LOCUS       NM_145914               2009 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 21 (ZSCAN21),
            transcript variant 3, mRNA.
ACCESSION   NM_145914
VERSION     NM_145914.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2009)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2009)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2009)
  AUTHORS   Lassot,I., Mora,S., Lesage,S., Zieba,B.A., Coque,E., Condroyer,C.,
            Bossowski,J.P., Mojsa,B., Marelli,C., Soulet,C., Tesson,C.,
            Carballo-Carbajal,I., Laguna,A., Mangone,G., Vila,M., Brice,A. and
            Desagher,S.
  TITLE     The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate alpha-Synuclein
            Expression by Regulating ZSCAN21
  JOURNAL   Cell Rep 25 (9), 2484-2496 (2018)
   PUBMED   30485814
  REMARK    GeneRIF: deregulation of the TRIM17/TRIM41/ZSCAN21 pathway may be
            involved in the pathogenesis of Parkinson's disease.
REFERENCE   4  (bases 1 to 2009)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2009)
  AUTHORS   Clough,R.L., Dermentzaki,G. and Stefanis,L.
  TITLE     Functional dissection of the alpha-synuclein promoter:
            transcriptional regulation by ZSCAN21 and ZNF219
  JOURNAL   J Neurochem 110 (5), 1479-1490 (2009)
   PUBMED   19549071
REFERENCE   6  (bases 1 to 2009)
  AUTHORS   Carneiro,F.R., Silva,T.C., Alves,A.C., Haline-Vaz,T., Gozzo,F.C.
            and Zanchin,N.I.
  TITLE     Spectroscopic characterization of the tumor antigen NY-REN-21 and
            identification of heterodimer formation with SCAND1
  JOURNAL   Biochem Biophys Res Commun 343 (1), 260-268 (2006)
   PUBMED   16540086
  REMARK    GeneRIF: This result indicates that NY-REN-21 can function either
            as a homodimer or as a heterodimer with SCAND1.
REFERENCE   7  (bases 1 to 2009)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   8  (bases 1 to 2009)
  AUTHORS   Rousseau-Merck,M.F., Duro,D., Berger,R. and Thiesen,H.J.
  TITLE     Chromosomal localization of two KOX zinc finger genes on chromosome
            bands 7q21-q22
  JOURNAL   Ann Genet 38 (2), 81-84 (1995)
   PUBMED   7486829
REFERENCE   9  (bases 1 to 2009)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093619.5, BI764964.1, BC047309.1 and BM991519.1.
            
            On May 17, 2019 this sequence version replaced NM_145914.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.232083.1,
                                           SRR1660803.104113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292450.9/ ENSP00000292450.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC093619.5         24137-24156         c
            21-27               BI764964.1         1-7
            28-2005             BC047309.1         1-1978
            2006-2009           BM991519.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..2009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2009
                     /gene="ZSCAN21"
                     /gene_synonym="NY-REN-21; Zipro1; ZNF38"
                     /note="zinc finger and SCAN domain containing 21"
                     /db_xref="GeneID:7589"
                     /db_xref="HGNC:HGNC:13104"
                     /db_xref="MIM:601261"
     exon            1..68
                     /gene="ZSCAN21"
                     /gene_synonym="NY-REN-21; Zipro1; ZNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            69..563
                     /gene="ZSCAN21"
                     /gene_synonym="NY-REN-21; Zipro1; ZNF38"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1586
                     /gene="ZSCAN21"
                     /gene_synonym="NY-REN-21; Zipro1; ZNF38"
                     /note="isoform 1 is encoded by transcript variant 3; zinc
                     finger protein 38 (KOX 25); zinc finger protein NY-REN-21
                     antigen; zinc finger and SCAN domain-containing protein
                     21; zfp-38; zinc finger protein 38 homolog; renal
                     carcinoma antigen NY-REN-21"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     21 isoform 1"
                     /protein_id="NP_666019.1"
                     /db_xref="CCDS:CCDS5681.1"
                     /db_xref="GeneID:7589"
                     /db_xref="HGNC:HGNC:13104"
                     /db_xref="MIM:601261"
                     /translation="MMTKVLGMAPVLGPRPPQEQVGPLMVKVEEKEEKGKYLPSLEMF
                     RQRFRQFGYHDTPGPREALSQLRVLCCEWLRPEIHTKEQILELLVLEQFLTILPQELQ
                     AWVQEHCPESAEEAVTLLEDLERELDEPGHQVSTPPNEQKPVWEKISSSGTAKESPSS
                     MQPQPLETSHKYESWGPLYIQESGEEQEFAQDPRKVRDCRLSTQHEESADEQKGSEAE
                     GLKGDIISVIIANKPEASLERQCVNLENEKGTKPPLQEAGSKKGRESVPTKPTPGERR
                     YICAECGKAFSNSSNLTKHRRTHTGEKPYVCTKCGKAFSHSSNLTLHYRTHLVDRPYD
                     CKCGKAFGQSSDLLKHQRMHTEEAPYQCKDCGKAFSGKGSLIRHYRIHTGEKPYQCNE
                     CGKSFSQHAGLSSHQRLHTGEKPYKCKECGKAFNHSSNFNKHHRIHTGEKPYWCHHCG
                     KTFCSKSNLSKHQRVHTGEGEAP"
     exon            564..756
                     /gene="ZSCAN21"
                     /gene_synonym="NY-REN-21; Zipro1; ZNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            757..2009
                     /gene="ZSCAN21"
                     /gene_synonym="NY-REN-21; Zipro1; ZNF38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN21"
                     /gene_synonym="NY-REN-21; Zipro1; ZNF38"
                     /note="hexamer: AATAAA"
     polyA_site      2009
                     /gene="ZSCAN21"
                     /gene_synonym="NY-REN-21; Zipro1; ZNF38"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggt gcgcggtccc gaggtacgcg gtgcggtctc ccggtacccg gagcggctct
       61 gattcatggt ttaacttgtg gccctaaaga actggaaacc caaaggaacg aatattcctg
      121 ccccacagag tcccatcttt ggtgaggctg tttctggagt ttacatgatg accaaggtac
      181 taggcatggc cccagttctg ggccctaggc ctccacagga gcaggtgggg cctctgatgg
      241 taaaagtcga ggagaaagaa gagaaaggca agtaccttcc tagcctggag atgttccgcc
      301 agcgcttcag gcagtttggg taccatgata cccctggacc ccgagaggcc ctgagccaac
      361 tccgggtgct ctgctgtgag tggctgaggc ccgagatcca caccaaggag cagatcctgg
      421 agctactggt gctggagcag ttcctgacca tcctgcccca ggagctccag gcctgggtgc
      481 aggagcattg cccggagagc gctgaagagg ctgtcactct cctcgaagat ctggagcggg
      541 aactggatga gccaggacac caggtctcaa ctcctccaaa cgaacagaaa ccggtgtggg
      601 agaagatatc ctcctcagga actgcaaagg aatccccgag cagcatgcag ccacagccct
      661 tggagaccag tcacaaatac gagtcttggg ggcccctgta catccaagag tctggtgagg
      721 agcaggagtt cgctcaagat ccaagaaagg tccgagattg cagattgagt acccagcacg
      781 aggaatcagc agatgagcag aaaggttctg aagcagaggg gctcaaaggg gatataattt
      841 ctgtgattat cgccaataaa cctgaggcca gcttagagag gcagtgcgta aaccttgaaa
      901 atgaaaaagg aacaaaaccc cctcttcaag aggcaggctc caagaaaggt agagaatcag
      961 ttcctactaa acctacccca ggagagagac gttatatatg tgctgaatgt ggcaaagcct
     1021 ttagtaatag ctcaaatctc accaaacaca ggagaacaca cactggggag aaaccttacg
     1081 tgtgcaccaa gtgtgggaaa gctttcagcc acagctcaaa cctcaccctc cactacagaa
     1141 cacacttggt ggaccggccc tatgactgta agtgtggaaa agcttttggg cagagctcag
     1201 accttcttaa acatcagaga atgcacacag aagaggcgcc atatcagtgc aaagattgtg
     1261 gcaaggcttt cagcgggaaa ggcagcctca ttcgtcacta tcggatccac actggggaga
     1321 agccttatca gtgtaacgaa tgtgggaaga gcttcagtca gcatgcgggc ctcagctccc
     1381 accagagact ccacaccgga gagaagccat ataagtgtaa ggagtgtggg aaagccttca
     1441 accacagctc caacttcaat aaacaccaca gaatccacac cggggaaaag ccctactggt
     1501 gtcatcactg tggaaagacc ttctgtagca agtccaatct ttccaaacat cagcgagtcc
     1561 acactggaga gggagaagca ccgtaacttt caagcgctcc tgttgttgtc gttgttttaa
     1621 actttagaat ctgaaaacca gaaagaagtc ttgtcattgc agcagcatcg attccggtga
     1681 tagagtttgt atcactcaac atcaggggat gcctgaggag tgcgagctcc acagcaacat
     1741 ggcaggcagg aggtcctcag aaggtgtcag gaggttccac actcgccagt tcactggagc
     1801 agagtccctt cgccacactt agggtcccag taagccatgc cagcattacc ttttgcgtag
     1861 ttaaacagac gtgtatccag tctagttaag gaagaaacat taagattgtt taatttttaa
     1921 catatattca agaattttaa tttgtaaaga attgagccac attgaacaca attgaatgag
     1981 attcagaata aacttataac atcttgtaa
//
