LOCUS       NM_007057               1857 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens ZW10 interacting kinetochore protein (ZWINT),
            transcript variant 1, mRNA.
ACCESSION   NM_007057
VERSION     NM_007057.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Ma,Z., Cai,Y. and Tian,C.
  TITLE     ZWINT promotes the proliferation, migration, and invasion of
            cervical cancer cells by regulating the p53/p21 signaling pathway
  JOURNAL   Chin J Physiol 66 (5), 372-378 (2023)
   PUBMED   37929349
  REMARK    GeneRIF: ZWINT promotes the proliferation, migration, and invasion
            of cervical cancer cells by regulating the p53/p21 signaling
            pathway.
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Nygaard,M., Dowsett,J., McGue,M., Christensen,K., Christiansen,L.,
            Tan,Q. and Mengel-From,J.
  TITLE     Genome-wide association analysis of cognitive function in Danish
            long-lived individuals
  JOURNAL   Mech Ageing Dev 195, 111463 (2021)
   PUBMED   33607172
  REMARK    GeneRIF: Genome-wide association analysis of cognitive function in
            Danish long-lived individuals.
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Yang,L., Han,N., Zhang,X., Zhou,Y., Chen,R. and Zhang,M.
  TITLE     ZWINT: A potential therapeutic biomarker in patients with
            glioblastoma correlates with cell proliferation and invasion
  JOURNAL   Oncol Rep 43 (6), 1831-1844 (2020)
   PUBMED   32323832
  REMARK    GeneRIF: ZWINT: A potential therapeutic biomarker in patients with
            glioblastoma correlates with cell proliferation and invasion.
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Wang,H., Hu,X., Ding,X., Dou,Z., Yang,Z., Shaw,A.W., Teng,M.,
            Cleveland,D.W., Goldberg,M.L., Niu,L. and Yao,X.
  TITLE     Human Zwint-1 specifies localization of Zeste White 10 to
            kinetochores and is essential for mitotic checkpoint signaling
  JOURNAL   J Biol Chem 279 (52), 54590-54598 (2004)
   PUBMED   15485811
  REMARK    GeneRIF: show that ZW10 interacting protein-1(Zwint-1) is required
            and is sufficient for kinetochore localization of Zeste White 10
            (ZW10) in HeLa cells
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Obuse,C., Iwasaki,O., Kiyomitsu,T., Goshima,G., Toyoda,Y. and
            Yanagida,M.
  TITLE     A conserved Mis12 centromere complex is linked to heterochromatic
            HP1 and outer kinetochore protein Zwint-1
  JOURNAL   Nat Cell Biol 6 (11), 1135-1141 (2004)
   PUBMED   15502821
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Musio,A., Mariani,T., Montagna,C., Zambroni,D., Ascoli,C., Ried,T.
            and Vezzoni,P.
  TITLE     Recapitulation of the Roberts syndrome cellular phenotype by
            inhibition of INCENP, ZWINT-1 and ZW10 genes
  JOURNAL   Gene 331, 33-40 (2004)
   PUBMED   15094189
REFERENCE   9  (bases 1 to 1857)
  AUTHORS   Van Hooser,A.A., Ouspenski,I.I., Gregson,H.C., Starr,D.A.,
            Yen,T.J., Goldberg,M.L., Yokomori,K., Earnshaw,W.C., Sullivan,K.F.
            and Brinkley,B.R.
  TITLE     Specification of kinetochore-forming chromatin by the histone H3
            variant CENP-A
  JOURNAL   J Cell Sci 114 (Pt 19), 3529-3542 (2001)
   PUBMED   11682612
REFERENCE   10 (bases 1 to 1857)
  AUTHORS   Starr,D.A., Saffery,R., Li,Z., Simpson,A.E., Choo,K.H., Yen,T.J.
            and Goldberg,M.L.
  TITLE     HZwint-1, a novel human kinetochore component that interacts with
            HZW10
  JOURNAL   J Cell Sci 113 (Pt 11), 1939-1950 (2000)
   PUBMED   10806105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG615304.1, BC020979.1,
            BC000411.1, BC016357.2 and AC010996.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007057.3.
            
            Summary: This gene encodes a protein that is clearly involved in
            kinetochore function although an exact role is not known. It
            interacts with ZW10, another kinetochore protein, possibly
            regulating the association between ZW10 and kinetochores. The
            encoded protein localizes to prophase kinetochores before ZW10 does
            and it remains detectable on the kinetochore until late anaphase.
            It has a uniform distribution in the cytoplasm of interphase cells.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) is the predominant transcript
            and differs in the 3' UTR compared to variant 2. Variants 1 and 2
            both encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.185059.1,
                                           SRR5189667.148865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385, SAMEA2161836
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373944.8/ ENSP00000363055.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               BG615304.1         15-340
            327-581             BC020979.1         328-582
            582-898             BC000411.1         208-524
            899-1279            BC000411.1         716-1096
            1280-1638           BC020979.1         1281-1639
            1639-1646           BC016357.2         957-964
            1647-1857           AC010996.9         120187-120397       c
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..1857
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /note="ZW10 interacting kinetochore protein"
                     /db_xref="GeneID:11130"
                     /db_xref="HGNC:HGNC:13195"
                     /db_xref="MIM:609177"
     exon            1..64
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..857
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /note="isoform a is encoded by transcript variant 1; human
                     ZW10 interacting protein-1; zwint-1; ZW10 interactor,
                     kinetochore protein; SNAP25 interacting protein of 30 kDa;
                     outer kinetochore KNL1 complex subunit ZWINT"
                     /codon_start=1
                     /product="outer kinetochore KNL1 complex subunit ZWINT
                     isoform a"
                     /protein_id="NP_008988.2"
                     /db_xref="CCDS:CCDS7249.1"
                     /db_xref="GeneID:11130"
                     /db_xref="HGNC:HGNC:13195"
                     /db_xref="MIM:609177"
                     /translation="MEAAETEAEAAALEVLAEVAGILEPVGLQEEAELPAKILVEFVV
                     DSQKKDKLLCSQLQVADFLQNILAQEDTAKGLDPLASEDTSRQKAIAAKEQWKELKAT
                     YREHVEAIKIGLTKALTQMEEAQRKRTQLREAFEQLQAKKQMAMEKRRAVQNQWQLQQ
                     EKHLQHLAEVSAEVRERKTGTQQELDRVFQKLGNLKQQAEQERDKLQRYQTFLQLLYT
                     LQGKLLFPEAEAEAENLPDDKPQQPTRPQEQSTGDTMGRDPGVSFKAVGLQPAGDVNL
                     P"
     exon            65..155
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..279
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..446
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..503
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..646
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..815
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..898
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1857
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1004..1009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /note="hexamer: ATTAAA"
     polyA_site      1027
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /note="major polyA site"
     regulatory      1622..1627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /note="hexamer: AATAAA"
     polyA_site      1639
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /note="major polyA site"
     regulatory      1811..1816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /note="hexamer: AATAAA"
     polyA_site      1837
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
                     /note="major polyA site"
     polyA_site      1857
                     /gene="ZWINT"
                     /gene_synonym="HZwint-1; KNTC2AP; SIP30; ZWINT1"
ORIGIN      
        1 agctgaactc ggcgcctgga aagatggagg cagcggagac agaggcggaa gctgcagccc
       61 tagaggtcct ggctgaggtg gcaggcatct tggaacctgt aggcctgcag gaggaggcag
      121 aactgccagc caagatcctg gttgagtttg tggtggactc tcagaagaaa gacaagctgc
      181 tctgcagcca gcttcaggta gcggatttcc tgcagaacat cctggctcag gaggacactg
      241 ctaagggtct cgaccccttg gcttctgaag acacgagccg acagaaggca attgcagcta
      301 aggaacaatg gaaagagctg aaggccacct acagggagca cgtagaggcc atcaaaattg
      361 gcctcaccaa ggccctgact cagatggagg aagcccagag gaaacggaca caactccggg
      421 aagcctttga gcagctccag gccaagaaac aaatggccat ggagaaacgc agagcagtcc
      481 agaaccagtg gcagctacaa caggagaagc atctgcagca tctggcggag gtttctgcag
      541 aggtgaggga gcgtaagaca gggactcagc aggagcttga cagggtgttt cagaaacttg
      601 gaaacctgaa gcagcaggca gaacaggagc gggacaagct gcagaggtat cagaccttcc
      661 tccagcttct gtataccctg cagggtaagc tgttgttccc tgaggctgag gctgaggcag
      721 agaatcttcc agatgataaa ccccagcagc cgactcgacc ccaggagcag agtacaggag
      781 acaccatggg gagagaccct ggtgtgtcct tcaaggctgt tggtctacaa cctgctggag
      841 atgtaaattt gccatgactt cctggaggac agcagcatgg agaaagatcc tagaaaaggc
      901 ctctgacttc cctcacctcc caaccatcat tacaggaaag actgtgaact cctgagttca
      961 gcttgatttc tgactacatc ccagcaagct ctggcatctg tggattaaaa tccctggatc
     1021 tctctcagtt gtgtatttgt tcatcttcat atgctggcag gaacaactat taatacagat
     1081 actcagaagc caataacatg acaggagctg ggactggttt gaacacaggg tgtgcagatg
     1141 gggagggggt actggccttg ggcctcctat gatgcagaca tggtgaattt aattcaagga
     1201 ggaggagaat gttttaggca ggtggttata tgtgggaaga taattttatt catggatcca
     1261 aatgtttgtt gagtcctttc tttgtgctaa ggttcttgcg gtgaaccaga attataacag
     1321 tgagctcatc tgactgtttt aggatgtaca gcctagtgtt aacattcttg gtatcttttt
     1381 gtgccttatc taaaacattt ctcgatcact ggtttcagat gttcatttat tatattcttt
     1441 tcaaagattc agagattggc ttttgtcatc cactattgta tgttttgttt cattgacctc
     1501 tagtgatacc ttgatctttc ccactttctg ttttcggatt ggagaagatg tacctttttt
     1561 gtcaactctt acttttatca gatgatcaac tcacgtattt ggatctttat ttgttttctc
     1621 aaataaatat ttaaggttat acatttcttc tgacttcctt tattttcaca atcattcaat
     1681 tcatagcatt tcctatattc tgttataatt atttcattga ttcataaatt tctttgaaaa
     1741 ataatttggt cttctattga ttgtgagaag ataatctaag tttaatttgg tcagagaata
     1801 tcatctgttt aataaacttt gaaatttggt gagtgaatta tcttttttac tgataaa
//
