LOCUS       NM_006299               1659 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 9 (ZSCAN9),
            transcript variant 2, mRNA.
ACCESSION   NM_006299
VERSION     NM_006299.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1659)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1659)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1659)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1659)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1659)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 1659)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   7  (bases 1 to 1659)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 1659)
  AUTHORS   Williams,A.J., Blacklow,S.C. and Collins,T.
  TITLE     The zinc finger-associated SCAN box is a conserved oligomerization
            domain
  JOURNAL   Mol Cell Biol 19 (12), 8526-8535 (1999)
   PUBMED   10567577
REFERENCE   9  (bases 1 to 1659)
  AUTHORS   Lee,P.L., Gelbart,T., West,C., Adams,M., Blackstone,R. and
            Beutler,E.
  TITLE     Three genes encoding zinc finger proteins on human chromosome
            6p21.3: members of a new subclass of the Kruppel gene family
            containing the conserved SCAN box domain
  JOURNAL   Genomics 43 (2), 191-201 (1997)
   PUBMED   9244436
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK304013.1, BC010374.1 and AK226035.1.
            
            On Jun 2, 2019 this sequence version replaced NM_006299.4.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            CDS, as compared to variant 1. The resulting isoform (2) lacks an
            internal segment, as compared to isoform 1. Variants 2 and 3 encode
            the same isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.189509.1,
                                           SRR1660803.222508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252207.10/ ENSP00000252207.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AK304013.1         1-184
            185-1654            BC010374.1         169-1638
            1655-1659           AK226035.1         1788-1792
FEATURES             Location/Qualifiers
     source          1..1659
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1659
                     /gene="ZSCAN9"
                     /gene_synonym="PRD51; ZNF193"
                     /note="zinc finger and SCAN domain containing 9"
                     /db_xref="GeneID:7746"
                     /db_xref="HGNC:HGNC:12984"
                     /db_xref="MIM:602246"
     exon            1..92
                     /gene="ZSCAN9"
                     /gene_synonym="PRD51; ZNF193"
                     /inference="alignment:Splign:2.1.0"
     exon            93..585
                     /gene="ZSCAN9"
                     /gene_synonym="PRD51; ZNF193"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1350
                     /gene="ZSCAN9"
                     /gene_synonym="PRD51; ZNF193"
                     /note="isoform 2 is encoded by transcript variant 2; cell
                     proliferation-inducing protein 12; cell
                     proliferation-inducing gene 12 protein; zinc finger and
                     SCAN domain-containing protein 9; zinc finger protein 193"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein 9
                     isoform 2"
                     /protein_id="NP_006290.1"
                     /db_xref="CCDS:CCDS4646.1"
                     /db_xref="GeneID:7746"
                     /db_xref="HGNC:HGNC:12984"
                     /db_xref="MIM:602246"
                     /translation="MNTNSKEVLSLGVQVPEAWEELLTMKVEAKSHLQWQESRLKRSN
                     PLAREIFRRHFRQLCYQETPGPREALTRLQELCYQWLRPHVSTKEQILDLLVLEQFLS
                     ILPKELQGWVREHCPESGEEAVILLEDLERELDEPQHEMVAHRHRQEVLCKEMVPLAE
                     QTPLTLQSQPKEPQLTCDSAQKCHSIGETDEVTKTEDRELVLRKDCPKIVEPHGKMFN
                     EQTWEVSQQDPSHGEVGEHKDRIERQWGNLLGEGQHKCDECGKSFTQSSGLIRHQRIH
                     TGERPYECNECGKAFSRSSGLFNHRGIHNIQKRYHCKECGKVFSQSAGLIQHQRIHKG
                     EKPYQCSQCSKSYSRRSFLIEHQRSHTGERPHQCIECGKSFNRHCNLIRHQKIHTVAE
                     LV"
     exon            586..733
                     /gene="ZSCAN9"
                     /gene_synonym="PRD51; ZNF193"
                     /inference="alignment:Splign:2.1.0"
     exon            734..1659
                     /gene="ZSCAN9"
                     /gene_synonym="PRD51; ZNF193"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1625..1630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN9"
                     /gene_synonym="PRD51; ZNF193"
                     /note="hexamer: AATAAA"
     polyA_site      1659
                     /gene="ZSCAN9"
                     /gene_synonym="PRD51; ZNF193"
                     /note="major polyA site"
ORIGIN      
        1 atctttgttc cctgcccggc cattgttcgt gccgcgcttc tagcaacgcc gggccggtaa
       61 ccccctctcc ctccttgcgc gttccgggtc tcgcaagcgc ctccaaggtt tgtcttgaag
      121 catagctcca gctggagggt accttttaag ctgttcaagg tcaagatgaa tacaaactca
      181 aaggaggttt tatccctggg tgttcaagtt cccgaggcat gggaagaact tctgacaatg
      241 aaagtggaag caaaaagtca ccttcaatgg caggaatcca gactgaaacg cagtaatcca
      301 ctggcaaggg aaatcttccg aaggcacttt cgacagctgt gctaccaaga gacccctgga
      361 ccaagggagg ctcttactcg actccaggaa ctttgctacc agtggttgag gccacatgtg
      421 agcacaaagg agcagatttt ggatctgctg gtgctggagc agtttctatc cattctgccc
      481 aaggagctcc agggctgggt gagggaacac tgtccagaga gtggagaaga ggctgtgatt
      541 ttgctggagg atctggagag agagctcgat gaaccacaac atgagatggt ggcccacaga
      601 cacagacaag aagtcctctg taaagagatg gtgcctctag cagagcagac accactgacc
      661 cttcagtccc agcctaagga gccacagctc acatgtgact ctgctcagaa gtgccattct
      721 attggagaga cagatgaagt aaccaagact gaggacagag agttggtgct aaggaaagac
      781 tgtcctaaga tagtggaacc acatgggaaa atgtttaatg agcagacctg ggaggtatca
      841 cagcaggatc cctcacatgg agaagttggt gaacataagg ataggataga gaggcagtgg
      901 ggaaacctct taggagaggg gcaacacaaa tgtgatgaat gtgggaagag ctttactcag
      961 agctcaggtc tcattcgaca tcaaagaatt catactggag aaagacctta tgaatgtaat
     1021 gaatgtggga aagccttcag tcgaagttct ggtcttttta atcaccgagg aatccacaat
     1081 atacagaaac ggtaccactg caaggagtgt gggaaggtct tcagtcagag tgcgggtctt
     1141 atccagcatc agagaatcca caaaggagaa aagccgtatc agtgcagcca gtgcagtaag
     1201 agctacagtc ggcgttcatt tctcattgaa catcagagaa gccacacagg ggagcgacct
     1261 caccagtgca ttgaatgtgg gaaaagcttt aatcgacact gcaacctcat tcgccatcag
     1321 aagatccaca cagtggctga gctggtctag ggcttggcta tgagcaagtt ttccagatca
     1381 ccacccaagt tgtgtggggc aggttgagac tagaaaatgc ctctttcttc ctttctccat
     1441 gaaatgtgtt tgaaacaaat cctgacttaa ggcccaggga cttccttaaa ggaaagttgg
     1501 gtgtttgaag ctactgtttt ctcttttgtt cattttacct ctttcttact cttactagct
     1561 gtgtccctct tatttataat ttatttattt ttttgagatg gctgctaaac ccttctaata
     1621 atataataaa tggcactgcc acagccaaca tgcctgaaa
//
