LOCUS       NM_181846               4654 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 22 (ZSCAN22),
            transcript variant 1, mRNA.
ACCESSION   NM_181846
VERSION     NM_181846.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4654)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4654)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4654)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4654)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4654)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4654)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   7  (bases 1 to 4654)
  AUTHORS   Matsumoto,N., Fujimoto,M., Kato,R. and Niikawa,N.
  TITLE     Assignment of the human GLI2 gene to 2q14 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 36 (1), 220-221 (1996)
   PUBMED   8812445
REFERENCE   8  (bases 1 to 4654)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   9  (bases 1 to 4654)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
REFERENCE   10 (bases 1 to 4654)
  AUTHORS   Ruppert,J.M., Kinzler,K.W., Wong,A.J., Bigner,S.H., Kao,F.T.,
            Law,M.L., Seuanez,H.N., O'Brien,S.J. and Vogelstein,B.
  TITLE     The GLI-Kruppel family of human genes
  JOURNAL   Mol Cell Biol 8 (8), 3104-3113 (1988)
   PUBMED   2850480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010642.5, BC112277.1 and AC012313.7.
            
            On Nov 23, 2018 this sequence version replaced NM_181846.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537741.1, SRR1803612.18217.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329665.5/ ENSP00000332433.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC010642.5         22934-23046
            114-1694            BC112277.1         1-1581
            1695-4565           AC010642.5         35313-38183
            4566-4654           AC012313.7         450-538
FEATURES             Location/Qualifiers
     source          1..4654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4654
                     /gene="ZSCAN22"
                     /gene_synonym="HKR2; ZNF50"
                     /note="zinc finger and SCAN domain containing 22"
                     /db_xref="GeneID:342945"
                     /db_xref="HGNC:HGNC:4929"
                     /db_xref="MIM:165260"
     exon            1..121
                     /gene="ZSCAN22"
                     /gene_synonym="HKR2; ZNF50"
                     /inference="alignment:Splign:2.1.0"
     exon            122..575
                     /gene="ZSCAN22"
                     /gene_synonym="HKR2; ZNF50"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1648
                     /gene="ZSCAN22"
                     /gene_synonym="HKR2; ZNF50"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 50; zinc finger and SCAN domain-containing
                     protein 22; GLI-Kruppel family member HKR2;
                     krueppel-related zinc finger protein 2"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     22 isoform 1"
                     /protein_id="NP_862829.1"
                     /db_xref="CCDS:CCDS12975.1"
                     /db_xref="GeneID:342945"
                     /db_xref="HGNC:HGNC:4929"
                     /db_xref="MIM:165260"
                     /translation="MAIPKHSLSPVPWEEDSFLQVKVEEEEEASLSQGGESSHDHIAH
                     SEAARLRFRHFRYEEASGPHEALAHLRALCCQWLQPEAHSKEQILELLVLEQFLGALP
                     PEIQAWVGAQSPKSGEEAAVLVEDLTQVLDKRGWDPGAEPTEASCKQSDLGESEPSNV
                     TETLMGGVSLGPAFVKACEPEGSSERSGLSGEIWTKSVTQQIHFKKTSGPYKDVPTDQ
                     RGRESGASRNSSSAWPNLTSQEKPPSEDKFDLVDAYGTEPPYTYSGKRSSKCRECRKM
                     FQSASALEAHQKTHSRKTPYACSECGKAFSRSTHLAQHQVVHTGAKPHECKECGKAFS
                     RVTHLTQHQRIHTGEKPYKCGECGKTFSRSTHLTQHQRVHTGERPYECDACGKAFSQS
                     THLTQHQRIHTGEKPYKCDACGRAFSDCSALIRHLRIHSGEKPYQCKVCPKAFAQSSS
                     LIEHQRIHTGEKPYKCSDCGKAFSRSSALMVHLRIHITVLQ"
     exon            576..4654
                     /gene="ZSCAN22"
                     /gene_synonym="HKR2; ZNF50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4630..4635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN22"
                     /gene_synonym="HKR2; ZNF50"
                     /note="hexamer: AATAAA"
     polyA_site      4654
                     /gene="ZSCAN22"
                     /gene_synonym="HKR2; ZNF50"
                     /note="major polyA site"
ORIGIN      
        1 gtagtcctgg cgggcgtggg cccttgaggt gtgctgggag ctgtggtccg ggtcggcggg
       61 cgcgcaagtt ggctagtctc tgcggccacc tccggaaggg tccgccggct gtgctggtga
      121 ggcccagttc caaggctccg gcatcctgtg tctcactgag cactgctgcc cgatggccat
      181 ccccaagcac tccctgagcc cagtgccgtg ggaagaggac agcttccttc aagtgaaggt
      241 ggaggaggaa gaggaagcca gcctctccca gggcggagaa tccagccatg accacattgc
      301 tcactctgag gctgcacgcc tgcgcttccg gcacttccgc tatgaggagg catctggtcc
      361 acacgaggcc ctggcccacc tccgagcgct gtgctgtcag tggctgcagc ccgaggcgca
      421 ctccaaggag cagatactgg agctgctggt gctggagcag ttcctgggtg cgctgccccc
      481 agagatccaa gcctgggtgg gagcccagag tcccaagagc ggagaggaag ccgctgtgct
      541 ggtggaggat ctgactcagg tgctggacaa gagaggatgg gatccaggag ccgagcccac
      601 agaggcaagc tgcaagcaga gtgacctggg agagtcagag ccatcaaatg tcactgagac
      661 cctcatggga ggtgtttccc ttggacccgc ctttgtcaag gcatgtgaac ctgagggcag
      721 ctcagagagg tctggactat caggggagat ctggacaaag tctgtcaccc aacagatcca
      781 cttcaagaaa acttcagggc cttacaagga tgtccccaca gaccagcgtg gccgtgaatc
      841 tggtgcctcg aggaacagtt ctagtgcgtg gccaaacctc acctcccaag agaagcctcc
      901 ttcagaagac aaatttgatc tggtggatgc ttatgggaca gagcctccat acacctactc
      961 agggaagagg tcctccaagt gtcgcgagtg taggaagatg ttccagagtg cttcggcgct
     1021 cgaggcacac cagaagaccc attctcggaa gaccccatat gcctgcagcg agtgtgggaa
     1081 agccttcagc cggagcactc acctcgccca gcaccaggtt gtccacacag gggcgaagcc
     1141 ccatgagtgt aaggaatgtg ggaaggcctt cagccgagtc acccacctga ctcagcacca
     1201 aaggattcat actggagaga aaccctacaa atgtggggaa tgtggtaaaa ccttcagccg
     1261 cagcactcac ctcacccagc accagcgggt gcacacgggg gagcggccct acgagtgtga
     1321 cgcgtgtggg aaagccttca gccagagcac gcacctgact caacaccagc gcatccacac
     1381 cggggagaag ccctacaagt gtgacgcgtg tggccgagcc ttcagcgact gctcagccct
     1441 gatccgacat ctgagaatcc actctggaga gaagccatat cagtgtaagg tttgtccgaa
     1501 ggcctttgca cagagctcct ccctcattga gcaccagagg atccacacgg gagagaagcc
     1561 ttataagtgc agcgactgtg ggaaggcctt cagtcgtagc tcagccctga tggttcactt
     1621 gcggatccac atcacggtgc tgcaatgacc ggaagtcgcc cctgggggcg tagcacagcg
     1681 tcttctcgga ggctcgaggt ctaagagaaa cgctgagttc ctgaagagcc acagacaggg
     1741 tgggtgattg atgagttgtc aaaatgatag gtgcctgagg gcagactcgg gctgtctagg
     1801 aaccactctg catttgagga accctgatga gcacaaggtg attcaggcca gctggagaag
     1861 cttccagaag ggccctgcac tgctaccctc tatttcccac tcagggctgt cccagagaga
     1921 aggcagccga actgaggatt tagactggtt ctgagggcca gggcaaatga aggcgcatgt
     1981 ctctcagaac tcagcgtccc aagacgctct gggcgggcca actgtagctt gttctcatgt
     2041 ggttcttctt gcctgctttt ctgctgctta gcccagaacg gacacctgcc atgcccacct
     2101 ctgtgccttg gcacctacta tttccactcc agactatttt gtgcctaact gcaaggctga
     2161 cttttgagac tgcctcttcc acgatgcctt ttctacactc tgcctctctc atggtttcct
     2221 gtcgtaatca gtggtgctgc ttgacacctg cccagcatgt tcctgtctct ccttttcctt
     2281 ccacatccca ccagtcacca gcgctattgt tttaacctaa agcttatctg taattcacct
     2341 ccttttccac cactgctacc ttatgtgagc cctcattgcc tcttgcctgg attatagccg
     2401 gggtctcctt cctgaccact tcctgccttt attctctgcc cctgtatcac tctccagggg
     2461 actcttgata ttacttagat ctgactgtgt cactccaagg tggaaagctc tccaacccat
     2521 cttctacagc acagcttcct gaacagggta taagtatgct gagatgcagg ctgctctggg
     2581 ccccgagcaa cctctccagt tatcctcata tgcatgtatg aatactgtca tttttctgtg
     2641 cgtgcagtga aaatggcctc atctcatacc atggctccac cttccataca ccagccacac
     2701 ggaactactg tggtccctga aggagccata cattttccca cttatgtgcc tttgtacctg
     2761 tgcctggaac cctcctcttc tttttctttt tcttttcttt tctttttttt tttttgagat
     2821 ggagtctcgc tctgtcgccc aggctggagt gcagtggcgc gatctcggct cactgcaagc
     2881 tctgcctccc gggttcatgc cattctcctg cctcagcctc ccaagtagct gggactacag
     2941 gcgcctgcca ccacgcccag ctagtttttt tttttttttg tatttttagt agagatggag
     3001 tttcaccatg ttagccagga tggtctcgat ctcctgacct cgtgatccac ccgcctcggc
     3061 ctcccaaagt gctgggatta caggcgtgag ccaccgcacc tggccctcct ttttcatcta
     3121 aggtgtttca aatgttgccc aaagaaacct ccctgctctc cgggagcaga cttcagcttg
     3181 ccctctctgc ttccagagca cctcctagat acctctctta caactcctgc caccttgttt
     3241 tacttatttg ctccttgtag agctgccttt tccaaggata ccataaactc ctgagagcag
     3301 gggccatgtc ttactctcag tatctacaac acacaagact cagtaggccc tgactgatgt
     3361 ctcttacatg aatgtgactg gtgcccccag gaggcagtca ccgtgctgtc tctgccccac
     3421 attgtcctta tgtatgttta catggatgtc tccccagcag cttgaaccct ggagagcaag
     3481 aataatctga ttttcctggg ggccagcacc caaataagcc tggcatgcag tggcctcaat
     3541 aaaatgtgac tgtattgagt cattttctag ggccccagat cccctggtgt catggactta
     3601 gtctttgcca gcattctgtc catgtgttct ctggtcttct ctcacaatgc tgcatccctg
     3661 tcccattttt agggtccctg tctatcactg gatgctgcag cttctgttca ttactgttag
     3721 tgtatcattc ttcatgcctc tgtttctgtg atggtctcat catatgtgaa ccatttgacc
     3781 tggcgtattg tgtactagtc accgtcacca tctctccata tgtatctccc tgtatttcgg
     3841 gcccattccc tctatgtcaa gagtaaatag aggcacagag actgatgaga aacgttcata
     3901 acatgaaggt aagactcagg gagacagaga ctttgtggaa gtatctctga gggagtccca
     3961 gacacaggca gagagggcca catatcgtgt gccagaggct gagagactga gagggatgac
     4021 aggcttaggg gaaaactcag agaggagaga tgcacattcc tagtgaaatt gcacaggctt
     4081 ccagcatgct ggagggaaca gaaaaggcat gggcctgaat tcaggctgca gagcctgact
     4141 cctccctgtg gctacttttg ggacctaaga taagtgactt tcctgaacct ccatgacctc
     4201 ctcatatgta aaccagggac aggacccacc ttgtgtagtg cctgacccaa agcctggccc
     4261 tgcacactgt ctctgactca cagcaatcat cagcacctct ctttgcctcc tacttgctca
     4321 gtctctgtca caagaactgg atctccatcc ccttgatgct ctgagcatct tcacccattt
     4381 ggtcgttgag acatatctgt ccatgtctgt ctaaaagggg aggagatgag ggagaaaaaa
     4441 gggaatctac tcagagcctg tgtgtgctgc ccagtctacc aaataattta tatacatctc
     4501 agtcctcaca caaccatccc tgttttatag aggaggaagt ggcttagaga atgtaactga
     4561 ccaaagtcac actgccagga actggaagca ctaggatttg acagcatatc caaatatgtc
     4621 agcaatttca ataaacatga ctgtactcaa caaa
//
