LOCUS       NM_152677               2246 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 4 (ZSCAN4),
            transcript variant 2, mRNA.
ACCESSION   NM_152677
VERSION     NM_152677.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2246)
  AUTHORS   Akiyama,T., Ishiguro,K.I., Chikazawa,N., Ko,S.B.H., Yukawa,M. and
            Ko,M.S.H.
  TITLE     ZSCAN4-binding motif-TGCACAC is conserved and enriched in CA/TG
            microsatellites in both mouse and human genomes
  JOURNAL   DNA Res 31 (1) (2024)
   PUBMED   38153767
  REMARK    GeneRIF: ZSCAN4-binding motif-TGCACAC is conserved and enriched in
            CA/TG microsatellites in both mouse and human genomes.
REFERENCE   2  (bases 1 to 2246)
  AUTHORS   He,H.L., Lai,H.Y., Chan,T.C., Hsing,C.H., Huang,S.K., Hsieh,K.L.,
            Chen,T.J., Li,W.S., Kuo,Y.H., Shiue,Y.L. and Li,C.F.
  TITLE     Low expression of ZSCAN4 predicts unfavorable outcome in urothelial
            carcinoma of upper urinary tract and urinary bladder
  JOURNAL   World J Surg Oncol 21 (1), 62 (2023)
   PUBMED   36841776
  REMARK    GeneRIF: Low expression of ZSCAN4 predicts unfavorable outcome in
            urothelial carcinoma of upper urinary tract and urinary bladder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2246)
  AUTHORS   Cheng,Z.L., Zhang,M.L., Lin,H.P., Gao,C., Song,J.B., Zheng,Z.,
            Li,L., Zhang,Y., Shen,X., Zhang,H., Huang,Z., Zhan,W., Zhang,C.,
            Hu,X., Sun,Y.P., Jiang,L., Sun,L., Xu,Y., Yang,C., Ge,Y., Zhao,Y.,
            Liu,X., Yang,H., Liu,P., Guo,X., Guan,K.L., Xiong,Y., Zhang,M. and
            Ye,D.
  TITLE     The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring
            and Enhances Proteostasis to Promote Reprogramming
  JOURNAL   Cell Rep 32 (2), 107877 (2020)
   PUBMED   32668244
  REMARK    GeneRIF: The Zscan4-Tet2 Transcription Nexus Regulates Metabolic
            Rewiring and Enhances Proteostasis to Promote Reprogramming.
REFERENCE   4  (bases 1 to 2246)
  AUTHORS   Portney,B.A., Arad,M., Gupta,A., Brown,R.A., Khatri,R., Lin,P.N.,
            Hebert,A.M., Angster,K.H., Silipino,L.E., Meltzer,W.A., Taylor,R.J.
            and Zalzman,M.
  TITLE     ZSCAN4 facilitates chromatin remodeling and promotes the cancer
            stem cell phenotype
  JOURNAL   Oncogene 39 (26), 4970-4982 (2020)
   PUBMED   32507861
  REMARK    GeneRIF: ZSCAN4 facilitates chromatin remodeling and promotes the
            cancer stem cell phenotype.
REFERENCE   5  (bases 1 to 2246)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2246)
  AUTHORS   Lee,K. and Gollahon,L.S.
  TITLE     ZSCAN4 and TRF1: A functionally indirect interaction in cancer
            cells independent of telomerase activity
  JOURNAL   Biochem Biophys Res Commun 466 (4), 644-649 (2015)
   PUBMED   26403970
  REMARK    GeneRIF: ZSCAN4 indirectly interacts with TRF1 in cancer cells. We
            show that ZSCAN4 plays an important role independent of telomere
            maintenance pathways (telomerase positive and alternative pathway)
            or cell lineage.
REFERENCE   7  (bases 1 to 2246)
  AUTHORS   Lee,K. and Gollahon,L.S.
  TITLE     Zscan4 interacts directly with human Rap1 in cancer cells
            regardless of telomerase status
  JOURNAL   Cancer Biol Ther 15 (8), 1094-1105 (2014)
   PUBMED   24840609
  REMARK    GeneRIF: The direct interaction between Zscan4 and Rap1 may explain
            how Zscan4 rapidly increases telomere length, yielding important
            information about the role of these proteins in telomere biology.
REFERENCE   8  (bases 1 to 2246)
  AUTHORS   Dan,J., Liu,Y., Liu,N., Chiourea,M., Okuka,M., Wu,T., Ye,X.,
            Mou,C., Wang,L., Wang,L., Yin,Y., Yuan,J., Zuo,B., Wang,F., Li,Z.,
            Pan,X., Yin,Z., Chen,L., Keefe,D.L., Gagos,S., Xiao,A. and Liu,L.
  TITLE     Rif1 maintains telomere length homeostasis of ESCs by mediating
            heterochromatin silencing
  JOURNAL   Dev Cell 29 (1), 7-19 (2014)
   PUBMED   24735877
REFERENCE   9  (bases 1 to 2246)
  AUTHORS   Zalzman,M., Falco,G., Sharova,L.V., Nishiyama,A., Thomas,M.,
            Lee,S.L., Stagg,C.A., Hoang,H.G., Yang,H.T., Indig,F.E.,
            Wersto,R.P. and Ko,M.S.
  TITLE     Zscan4 regulates telomere elongation and genomic stability in ES
            cells
  JOURNAL   Nature 464 (7290), 858-863 (2010)
   PUBMED   20336070
REFERENCE   10 (bases 1 to 2246)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004017.1.
            
            On Sep 30, 2021 this sequence version replaced NM_152677.3.
            
            Summary: The ZSCAN4 gene encodes a protein involved in telomere
            maintenance and with a key role in the critical feature of mouse
            embryonic stem (ES) cells, namely, defying cellular senescence and
            maintaining normal karyotype for many cell divisions in culture
            (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092424.1, SRR14478891.512743.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2163623
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318203.9/ ENSP00000321963.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AC004017.1         7600-7868
            270-592             AC004017.1         8910-9232
            593-1093            AC004017.1         14706-15206
            1094-1259           AC004017.1         16579-16744
            1260-2246           AC004017.1         16831-17817
FEATURES             Location/Qualifiers
     source          1..2246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2246
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /note="zinc finger and SCAN domain containing 4"
                     /db_xref="GeneID:201516"
                     /db_xref="HGNC:HGNC:23709"
                     /db_xref="MIM:613419"
     exon            1..269
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /inference="alignment:Splign:2.1.0"
     exon            270..592
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /inference="alignment:Splign:2.1.0"
     exon            593..1093
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /inference="alignment:Splign:2.1.0"
     CDS             698..1999
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /note="zinc finger protein 494"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     4"
                     /protein_id="NP_689890.1"
                     /db_xref="CCDS:CCDS12958.1"
                     /db_xref="GeneID:201516"
                     /db_xref="HGNC:HGNC:23709"
                     /db_xref="MIM:613419"
                     /translation="MALDLRTIFQCEPSENNLGSENSAFQQSQGPAVQREEGISEFSR
                     MVLNSFQDSNNSYARQELQRLYRIFHSWLQPEKHSKDEIISLLVLEQFMIGGHCNDKA
                     SVKEKWKSSGKNLERFIEDLTDDSINPPALVHVHMQGQEALFSEDMPLRDVIVHLTKQ
                     VNAQTTREANMGTPSQTSQDTSLETGQGYEDEQDGWNSSSKTTRVNENITNQGNQIVS
                     LIIIQEENGPRPEEGGVSSDNPYNSKRAELVTARSQEGSINGITFQGVPMVMGAGCIS
                     QPEQSSPESALTHQSNEGNSTCEVHQKGSHGVQKSYKCEECPKVFKYLCHLLAHQRRH
                     RNERPFVCPECQKGFFQISDLRVHQIIHTGKKPFTCSMCKKSFSHKTNLRSHERIHTG
                     EKPYTCPFCKTSYRQSSTYHRHMRTHEKITLPSVPSTPEAS"
     exon            1094..1259
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..2246
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /note="hexamer: AATAAA"
     regulatory      2229..2234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /note="hexamer: AATAAA"
     polyA_site      2238
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
                     /note="major polyA site"
     polyA_site      2246
                     /gene="ZSCAN4"
                     /gene_synonym="ZNF494"
ORIGIN      
        1 ccttgtaatt cataaatctc tgaaaactta aaagtttgag caaaagtttg tcatgtttct
       61 atgagtaatt tataataaaa cttgatcaga atttgtgaga ctaacgtttg tctttatatt
      121 ttcctttttt tttttttttt ttttgagaca cagtctcgct ctgtcgtcca ggctggagtg
      181 ccgtggcgta atctcggctc actgcaacct ctgcctcctg gattcaaaca attcttctgc
      241 ctcagcctcc tgagtagctg ggattacagg accagtgatg gtatagaaca ctgtattaga
      301 gacatggagc tggggctgga tgaagattcc atcagtaatt caatcaacag acaagtgtta
      361 tccaatcacg tctttaaatc aatcactgac atggagctgg ggctggatga agattccatc
      421 agtaattcaa tcaacagaca agtgttatcc aatcacgtct ttaaatcaat cactgatccc
      481 agcccctata aaagggagca gccttaggag gcacatcaga taaacccagt gtggaaagct
      541 agtcacacat cagctcagtg ttcggcccgg gattacccag tcaaccaagg agcttgcagt
      601 tttaaagaat ccaccaactg ttgaaacaaa tccctagaga cacaaggcaa gagactgaat
      661 catcaaagta aagtctctct gagaattatt gctaagaatg gctttagatc taagaaccat
      721 atttcagtgt gaaccatccg agaataatct tggatcagaa aattcagcgt ttcaacaaag
      781 ccaaggacct gctgttcaga gagaagaagg gatttctgag ttctcaagaa tggtgctcaa
      841 ttcatttcaa gacagcaata attcatatgc aaggcaggaa ttgcaaagac tttataggat
      901 ctttcactca tggctgcaac cagaaaagca cagcaaggat gaaattattt ctctattagt
      961 cctggagcag tttatgattg gtggccactg caatgacaaa gccagtgtga aagagaaatg
     1021 gaaatcaagt ggcaaaaact tggagagatt catagaagac ctgactgatg acagcataaa
     1081 tccacctgcc ttagtccacg tccacatgca gggacaggaa gctctctttt ctgaggatat
     1141 gcccttaaga gatgtcattg ttcatctcac aaaacaagtg aatgcccaaa ccacaagaga
     1201 agcaaacatg gggacaccct cccagacttc ccaagatact tccttagaaa caggacaagg
     1261 atatgaagat gaacaagatg gctggaacag ttcttcgaaa actactcgag taaatgaaaa
     1321 tattactaat caaggcaatc aaatagtttc cctaatcatc atccaggaag agaacggtcc
     1381 taggcctgaa gagggaggtg tttcttctga caacccatac aactcaaaaa gagcagagct
     1441 agtcactgct agatctcagg aagggtccat aaatggaatc actttccaag gtgtccctat
     1501 ggtgatggga gcagggtgta tctctcaacc agagcagtcc tcccctgagt ctgcccttac
     1561 ccaccagagc aatgagggaa attccacatg tgaggtacat cagaaaggat cccatggagt
     1621 ccaaaaatca tacaaatgtg aagaatgccc caaggtcttt aagtatctct gtcacttatt
     1681 agctcaccag agaagacaca ggaatgagag gccatttgtt tgtcccgagt gtcaaaaagg
     1741 cttcttccag atatcagacc tacgggtgca tcagataatt cacacaggaa agaagccttt
     1801 cacatgcagc atgtgtaaaa agtccttcag ccacaaaacc aacctgcggt ctcatgagag
     1861 aatccacaca ggagaaaagc cttatacatg tcccttttgt aagacaagct accgccagtc
     1921 atccacatac caccgccata tgaggactca tgagaaaatt accctgccaa gtgttccctc
     1981 cacaccagaa gcttcctaag ctgctggtct gataatgtgt ataaatatgt atgcaagtat
     2041 gtatattcct atagtattta tctacttagg atataagata taatctcctg attatgcttt
     2101 caatttattg tcttgcttca ttaaaatgta aggctaagga gagcatggaa tttgtcagtt
     2161 ttgttcacta aagtattcca agtggttggg aaagtggaac atttccaaga accaataaat
     2221 ttctgttgaa taaatgaatg aatcca
//
