LOCUS       NM_001367834            4731 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens zinc finger SWIM-type containing 4 (ZSWIM4),
            transcript variant 2, mRNA.
ACCESSION   NM_001367834 XM_005260023
VERSION     NM_001367834.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4731)
  AUTHORS   Gong,K., Huang,Y., Zheng,Y., Hao,W. and Shi,K.
  TITLE     ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian
            cancer cells by suppressing intracellular glycine biosynthesis
  JOURNAL   J Transl Med 22 (1), 192 (2024)
   PUBMED   38383406
  REMARK    GeneRIF: ZSWIM4 inhibition improves chemosensitivity in epithelial
            ovarian cancer cells by suppressing intracellular glycine
            biosynthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4731)
  AUTHORS   Gong,K., Song,K., Zhu,Z., Xiang,Q., Wang,K. and Shi,J.
  TITLE     SWIM domain protein ZSWIM4 is required for JAK2 inhibition
            resistance in breast cancer
  JOURNAL   Life Sci 279, 119696 (2021)
   PUBMED   34102191
  REMARK    GeneRIF: SWIM domain protein ZSWIM4 is required for JAK2 inhibition
            resistance in breast cancer.
REFERENCE   3  (bases 1 to 4731)
  AUTHORS   Alleyne,D., Witonsky,D.B., Mapes,B., Nakagome,S., Sommars,M.,
            Hong,E., Muckala,K.A., Di Rienzo,A. and Kupfer,S.S.
  TITLE     Colonic transcriptional response to 1alpha,25(OH)2 vitamin D3 in
            African- and European-Americans
  JOURNAL   J Steroid Biochem Mol Biol 168, 49-59 (2017)
   PUBMED   28163244
  REMARK    GeneRIF: there are inter-ethnic differences for uridine
            phosphorylase 1 (UPP1) and zinc finger-SWIM containing 4 (ZSWIM4)
            in response to 1alpha,25(OH)2D3
REFERENCE   4  (bases 1 to 4731)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020916.8.
            
            On Mar 24, 2021 this sequence version replaced NM_001367834.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2382457.1,
                                           SRR14038193.2845728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590508.6/ ENSP00000468285.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AC020916.8         8584-8942
            360-561             AC020916.8         12861-13062
            562-918             AC020916.8         17933-18289
            919-1067            AC020916.8         21977-22125
            1068-1218           AC020916.8         22211-22361
            1219-1386           AC020916.8         26138-26305
            1387-1737           AC020916.8         27656-28006
            1738-1875           AC020916.8         30357-30494
            1876-2130           AC020916.8         30863-31117
            2131-2266           AC020916.8         32498-32633
            2267-2421           AC020916.8         36487-36641
            2422-2585           AC020916.8         38691-38854
            2586-2667           AC020916.8         41786-41867
            2668-4731           AC020916.8         43332-45395
FEATURES             Location/Qualifiers
     source          1..4731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13-p13.12"
     gene            1..4731
                     /gene="ZSWIM4"
                     /note="zinc finger SWIM-type containing 4"
                     /db_xref="GeneID:65249"
                     /db_xref="HGNC:HGNC:25704"
                     /db_xref="MIM:620539"
     exon            1..359
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..3527
                     /gene="ZSWIM4"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger SWIM domain-containing protein 4"
                     /codon_start=1
                     /product="zinc finger SWIM domain-containing protein 4
                     isoform 2"
                     /protein_id="NP_001354763.1"
                     /db_xref="CCDS:CCDS92534.1"
                     /db_xref="GeneID:65249"
                     /db_xref="HGNC:HGNC:25704"
                     /db_xref="MIM:620539"
                     /translation="MEPPAAKRSRGCPAGPEERDAGAGAARGRGRPEALLDLSAKRVA
                     ESWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYPPPEGEHDARVPFTR
                     GLHLLQSGAVDRVLQVGFHLSGNIREPGSPGEPERLYHVSISFDRCKITSVSCGCDNR
                     DLFYCAHVVALSLYRIRHAHQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPT
                     AQRLADEILLLGSEINLVNGAPDPTAGAGIEDANCWHLDEEQIQEQVKQLLSNGGYYG
                     ASQQLRSMFSKVREMLRMRDSNGARMLILMTEQFLQDTRLALWRQQGAGMTDKCRQLW
                     DELGALWVCVVLSPHCKPEERAGWLQLLSRWDKLDVCPLEEGNYSFDGPSLQPTMAPA
                     PGSEEEEEVAATSPRHTVFGRALLAGELHWNDAYLQRILASDSYGPSLTGSVGGDKPT
                     FDPQGRPLWLGEPFPTACARVDTLRAHGYPRQALRLASAIINTLRLQQRHQLESYKQQ
                     KKELLQKGSTCITNTEGWVGHPLDPIGCLCRALLEACRLEEETLTLYPDSGPEKRKVA
                     YQHVPVPGSPGESYLVLALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVEL
                     DERLVQVLRKQAGLLLEGGPFSGFGEVLFRESVPMHTCARYLFTALLPHDPDLAYRLA
                     LRAMRLPILETAFPAGEPHPSPLDSIMSNRFPRWFILGHLETRQCELASTMLTAAKGD
                     PKWLHTVLGSIQQNIHSPALLFKLAQDACKTATPVSAPPDTTLLGIALELGLQVMRMT
                     LNVMTWRRREMVRWLVSCATEIGPQALMNIMQNWYSLFTPVEAATIVAVTGTTHATLL
                     RLQLDTSRREELWACARTLALQCAMKDPQNCALPALTLCEKNHSAFEAAYQIVLDAAA
                     GGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSH
                     SLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRAAKPLGADRAPLC
                     QLLDAAVTAYITTSHSRLTHISPRHYGDFIEFLGKARETFLLAPDGHLQFSQFLENLK
                     QTYKGKKKLMLLVRERFG"
     exon            360..561
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            562..918
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1067
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1218
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1386
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1737
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1875
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2130
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2266
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2421
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2585
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2667
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..4731
                     /gene="ZSWIM4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgttgtga agagtcttaa aggggccgca tcaccctgcc ggcccggcgc gggtcggggg
       61 tgggtgcggt aggggtcccg gggcggccga gcgcagagga cggacgggaa ggagggcagg
      121 gggcgcggga gccggcgaag cggagcgggc atcggaccga gccccccaaa gaggccccgc
      181 cccggccctg gccccggccg ggccggatgg aaccccccgc ggccaagcgg agccggggct
      241 gccccgcggg acccgaggag cgcgatgccg gggccggggc cgcgcgtggc cggggccggc
      301 ccgaggcgct gctggacctc agcgccaagc gggtagccga gagctgggcc ttcgagcagg
      361 tggaggagcg gttctcccgg gtgcctgagc ccgtccagaa gcgcatcgtg ttttggtcgt
      421 ttccacgcag tgaacgggaa atatgtatgt actcgtcgct gggttacccg cccccagagg
      481 gcgagcacga tgcccgggtg ccctttaccc gcgggctgca cctgctccag agcggggccg
      541 tggaccgcgt gttgcaagtg ggattccacc tgagcggaaa catccgcgag ccagggagtc
      601 ctggagagcc cgagcgcctc taccatgtct ccatcagctt tgatcgctgc aagatcacgt
      661 ccgtgagctg cggctgtgac aaccgcgacc tcttctactg tgcccacgtg gtggccctgt
      721 ccctgtaccg cattcggcac gcccaccagg tggagctgcg gctgcccatc tccgagacgc
      781 tctcccagat gaaccgggac cagctgcaga agttcgtgca gtacctcatc agcgcccatc
      841 acactgaggt gctgcccact gctcagcgct tggctgatga gatcctcctg ctgggctccg
      901 agatcaactt ggtgaatggt gccccagacc ccaccgccgg cgcaggaatc gaggacgcca
      961 actgctggca cctggacgag gagcagatcc aggagcaggt gaagcagcta ctgtccaatg
     1021 gcggctacta cggggccagc cagcagctgc gctccatgtt cagcaaggtg cgggagatgc
     1081 tgcgaatgcg ggactccaac ggggcgcgca tgctgattct catgaccgag cagttcctgc
     1141 aggacacgcg cctggccctg tggcggcagc agggcgcggg catgacggac aagtgccggc
     1201 agctctggga tgagctgggg gccctgtggg tttgcgtcgt cctgagcccc cactgcaaac
     1261 cagaggaaag ggcaggctgg ctccagctac tcagcaggtg ggacaagctc gacgtctgcc
     1321 cactggaaga gggcaactac tccttcgacg gccccagcct gcagcccacc atggcccccg
     1381 ccccaggctc ggaggaagag gaagaggtgg cagccacaag tccccgccac acggtatttg
     1441 gccgcgcctt gctggctgga gagctacact ggaatgacgc ctacctgcag aggatcctgg
     1501 ccagtgactc ctacgggccc agcctcacag gcagcgtggg tggggacaaa ccgactttcg
     1561 acccccaggg ccgcccactg tggctgggag aacctttccc cactgcctgt gcccgtgtgg
     1621 acaccctgcg tgcccacgga tacccccgcc aggccctgcg gctggcaagt gccatcatca
     1681 acacactccg gctgcagcag cggcatcagc tagagagcta caagcagcag aaaaaagagc
     1741 tgctccagaa gggctccacc tgcatcacca acaccgaagg atgggtgggg caccccctgg
     1801 accccattgg ctgcctctgc agggcgctcc tggaggcctg tcgtctggag gaggagacac
     1861 ttacccttta cccagactca ggccccgaga agcggaaggt ggcctaccag cacgtgcctg
     1921 tgcccgggag ccctggggag tcctacttgg tgctggcgct ggaggtggca ctgctggggc
     1981 tggggcagca gcgggccctg ccggaggggc tgtacgccca ggacaaggtg gtgcgcaacg
     2041 aggagcagct gctggccctg ctggaggagg tggagttgga tgagcggttg gtgcaggtgc
     2101 tgcgcaagca ggcggggctg ctgctggaag ggggtccctt cagtggcttt ggggaggtgc
     2161 tgttccggga gagcgtgccc atgcacacct gtgcccgcta cctgttcacc gcactgctgc
     2221 ctcatgaccc ggacctggcc tatcgcctcg cgctgcgagc tatgaggctg cccatactgg
     2281 agacagcatt tcctgctgga gaacctcatc ccagcccgct ggactccatc atgagcaacc
     2341 gcttcccccg ctggttcatc cttggccacc tggagacccg ccagtgtgaa ctggcttcca
     2401 ccatgttgac ggccgccaag ggagacccca agtggctgca cacggtactg ggctccatcc
     2461 agcagaacat ccactctccg gccctgctct ttaagctggc gcaggacgcc tgcaagacag
     2521 ccaccccggt cagcgcccca ccagacacca cgctgctggg catcgcactg gagctggggc
     2581 tgcaggtgat gcggatgact ctgaacgtaa tgacctggcg gcggagggag atggtgcgct
     2641 ggctggtcag ctgtgccaca gagattggcc cgcaagccct gatgaatatc atgcagaact
     2701 ggtattcctt attcacacca gtggaggcgg ctaccatcgt ggcagtgacg ggcaccacac
     2761 acgccactct gctgcgactg cagctggaca catcgcggag ggaggagctc tgggcctgcg
     2821 cccgcaccct ggccttgcag tgcgcgatga aggaccctca gaactgcgcc ttgcctgccc
     2881 tgaccctgtg cgagaagaac cactcggcct tcgaggcggc ctaccagatc gtgctggacg
     2941 cggcggccgg cggcctgggc cacgcccacc tcttcactgt ggcccgctat atggagcacc
     3001 gcgggctgcc gctccgggcc tacaagctgg cgacgctggc cctggcgcag ctcagcatcg
     3061 ccttcaacca ggacagccac cctgccgtca acgacgtgct ttgggcctgc tctctcagcc
     3121 actccctggg ccggcacgag ctctctgcca tcgtccccct catcattcgc agcatccact
     3181 gtgccccaat gctgtccgat attctgcgcc gctggactct ctcggcgccc ggtctgggcc
     3241 ccttaggggc acgccgggcc gccaagccac tgggtgccga ccgggcgccg ctctgccagc
     3301 tcctggacgc ggcagtcacc gcctacatca ccaccagcca ctcgcgcctc acgcacatca
     3361 gcccgcggca ctatggggat ttcatcgaat tcctgggcaa ggcccgggag accttcctgc
     3421 tggcgcccga cgggcacctc cagttctcac agttcttgga gaacctcaaa cagacctaca
     3481 agggcaagaa gaaactcatg cttttggtgc gggagcgttt tggttgaggg acagtggggt
     3541 gcgtgggagt ggggatcccc ctcgcccctg cgtcccccac ccttgctctc caattaggcc
     3601 cacgtggcat ttcagtatta ttaagtcagg gaaggagccc ggctggagat gggggcaggg
     3661 ggagcagcat cctgccacgt gtgtgcctgg gagtctgtga gcaagtgtgc aagactccag
     3721 aagcagaagc catactgcca cccagaagcc tggaaggggt gtgtgcttgg gctgctggta
     3781 tgaccccact ttgggcaccc caaaagcaat aggcaaactc cccttaccca gactggcttg
     3841 ggctccagga gggaggctgg gaggcaggac tttccagaaa tcgaccctct aagtcaatgt
     3901 agcacatttt cccccaaccc caccctgggt ggccaagggt cctcccccac cccctactgc
     3961 tcagggcccc ccattatgcc acctccaaag tggctgccca gccaggacca ttggctcacc
     4021 cccactgaag gaattgaaga ggcctcaggc ctcagcctca tacctcaccc ccttatccta
     4081 tccggccagg acccccattt ccttgggcac tagggtccca gggtgggctc agggttgggg
     4141 aagtcctcgc tgccctctct tctcacctgc tagtcactgg acgtacaact caggaactga
     4201 gcgaggctca cactgcccct tccaacctgg ggttggggga cacagacgcg agagagccgg
     4261 agacccccac ccccgatctg gaaaggaaag agacctgtat cttggtgttt ttctggcttt
     4321 ttcacccttt cgcctcctgt ctttctgctt cgccccttca tcttactctg tttccatttt
     4381 tcccggcact tacctgcctt tctctctgca cctaagtccc tgccgccctc tctctttggc
     4441 catccttcct ttcccccacc ttgacccagg gaggagaagg gagaacatca cccccccaag
     4501 tcacccccac atcttttccc ttcttgtata ttaaggacaa aataccacat cattttgtaa
     4561 ctttttttct atttattgaa cggtgtatta catgtccttt tccttttttt ttttcaaaga
     4621 ttgaacagaa atttttcttt ttaattttat tttgagactg gggtgcatct ccagagccac
     4681 tcacaccctc aacctcgttt cctccgcaaa aaaaaaaaaa aaaaaaaaaa a
//
