ctgctgcccc
      181 ggggccccca agatggcggg cccgggcggc ggcgcgagga ggccagcacg gcatcacggg
      241 gccctggccc aagcctgttc gcgccgaggc cccatcaacc tagcggcggc ggcgacgact
      301 tcttcctggt gctgcttgac ccggtgggtg gcgacgtgga gaccgcgggc tccggtcagg
      361 ccgcagggcc tgtgttgagg gaggaggcca aggcgggccc ggggctccag ggggacgaga
      421 gcggcgcgaa ccccgcgggc tgctctgcgc agggccccca ctgcctgtcc gcggttccca
      481 ctccggcccc gatctccgcc cccggccccg ccgcggcctt cgcgggcaca gtcactatcc
      541 acaaccagga cctgctgttg cgctttgaga acggcgtcct caccctggcc acgcccccac
      601 cacacgcctg ggagccaggg gccgctcctg cccagcagcc caggtgtctg atcgcccccc
      661 aagctgggtt cccgcaagcc gcgcacccgg gtgactgccc agagctgcgg tccgacctcc
      721 tgctagccga gcccgcagaa cccgcgcctg ctccggcgcc ccaggaggag gcggagggcc
      781 tggccgccgc cctgggcccc cgcggactgc tgggctctgg tccaggcgtg gtgctgtacc
      841 tgtgccccga ggcgctgtgc gggcaaacct tcgccaagaa gcaccagctg aagatgcacc
      901 tgctgacgca cagcagcagc cagggccaga ggcccttcaa atgccccctg ggtggctgcg
      961 gctggacctt caccacctct tacaagctca agaggcacct gcagtcgcac gataaactgc
     1021 ggcccttcgg ctgccctgcg gagggctgtg gcaagagctt caccaccgtg tacaacctca
     1081 aggcgcacat gaagggccat gagcaggaga actcgttcaa atgtgaggtg tgcgaggaga
     1141 gcttccccac gcaggccaaa ctcggcgccc accagcgcag ccacttcgaa cccgagaggc
     1201 cttaccagtg cgcgttttct ggctgcaaga agacatttat cacagtgagt gctctgtttt
     1261 cccataaccg cgcccatttc agggaacagg aactgttttc ctgctctttc cctggctgca
     1321 gcaagcaata tgacaaggct tgtaggctga aaattcacct gcggagtcac accggcgaga
     1381 gacctttcct ttgtgacttt gatggctgtg gctggaactt caccagcatg tccaaactct
     1441 taaggcacaa aaggaagcac gacgatgacc ggaggttcat gtgccctgtg gaaggctgtg
     1501 ggaaatcttt cacgagggcc gaacatctga aaggccacag cattacccac ctgggcacaa
     1561 agcctttcgt gtgtcctgtg gcaggctgct gtgccaggtt ctctgctcgc agtagcctct
     1621 acattcactc caagaaacac ctgcaggatg tggacacttg gaaaagccgt tgcccgatct
     1681 cctcttgtaa taaactcttc acatccaagc acagcatgaa gacgcacatg gttaaaaggc
     1741 ataaggtggg ccaggatctc ttagctcagc tagaagcagc aaattctctt acacccagca
     1801 gtgaacttac cagccagaga cagaatgatc tcagtgatgc agagatagtg tctctcttct
     1861 ctgatgtacc tgacagtact tctgctgcat tgctggacac agcattggtg aactctggaa
     1921 tcttgactat tgatgtggct tctgtgagct cgactctggc agggcacctc cctgctaata
     1981 ataataattc cgtagggcag gctgtggacc ctccgtcctt gatggccacc agcgaccctc
     2041 ctcaaagtct ggatacctct ctcttttttg gaacggcggc cactggtttt cagcagagct
     2101 ccttaaatat ggatgaggtc tcaagtgtaa gtgtggggcc attgggatct ctggactctt
     2161 tggccatgaa aaactccagt ccagagcctc aggctttgac acccagcagt aagctaacag
     2221 tggacacaga tactctgact ccttcgagca ccctttgtga aaacagtgtc tcagaactac
     2281 tgacaccagc caaagcggag tggagcgtac atcctaactc tgacttcttt ggacaggagg
     2341 gagaaaccca gtttggattc cccaatgcag caggaaacca tggttctcag aaagaaagaa
     2401 atcttatcac tgtgactggc agctcatttt tggtatgaag caactctatt cattccttgc
     2461 catgtggcta acttttatta cagtcaattt tgaggatatt ctggactaaa tatttaagtg
     2521 cagtcatttc tttttggttt gcaaaaagag cacagccctg gactatgagt ttggagatct
     2581 aaattctgat cttgagtctg gaactgacaa gttgtgtgac cctcagcaag tcacttaacc
     2641 tatctgagcc ttaatttcct tatttataaa ttgtggtggt ttgaacacat tgctcataag
     2701 gtcttttcag ttttgttttg ttttgttttg tgattttgtg ctttttcttg aaaattttcg
     2761 ggcattttgc aattattatt gtttgtactt gtaatcagaa gcggtttgag ccctgtagca
     2821 ctaaataatg aaagattgag gaactggtgt tttacattaa aaatttaatg gaaattttac
     2881 acagtacgaa aatctaatga tagagctcaa aaaaaaagag ctaaaaatag gagttggttc
     2941 ttcttagctg tttatccttc taaccttttt tttaaatgat gaaggtatgt ttttgttgtg
     3001 gaaaatacaa gggcttttgt tatcactcag acccagagtg aaatgtttgc tttgtggttt
     3061 tgaataagtt ggcctttaat aagttattta gtctctctta gcctcagttt tctatctgta
     3121 aaatggtcat agcaatgtga acatatgtgt tacatcctag acttattttt ctaccccagt
     3181 aggttgtatt gaaaggaaaa tgttatatgt gtttcagcat gttttggtga atcttcattc
     3241 cctttcctgc cccttgtttt ccctcctcaa aggggagaaa ttagcacaaa ttagtatcag
     3301 gattgtgcag gaaataaaca tttgtgaagg ttaagaaaga ggaaaaggaa gttatttctt
     3361 caacagatta aggatttttc tacacacagt tcttttgtgg cattggccac atgtccatta
     3421 gaccaatttg atagtatctt cggtctgcat tcaaagccag ctcatgcaat gagtattcag
     3481 cctattcttc caagacaatc tggacataga ccagagggag atttttctcc cctctgtgcc
     3541 ctagagagct cattgctggc ttactcttag agttgaaatg agagggtttt gtctgcattt
     3601 tgagtagata ccatctatct tatgtgagta tagcatttta caatttagca ctttcacaac
     3661 tattatattt gatcctcaca atcctgtgag gtaattatgg caaagtcaga tctacaattc
     3721 atattaaaat ttacctagct cagattacaa atgtatttca cttagtaatg tgtgtgtgtg
     3781 tgtgtgtgtg tgtgtgtgtg tagctcaaaa caaagaggaa atatttccca ctctcccatt
     3841 cgactcttga gtttcatgac tattttgttt ataactgttt gctgcctccc accttaattg
     3901 atttctctta cattctttgt actccatgct atttccttgt aggtgtacac cagtccttgc
     3961 catgaatctc ttttacttac atttaaatta gacacgtctc tttcatggtc accatctctc
     4021 agccattctt cttatggccc atttttcagt cacagtatta ctgcaagtat gtgtgtacat
     4081 tgagaagtaa ttttctggat ttagatggca atgtgtttat acatgaatca gataataatg
     4141 gagacatttt atataaggtg ttagtgagaa gtagttctac ttttcctttt ttacagtgtg
     4201 gtcctggtag caaacactat tagttgcttt caactattgt aacccagtat tgtttacatg
     4261 tggatacttg gggataacaa ttattatggc actttaacag tgcactttaa tatataccac
     4321 cttgatatac atctttactg tctttataat ttttaagttg gttgtactta ttcaatgaaa
     4381 aagcaaaaaa tacacataaa tttgtaattc aaagaaatag aattttgtgt ctaaccattt
     4441 aacagttctc ccttagtatt ttagaaagat tttaagccat tttagaaatg tgttgtcatt
     4501 agttaagtcc tcttaaatag attattatta ttttcctata gaaaatgcag aggcctgagg
     4561 tgaacgcaag ggtcataggc atccattaag atacataact atatagatat cttaaaactc
     4621 tgtcacattg tttccttaat cccttagacc tatttcctcc catgaaaact atcataagct
     4681 atgcttttgt tatggtctat agaattttca aaggacaaat tttttttttt taggataaag
     4741 atcttgtgat tgtccgtggg ctcacatggt ttcttttgtt caattttttc aaaagatttc
     4801 tttttcaata ctgttgtccc accatgatag ttgacatggc atgtaattac agacagaagt
     4861 gtgactgtaa acatattagt gtttctgtta gtgttggcat aagcttgcct ttttgtttaa
     4921 acaatggaac atgatttaat tttatctcat ttgccttttg tttatcttca gtccttgatt
     4981 tattaacatt ttgccaattg aaaacacaat aaaaaatgcc ttgcaggaa
//
