LOCUS       NM_145115               4352 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 25 (ZSCAN25),
            transcript variant 1, mRNA.
ACCESSION   NM_145115
VERSION     NM_145115.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4352)
  AUTHORS   Andersen,A., Milefchik,E., Papworth,E., Penaluna,B., Dawes,K.,
            Moody,J., Weeks,G., Froehlich,E., deBlois,K., Long,J.D. and
            Philibert,R.
  TITLE     ZSCAN25 methylation predicts seizures and severe alcohol withdrawal
            syndrome
  JOURNAL   Epigenetics 19 (1), 2298057 (2024)
   PUBMED   38166538
  REMARK    GeneRIF: ZSCAN25 methylation predicts seizures and severe alcohol
            withdrawal syndrome.
REFERENCE   2  (bases 1 to 4352)
  AUTHORS   Zhang,X., Zheng,Q., Yue,X., Yuan,Z., Ling,J., Yuan,Y., Liang,Y.,
            Sun,A., Liu,Y., Li,H., Xu,K., He,F., Wang,J., Wu,J., Zhao,C. and
            Tian,C.
  TITLE     ZNF498 promotes hepatocellular carcinogenesis by suppressing
            p53-mediated apoptosis and ferroptosis via the attenuation of p53
            Ser46 phosphorylation
  JOURNAL   J Exp Clin Cancer Res 41 (1), 79 (2022)
   PUBMED   35227287
  REMARK    GeneRIF: ZNF498 promotes hepatocellular carcinogenesis by
            suppressing p53-mediated apoptosis and ferroptosis via the
            attenuation of p53 Ser46 phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4352)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4352)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   5  (bases 1 to 4352)
  AUTHORS   Thompson,E.E., Kuttab-Boulos,H., Yang,L., Roe,B.A. and Di Rienzo,A.
  TITLE     Sequence diversity and haplotype structure at the human CYP3A
            cluster
  JOURNAL   Pharmacogenomics J 6 (2), 105-114 (2006)
   PUBMED   16314882
REFERENCE   6  (bases 1 to 4352)
  AUTHORS   Laity,J.H., Lee,B.M. and Wright,P.E.
  TITLE     Zinc finger proteins: new insights into structural and functional
            diversity
  JOURNAL   Curr Opin Struct Biol 11 (1), 39-46 (2001)
   PUBMED   11179890
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005020.5, BX648158.1 and AW195325.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145115.2.
            
            Summary: This gene encodes a protein that bears some similarity to
            zinc finger proteins, which are involved in DNA binding and
            protein-protein interactions. Multiple alternatively spliced
            transcript variants have been identified, but the full-length
            nature for most of them has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), as well as variants 2 and 3,
            encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.180099.1,
                                           SRR1660809.124939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394152.7/ ENSP00000377708.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC005020.5         78862-78863         c
            3-716               BX648158.1         5-718
            717-4343            BX648158.1         2098-5724
            4344-4351           AW195325.1         11-18               c
            4352-4352           AC005020.5         63401-63401         c
FEATURES             Location/Qualifiers
     source          1..4352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..4352
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /note="zinc finger and SCAN domain containing 25"
                     /db_xref="GeneID:221785"
                     /db_xref="HGNC:HGNC:21961"
     exon            1..71
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /inference="alignment:Splign:2.1.0"
     exon            72..198
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /inference="alignment:Splign:2.1.0"
     exon            199..283
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /inference="alignment:Splign:2.1.0"
     exon            284..716
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1964
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger and SCAN domain-containing protein 25; zinc finger
                     protein 498"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     25 isoform a"
                     /protein_id="NP_660090.2"
                     /db_xref="CCDS:CCDS5671.2"
                     /db_xref="GeneID:221785"
                     /db_xref="HGNC:HGNC:21961"
                     /translation="MLKEHPEMAEAPQQQLGIPVVKLEKELPWGRGREDPSPETFRLR
                     FRQFRYQEAAGPQEALRELQELCRRWLRPELHTKEQILELLVLEQFLTILPREFYAWI
                     REHGPESGKALAAMVEDLTERALEAKAVPCHRQGEQEETALCRGAWEPGIQLGPVEVK
                     PEWGMPPGEGVQGPDPGTEEQLSQDPGDETRAFQEQALPVLQAGPGLPAVNPRDQEMA
                     AGFFTAGSQGLGPFKDMALAFPEEEWRHVTPAQIDCFGEYVEPQDCRVSPGGGSKEKE
                     AKPPQEDLKGALVALTSERFGEASLQGPGLGRVCEQEPGGPAGSAPGLPPPQHGAIPL
                     PDEVKTHSSFWKPFQCPECGKGFSRSSNLVRHQRTHEEKSYGCVECGKGFTLREYLMK
                     HQRTHLGKRPYVCSECWKTFSQRHHLEVHQRSHTGEKPYKCGDCWKSFSRRQHLQVHR
                     RTHTGEKPYTCECGKSFSRNANLAVHRRAHTGEKPYGCQVCGKRFSKGERLVRHQRIH
                     TGEKPYHCPACGRSFNQRSILNRHQKTQHRQEPLVQ"
     exon            717..918
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1010
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1134
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..4352
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4297..4302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /note="hexamer: AATAAA"
     polyA_site      4329
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
     regulatory      4331..4336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /note="hexamer: TATAAA"
     polyA_site      4352
                     /gene="ZSCAN25"
                     /gene_synonym="ZNF498"
                     /note="major polyA site"
ORIGIN      
        1 gcagctcact tccggaccgc ggatagcact ggcgacccta gcgggtgaga ggcccttcag
       61 ggccgcggcg ggttgagcgc accatcacat ctaagccatc agcaagtttg ttggttttaa
      121 tctccaaaat acgtcttgat tttgtctgac tctttgccac caccctgatc taagccctta
      181 tcatctgctt gaatcactaa cttgtctcca cttgcagttt ttaaaagagt tgcttccatt
      241 tgactttttc tgtctgctgt accagcatat gagtttcagg aggggtcatt gatgcagtca
      301 ttctcagtct cctcggaggg agtctgaaga tgcttaaaga gcatccagag atggcggaag
      361 ctcctcagca gcagttgggt attcctgtgg tgaaactgga gaaagagttg ccatggggca
      421 gaggaaggga ggaccctagt ccagagactt ttcggctgag gtttcggcag ttccgctacc
      481 aggaggcagc tggaccccag gaagctctta gggagctcca ggagctctgt cgtcggtggc
      541 tgaggcccga gttgcacacc aaggagcaga tcctggagct gctggtgctg gagcagttcc
      601 tcactatcct gccccgcgag ttctacgcct ggatccggga gcatggccca gagagtggca
      661 aggccctggc cgccatggtg gaggacctga cagaaagagc actggaggcc aaggcggttc
      721 catgccacag gcagggagag caggaggaaa cagcactttg cagaggcgct tgggagccag
      781 gcatccagct ggggccagtg gaggtcaagc ctgaatgggg gatgccccct ggggaaggag
      841 ttcaaggtcc agacccaggt accgaggagc agctcagtca ggaccctgga gatgagacac
      901 gggccttcca ggagcaagca ctacctgttc tgcaggcggg tcctggcctc cccgcagtga
      961 atcccagaga ccaagagatg gcagctgggt tctttactgc tggatcgcag gggttggggc
     1021 catttaaaga tatggccctg gccttccctg aggaggagtg gaggcatgtg accccagccc
     1081 agatagactg ctttggggag tatgtggaac cgcaggactg cagggtctct ccaggcggtg
     1141 ggagcaagga aaaggaggca aaacccccac aggaagacct gaaaggggcg ctggtggcac
     1201 tgacatcaga gaggtttggg gaagcctctc tccagggccc tgggctcgga agggtctgtg
     1261 agcaggagcc tggtggccct gcaggcagtg cgcctgggct tcctcctccc cagcacggtg
     1321 ccatccccct gcctgacgaa gtcaaaaccc acagctcctt ctggaagcct ttccagtgcc
     1381 ctgagtgtgg gaaaggattc agtcggagct ccaatctcgt caggcaccag cgaacccacg
     1441 aagagaagtc ttatggctgt gtggagtgtg ggaagggctt taccctgaga gaatacctga
     1501 tgaagcacca gagaacccac ctgggaaaga ggccctacgt gtgcagcgag tgctggaaaa
     1561 ccttcagcca gagacaccac ctggaggtgc accagcgcag ccacactggg gagaagccct
     1621 acaagtgcgg ggactgctgg aagagcttca gccgcaggca gcacctgcag gtgcaccgga
     1681 ggacgcacac cggggagaag ccctacacct gcgagtgtgg caagagcttc agcaggaatg
     1741 ccaatctggc ggtgcaccgg cgtgcccaca ctggcgagaa gccatatggg tgccaggtgt
     1801 gcgggaagcg gttcagcaaa ggggagcggc tggtccgaca ccagagaatc catacagggg
     1861 agaagcccta ccactgtcct gcctgcgggc gaagcttcaa ccagaggtcc atcctcaacc
     1921 ggcaccagaa gacccagcac cgccaggagc cgctggtgca gtgagcatag caggtggcag
     1981 gcagcaccat cattcatctt tctcactgca gggccttgcg gggtgcaagg tgatggctgc
     2041 aggaaagcac tggtcccatc gccttcccac ccattcgcca acgcgggaaa ggcaaggcct
     2101 ggcttactta gagcttccag agagcatagc tgcttccatc tcttacccaa gtggtgctaa
     2161 acaatttttc ttccaatgtt tgagggaagc agtctcctgc ggttcagttc aggctgagat
     2221 tttctccttc agtggactgt ctgtgtcccc ctgccgaaca aagctgggag taaaggcaaa
     2281 accttgacac gtgttggtag ctgggacctc atcttcctga gggctctgtc ttgcctgcag
     2341 ggtcatagct cagactcttc ccccaccccc tctcttttcc attgaacaaa catttattga
     2401 acatcctctg agcacctggc cgtgggaatg ccgtggtgaa tgagagacta gacgtgatgc
     2461 ctctgggggt tgtgcgttgg ggatgcatgc gacagcccat gacccgaggc attctcaggg
     2521 tatctgtgct gtgtgcccgt gagaacatct tcccatgacc actcctgccc tcctgccccg
     2581 tgctggatct tccctcccca gctgggatct gctcccaggc aactgtgtga attttacatt
     2641 atttggagcc tcatctgtgt caggctataa cattctatcc tcatctgtaa aacttccccg
     2701 tccattattc cttgcactat aacaactgtc aacacaccaa ctattaggaa gttagtattt
     2761 tgctattgat cactgaataa acatcagagt attttaaaaa acagttctct agaaagaact
     2821 gttataatta aaatgagtct gaaagatgaa ctctagtatt aatgccctat atttgatggc
     2881 actttatagt tcataaaatt aatttcaccc cattctcatt ggacccattt cccaagtatt
     2941 tattgaggcc ctgtaacaaa catgtcagga actcttctgg gtgcttgaga cacatccatg
     3001 aataaaatag ggggagaagc tgttgacctc gtagagctta tgtctcgtgg atgtacctga
     3061 tcttcagaac ccgtggatat tcctgcaaat cctctgggcc tgtattcatt gctttgtcag
     3121 catcttgccc tgaaatgcat ttgtcaccta cctcttgtta ctaaatggtc tctgccctcc
     3181 agacccttgt catccaaggc actaggggtc ctggacaccc actggggatg atgagctggt
     3241 agcgacctgt tttgcatgag tgccaagtca ggaaaaataa agatatttgt aggcattaaa
     3301 aaaaaataca tttctttaaa aatgagaaga tgcaatattt gtaaactgtt gaagcttcct
     3361 tattgtgcca tcacttaagg gtttcatttc tgtttaaagt tctggaagct gcataactag
     3421 cgtggactga ctgctgtgtc attgtgctgt gcctttgaac cctggctgag tgagtgagtt
     3481 tgtcctttgt tgatagtgtc ctataattgc aaaatgtggt ttgtcttctg atgcctctta
     3541 ataccagatt cttttactga gatttttttt tttcattttc cattgtaaat aaggtaaatg
     3601 gtaatgacta acacaaagct gtattactca gcccactttg aaacgtggtt ttatcacctg
     3661 ttcttgttag gcagcatggt gtctaatttt ggcttagcaa atgacgctcc ttggtcttcc
     3721 tggctcatta gctgtgccca cgaggctgca ctgactgggt cgtaaatgta tctgagatgt
     3781 ccacacgggg ctgctgctgc tcctctgtaa tactgaggtc cacatgcaaa atcagctttt
     3841 tttcccccgt aattatcaga gcagctaggc agggctgaca gccaggcaga ctcagtggga
     3901 ggcttctggc ctgagtgtgg ccttccccag agggtggttt tccaaaggca ggtggggact
     3961 ggggaggcct cggggggctg cttgtcatta cctgaatcac agatgctctt ttgtcataca
     4021 cagccagcat tcctctgggt ttcagcaagt tggcatatct taagcttcag aaggagctgg
     4081 gccttgctga ctttcctatc tggcctcttc cctatctcct gtggggccaa gagcttagga
     4141 cagtgtctca gaaaagcctc taagtagggg gtttttccca tgggattgtg gtagtctgat
     4201 ttttcatatc tattcaaatg ttaagaaata ttttgttttc tgtatttttc tattctttag
     4261 aaattttttt ataatagata atttcaaacc tatataaata aatccttatg tatttatcat
     4321 ttgactttat tataaactca taatcaatct tg
//
