LOCUS       NM_080603               2769 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens zinc finger SWIM-type containing 1 (ZSWIM1), mRNA.
ACCESSION   NM_080603
VERSION     NM_080603.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2769)
  AUTHORS   Chen,L., Lian,Q., Zhang,G., Wu,J., Zeng,G. and Gao,X.
  TITLE     [TRIM21 Inhibits the Proliferation and Migration of Lung
            Adenocarcinoma Cells by Interacting with ZSWIM1]
  JOURNAL   Zhongguo Fei Ai Za Zhi 27 (5), 337-344 (2024)
   PUBMED   38880921
  REMARK    GeneRIF: [TRIM21 Inhibits the Proliferation and Migration of Lung
            Adenocarcinoma Cells by Interacting with ZSWIM1].
REFERENCE   2  (bases 1 to 2769)
  AUTHORS   Gao,X., Lian,Q., Guan,B., Liu,Q.Y., Meng,M., Chen,Y., Jin,J.,
            Li,H., Liu,X., Sun,Z., Liu,L., He,Q.Y. and Zhang,G.
  TITLE     ZSWIM1 Promotes the Proliferation and Metastasis of Lung
            Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis
  JOURNAL   J Proteome Res 22 (4), 1080-1091 (2023)
   PUBMED   36511424
  REMARK    GeneRIF: ZSWIM1 Promotes the Proliferation and Metastasis of Lung
            Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis.
REFERENCE   3  (bases 1 to 2769)
  AUTHORS   Ko,K.K., Powell,M.S. and Hogarth,P.M.
  TITLE     ZSWIM1: a novel biomarker in T helper cell differentiation
  JOURNAL   Immunol Lett 160 (2), 133-138 (2014)
   PUBMED   24508175
  REMARK    GeneRIF: The activation sensitive nature of ZSWIM1 expression
            suggests that it may play a novel role in the development or
            function of T helper cells.
REFERENCE   4  (bases 1 to 2769)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL008726.3.
            
            On Nov 22, 2018 this sequence version replaced NM_080603.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP281440.1, SRR1163657.544112.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372523.1/ ENSP00000361601.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL008726.3         53623-53657
            36-2769             AL008726.3         54929-57662
FEATURES             Location/Qualifiers
     source          1..2769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2769
                     /gene="ZSWIM1"
                     /gene_synonym="C20orf162"
                     /note="zinc finger SWIM-type containing 1"
                     /db_xref="GeneID:90204"
                     /db_xref="HGNC:HGNC:16155"
     exon            1..35
                     /gene="ZSWIM1"
                     /gene_synonym="C20orf162"
                     /inference="alignment:Splign:2.1.0"
     exon            36..2769
                     /gene="ZSWIM1"
                     /gene_synonym="C20orf162"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1553
                     /gene="ZSWIM1"
                     /gene_synonym="C20orf162"
                     /note="zinc finger, SWIM domain containing 1"
                     /codon_start=1
                     /product="zinc finger SWIM domain-containing protein 1"
                     /protein_id="NP_542170.3"
                     /db_xref="CCDS:CCDS13382.2"
                     /db_xref="GeneID:90204"
                     /db_xref="HGNC:HGNC:16155"
                     /translation="MLERLKAPWSAALQRKYFDLGIWTAPISPMALTMLNGLLIKDSS
                     PPMLLHQVNKTAQLDTFNYQSCFMQSVFDHFPEILFIHRTYNPRGKVLYTFLVDGPRV
                     QLEGHLARAVYFAIPAKEDTEGLAQMFQVFKKFNPAWERVCTILVDPHFLPLPILAME
                     FPTAEVLLSAFHICKFLQAKFYQLSLERPVERLLLTSLQSTMCSATAGNLRKLYTLLS
                     NCIPPAKLPELHSHWLLNDRIWLAHRWRSRAESSHYFQSLEVTTHILSQFFGTTPSEK
                     QGMASLFRYMQQNSADKANFNQGLCAQNNHAPSDTIPESPKLEQLVESHIQHSLNAIC
                     TGPAAQLCLGELAVVQKSTHLIGSGSEKMNIQILEDTHKVQPQPPASCSCYFNQAFHL
                     PCRHILAMLSARRQVLQPDMLPAQWTAGCATSLDSILGSKWSETLDKHLAVTHLTEEV
                     GQLLQHCTKEEFERRYSTLRELADSWIGPYEQVQL"
     regulatory      2744..2749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSWIM1"
                     /gene_synonym="C20orf162"
                     /note="hexamer: AATAAA"
     polyA_site      2769
                     /gene="ZSWIM1"
                     /gene_synonym="C20orf162"
                     /note="major polyA site"
ORIGIN      
        1 aaatagggag aaatggcgac ggagcctggc tgtgggccca tctttggaaa aaagatctgg
       61 gaatgattgt ctagcctcca gcctcaactt acttgatgct tgagagactc aaagccccgt
      121 ggtcagctgc cctgcaaaga aagtattttg accttggcat ttggacagct cccatctctc
      181 ccatggccct gacaatgctg aatgggctcc tgattaagga ctcaagccca cctatgctgc
      241 tgcaccaggt taacaagact gcccagttag ataccttcaa ctaccagagc tgctttatgc
      301 aaagtgtctt tgaccatttc cctgagatct tatttatcca ccggacctat aacccaaggg
      361 gtaaggtctt atataccttc ctggtggatg gacctcgggt gcagctggag ggtcatcttg
      421 cccgagcagt ctactttgcc atccctgcca aggaggacac tgaaggcctg gcccagatgt
      481 tccaagtatt caagaagttt aatccagcat gggagagagt ctgtaccatc ctggtggatc
      541 ctcatttcct tccactgcct atcctagcta tggagttccc cacagctgag gtccttctct
      601 cagccttcca catttgtaag ttcctccagg ccaagttcta tcagctgtcc cttgaacggc
      661 ccgtggaaag gctgctcctg acctccctgc agagcacaat gtgctcagcc acagcaggca
      721 acctgagaaa gttgtataca ctcctgagca actgcatccc tccagccaag ctgcccgagc
      781 ttcactcaca ctggctgctc aacgaccgca tctggctggc tcaccgctgg agaagccgag
      841 ctgagagcag ccactacttc cagagcctcg aggtcaccac ccacatcctc agccagttct
      901 ttggtaccac cccatctgag aaacaaggta tggcttctct gttccgttac atgcagcaga
      961 actctgcaga caaggcaaac ttcaaccagg gcctgtgtgc ccagaacaat catgctccct
     1021 cagacaccat ccccgaaagc cccaaactgg agcagctggt agaatcccac atccagcact
     1081 ccctcaatgc catctgcaca gggccagcag cccaactgtg cctgggcgag cttgctgtgg
     1141 tccagaaatc cacacacctc attggctctg gctcagaaaa gatgaacata cagatcctgg
     1201 aagataccca taaggtgcag ccccagcccc ctgccagctg cagctgctac tttaaccagg
     1261 ccttccacct gccctgccgc cacatcctag ccatgctcag tgcccgccgc caggtgctcc
     1321 agcccgacat gctgccggct cagtggacgg caggctgtgc taccagtcta gacagcatcc
     1381 tgggcagcaa gtggagtgag accctggata agcacctggc agtgactcac ctcaccgagg
     1441 aggtgggtca gctgttgcag cactgcacca aggaggagtt tgagcggagg tatagcaccc
     1501 tgcgggaact ggccgacagc tggattgggc cttatgagca ggtccaactc tgattattct
     1561 cgatgcccag agatgctcat gcacctgtgc acactcacat ccacccatac acacacacac
     1621 acacacacac acacacacac acacactccc ttacactgtt gtacttccgt gggccctcct
     1681 tccagaacaa ggacaacaag gacaaggttg aagggtcttc tcatctacca tggcctgcta
     1741 cctagcatgt gtctagctca atgagacagg agtcagcaaa tcttaatctg tttagtttac
     1801 tcaggtggcc acatacagtc tctgttgtat attcttggtt ttgttttaat attttttttc
     1861 tttttttttt tttttttttt tttgagaagg agtctgtctc cgtcacccag gctggagtgc
     1921 agtggcgcaa tctctgctca ctgcaagctc cacctcctgg gttcacacca ttctcctgcc
     1981 tcagcctccc gagtatctgg gactacaggc gcccgccaca atgccgggct aattttttgt
     2041 atttttagta gagacggggt ttcaccgtgt tagccaggat ggtctcgatc tcctgacttc
     2101 gtgatctgcc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc catcgcaccc
     2161 ggcctgtttt aacattttca taaggtaaaa acctttctta gctcaaaggt ctttaaaaaa
     2221 gcaggcaatc cagctgggca tggtggctca cgcctgtaat cccagcattt tgggaggctg
     2281 aggtggacag atgacttgag gtcaggagtt caagaccagc ctggccaaca tagtgaaacc
     2341 ctgtctctac taaaaataca caaattagcc aggtgtggtg gcgggggccc tgtaatccca
     2401 gctactcggg aggctgaggc aggagaatcg cttgaacctg ggaggcagag gttgcagtag
     2461 gccaagatcc tgctgccact gcactccagc ctgggagggt gagactccat ctaaaaaaaa
     2521 taaaataaat ggcaacccct ggtctaagat aagagataaa acatcaggtg gtgaggttga
     2581 ggtttggggc ttggtagcag ttgccccagt catgagatga ctcacttaac ccgtctcctt
     2641 taagtgagct gggctgggag gcttcctaca ggggaagagg cccctctggg gagctgactc
     2701 agccaggctc cctgaacttt tttccttgtc ccatcctggg gtcaataaaa ctgaatgttg
     2761 catattcta
//
