LOCUS       NM_001367799            6052 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens zinc finger SWIM-type containing 8 (ZSWIM8),
            transcript variant 4, mRNA.
ACCESSION   NM_001367799 XM_005269653
VERSION     NM_001367799.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6052)
  AUTHORS   Wang,G., Lei,J., Wang,Y., Yu,J., He,Y., Zhao,W., Hu,Z., Xu,Z.,
            Jin,Y., Gu,Y., Guo,X., Yang,B., Gao,Z. and Wang,Z.
  TITLE     The ZSWIM8 ubiquitin ligase regulates neurodevelopment by guarding
            the protein quality of intrinsically disordered Dab1
  JOURNAL   Cereb Cortex 33 (7), 3866-3881 (2023)
   PUBMED   35989311
REFERENCE   2  (bases 1 to 6052)
  AUTHORS   Molina-Pelayo,C., Olguin,P., Mlodzik,M. and Glavic,A.
  TITLE     The conserved Pelado/ZSWIM8 protein regulates actin dynamics by
            promoting linear actin filament polymerization
  JOURNAL   Life Sci Alliance 5 (12), e202201484 (2022)
   PUBMED   35940847
  REMARK    GeneRIF: The conserved Pelado/ZSWIM8 protein regulates actin
            dynamics by promoting linear actin filament polymerization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6052)
  AUTHORS   Okumura,F., Oki,N., Fujiki,Y., Ikuta,R., Osaki,K., Hamada,S.,
            Nakatsukasa,K., Hisamoto,N., Hara,T. and Kamura,T.
  TITLE     ZSWIM8 is a myogenic protein that partly prevents C2C12
            differentiation
  JOURNAL   Sci Rep 11 (1), 20880 (2021)
   PUBMED   34686700
  REMARK    GeneRIF: ZSWIM8 is a myogenic protein that partly prevents C2C12
            differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6052)
  AUTHORS   Shi,C.Y., Kingston,E.R., Kleaveland,B., Lin,D.H., Stubna,M.W. and
            Bartel,D.P.
  TITLE     The ZSWIM8 ubiquitin ligase mediates target-directed microRNA
            degradation
  JOURNAL   Science 370 (6523) (2020)
   PUBMED   33184237
  REMARK    GeneRIF: The ZSWIM8 ubiquitin ligase mediates target-directed
            microRNA degradation.
REFERENCE   5  (bases 1 to 6052)
  AUTHORS   Han,J., LaVigne,C.A., Jones,B.T., Zhang,H., Gillett,F. and
            Mendell,J.T.
  TITLE     A ubiquitin ligase mediates target-directed microRNA decay
            independently of tailing and trimming
  JOURNAL   Science 370 (6523) (2020)
   PUBMED   33184234
  REMARK    GeneRIF: A ubiquitin ligase mediates target-directed microRNA decay
            independently of tailing and trimming.
REFERENCE   6  (bases 1 to 6052)
  AUTHORS   Sogayar,M.C., Camargo,A.A., Bettoni,F., Carraro,D.M., Pires,L.C.,
            Parmigiani,R.B., Ferreira,E.N., de Sa Moreira,E., do Rosario D de O
            Latorre,M., Simpson,A.J., Cruz,L.O., Degaki,T.L., Festa,F.,
            Massirer,K.B., Sogayar,M.C., Filho,F.C., Camargo,L.P., Cunha,M.A.,
            De Souza,S.J., Faria,M. Jr., Giuliatti,S., Kopp,L., de
            Oliveira,P.S., Paiva,P.B., Pereira,A.A., Pinheiro,D.G., Puga,R.D.,
            S de Souza,J.E., Albuquerque,D.M., Andrade,L.E., Baia,G.S.,
            Briones,M.R., Cavaleiro-Luna,A.M., Cerutti,J.M., Costa,F.F.,
            Costanzi-Strauss,E., Espreafico,E.M., Ferrasi,A.C., Ferro,E.S.,
            Fortes,M.A., Furchi,J.R., Giannella-Neto,D., Goldman,G.H.,
            Goldman,M.H., Gruber,A., Guimaraes,G.S., Hackel,C.,
            Henrique-Silva,F., Kimura,E.T., Leoni,S.G., Macedo,C., Malnic,B.,
            Manzini,B. CV, Marie,S.K., Martinez-Rossi,N.M., Menossi,M.,
            Miracca,E.C., Nagai,M.A., Nobrega,F.G., Nobrega,M.P.,
            Oba-Shinjo,S.M., Oliveira,M.K., Orabona,G.M., Otsuka,A.Y.,
            Paco-Larson,M.L., Paixao,B.M., Pandolfi,J.R., Pardini,M.I., Passos
            Bueno,M.R., Passos,G.A., Pesquero,J.B., Pessoa,J.G., Rahal,P.,
            Rainho,C.A., Reis,C.P., Ricca,T.I., Rodrigues,V., Rogatto,S.R.,
            Romano,C.M., Romeiro,J.G., Rossi,A., Sa,R.G., Sales,M.M.,
            Sant'Anna,S.C., Santarosa,P.L., Segato,F., Silva,W.A. Jr.,
            Silva,I.D., Silva,N.P., Soares-Costa,A., Sonati,M.F., Strauss,B.E.,
            Tajara,E.H., Valentini,S.R., Villanova,F.E., Ward,L.S. and
            Zanette,D.L.
  CONSRTM   Ludwig-FAPESP Transcript Finishing Initiative
  TITLE     A transcript finishing initiative for closing gaps in the human
            transcriptome
  JOURNAL   Genome Res 14 (7), 1413-1423 (2004)
   PUBMED   15197164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022400.9.
            
            On Dec 18, 2018 this sequence version replaced XM_005269653.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000604729.6/ ENSP00000474944.1
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               AC022400.9         118317-118797
            482-635             AC022400.9         121381-121534
            636-730             AC022400.9         121807-121901
            731-903             AC022400.9         122078-122250
            904-1011            AC022400.9         122428-122535
            1012-1093           AC022400.9         122667-122748
            1094-1214           AC022400.9         122883-123003
            1215-1416           AC022400.9         123686-123887
            1417-1592           AC022400.9         124035-124210
            1593-2586           AC022400.9         124570-125563
            2587-2718           AC022400.9         126299-126430
            2719-2898           AC022400.9         126576-126755
            2899-3082           AC022400.9         126858-127041
            3083-3181           AC022400.9         127252-127350
            3182-3306           AC022400.9         128250-128374
            3307-3547           AC022400.9         129485-129725
            3548-3706           AC022400.9         129824-129982
            3707-3935           AC022400.9         130088-130316
            3936-4225           AC022400.9         130492-130781
            4226-4449           AC022400.9         130941-131164
            4450-4938           AC022400.9         131713-132201
            4939-5098           AC022400.9         132722-132881
            5099-5275           AC022400.9         133007-133183
            5276-5395           AC022400.9         133351-133470
            5396-5574           AC022400.9         133728-133906
            5575-6052           AC022400.9         134027-134504
FEATURES             Location/Qualifiers
     source          1..6052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..6052
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /note="zinc finger SWIM-type containing 8"
                     /db_xref="GeneID:23053"
                     /db_xref="HGNC:HGNC:23528"
                     /db_xref="MIM:619213"
     exon            1..481
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..5778
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /note="isoform 4 is encoded by transcript variant 4; zinc
                     finger SWIM domain-containing protein 8; Pelado; Dorado"
                     /codon_start=1
                     /product="zinc finger SWIM domain-containing protein 8
                     isoform 4"
                     /protein_id="NP_001354728.1"
                     /db_xref="CCDS:CCDS91266.1"
                     /db_xref="GeneID:23053"
                     /db_xref="HGNC:HGNC:23528"
                     /db_xref="MIM:619213"
                     /translation="MELMFAEWEDGERFSFEDSDRFEEDSLCSFISEAESLCQNWRGW
                     RKQSAGPNSPTGGGGGGGSGGTRMRDGLVIPLVELSAKQVAFHIPFEVVEKVYPPVPE
                     QLQLRIAFWSFPENEEDIRLYSCLANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATV
                     VPPQMVPPKGAYNVAVMFDRCRVTSCSCTCGAGAKWCTHVVALCLFRIHNASAVCLRA
                     PVSESLSRLQRDQLQKFAQYLISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPT
                     AGPSASDQSTWYLDESTLTDNIKKTLHKFCGPSPVVFSDVNSMYLSSTEPPAAAEWAC
                     LLRPLRGREPEGVWNLLSIVREMFKRRDSNAAPLLEILTDQCLTYEQITGWWYSVRTS
                     ASHSSASGHTGRSNGQSEVAAHACASMCDEMVTLWRLAVLDPALSPQRRRELCTQLRQ
                     WQLKVIENVKRGQHKKTLERLFPGFRPAVEACYFNWEEAYPLPGVTYSGTDRKLALCW
                     ARALPSRPGASRSGGLEESRDRPRPLPTEPAVRPKEPGTKRKGLGEGVPSSQRGPRRL
                     SAEGGDKALHKMGPGGGKAKALGGAGSGSKGSAGGGSKRRLSSEDSSLEPDLAEMSLD
                     DSSLALGAEASTFGGFPESPPPCPLHGGSRGPSTFLPEPPDTYEEDGGVYFSEGPEPP
                     TASVGPPGLLPGDVCTQDDLPSTDESGNGLPKTKEAAPAVGEEDDDYQAYYLNAQDGA
                     GGEEEKAEGGAGEEHDLFAGLKPLEQESRMEVLFACAEALHAHGYSSEASRLTVELAQ
                     DLLANPPDLKVEPPPAKGKKNKVSTSRQTWVATNTLSKAAFLLTVLSERPEHHNLAFR
                     VGMFALELQRPPASTKALEVKLAYQESEVAALLKKIPLGPSEMSTMRCRAEELREGTL
                     CDYRPVLPLMLASFIFDVLCAPVVSPTGSRPPSRNWNSETPGDEELGFEAAVAALGMK
                     TTVSEAEHPLLCEGTRREKGDLALALMITYKDDQAKLKKILDKLLDRESQTHKPQTLS
                     SFYSSSRPTTASQRSPSKHGGPSAPGALQPLTSGSAGPAQPGSVAGAGPGPTEGFTEK
                     NVPESSPHSPCEGLPSEAALTPRPEGKVPSRLALGSRGGYNGRGWGSPGRPKKKHTGM
                     ASIDSSAPETTSDSSPTLSRRPLRGGWAPTSWGRGQDSDSISSSSSDSLGSSSSSGSR
                     RASASGGARAKTVEVGRYKGRRPESHAPHVPNQPSEAAAHFYFELAKTVLIKAGGNSS
                     TSIFTHPSSSGGHQGPHRNLHLCAFEIGLYALGLHNFVSPNWLSRTYSSHVSWITGQA
                     MEIGSAALTILVECWDGHLTPPEVASLADRASRARDSNMVRAAAELALSCLPHAHALN
                     PNEIQRALVQCKEQDNLMLEKACMAVEEAAKGGGVYPEVLFEVAHQWFWLYEQTAGGS
                     STAREGATSCSASGIRAGGEAGRGMPEGRGGPGTEPVTVAAAAVTAAATVVPVISVGS
                     SLYPGPGLGHGHSPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSA
                     YPQGVHPAFLGAQYPYSVTPPSLAATAVSFPVPSMAPITVHPYHTEPGLPLPTSVALS
                     SVHPASTFPAIQGASLPALTTQPSPLVSGGFPPPEEETHSQPVNPHSLHHLHAAYRVG
                     MLALEMLGRRAHNDHPNNFSRSPPYTDDVKWLLGLAAKLGVNYVHQFCVGAAKGVLSP
                     FVLQEIVMETLQRLSPAHAHNHLRAPAFHQLVQRCQQAYMQYIHHRLIHLTPADYDDF
                     VNAIRSARSAFCLTPMGMMQFNDILQNLKRSKQTKELWQRVSLEMATFSP"
     exon            482..635
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            636..730
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            731..903
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1011
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1093
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1214
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1416
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1592
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..2586
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2718
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2898
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3082
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3181
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3306
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3547
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..3706
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3935
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4225
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..4449
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..4938
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            4939..5098
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            5099..5275
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5395
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            5396..5574
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            5575..6052
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6031..6036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /note="hexamer: TATAAA"
     polyA_site      6052
                     /gene="ZSWIM8"
                     /gene_synonym="KIAA0913"
                     /note="major polyA site"
ORIGIN      
        1 agccgcctag aggccccagc cgccgagcgc ttcgtcccgg ccctaagtct cggagactgg
       61 ccaagatcac cgcttgcacc gcgctgttgg gcgaggcccg gtcccgtctc tttcccaggc
      121 ctgagattct cgcccggcac ggccgccctg agcgccccgg ccacccccag ccccggctcg
      181 cccctcaggc cccgggcctc ccctcaaccc ccggccggcg gcccaggccc cggatccgcg
      241 gggggggacc cggccccggg gggtgcgggc cccatggagc tgatgtttgc agagtgggag
      301 gacggagagc gcttctcatt cgaggattcg gaccgttttg aggaggattc actctgttcc
      361 ttcatctccg aggccgagag cctctgccag aactggcggg gatggcgcaa acagtcagcg
      421 gggcccaatt cccccactgg cggcggtggc ggaggtggca gtggcggtac cagaatgcga
      481 gatggactgg tgatcccatt ggtggagctg tcagcaaagc aggtggcatt tcatatccca
      541 tttgaagtgg tggagaaagt ttacccacca gtgcctgagc agctacagct ccgaattgct
      601 ttttggagct tccctgagaa tgaagaggac attcggctgt attcgtgcct ggccaatggc
      661 agtgcggatg agtttcagcg aggggatcag ctcttccgca tgcgggctgt gaaggaccca
      721 ttgcagatag ggttccacct gagtgctaca gtggtgccac ctcagatggt ccctcctaaa
      781 ggggcctaca acgtggctgt gatgtttgac cgctgccggg tcacttcctg cagctgtacc
      841 tgtggggctg gggccaaatg gtgcacccac gtcgtggcac tctgtctctt ccgcatccac
      901 aacgcttctg cagtctgcct gcgagcccca gtctcagagt ccctgtcccg gctacagagg
      961 gaccagctgc aaaagtttgc tcagtacctc atcagtgagc tccctcagca gatcctcccc
     1021 acagctcagc gtctcctgga cgaactcctg tcttcccagt caacagccat caatacagtg
     1081 tgtggagctc cggaccccac agcagggccc tcagcatcgg accagagtac ttggtatctg
     1141 gatgaatcga cactcactga caacatcaaa aagacactgc acaagttctg tggcccctcc
     1201 cctgtggtct tcagtgatgt gaactccatg tatctgtctt ccacggagcc gccagccgct
     1261 gctgaatggg catgtctgct gcgccctctg aggggccgtg agccagaggg cgtctggaac
     1321 ctgctaagca ttgtgcggga gatgttcaag cggagggaca gcaatgctgc ccccttgttg
     1381 gaaatcctca ctgaccagtg cctcacctat gaacagataa caggttggtg gtatagcgta
     1441 cgtacctcag cctcacacag cagtgccagt gggcacacgg gccgtagcaa cgggcagtca
     1501 gaggtggcag cccatgcctg tgccagcatg tgtgacgaga tggtcacact gtggaggctg
     1561 gccgtgctgg accctgcact cagcccccag cggcgccggg aactgtgtac gcagctgcgg
     1621 cagtggcaac tgaaggtgat tgagaacgtc aagcggggcc aacacaagaa gacgctggag
     1681 cggctcttcc ccggcttccg gccagcggtg gaggcctgct acttcaactg ggaagaggcc
     1741 tacccacttc ctggtgtcac ctacagcggc actgacagga agctggcact gtgctgggcc
     1801 cgggccctgc cctctcggcc aggtgcctcc cgctctgggg gcctggagga atcccgggac
     1861 cggccccgac cccttcctac tgagccagct gtgcggccca aggagcctgg gaccaagcga
     1921 aagggcttgg gtgagggggt cccctcatca cagcggggtc cccgccgcct ctcagctgaa
     1981 gggggagata aagctctaca taagatgggt ccaggtgggg gcaaagccaa ggcactgggt
     2041 ggggctggca gtgggagcaa gggctcagca ggtggcggaa gcaagcgacg gctgagcagc
     2101 gaagacagct ccctggagcc agacctggcc gagatgagcc tggatgacag cagcctggcc
     2161 ctgggcgcag aggccagcac cttcggggga ttccctgaga gccctccacc ctgtcctctc
     2221 cacggtggct cccgaggccc ttccactttc cttcctgagc ccccagatac ttatgaagaa
     2281 gatggtggtg tgtacttctc ggaagggcct gagcctccca cagcctctgt tggcccccct
     2341 ggcctactgc ctggggatgt ctgtacccag gacgacctcc cttctacaga tgagagtggc
     2401 aatgggcttc ccaaaaccaa agaggcagcc cctgcagttg gagaggagga tgatgactac
     2461 caggcgtact atctgaatgc ccaggatggg gctgggggcg aggaagagaa ggccgagggc
     2521 ggggctgggg aggagcacga cctgtttgct gggctgaagc cactggaaca ggagagtcgc
     2581 atggaggtac tgtttgcctg tgctgaggcc ctgcatgcgc atggctatag cagtgaggcc
     2641 tcccgtctca ctgtggagct tgcccaggat ctgctagcca acccacccga cctcaaggta
     2701 gagccgcccc ctgccaaggg caagaagaac aaggtatcca cgagccgtca gacctgggtg
     2761 gctaccaaca ccctgagcaa ggcggccttc ctgttgacag tgctaagtga gcgtccagag
     2821 caccacaacc tggccttccg agttggcatg tttgccttgg agctacagag gcctccagct
     2881 tctaccaagg ccttggaggt gaagctggca taccaggagt ctgaggtggc tgccctgctc
     2941 aagaagatcc ctctgggtcc aagtgagatg agtaccatgc ggtgccgggc agaggaactt
     3001 cgggagggga cactctgtga ctatcggcct gtgttgcctc tcatgctggc cagtttcatc
     3061 tttgacgttc tctgtgctcc agtggtttct cccacaggtt cccggccccc aagtcgcaac
     3121 tggaacagcg agacacctgg ggatgaggag cttggatttg aagcagcagt tgctgccttg
     3181 ggcatgaaga caacagtgag cgaggcagaa catcccctct tatgtgaagg cacacgtcgg
     3241 gagaagggtg acctggcatt agcactaatg atcacttaca aggacgacca ggccaagctt
     3301 aagaagatct tagacaaact cttggaccga gagagccaga cacataagcc acagacgctg
     3361 agttctttct actcatctag ccgcccaacc acagccagcc agaggtctcc ttcaaagcac
     3421 gggggcccat ctgccccagg ggccctgcaa ccactgacct caggctctgc agggcctgct
     3481 caaccaggga gtgtggcagg ggctgggcca ggccccactg agggcttcac agagaagaat
     3541 gtgcctgaga gttccccaca ttccccctgt gagggtcttc catctgaggc agctttgacc
     3601 ccaaggccag aagggaaggt tcctagccgc ttggcacttg gcagtcgtgg aggctataat
     3661 ggacggggat gggggtcccc aggacggcct aagaagaagc acacaggcat ggccagcatt
     3721 gacagcagtg cccctgaaac aacatcggat agttccccca ccttaagccg gagaccactt
     3781 cgagggggct gggcccccac ctcctggggt cgaggtcagg acagtgacag cattagcagc
     3841 tcttcttcgg actccctggg ctcctcatcc tccagtggaa gtcgccgggc cagtgccagt
     3901 ggaggagccc gggcgaagac tgttgaagtt ggcaggtaca agggccgccg ccccgagagt
     3961 catgcccctc atgtacccaa tcagccatca gaggcagctg cacacttcta cttcgagctg
     4021 gcgaagacag tgctgatcaa ggcagggggc aacagcagca cttccatttt cacacatcca
     4081 tcttcctcag ggggccacca gggtcctcac cgcaacctgc acctttgcgc cttcgagatt
     4141 gggctttatg cccttggcct gcacaacttt gtttctccca actggctctc acgtacttat
     4201 tcttcccacg tttcctggat tacaggccag gccatggaga taggcagcgc agccctgact
     4261 atactggtag aatgctggga tgggcacctg acaccccctg aggttgcatc cctggctgac
     4321 agggcatcac gggcaagaga ctccaatatg gtgagggcgg cagcagagct ggccctgagc
     4381 tgcctgcctc acgcccatgc attgaaccct aatgagatcc agcgggccct ggtgcagtgc
     4441 aaggaacagg acaacctgat gttggagaag gcctgcatgg cagtggaaga ggcagctaag
     4501 ggtgggggcg tgtaccctga agtgttgttt gaggttgctc accagtggtt ctggctgtat
     4561 gagcaaactg caggtggctc atccacagcc cgtgaagggg ctacaagctg tagtgccagt
     4621 gggatcaggg caggtgggga agctgggcgg ggtatgcctg agggtagagg gggcccaggg
     4681 actgagccgg ttacagtggc agcggcagca gtgacagcag cagccacagt ggtgcccgtc
     4741 atatcggtgg ggtctagttt atacccgggt ccaggactgg ggcatggcca ctcccctggc
     4801 ctgcacccct acactgctct acagccccac ctgccctgta gccctcagta tctcactcac
     4861 ccagctcacc ctgcccaccc catgcctcac atgccccggc ctgccgtctt ccctgtgccc
     4921 agctctgcat acccacaggg tgtgcatcct gcattcctag gggctcagta cccttattca
     4981 gtgactcctc cctcacttgc tgccactgct gtgtctttcc ccgttccttc catggcaccc
     5041 atcacagtac atccctacca cacagagcca gggcttccac tgcccaccag tgtggccttg
     5101 agcagtgtcc atccagcatc cacgtttcca gccatccaag gtgcctcact gcctgccctg
     5161 accacacagc ccagccctct ggtgagcgga ggttttccac cgcccgagga ggagacacac
     5221 agtcagccag tcaatcccca cagcctgcac cacctgcatg ctgcctaccg tgtcggaatg
     5281 ctggcactgg agatgctggg tcgccgggca cacaacgatc accccaacaa cttctcccgc
     5341 tcccccccct acactgatga tgtcaaatgg ttgctggggc tggcagcaaa gctgggagtg
     5401 aactacgtgc accagttctg tgtgggggca gccaaggggg tgctgagccc gtttgtgctg
     5461 caggagatcg tcatggagac gctgcagcgg ctgagtcccg ctcatgccca caaccacctg
     5521 cgtgccccgg ccttccacca actggtgcag cgctgccagc aggcatacat gcagtacatc
     5581 caccaccgct tgattcacct gactcctgcg gactacgacg actttgtgaa tgcgatccgg
     5641 agtgcccgca gcgccttctg cctgacgccc atgggcatga tgcagttcaa cgacatccta
     5701 cagaacctca agcgcagcaa acagaccaag gagctgtggc agcgggtctc actcgagatg
     5761 gccaccttct ccccctgagt ctttcaccct tagggtccta tacagggacc caggcctgtg
     5821 gctatggggg cccctcacac agggggagtg aaacttggct ggacagatca tcctcactca
     5881 gttccctggt agcacagact gacagctgct cttgggctat agcttggggc caagatgtct
     5941 cacaccctag aagcctaggg ctgggggaga cagccctgtc tgggaggggg cgttgggtgg
     6001 cctctggtat ttatttggca tttataaata tataaactcc ttttttactc ta
//
