LOCUS       NM_001042697            2020 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger SWIM-type containing 7 (ZSWIM7),
            transcript variant 1, mRNA.
ACCESSION   NM_001042697
VERSION     NM_001042697.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Hengel,S.R., Oppenheimer,K.G., Smith,C.M., Schaich,M.A., Rein,H.L.,
            Martino,J., Darrah,K.E., Witham,M., Ezekwenna,O.C., Burton,K.R.,
            Van Houten,B., Spies,M. and Bernstein,K.A.
  TITLE     The human Shu complex promotes RAD51 activity by modulating RPA
            dynamics on ssDNA
  JOURNAL   Nat Commun 15 (1), 7197 (2024)
   PUBMED   39169038
  REMARK    GeneRIF: The human Shu complex promotes RAD51 activity by
            modulating RPA dynamics on ssDNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Hussain,S., Nawaz,S., Khan,I., Khan,N., Hussain,S., Ullah,I.,
            Fakhro,K.A. and Ahmad,W.
  TITLE     A novel homozygous variant in homologous recombination repair gene
            ZSWIM7 causes azoospermia in males and primary ovarian
            insufficiency in females
  JOURNAL   Eur J Med Genet 65 (11), 104629 (2022)
   PUBMED   36202298
  REMARK    GeneRIF: A novel homozygous variant in homologous recombination
            repair gene ZSWIM7 causes azoospermia in males and primary ovarian
            insufficiency in females.
            Review article
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Yatsenko,S.A., Gurbuz,F., Topaloglu,A.K., Berman,A.J., Martin,P.M.,
            Rodrigue-Escriba,M., Qin,Y. and Rajkovic,A.
  TITLE     Pathogenic Variants in ZSWIM7 Cause Primary Ovarian Insufficiency
  JOURNAL   J Clin Endocrinol Metab 107 (6), e2359-e2364 (2022)
   PUBMED   35218660
  REMARK    GeneRIF: Pathogenic Variants in ZSWIM7 Cause Primary Ovarian
            Insufficiency.
            Erratum:[J Clin Endocrinol Metab. 2022 Aug 18;107(9):e3969. doi:
            10.1210/clinem/dgac345.. PMID: 35689663]
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   McGlacken-Byrne,S.M., Le Quesne Stabej,P., Del Valle,I., Ocaka,L.,
            Gagunashvili,A., Crespo,B., Moreno,N., James,C., Bacchelli,C.,
            Dattani,M.T., Williams,H.J., Kelberman,D., Achermann,J.C. and
            Conway,G.S.
  TITLE     ZSWIM7 Is Associated With Human Female Meiosis and Familial Primary
            Ovarian Insufficiency
  JOURNAL   J Clin Endocrinol Metab 107 (1), e254-e263 (2022)
   PUBMED   34402903
  REMARK    GeneRIF: ZSWIM7 Is Associated With Human Female Meiosis and
            Familial Primary Ovarian Insufficiency.
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Martino,J., Brunette,G.J., Barroso-Gonzalez,J., Moiseeva,T.N.,
            Smith,C.M., Bakkenist,C.J., O'Sullivan,R.J. and Bernstein,K.A.
  TITLE     The human Shu complex functions with PDS5B and SPIDR to promote
            homologous recombination
  JOURNAL   Nucleic Acids Res 47 (19), 10151-10165 (2019)
   PUBMED   31665741
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Sung,Y.J., de las Fuentes,L., Schwander,K.L., Simino,J. and
            Rao,D.C.
  TITLE     Gene-smoking interactions identify several novel blood pressure
            loci in the Framingham Heart Study
  JOURNAL   Am J Hypertens 28 (3), 343-354 (2015)
   PUBMED   25189868
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Liu,T., Wan,L., Wu,Y., Chen,J. and Huang,J.
  TITLE     hSWS1.SWSAP1 is an evolutionarily conserved complex required for
            efficient homologous recombination repair
  JOURNAL   J Biol Chem 286 (48), 41758-41766 (2011)
   PUBMED   21965664
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Martin,V., Chahwan,C., Gao,H., Blais,V., Wohlschlegel,J.,
            Yates,J.R. 3rd, McGowan,C.H. and Russell,P.
  TITLE     Sws1 is a conserved regulator of homologous recombination in
            eukaryotic cells
  JOURNAL   EMBO J 25 (11), 2564-2574 (2006)
   PUBMED   16710300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006251.3, BU075283.1 and DQ530600.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001042697.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA593990.1, SRR1660803.219346.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399277.6/ ENSP00000382218.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC006251.3         111697-111708       c
            13-110              BU075283.1         4-101
            111-533             DQ530600.1         1-423
            534-2020            AC006251.3         88564-90050         c
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..2020
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /note="zinc finger SWIM-type containing 7"
                     /db_xref="GeneID:125150"
                     /db_xref="HGNC:HGNC:26993"
                     /db_xref="MIM:614535"
     exon            1..186
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..533
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /note="SWIM domain-containing and Srs2-interacting protein
                     1 homolog; SWIM-type zinc finger domain-containing protein
                     7"
                     /codon_start=1
                     /product="zinc finger SWIM domain-containing protein 7"
                     /protein_id="NP_001036162.1"
                     /db_xref="CCDS:CCDS42266.1"
                     /db_xref="GeneID:125150"
                     /db_xref="HGNC:HGNC:26993"
                     /db_xref="MIM:614535"
                     /translation="MAVVLPAVVEELLSEMAAAVQESARIPDEYLLSLKFLFGSSATQ
                     ALDLVDRQSITLISSPSGRRVYQVLGSSSKTYTCLASCHYCSCPAFAFSVLRKSDSIL
                     CKHLLAVYLSQVMRTCQQLSVSDKQLTDILLMEKKQEA"
     exon            187..208
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..311
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..416
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..2020
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      821..826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /note="hexamer: AATAAA"
     polyA_site      850
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /note="major polyA site"
     regulatory      1984..1989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
                     /note="hexamer: GATAAA"
     polyA_site      2020
                     /gene="ZSWIM7"
                     /gene_synonym="ODG10; SPGF71; SWS1"
ORIGIN      
        1 actccgtctc gccctgcccc ggcggggggt caggatcctc cacaggtagg cgcagtcagc
       61 tggagcgtcg cggcggtccg ccggtcgtgg agggcgtgtc ctgcggcgcg atggccgtag
      121 tgttgccggc ggttgtggag gagctcctga gcgagatggc ggcggcggtg caggagagcg
      181 cgcgaattcc tgatgaatat ctgttatcgc tgaagtttct ctttggctca tcagccaccc
      241 aggccttgga cctagttgat cgacagtcca tcaccttaat ctcatcaccc agtggaaggc
      301 gtgtttacca ggtccttgga agttccagta aaacatacac atgtttggct tcttgtcatt
      361 actgttcatg tcctgcattt gcattctcag tgctacggaa gagtgacagc atcctgtgca
      421 agcatctctt ggcagtttac ctgagtcagg ttatgaggac ctgtcagcag ctaagtgtct
      481 ctgacaagca gttgactgac atattattga tggagaagaa acaagaagca taaaaggtac
      541 agattgagca tcattctttc aaaatagaat cctgtcaaga aatgcattga aagcgtcatg
      601 attcacatgg aaaagaggtg aaatggatct tcagacactt catgttactg tcccttttcc
      661 ctccaggact gcaggaggtg ctgtgggttg gagccgtggg ctgtggaggg tttgtgtatg
      721 atgagaagcc ctgtacagtc ttgtcaagaa ataccctgag ccagtctctg agacgcttcg
      781 gtaaaaaatg tccctggatg gaatcaagat tttaaattca aataaagcct aatatcatgt
      841 tgtgtccaca ttatttagtc tttttttttt tcttttgaga tggagtctca ctttgtcgcc
      901 caggctgggg tgcagtggcg tgatctcagc tcactgcaag ctccgcctcc cgggttcacg
      961 ccattctcct gcctcagcct cccgagtagc tgggactaca ggtacccgcc accatgcccg
     1021 gctaaatttt tgtatttttt ttttagtaga gatggggttt caccgtgtta gccaggatgg
     1081 tctccatctc ctgacctagt ggtctgcccg cctcgacctc ccaaagtgct ggaattacat
     1141 gcatgagcca ctgcgcctga ccctatttag tcttaagtaa ctaactgaat tactagtaat
     1201 ttttaaaagg ttggaatggt gggccaaaca gtaagatgaa gtttcgacga gtaggtcagt
     1261 tcttttcctt gggtccagga aactattgag cagcaacaga agatcagagc agagatgtgg
     1321 ctaaacagta gcaggtatga aaagacttag aggttctggt ttctgtaagc ttcaaatatc
     1381 tgtgatgctt gtgccaaaac agcttaagta gactgtattg tttgagagtt agtatcgaga
     1441 acaagggaag aactggtttc actctgcact tctgatcttt acaacagggc aattgaagga
     1501 acagactaaa aatcgtgtcc tggaaggaaa ctacaggtac taccagggat tttcagtctg
     1561 aagaagaaaa gacaaaatag atgacagaag gagtattaga agggagagcg atgagactca
     1621 gttggacacc gagagagcaa agaagcaata atacgtgaag atgaaaatga aatcaatttc
     1681 agcataagaa gacaagaact tatggtaaag ctgcccacag ccagaagagg atcctagaag
     1741 gacaggaatt ccctgtctgc agcatttcat aagcatgtaa tattgttgca gggatactgc
     1801 agaaggagtt gaagcagtgg acagacagat gatataggtg attttacagc ctaagaaagc
     1861 cctgtgcttg tgcccccaaa acatgaggtg ctagtgaatg aatgctgggg gaaagcccag
     1921 ggcctaggtg ttgcaatgtt ctgtggttgg cagatgcttt ttgttttgtt aaaaagtgca
     1981 acagataaaa tttatcaata cttttctgct actcaggaaa
//
