LOCUS       NM_020928               5518 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger SWIM-type containing 6 (ZSWIM6), mRNA.
ACCESSION   NM_020928 XM_001716154 XM_035299 XM_936273
VERSION     NM_020928.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5518)
  AUTHORS   Cha,M.Y., Hong,Y.J., Choi,J.E., Kwon,T.S., Kim,I.J. and Hong,K.W.
  TITLE     Classification of early age facial growth pattern and
            identification of the genetic basis in two Korean populations
  JOURNAL   Sci Rep 12 (1), 13828 (2022)
   PUBMED   35970861
  REMARK    GeneRIF: Classification of early age facial growth pattern and
            identification of the genetic basis in two Korean populations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5518)
  AUTHORS   Palmer,E.E., Kumar,R., Gordon,C.T., Shaw,M., Hubert,L., Carroll,R.,
            Rio,M., Murray,L., Leffler,M., Dudding-Byth,T., Oufadem,M.,
            Lalani,S.R., Lewis,A.M., Xia,F., Tam,A., Webster,R., Brammah,S.,
            Filippini,F., Pollard,J., Spies,J., Minoche,A.E., Cowley,M.J.,
            Risen,S., Powell-Hamilton,N.N., Tusi,J.E., Immken,L., Nagakura,H.,
            Bole-Feysot,C., Nitschke,P., Garrigue,A., de Saint Basile,G.,
            Kivuva,E., Scott,R.H., Rendon,A., Munnich,A., Newman,W., Kerr,B.,
            Besmond,C., Rosenfeld,J.A., Amiel,J., Field,M. and Gecz,J.
  CONSRTM   DDD Study
  TITLE     A Recurrent De Novo Nonsense Variant in ZSWIM6 Results in Severe
            Intellectual Disability without Frontonasal or Limb Malformations
  JOURNAL   Am J Hum Genet 101 (6), 995-1005 (2017)
   PUBMED   29198722
  REMARK    GeneRIF: This study builds support for a key role for ZSWIM6 in
            neuronal development and function, in addition to its putative
            roles in limb and craniofacial development, and provides a striking
            example of different variants in the same gene leading to distinct
            phenotypes.
REFERENCE   3  (bases 1 to 5518)
  AUTHORS   Twigg,S.R., Ousager,L.B., Miller,K.A., Zhou,Y., Elalaoui,S.C.,
            Sefiani,A., Bak,G.S., Hove,H., Hansen,L.K., Fagerberg,C.R.,
            Tajir,M. and Wilkie,A.O.
  TITLE     Acromelic frontonasal dysostosis and ZSWIM6 mutation: phenotypic
            spectrum and mosaicism
  JOURNAL   Clin Genet 90 (3), 270-275 (2016)
   PUBMED   26706854
  REMARK    GeneRIF: A single recurrent heterozygous missense substitution in
            ZSWIM6, encoding a protein of unknown function, was previously
            shown to underlie this disorder in four unrelated cases. Here we
            describe four additional individuals from three families,
            comprising two sporadic subjects (one of whom had no limb
            malformation) and a mildly affected female with a severely affected
            son
REFERENCE   4  (bases 1 to 5518)
  AUTHORS   Smith,J.D., Hing,A.V., Clarke,C.M., Johnson,N.M., Perez,F.A.,
            Park,S.S., Horst,J.A., Mecham,B., Maves,L., Nickerson,D.A. and
            Cunningham,M.L.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Exome sequencing identifies a recurrent de novo ZSWIM6 mutation
            associated with acromelic frontonasal dysostosis
  JOURNAL   Am J Hum Genet 95 (2), 235-240 (2014)
   PUBMED   25105228
  REMARK    GeneRIF: Exome sequencing of one trio and two unrelated probands
            revealed the same heterozygous variant (c.3487C>T [p.
            Arg1163Trp])associated with acromelic frontonasal dysostosis in a
            highly conserved protein domain of ZSWIM6; this variant has not
            been seen in the 1000 Genomes data, dbSNP, or the Exome Sequencing
            Project
REFERENCE   5  (bases 1 to 5518)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 5518)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   7  (bases 1 to 5518)
  AUTHORS   Bergen,S.E., O'Dushlaine,C.T., Ripke,S., Lee,P.H., Ruderfer,D.M.,
            Akterin,S., Moran,J.L., Chambert,K.D., Handsaker,R.E., Backlund,L.,
            Osby,U., McCarroll,S., Landen,M., Scolnick,E.M., Magnusson,P.K.,
            Lichtenstein,P., Hultman,C.M., Purcell,S.M., Sklar,P. and
            Sullivan,P.F.
  TITLE     Genome-wide association study in a Swedish population yields
            support for greater CNV and MHC involvement in schizophrenia
            compared with bipolar disorder
  JOURNAL   Mol Psychiatry 17 (9), 880-886 (2012)
   PUBMED   22688191
REFERENCE   8  (bases 1 to 5518)
  AUTHORS   Kai,N., Iwase,K., Imai,K., Nakahira,E., Soma,M., Ohtsuka,S.,
            Yagi,T., Kobayashi,K., Koga,H., Takiguchi,M. and Yuasa,S.
  TITLE     Altered gene expression in the subdivisions of the amygdala of
            Fyn-deficient mice as revealed by laser capture microdissection and
            mKIAA cDNA array analysis
  JOURNAL   Brain Res 1073-1074, 60-70 (2006)
   PUBMED   16427614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122718.2, AC008836.6,
            BF751445.1, BF750632.1, AA740254.1, AB046797.1 and AW136453.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020928.1.
            
            Summary: The protein encoded by this gene contains a zinc finger
            SWI2/SNF2 and MuDR (SWIM) domain. Proteins with SWIM domains have
            been found in a diverse number of species and are predicted to
            interact with DNA or proteins. Mutations in this gene result in
            acromelic frontonasal dysostosis. [provided by RefSeq, Apr 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by orthologous and paralogous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000252744.6/ ENSP00000252744.5
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC122718.2         47991-48005
            16-691              AC122718.2         48006-48681
            692-788             AC008836.6         18764-18860
            789-944             BF751445.1         1-156
            945-1375            BF750632.1         149-579
            1376-1603           AA740254.1         1-228               c
            1604-5516           AB046797.1         175-4087
            5517-5518           AW136453.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..5518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.1"
     gene            1..5518
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /note="zinc finger SWIM-type containing 6"
                     /db_xref="GeneID:57688"
                     /db_xref="HGNC:HGNC:29316"
                     /db_xref="MIM:615951"
     exon            1..691
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..3663
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /note="zinc finger, SWIM domain containing 6"
                     /codon_start=1
                     /product="zinc finger SWIM domain-containing protein 6"
                     /protein_id="NP_065979.1"
                     /db_xref="CCDS:CCDS47215.1"
                     /db_xref="GeneID:57688"
                     /db_xref="HGNC:HGNC:29316"
                     /db_xref="MIM:615951"
                     /translation="MAERGQQPPPAKRLCCRPGGGGGGGGSSGGGGGAGGGYSSACRP
                     GPRAGGAAAAAACGGGAALGLLPPGKTQSPESLLDIAARRVAEKWPFQRVEERFERIP
                     EPVQRRIVYWSFPRSEREICMYSSFNTGGGAAGGPGDDSGGGGGAGGGGGGGSSSSPA
                     ATSAAATSAAAAAAAAAAAAAAAAGAGAPSVGAAGAADGGDETRLPFRRGIALLESGC
                     VDNVLQVGFHLSGTVTEPAIQSEPETVCNVAISFDRCKITSVTCSCGNKDIFYCAHVV
                     ALSLYRIRKPDQVKLHLPISETLFQMNRDQLQKFVQYLITVHHTEVLPTAQKLADEIL
                     SQNSEINQVHGAPDPTAGASIDDENCWHLDEEQVQEQVKLFLSQGGYHGSGKQLNLLF
                     AKVREMLKMRDSNGARMLTLITEQFMADPRLSLWRQQGTAMTDKYRQLWDELGALWMC
                     IVLNPHCKLEQKASWLKQLKKWNSVDVCPWEDGNHGSELPNLTNALPQGANANQDSSN
                     RPHRTVFTRAIEACDLHWQDSHLQHIISSDLYTNYCYHDDTENSLFDSRGWPLWHEHV
                     PTACARVDALRSHGYPREALRLAIAIVNTLRRQQQKQLEMFRTQKKELPHKNITSITN
                     LEGWVGHPLDPVGTLFSSLMEACRIDDENLSGFSDFTENMGQCKSLEYQHLPAHKFLE
                     EGESYLTLAVEVALIGLGQQRIMPDGLYTQEKVCRNEEQLISKLQEIELDDTLVKIFR
                     KQAVFLLEAGPYSGLGEIIHRESVPMHTFAKYLFTSLLPHDAELAYKIALRAMRLLVL
                     ESTAPSGDLTRPHHIASVVPNRYPRWFTLSHIESQQCELASTMLTAAKGDVRRLETVL
                     ESIQKNIHSSSHIFKLAQDAFKIATLMDSLPDITLLKVSLELGLQVMRMTLSTLNWRR
                     REMVRWLVTCATEVGVYALDSIMQTWFTLFTPTEATSIVATTVMSNSTIVRLHLDCHQ
                     QEKLASSARTLALQCAMKDPQNCALSALTLCEKDHIAFETAYQIVLDAATTGMSYTQL
                     FTIARYMEHRGYPMRAYKLATLAMTHLNLSYNQDTHPAINDVLWACALSHSLGKNELA
                     AIIPLVVKSVKCATVLSDILRRCTLTTPGMVGLHGRRNSGKLMSLDKAPLRQLLDATI
                     GAYINTTHSRLTHISPRHYSEFIEFLSKARETFLMAHDGHIQFTQFIDNLKQIYKGKK
                     KLMMLVRERFG"
     exon            692..1048
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1197
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1348
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1528
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1705
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1852
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1999
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2260
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2396
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2554
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2718
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2800
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..5518
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /note="hexamer: ACTAAA"
     polyA_site      3824
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
     regulatory      5493..5498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /note="hexamer: ATTAAA"
     polyA_site      5518
                     /gene="ZSWIM6"
                     /gene_synonym="AFND; NEDMAGA"
                     /note="major polyA site"
ORIGIN      
        1 agaagcggcg cggtcatggc ggagcgcgga cagcagcctc ctcccgcgaa acggctttgc
       61 tgccggccgg gcggcggcgg cggcggcggg ggcagcagcg gcggcggcgg cggcgcgggt
      121 ggcggctaca gctctgcctg tcggccaggc ccgcgggcgg gtggcgcggc ggcggcggcg
      181 gcgtgcgggg gcggcgcggc gctggggttg ctgccgccgg gcaagaccca gagccccgag
      241 tcgctgctgg acatcgcggc gcgcagggtg gcggagaagt ggccgttcca gcgcgtggag
      301 gagcgctttg agcgcatccc ggagccggtg cagcgccgca tagtctattg gtccttcccc
      361 cgcagcgagc gggagatctg catgtactcg tccttcaaca ccggcggcgg cgccgcgggc
      421 ggccccggcg acgacagcgg tggcggcggc ggcgcgggcg gcggcggcgg cggcggctcc
      481 tcgtcttccc cggccgcaac ctcggcggcc gcaacctcgg ccgccgccgc cgctgccgcc
      541 gccgccgccg ccgccgccgc cgccgcgggg gccggggccc cgtcggtggg ggctgccggg
      601 gcggcggacg gcggcgacga gacgcggctg cctttccgcc ggggcatcgc gctgttggaa
      661 agcggctgcg tagacaacgt cctgcaagtc ggtttccact tgagcggcac agtgacagaa
      721 cctgcaatac aatcggagcc agaaactgtt tgcaacgtgg ccatcagctt tgatcgttgc
      781 aagattacct cagtgacctg cagctgtgga aacaaggaca tattttattg tgcccatgtt
      841 gtggcactgt ctttataccg catccgcaag ccagatcagg tcaaactgca tcttcctatt
      901 tcagagactc tctttcaaat gaatagagac caactgcaaa agtttgtaca gtatttgatc
      961 acagtgcacc acacagaagt tttgccaact gctcaaaaat tagcagatga aattctttcc
     1021 caaaattcag aaatcaacca agttcatggt gctcctgatc caacagcagg tgctagtata
     1081 gatgatgaaa actgctggca cttagatgaa gagcaggttc aagaacaggt taaactgttc
     1141 ctttcccagg gcgggtacca cggatcaggg aagcagctta atttgctctt tgcaaaggtg
     1201 cgggagatgt taaagatgag ggactccaat ggggcccgca tgttgacctt gataacagag
     1261 caattcatgg ctgaccctcg cctgtcactt tggcggcaac aaggcactgc aatgactgac
     1321 aaatacaggc agctctggga tgagctgggt gctctgtgga tgtgtatagt tttaaacccc
     1381 cactgcaagt tggagcaaaa ggccagttgg ctaaaacagc tgaagaaatg gaatagtgtt
     1441 gatgtctgtc catgggaaga tggaaatcat ggcagtgaat tacccaactt aaccaatgct
     1501 ctgcctcagg gtgcaaatgc caaccaagat tcatcgaaca ggccacatcg gacagtgttc
     1561 acccgagcca tcgaggcatg cgatctccac tggcaggata gccacttgca gcacattatc
     1621 agcagtgacc tatacaccaa ctactgttac catgacgaca ctgaaaactc cctcttcgac
     1681 tcccgcgggt ggcccctctg gcatgaacat gttcctacag cctgtgcaag agtggacgca
     1741 ttacgttctc atgggtaccc cagagaagca ctgagactag caatagctat tgttaataca
     1801 ttaagacgac agcagcagaa acagttggaa atgttccgaa cccaaaaaaa agagctaccc
     1861 cataaaaaca taacctcgat aaccaatctg gagggctggg ttggacatcc cctggaccct
     1921 gtgggcactc tcttcagtag ccttatggaa gcctgccgca ttgatgatga gaacctctct
     1981 gggttctcag attttacaga gaatatggga cagtgcaagt ctctggaata ccagcatcta
     2041 cctgcacaca aattcttaga agaaggggaa tcctatttaa cgctggctgt ggaagtagcc
     2101 ctgatagggc taggacagca gcgtatcatg cctgatgggc tgtacacaca agagaaagtt
     2161 tgccggaatg aggagcagct catttctaag cttcaggaaa ttgaattgga tgacacactg
     2221 gtgaaaattt ttcgcaagca agcagtcttc ctattagaag ccggaccata tagtggttta
     2281 ggtgaaataa tccatcggga gagcgttcca atgcacacat ttgccaagta tctcttcacc
     2341 tctctcctac ctcacgatgc tgaattggca tacaaaattg cactgagagc aatgcggtta
     2401 ctagtattgg aatctactgc tccatcagga gacctcaccc gcccacacca cattgcatca
     2461 gttgttccca accgctaccc tcgctggttc actctaagcc acattgagtc ccagcagtgt
     2521 gagctggcat ccaccatgct aactgcagcc aaaggcgatg ttcggaggct ggaaacagta
     2581 ttagaatcca tccagaaaaa cattcactcc tcatcacaca tcttcaagct tgcccaagat
     2641 gcatttaaaa tagcaactct catggacagt ttgccagaca tcactctttt gaaagtgtct
     2701 ctggagctgg gcctgcaggt tatgcgaatg acactgtcaa ccttaaattg gcgacggcgg
     2761 gagatggtga ggtggctggt aacgtgtgct actgaagtcg gggtttatgc cctggacagc
     2821 atcatgcaga cctggtttac actctttact cccaccgagg ccacaagtat agttgcaact
     2881 accgtgatgt ccaacagcac catcgtccgc ctccacctgg actgccacca gcaggaaaag
     2941 ctggccagca gcgcccggac acttgcactg cagtgtgcca tgaaggatcc acagaactgt
     3001 gccctctctg cgctaaccct ttgtgaaaag gatcacatag cttttgagac ggcgtaccaa
     3061 attgttctcg acgctgctac gactggcatg agctatacac agctctttac aatagcacgg
     3121 tacatggagc accgcgggta ccccatgagg gcctacaagc tggccaccct ggccatgacc
     3181 catctcaacc tgagctacaa tcaggacaca caccctgcca ttaatgatgt tttgtgggcc
     3241 tgtgcgctta gccactccct tggtaaaaat gagcttgcag ctataatacc tctggtggtc
     3301 aagagtgtca agtgtgcaac ggtactgtca gacattttgc gcagatgcac tctgaccact
     3361 cctggcatgg tgggacttca tgggaggagg aactctggta agctcatgtc actggacaaa
     3421 gcccccttga ggcaactctt ggatgccacg atcggggcct acatcaacac aacgcactca
     3481 cggctcacac acatcagtcc tcggcactat agtgagttta tagagttcct cagcaaagcc
     3541 cgagagacct tcttaatggc gcatgatgga cacattcagt ttacacagtt tattgacaac
     3601 ctgaaacaaa tctacaaagg caaaaagaaa ctgatgatgt tggttcggga gaggtttggt
     3661 tgatagatct tgtatgaatg gggtgggggg tggggatggg agggatggtt tgtttttact
     3721 tgagcctgcc tttgtaccct ttttaactta aagaacagag ccacaccggt attatatgtg
     3781 tatagttata ttgcgtttgc agactaaatt gtcatgttgt gaaagtttgt gtgtttttta
     3841 ttttttccct atttctttct ttcctttatt ttattatttt ttttaatttt ttttttctgg
     3901 ttttgtatga gagagaggtt aaaaaggttt ggtttacact gagtatatgt tgtcaagtgg
     3961 caaaagtcca catagctctc ctgttttctg tatacgttca cagcctcaaa aaaaataatt
     4021 gaaatggctt taaaaaccaa acaaaacacc tccatcctgt gataagtacc tcgaatggat
     4081 tcagctttac tcctttgtaa ctcatcttta cattttcagc atatttaaac aaaccaacaa
     4141 aatgaaatac taatagtaaa aaggctgacc catgtggctt tgcagtgctg ttcgtccaga
     4201 agcatggcac acgatgcttg tgcatgtgga aacttagcga ctgtcaacat acattctcag
     4261 ggatttatcc aaaaaaatta aaaaaagaat gagagcattt attgtactgt atatatatta
     4321 tagtatatgt ctgaatattg aaaatataac attaactaat ttataaaaaa tattctatgt
     4381 aatgcaaaat acttgaagct gcagtagctt ggttttaaac aaaaacaaaa aaaaaactga
     4441 gagaaaacct atcagaagga ctaaaagtac gccttgcttc agggttggct caggtggtga
     4501 acttcatgct gggcatctat gcagagccac cttttggatt gcatggttgg actgagatct
     4561 attgggagaa attatatatg tatatatatt tatacaactt atgtatacat atatatatgt
     4621 atacacacag acacacacac acaccaccaa caaccaccac tacaccacac atgcttataa
     4681 caggcactag aataaagagg gacaacaaaa tacacagcca gagcagcaag ccttagcatt
     4741 aagaatatac aatatgccgg aattggggtt cgtgcctcct agcctaggaa acttaaaaga
     4801 aatatccttt tgacacaaaa cacaaaatgt tttccaaaac aattgacata atgatacatt
     4861 acgcctttgc agtgagctaa taataagcta acctttgtgc acaaataaca ttatatatat
     4921 tatatatcta ttctgcatag gtattttgac tttgtgcagg acagaaagtt gtgtaggtat
     4981 gactgttcta cttttcagtt ttcttttttt ttaatatatt ttattttctc tagaaattac
     5041 tcaaacaaaa gcagccttct atcttgcctt gtcttaatgc tttaaaataa ccaaactgga
     5101 gatctaacta ccaaactgtt cattatatta ttaaatacca actttggtta cagtatagtg
     5161 tctttacttt agctgatggt tctgtaacct tgtgcttttt aaagcaattt ttatgttttg
     5221 gtgcaaaagt tgtccagtgt ctcttgttcc cttcactaga gaacatgctt agaggtatgt
     5281 ttgtaggtat ttttgtttag aagaactatt tcatgcgctc cattttattt attataatag
     5341 gtaaaaagaa aaaaaaaggt tgtaattcat cacccatgta aacatgctca tgaagttgaa
     5401 agtaattaag atttgataca ctgatatcaa tttatttatg taactaaatc actgttttat
     5461 aaacttgtta atgatcaaca atttttgttt tgattaaaat tagttttttg aaagttga
//
