LOCUS       NM_001012455            3150 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 23 (ZSCAN23),
            mRNA.
ACCESSION   NM_001012455 XM_001715453 XM_001715639 XM_001717784
VERSION     NM_001012455.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3150)
  AUTHORS   Du,Q., Zhang,M., Gao,A., He,T. and Guo,M.
  TITLE     Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by
            activating Wnt signaling
  JOURNAL   Cancer Biol Ther 25 (1), 2302924 (2024)
   PUBMED   38226836
  REMARK    GeneRIF: Epigenetic silencing ZSCAN23 promotes pancreatic cancer
            growth by activating Wnt signaling.
REFERENCE   2  (bases 1 to 3150)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3150)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3150)
  AUTHORS   Majewska,M., Lipka,A., Paukszto,L., Jastrzebski,J.P.,
            Gowkielewicz,M., Jozwik,M. and Majewski,M.K.
  TITLE     Preliminary RNA-Seq Analysis of Long Non-Coding RNAs Expressed in
            Human Term Placenta
  JOURNAL   Int J Mol Sci 19 (7), 1894 (2018)
   PUBMED   29954144
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3150)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 3150)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX283350.1, AL833347.1 and Z98745.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001012455.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833347.1, SRR18074969.2532753.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289788.5/ ENSP00000289788.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BX283350.1         13-36
            25-2615             AL833347.1         1-2591
            2616-2897           Z98745.1           51568-51849         c
            2898-3150           AL833347.1         2874-3126
FEATURES             Location/Qualifiers
     source          1..3150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3150
                     /gene="ZSCAN23"
                     /gene_synonym="dJ29K1.3; dJ29K1.3.1; ZNF390; ZNF453"
                     /note="zinc finger and SCAN domain containing 23"
                     /db_xref="GeneID:222696"
                     /db_xref="HGNC:HGNC:21193"
     exon            1..93
                     /gene="ZSCAN23"
                     /gene_synonym="dJ29K1.3; dJ29K1.3.1; ZNF390; ZNF453"
                     /inference="alignment:Splign:2.1.0"
     exon            94..578
                     /gene="ZSCAN23"
                     /gene_synonym="dJ29K1.3; dJ29K1.3.1; ZNF390; ZNF453"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1340
                     /gene="ZSCAN23"
                     /gene_synonym="dJ29K1.3; dJ29K1.3.1; ZNF390; ZNF453"
                     /note="zinc finger protein 453; zinc finger protein 390"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     23"
                     /protein_id="NP_001012458.1"
                     /db_xref="CCDS:CCDS47393.1"
                     /db_xref="GeneID:222696"
                     /db_xref="HGNC:HGNC:21193"
                     /translation="MAITLTLQTAEMQEGLLAVKVKEEEEEHSCGPESGLSRNNPHTR
                     EIFRRRFRQFCYQESPGPREALQRLQELCHQWLRPEMHTKEQILELLVLEQFLTILPE
                     ELQAWVRQHRPVSGEEAVTVLEDLERELDDPGEQVLSHAHEQEEFVKEKATPGAAQES
                     SNDQFQTLEEQLGYNLREVCPVQEIDGKAGTWNVELAPKREISQEVKSLIQVLGKQNG
                     NITQIPEYGDTCDREGRLEKQRVSSSVERPYICSECGKSFTQNSILIEHQRTHTGEKP
                     YECDECGRAFSQRSGLFQHQRLHTGEKRYQCSVCGKAFSQNAGLFHHLRIHTGEKPYQ
                     CNQCNKSFSRRSVLIKHQRIHTGERPYECEECGKNFIYHCNLIQHRKVHPVAESS"
     exon            579..726
                     /gene="ZSCAN23"
                     /gene_synonym="dJ29K1.3; dJ29K1.3.1; ZNF390; ZNF453"
                     /inference="alignment:Splign:2.1.0"
     exon            727..3150
                     /gene="ZSCAN23"
                     /gene_synonym="dJ29K1.3; dJ29K1.3.1; ZNF390; ZNF453"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2234..2239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN23"
                     /gene_synonym="dJ29K1.3; dJ29K1.3.1; ZNF390; ZNF453"
                     /note="hexamer: AATAAA"
     polyA_site      2257
                     /gene="ZSCAN23"
                     /gene_synonym="dJ29K1.3; dJ29K1.3.1; ZNF390; ZNF453"
                     /note="major polyA site"
ORIGIN      
        1 ctttgtagtt tatcattctt tgggctgcgg ttgtcaagga ttcagagcag atgtgatctg
       61 cgctaggtgg catctcctct cacggatgcc tcgatctcgg ggtttccaga agaaaagatc
      121 aagggagaat tatcaagaat agattatttt tctgaatagt taaacctttg atggccataa
      181 ccttgaccct tcagactgca gagatgcagg aaggacttct ggcagtgaag gtaaaggagg
      241 aagaggagga acattcctgt gggccagaat caggcctgtc aagaaataac cctcatacca
      301 gagagatctt tcgtagacgc ttcaggcagt tctgctatca ggagtcccct gggccccggg
      361 aggctcttca aagactccag gagctctgcc atcagtggct gagaccagag atgcacacca
      421 aggagcagat cctagagctg ctggtgctgg agcagttcct gactatcctg cctgaggagc
      481 tccaggcctg ggtcagacag caccgtcctg tgagtggaga ggaggcagtg actgtgctgg
      541 aggatttgga gagagagctg gatgacccag gagagcaggt cctgagccat gctcatgaac
      601 aggaagagtt tgtaaaggag aaggcaactc caggagcagc tcaggagtca tcaaatgacc
      661 aattccaaac cttggaagag caacttgggt ataatttgcg agaggtgtgc ccagttcaag
      721 agattgatgg caaggctggg acttggaatg tggagttagc cccaaagagg gagatttctc
      781 aggaagtgaa atctcttata caagttcttg gaaaacagaa tggtaatatt actcagattc
      841 ctgagtatgg agatacctgt gaccgtgagg gcagattgga aaagcaaagg gtgagctctt
      901 cagtggagag accctatatc tgtagtgaat gtggaaaaag cttcacccag aattccatcc
      961 ttatcgagca ccagagaaca cacacaggtg agaagcctta tgaatgtgat gagtgtgggc
     1021 gggccttcag ccagaggtca ggcctattcc agcaccagag actccacact ggggagaagc
     1081 gctaccagtg cagtgtttgt ggcaaagcct tcagccagaa tgccgggctt ttccatcacc
     1141 tcagaattca cactggggag aagccttacc agtgcaatca gtgcaataag agttttagtc
     1201 gacgttcagt cctcattaag catcagagaa ttcacactgg agagagacct tatgaatgtg
     1261 aagaatgtgg caagaacttc atttaccatt gcaacctaat ccagcatcgg aaagtccacc
     1321 cagtggctga atcaagctag ctccttggaa caggtagggg ataatatttc ttactttgtc
     1381 cctgctgtgt cctctagcat agaaaagttc aagggaaagc cagtaaaaat tcccttactt
     1441 ttatgcagag agaagcataa tatcttaaat acatctgccg agttctctga tcagtgacat
     1501 ccacagcttt gcaatactga atgttgcctc ttgtgttgat ttcatcatgt atgctgtaga
     1561 cctagtttca cacacatctg tgcaagaagt tttctatttc aggaaaactt cttcatccta
     1621 gtttttaaaa acttttttta aaagtttaaa atagttatat gtaggctgag tacaaaataa
     1681 tctcaaatgc agttcaccga gtatttaaaa attaacttaa aaataattgt aataaaattc
     1741 ataatatagg tttcctgact tctttccatt cacataaaat atgataattt gttttgtaac
     1801 ctacaaaaag gggcagatga atcctcctat ataaatgtag atttatagta agttagattt
     1861 ctatagattt tttagttagc ctttaggaac caaggaactg aagcagccat atgttattag
     1921 cagctcagtg gctcctcata acaaatattg ctcatgattt taaatttacg cagaggctaa
     1981 gaaacttagc taaaaatctg atatctcacc tcagatttct tattggaaaa tacaggcctc
     2041 tttgtatttt tcccgtaaca tataatgagc atttttttgt ttttgccttt ttctccttta
     2101 ttcaatattt tgtatggaaa atttgaaaca tattcaagat tgaagagaag agtatgatca
     2161 ctctttcatg ttgattgttt ttataacctc cacattttct cagcatttac tattgattac
     2221 caccaagatc ataaataaaa aaatttattt cccttaacat tgacttagta actctttaca
     2281 aagctttaca caaggtccag gagacaaaga aatggaaaac ctatggtgaa aacaatctgg
     2341 tttggaatac acccaaatac ccaatacata gcaagtaact ttagaataac agaatcactc
     2401 taagggacct tagagatcac ttctgcttgc tcttatttga cagataagag aaaaggaagt
     2461 tctgggaagt aactaagatc atacagccag ttaaaagcag agctggaact agaaccctgt
     2521 ctcctacttc ctagtgtaac attctattaa gccactggag gcattatatc accaaataaa
     2581 aattacaagt atatggaatt tataggattt ataagtcact gaagttgctc aacaaaccca
     2641 cccatttata tgtttcaata aagcacaact cctctattta atttacagtg gagtccagga
     2701 aagactcttc tcatttattc ctcattgaaa gcattttatt tttgtaatta ttatttttag
     2761 cttttaaaat ttaatttact cagtaggact tttttaaaaa gataattcat tcttcacctg
     2821 gttcaaaaat caaaataata caaaaaggtc tactttccct ttataagtag ccattgtact
     2881 agtttcttat gtatctttca gtgtttcttt atgtaaatat aggcaaatat gaatgtataa
     2941 tcttatttct tccattactc aggaagatgg catattattt atactcttct aataccttgc
     3001 tgttttcatg aaagaatata atctttagag atgtccacat cataacagaa cttcttcatt
     3061 ctttttataa gtgaatagaa ttttatttgt tcatactcca tagtttaaca aactcctata
     3121 gatgaaaaat ctcactattt taaaatgtta
//
